damage – Page 7 – Communicable Diseases Research

The COVIDome Explorer researcher portal

COVIDome Explorer 연구원 포털

Article

Published on 2021-08-172022-09-11
Journal: Cell Reports [Category] MERS, 유전자 메커니즘, 진단,

Patterns of within-host genetic diversity in SARS-CoV-2

SARS-CoV-2의 숙주 내 유전적 다양성 패턴

Research Article

Published on 2021-08-132022-09-10
Journal: eLife [Category] MERS, SARS, 변종, 치료기술,

[키워드] accumulation addition allele frequencies allele frequency analyses Analysis caution Co-infection consensus genome convergent evolution COVID-19 pandemic damage detectable determine develop Diversity driving eLife epidemiological Evolution example Factor focus genetic code genetic diversity genetic material Genetic testing genetic tests genetics globe Government Health help homoplasies Host hosts identify Impact individual individuals infected individuals Infection information Intervention Lineage MONITOR monitoring mutate Mutation mutation rate mutational hotspot Mutational hotspots mutational spectrum mutations Nonsense mutations occurred Other pandemic pattern Phylogenetic predict Prevent public health Recombination reconstruction Recurrent Replication responsible RNA SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 pandemic SARS-CoV-2 virus SARS-CoV-2 viruses Scientific community sequenced Sequencing Spectrum Spread spreads strain superinfection the SARS-CoV-2 the SARS-CoV-2 genome Transmission transmission of SARS-CoV-2 Vaccines variant variants Viral viral samples virus viruses while within-host
[DOI] 10.7554/eLife.66857 PMC 바로가기 [Article Type] Research Article

Evolution of NETosis markers and DAMPs have prognostic value in critically ill COVID-19 patients

Netosis 마커 및 습기의 진화는 중환자가 아픈 Covid-19 환자에서 예후 가치가 있습니다.

Article

Published on 2021-08-032022-08-31
Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 진단, 치료기술,

[키워드] (cfDNA) Acute inflammation Cell cfDNA Clinical parameters controls coronavirus coronavirus disease coronavirus disease 19 correlated COVID-19 COVID-19 patient COVID-19 patients Critically ill damage DAMP decrease disease severities disease severity Disease-free survival DNA event Evolution Extracellular GAS6 ICU ICU admission immune Infection intensive care intensive care unit lead lowering lowest marker measure molecular pattern molecular patterns Mortality multi-organ dysfunction NETosis neutrophil neutrophil counts Neutrophil elastase Neutrophils Occurrence parameter parameters Patient patient survival plasma Prognostic value Respiratory failure Respiratory tract diseases scoring system Sepsis severe COVID-19 survival the patient tissue damage Ventilator-free days viral infection weakness
[DOI] 10.1038/s41598-021-95209-x PMC 바로가기 [Article Type] Article

Liver Damage and Exposure to Toxic Concentrations of Endogenous Retinoids in the Pathogenesis of COVID-19 Disease: Hypothesis

Reviews

Published on 2021-08-012022-10-28
Journal: Viral immunology [Category] COVID-19, SARS,

Muscle Damage Biomarkers in Congestion Weeks in English Premier League Soccer Players: A Prospective Study for Two Consecutive Seasons

잉글랜드 프리미어 리그 축구 선수의 혼잡 주간 근육 손상 바이오마커: 연속 2시즌에 대한 전향적 연구

Article

Published on 2021-07-282022-09-10
Journal: International Journal of Environmental Research an [Category] SARS, 바이오마커,

Human Coronaviruses: Counteracting the Damage by Storm

Review

Published on 2021-07-272022-10-28
Journal: Viruses [Category] COVID-19, SARS,

Severe Acute Respiratory Syndrome Coronavirus 2 Infects and Damages the Mature and Immature Olfactory Sensory Neurons of Hamsters

중증 급성 호흡기 증후군 코로나바이러스 2는 햄스터의 성숙하고 미성숙한 후각 감각 뉴런을 감염시키고 손상시킵니다

Article

Published on 2021-07-152022-09-11
Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료기술,

