Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors †Chemistry Published on 2020-09-012022-10-31 Journal: Chemical Science [Category] COVID-19, [키워드] acting clinically compounds conserved coronavirus cysteine cysteine protease domain drug resistance drug target Ebselen FIVE functional Helicase identify in viral inhibit inhibit SARS-CoV-2 nsp13 outbreak pandemic physical predicted protease Protein Proteins reduce Replication Safe SARS-CoV-2 Stage transcription factor Treatment Virus life cycle virus replication [DOI] 10.1039/d0sc02646h PMC 바로가기 [Article Type] Chemistry
Structural basis of SARS-CoV-2 3CLpro and anti-COVID-19 drug discovery from medicinal plantsResearch article Published on 2020-08-012022-10-05 Journal: Journal of Pharmaceutical Analysis [Category] 변종, 신약개발, [키워드] 3CLpro acute respiratory syndrome analysed Analysis Anti-viral caused Chinese compounds Control coronavirus coronavirus disease Coronavirus replication COVID-19 cysteine protease Drug discovery enzyme genome sequence Health homology model MERS-CoV Middle East molecular docking Molecular dynamics simulation natural products nine pandemic plant Protein homology modelling raised recent respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 screened sequence [DOI] 10.1016/j.jpha.2020.03.009 [Article Type] Research article
Evolving geographic diversity in SARS-CoV2 and in silico analysis of replicating enzyme 3CL pro targeting repurposed drug candidatesResearch Published on 2020-07-092022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, SARS, [키워드] 3CL pro acute respiratory syndrome African analysed anti-malarial drug Anti-viral bat-CoV Clustal Omega collected Complete Compound cysteine protease database drug candidate enzyme fatality Genetic Genome genomic sequence GISAID high mutation rate host genome host immunity identity implication in silico analysis in silico approaches in-depth analysis individual infection rate inhibitor initiative Interaction isolate Local Multiple mutagenic mutations occurred pandemic Pandemics pangolin-CoV pathogen pathogenicity pharmacological populations provide recurrent mutation reference genome regulate reported Repurposed drug Result RNA SARS Coronavirus SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 infected patients SARS-CoV2 sequence South South America the SARS-CoV-2 unique viral genome viral pathogenicity viral replication viral sequence was collected was used Wuhan [DOI] 10.1186/s12967-020-02448-z PMC 바로가기 [Article Type] Research
Potential therapeutic use of ebselen for COVID-19 and other respiratory viral infectionsArticle Published on 2020-06-262023-06-16 Journal: Free radical biology & medicine [Category] MERS, SARS, [키워드] cysteine protease Lung inflammation Organoselenium compounds SARS-CoV-2 [DOI] 10.1016/j.freeradbiomed.2020.06.032 PMC 바로가기
Docking, synthesis and antimalarial activity of novel 4-anilinoquinoline derivativesArticle Published on 2017-04-152024-08-27 Journal: Bioorganic & Medicinal Chemistry Letters [Category] 말라리아, [키워드] 4-Anilinoquinoline triazine cysteine protease Falcipain-2 malaria Plasmodium falciparum β-haematin
The Salmonella Effector SpvD Is a Cysteine Hydrolase with a Serovar-specific Polymorphism Influencing Catalytic Activity, Suppression of Immune Responses, and Bacterial Virulence *살모넬라 효과 인자 SpvD는 카탈리틱 활성, 면역 반응 억제 및 박테리아 병원성에 영향을 미치는 세로바 특이적 다형성을 가진 시스테인 하이드롤라제입니다.Article Published on 2016-12-092024-07-29 Journal: Brain stimulation [Category] 살모넬라증, [키워드] Bacterial pathogenesis crystal structure cysteine protease effector Salmonella enterica structure-function [DOI] 10.1074/jbc.M116.752782 PMC 바로가기
Independent amino acid residues in the S2 pocket of falcipain-3 determine its specificity for P2 residues in substratesarticle Published on 2015-08-312024-09-01 Journal: Molecular and Biochemical Parasitology [Category] 말라리아, [키워드] cysteine protease Falcipain malaria Plasmodium S2 pocket [Article Type] article
New Tetromycin Derivatives with Anti-Trypanosomal and Protease Inhibitory Activities †Article Published on 2011-09-262022-10-30 Journal: Marine Drugs [Category] Coronavirus, [키워드] activity Analysis anti-trypanosomal antiparasitic assigned Axinella cathepsin B cathepsin L Compound cysteine protease derivative derivatives Leishmania major marine sponge New NMR spectroscopy protease protease inhibition SARS-CoV M Streptomyce Streptomyces axinellae Structure tested tetromycin Trypanosoma [DOI] 10.3390/md9101682 PMC 바로가기 [Article Type] Article