Aerosolized Hydrogen Peroxide Decontamination of N95 Respirators, with Fit-Testing and Viral Inactivation, Demonstrates Feasibility for Reuse during the COVID-19 PandemicArticle Published on 2022-10-262022-11-15 Journal: mSphere [Category] COVID19(2023년), SARS, 진단, [키워드] absorbed acute respiratory syndrome aerosolized hydrogen peroxide Aerosols Bacterial baseline Biosafety Level 3 BSL3 Care Clinical use comparable coronavirus COVID-19 COVID-19 pandemic coxsackievirus Critical CURIS decontamination develop Disinfection effective Efficiency evaluated experimental validation External filtering facepiece (FFP) respirators (FFR) filtration fit-testing greater Health Health care worker herpes simplex HSV-1 hydrogen hydrogen peroxide inactivation include indicated limit limitation Multiple N95 respirator N95 respirators occupational pandemic pathogen peroxide Personal protective equipment Protective provided Quantitative Research Respirator respirators respiratory droplet Result reuse Safe Safety SARS-CoV-2 SARS-CoV2 spores Sterilization These data transmitted Treatment viral inactivation virologic testing virus while [DOI] 10.1128/msphere.00303-22 PMC 바로가기
A Multicenter Clinical Diagnostic Accuracy Study of SureStatus, an Affordable, WHO Emergency Use-Listed, Rapid, Point-Of-Care Antigen-Detecting Diagnostic Test for SARS-CoV-2Article Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] 95% confidence interval access Accuracy acute respiratory syndrome Ag-RDT Ag-RDTs Analysis Antigen-detecting rapid diagnostic tests B.1.1.7 characterized circulating clinical Combination complement coronavirus COVID-19 Critical cycle threshold demonstrated diagnostic Emergency Emergency use evaluated facilitate Factor Germany gold standard highlight independent India multicenter nasopharyngeal Oropharyngeal overcome participant Participants performance performed point-of-care positive post-symptom onset questionnaire raised Rapid Rapid diagnostic test recruited resources reverse transcription-PCR RT-PCR RT-PCR testing SARS-CoV-2 SARS-COV-2 infection sensitivity specificity subgroup subgroups Support SUS Swab symptom duration symptom onset Symptoms Test Transmission variant Viral load was used WHO widespread World Health Organization [DOI] 10.1128/spectrum.01229-22 PMC 바로가기
Comparative Assessment of Severe Acute Respiratory Syndrome Coronavirus 2 Variants in the Ferret ModelArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome Airborne transmission Analysis assessment Beta changes Comparative Contact coronavirus coronavirus 2 COVID-19 Critical Delta disease evaluate ferret ferrets genomic variant Heterologous highest histopathological homologous homologous or heterologous Human in vivo infection with SARS-CoV-2 inoculated lineages lowest Mild Model offered pandemic Particle pathogenicity provided Reinfection replicated Replication replication kinetics respiratory respiratory tract risk RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strains SARS-CoV-2 variant Spread Strains Surveillance the spike protein the United State Transmissibility Transmission transmitted upper respiratory tract USA-WA1/2020 variant variants virulence virus virus infection virus load WA1 while [DOI] 10.1128/mbio.02421-22 PMC 바로가기
SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived CellsArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] activate Activation activities activity acute respiratory syndrome betacoronaviruses Cell cellular change coronavirus country Critical death downstream Endoplasmic reticulum enzyme ER stress examined expression of gene functions Gene Expression HCoV-OC43 Host host cell host cells host immune system Human human cell human cells imperative individual induce infect Infection inhibit interact IRE1α pathway less limit MERS-CoV MHV Middle East molecular mechanism mRNA murine OC43 Other other coronavirus pathway Prevent processed Replication required Respiratory Coronavirus respiratory syndrome coronavirus Reticulum RNase SARS-CoV SARS-CoV-2 SARS-COV-2 infection severe respiratory disease signaling pathway similarity splice Spread Stress tested the interferon transcription factor Trigger unfolded protein response UPR Vaccine viral replication virus XBP1 [DOI] 10.1128/mbio.02415-22 PMC 바로가기
