Distinct Antibody Responses to Endemic Coronaviruses Pre- and Post-SARS-CoV-2 Infection in Kenyan Infants and Mothers케냐 유아와 산모의 SARS-CoV-2 감염 전 및 후 풍토성 코로나바이러스에 대한 독특한 항체 반응Article Published on 2022-07-122022-09-12 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] alphacoronavirus antibody Antibody binding association Betacoronavirus boosting cause Cohort coronavirus COVID-19 cross-react cross-reactive cross-reactive antibody cross-reactivity Endemic endemic human coronavirus Evidence HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 highly pathogenic IgG IgG antibody titer Infant Infants Kenya lack levels of antibody memory response mother mothers. response risk SARS-CoV-1 SARS-CoV-1 infection SARS-CoV-2 SARS-CoV-2 antibodies SARS-COV-2 infection Seroconversion unlikely women [DOI] 10.3390/v14071517 PMC 바로가기 [Article Type] Article
Omicron Booster in Ancestral Strain Vaccinated Mice Augments Protective Immunities Against Both Delta and Omicron Variants조상 균주 백신 접종 마우스의 오미크론 부스터는 델타 및 오미크론 변이체 모두에 대한 보호 면역 강화Article Published on 2022-07-062022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] Against antibody Antibody Response Antibody responses boost booster booster vaccination CD8 COVID-19 vaccine cross-protective cross-reactive cross-reactivity cross-reactivity. Delta DNA vaccine DNA vaccines elicited Epidemic immunized mice mice Neutralizing antibody response neutralizing antibody responses no significant difference omicron Omicron variant Omicron variants Omicron-matched vaccine RBD binding SARS-CoV-2 significant difference Specific Spike protein Spike proteins strain T cell T cell response T cell responses the spike protein Vaccine variant variants were measured Wuhan strain [DOI] 10.3389/fimmu.2022.897879 PMC 바로가기 [Article Type] Article
Dengue Infection – Recent Advances in Disease Pathogenesis in the Era of COVID-19뎅기열 감염 - COVID-19 시대의 질병 병인의 최근 발전Review Published on 2022-07-062022-09-12 Journal: Frontiers in Immunology [Category] MERS, 진단, [키워드] activated activating advance anti-SARS-CoV-2 Antibody-dependent enhancement antibody-dependent enhancement (ADE) consequence COVID-19 cross-protection cross-reactivity cytokine Cytokine storm demonstrated Dengue dengue (DENV) dengue virus element Endemic endothelial Endothelial dysfunction Host host-virus interactions immune Immune cell immune response Immunopathogenesis impairment implication Inflammasome inflammatory cascade Pathogenesis plasmablast plasmablasts preclinical study recent response secondary infections serotype severe disease Severity of disease Surveillance virus [DOI] 10.3389/fimmu.2022.889196 PMC 바로가기 [Article Type] Review
Clinical Performance of Three Commercial SARS-CoV-2 Rapid Antigen Tests for Community-Dwelling Individuals in a Tropical Setting열대 환경에서 커뮤니티 거주 개인을 위한 3가지 상용 SARS-CoV-2 신속 항원 검사의 임상 성능Multicenter Study Published on 2022-07-052022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] analytical sensitivity Antigen antigen test biosensor carried Certest clinical clinical performance. Clinical use country COVID-19 pandemic cross-reactivity detect Ecuador genomic Genomic surveillance gold gold standard IMPROVE individual individuals infectious agent International Laboratory limit of detection market multicenter Mutation Nasopharyngeal swab nasopharyngeal swabs new SARS-CoV-2 performance point of care positive prevalent Rapid RapiGEN RapiGEN® Ag test kit reduction in regulatory agencies RT-qPCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 surveillance SARS-CoV-2 transmission SARS-CoV-2 variants SARS–CoV–2 SD-Biosensor sensitivity setting shown South America South Korea Spain specificity Surveillance symptomatic individuals Test tested tropical variant [DOI] 10.3389/fcimb.2022.832235 PMC 바로가기 [Article Type] Multicenter Study
Clinical evaluation of the GSD NovaPrime® SARS-CoV-2 RTq-PCR assayGSD NovaPrime® SARS-CoV-2 RTq-PCR 분석의 임상 평가Article Published on 2022-07-012022-09-11 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification analyses another respiratory virus clinical clinical evaluation clinical history collected coronavirus COVID-19 COVID-19 outbreak cross-reactivity cycle threshold detect Discordance evaluated GSD nasopharyngeal sample Nasopharyngeal samples nucleocapsid other respiratory virus Other respiratory viruses positive qPCR respiratory viruses RNA sequence RNA sequences RT-qPCR SARS-CoV-2 severe acute respiratory syndrome Coronavirus specimen the patient [DOI] 10.1016/j.diagmicrobio.2022.115718 PMC 바로가기 [Article Type] Article
Sensitive and specific clinically diagnosis of SARS-CoV-2 employing a novel biosensor based on boron nitride quantum dots/flower-like gold nanostructures signal amplification질화붕소 양자점/꽃모양 금 나노구조 신호 증폭 기반의 새로운 바이오센서를 이용한 SARS-CoV-2의 민감하고 구체적인 임상 진단Article Published on 2022-07-012022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] amplification biosensor Boron boron nitride carbon characteristic clinical sample clinical samples clinical trials clinically comparable COVID-19 COVID-19 outbreak COVID-19 pandemic cross-reactivity cutoff value Detection limit Diagnosis diagnosis of SARS-CoV-2 DNA Effect electrochemical biosensor evaluate form gold group growth Health Health crisis IAV Influenza influenza A Mutation nucleic acid nucleic acid amplification Patient platform point-of-care positive quantitation Quantitative receiver operating characteristic receiver operating characteristic curve remained RNA RNA fragment RT-PCR SARS-CoV-2 SARS-CoV-2 RNA Screen sensitive sensitivity significant difference specificity ssDNA statistical analysis t-test virus diagnosis was tested [DOI] 10.1016/j.bios.2022.114209 PMC 바로가기 [Article Type] Article
Anti-IFN-α/-ω neutralizing antibodies from COVID-19 patients correlate with downregulation of IFN response and laboratory biomarkers of disease severityCOVID-19 환자의 항-IFN-α/-ω 중화 항체는 IFN 반응의 하향조절 및 질병 중증도의 실험실 바이오마커와 상관관계가 있습니다Article Published on 2022-07-012022-09-11 Journal: European Journal of Immunology [Category] MERS, 바이오마커, 진단, 치료기술, [키워드] Antiviral association autoantibodies autoantibodies, SARS-CoV-2 binding binding antibodies binding antibody biochemical characterized COVID-19 COVID-19 patient cross-reactivity CRP D-dimer dimer disease severity downregulation fluctuation Gene Expression hematological parameters ICU IFN IFN response IFN-stimulated gene IFN-stimulated genes IFN-α interferon ISG ISGs laboratory biomarker laboratory biomarkers LDH male Neutralizing antibodies neutralizing antibody outcome Patient patients positive positive patient proportion quantified reduced respiratory Respiratory samples screened sera serum severe COVID-19 shown specificity subset tested transcript levels [DOI] 10.1002/eji.202249824 PMC 바로가기 [Article Type] Article
Serological Follow-Up Study Indicates High Seasonal Coronavirus Infection and Reinfection Rates in Early Childhood혈청학적 후속 연구는 유아기에 높은 계절성 코로나바이러스 감염 및 재감염율을 나타냅니다Article Published on 2022-06-292022-09-12 Journal: Microbiology Spectrum [Category] MERS, 진단, [키워드] 229E age analyzed antibodies antibody antibody level Antibody Response caused changes in Characteristics childhood children collected coronavirus Coronavirus infection correlation cross-reactivity declined elicited enzyme enzyme immunoassay Follow-up follow-up study groups HKU1 human coronavirus humoral immune response IgG antibody immunoassay Increased indicated Infection information knowledge NL63 observation OC43 Primary infection Rate Reinfection respiratory infection respiratory infections seasonal seasonal coronavirus serological serology seropositive serum specific antibody specimen spread of COVID-19 suggested the antibody virus were measured [DOI] 10.1128/spectrum.01967-21 PMC 바로가기 [Article Type] Article
Antibodies targeting conserved non-canonical antigens and endemic coronaviruses associate with favorable outcomes in severe COVID-19보존된 비정규 항원 및 풍토성 코로나바이러스를 표적으로 하는 항체는 심각한 COVID-19에서 유리한 결과와 연관됩니다Article Published on 2022-06-282022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis antibody antibody profiling Antigen antigenic association canonical cellular Cellular and humoral responses conserved coronavirus Coronaviruses COVID-19 CP: Immunology CP: Microbiology cross-reactive cross-reactivity defined disease domain Endemic Endemic coronaviruses healthy control Humoral response immunology less membrane Microbiology molecular non-canonical antigens nsp13 Nsp3 nucleocapsid ORF3a ORF8 outcome predict predictor profile profiles Protein Receptor-binding domain respiratory SARS-CoV-2 severe COVID-19 severe COVID-19 patients severity Specificities specificity survival systems immunology Viral Viral antigen viral antigens while [DOI] 10.1016/j.celrep.2022.111020 PMC 바로가기 [Article Type] Article
Electrochemical Impedance-Based Biosensors for the Label-Free Detection of the Nucleocapsid Protein from SARS-CoV-2SARS-CoV-2에서 뉴클레오캡시드 단백질의 라벨 없는 검출을 위한 전기화학적 임피던스 기반 바이오센서Article Published on 2022-06-242022-09-11 Journal: ACS Sensors [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] 96-well plates acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen antigens biosensor Chain Reaction coronavirus coronavirus disease COVID-19 cross-reactivity detect detection detection antibody diagnose Diagnosis Electrochemical sensor impedance interactions involved Label-free detection limit of detection measure N protein nucleocapsid nucleocapsid protein offer PCR polymerase chain polymerase chain reaction Protein quantified real-time polymerase chain reaction S protein SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spread the N protein the S protein time-consuming ToAD while [DOI] 10.1021/acssensors.2c00317 PMC 바로가기 [Article Type] Article