Singleplex, multiplex and pooled sample real-time RT-PCR assays for detection of SARS-CoV-2 in an occupational medicine settingArticle Published on 2022-10-222022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] 2019-nCoV addition Analysis Asymptomatic CDC clinical sample condition Contact COVID COVID-19 COVID-19 disease Critical defined Detection limit diagnostic diagnostic test disease equipment FDA flexible healthcare high risk implication include Infection limit methodology multiplex overlap pandemic Pandemics Panel Patient Population positive sample progressed reagent real-time RT-PCR resource resources RT-PCR SARS-CoV-2 sensitivity spread of COVID-19 symptomatic Symptomatic patients tested Transmission was determined [DOI] 10.1038/s41598-022-22106-2 PMC 바로가기
Effectiveness of inactivated and Ad5-nCoV COVID-19 vaccines against SARS-CoV-2 Omicron BA. 2 variant infection, severe illness, and deathArticle Published on 2022-10-202022-11-15 Journal: BMC Medicine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] 1:1 Administering administration all age group all age groups booster dose case-control study conducted Control COVID-19 COVID-19 vaccine COVID-19-related death Critical death deaths diagnosed died dose effective Effectiveness eligible Gender illness onset inactivated Inactivated vaccine individual individuals infected individual Infection Limited omicron outcomes progressed provided SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2-infected individuals selected severe COVID-19 subset sustained vaccination Vaccine vaccine effectiveness variant [DOI] 10.1186/s12916-022-02606-8 PMC 바로가기
A Closed-Loop Approach to Fight Coronavirus: Early Detection and Subsequent TreatmentArticle Published on 2022-10-202022-11-15 Journal: Biosensors [Category] COVID19(2023년), SARS, 치료기술, [키워드] biosensing caused Complication coronavirus COVID-19 COVID-19 pandemic Critical detection Diagnosis early diagnosis effective electrical Epidemic epidemic control Health helping include Infection invasive manuscript MONITOR neurostimulation patients photoacoustic imaging reducing respiration monitor. SARS-CoV-2 Severe patient Ventilation ventilator [DOI] 10.3390/bios12100900 PMC 바로가기
Prevention of ribosome collision-induced neuromuscular degeneration by SARS CoV-2-encoded Nsp1Article Published on 2022-10-182022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ABCE1 abort acute respiratory syndrome affecting AKT Alzheimer’s disease autophagy biochemical analysis combating condition coronavirus COVID-19 pandemic Critical disease Diseases Drosophila effective exhibited Factors Genetic Host hosts mechanism modify neurodegenerative nonstructural protein 1 nsp1 overexpression pathogenic mechanism phenotype prevention Protein Quality control quality-control rescued Research ribosome collision ribosome-associated quality control. ribosomes SARS-CoV-2 Signaling specificity therapeutic strategy translation Treatment virus [DOI] 10.1073/pnas.2202322119 PMC 바로가기
Therapeutic strategy targeting host lipolysis limits infection by SARS-CoV-2 and influenza A virusArticle Published on 2022-10-172022-11-15 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 치료제, [키워드] Activation administration antiviral target cell injury Combination COVID-19 Critical Cytokine storm dependent on drugs facilitate FFA FFAs free fatty acid Host humans IAV Infection influenza A virus inhibitor inhibitors investigated late stage LDs limit Lipid lipid droplet lipolytic lung lung lesion Malnutrition membrane transporter mice mitigate Mortality outbreak pandemic patients pharmacological Proinflammatory cytokine PROTECT reduce Replication replication of SARS-CoV-2 rescued RNA RNA virus SARS-CoV-2 SARS-CoV-2-infected hamsters significantly suppressed therapeutic target Treatment viral infections virus virus-infected cell [DOI] 10.1038/s41392-022-01223-4 PMC 바로가기
Development of Single-Cell Transcriptomics and Its Application in COVID-19Article Published on 2022-10-162022-11-16 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory distress acute respiratory syndrome application ARDS asymptomatic infection basic reproduction number caused claimed clinical manifestation clinical manifestations component coronavirus coronavirus disease COVID-19 COVID-19 diagnosis COVID-19 research Critical death development differentially expressed gene examined Health immune immune response IMPROVE individual cells mutate offered over physiological resulting SARS-CoV-2 Sequencing single-cell Single-cell transcriptomics syndrome transcriptomics Treatment variety [DOI] 10.3390/v14102271 PMC 바로가기