[키워드] Acute inflammation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition affecting Antigen Apoptosis Cell cells chemokine ciliated contribute coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 patient Cytokines damage destruction develop epithelial cells hamster hamsters highest immature Infection Inflammatory inflammatory cell inflammatory cell infiltration Inflammatory cytokine Inflammatory cytokines intranasal Invasion investigated less location Loss of Smell marker nasal nasal turbinate Neuron neuronal function olfactory olfactory bulb olfactory bulbs olfactory dysfunction Olfactory epithelium olfactory neuron olfactory neuron. Pathogenesis patients peaked Postinfection proinflammatory Proinflammatory cytokine proportion Protein reported respiratory respiratory epithelial cells respiratory tract infection response resulting SARS-CoV-2 SARS-CoV-2 viral Sensory sensory neuron severe acute respiratory syndrome Coronavirus Symptom tissues unique Viral load β-tubulin
[DOI] 10.1093/cid/ciaa995 PMC 바로가기 [Article Type] Article

SARS-CoV-2 infection in the Syrian hamster model causes inflammation as well as type I interferon dysregulation in both respiratory and non-respiratory tissues including the heart and kidney

시리아 햄스터 모델의 SARS-COV-2 감염은 심장과 신장을 포함한 호흡기 및 비-자극 조직 모두에서 I 형 INTERFERON DYSREGUM뿐만 아니라 염증을 유발합니다.

Research Article

Published on 2021-07-152022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, COVID-19, SARS,

[키워드] (coronavirus disease 2019 acute respiratory syndrome Affect affecting antiviral cytokine antiviral cytokines antiviral response captures cardiovascular system cause caused clinical symptom coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cytokines damage disease dysregulation evaluate Evidence evidence of examination extrapulmonary tissue hamsters heart host response host responses IL-1beta IL-6 immune host response immune responses indicated Infection Inflammation Inflammatory cytokine Inflammatory cytokines inhibited interferon interferons investigated kidney kidneys liver microthrombi multiorgan disease myocarditis neurological system non-respiratory tissue occur organ system organ systems PASC people with COVID-19 prolonged disease regulated required respiratory respiratory tract SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severity significant increases in Symptom Therapeutics TNF tubular inflammation type I interferon type I interferons type II interferon type II interferons upregulation Urinary tract Viral viral infection with infection
[DOI] 10.1371/journal.ppat.1009705 PMC 바로가기 [Article Type] Research Article

Persistent Systemic Microbial Translocation and Intestinal Damage During Coronavirus Disease-19

코로나바이러스 질병-19 동안 지속되는 전신 미생물 이동 및 장 손상

Immunology

Published on 2021-07-142022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커,

[키워드] acid Admission admitted to ICU age aims alteration AUC bloodstream BSI cell integrity control group COVID-19 COVID-19 diagnosis COVID-19 patient COVID-19 patients damage enrolled evaluated exhibited Fatty acid Gut healthy donor ICU ICU patient ICU Patients IgM in-hospital mortality Infection influence intensive care unit intestinal intestinal damage intestinal damage and permeability intestinal fatty acid binding protein (I-FABP) lipopolysacharide binding protein marker median age microbial translocation microbial translocation in COVID-19 Mortality non-ICU over Patient persistent Predictive SARS-CoV-2 Severe infection severe infections study period subject subsequent systemic translocation with COVID-19
[DOI] 10.3389/fimmu.2021.708149 PMC 바로가기 [Article Type] Immunology

Obesity and severe coronavirus disease 2019: molecular mechanisms, paths forward, and therapeutic opportunities

비만 및 중증 코로나 바이러스 질병 2019 : 분자 메커니즘, 경로 및 치료 기회

Review

Published on 2021-07-132022-09-10
Journal: Theranostics [Category] MERS, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adverse events antiviral immunity antiviral responses appear assist B cell body mass body mass index caused chronic Clinicians Comorbidity Complication contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic cytokine Cytokine storm damage deficiency demonstrated dendritic cell disease severity disorder dyslipidemia early stage Endothelial dysfunction exacerbate greater Host-directed therapies host-directed therapy hypercoagulability hyperglycemia Immunity impair increase Inflammation interferon leads mechanism Metabolic disorders metabolism molecular mechanisms natural killer Natural killer cells obesity open organ dysfunction pandemic pathogenicity patients with obesity platelet hyperactivation polymorphism Polymorphisms poor prognosis progression prothrombotic state researcher respiratory resulting risk SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe coronavirus disease severe COVID-19 severe symptom severe symptoms susceptibility systemically T cell T cells therapeutic thrombosis tissue damage underlying diseases Ventilation vicious cycle Viral Viral load viral mutation Vitamin D vitamin D deficiency worsening
[DOI] 10.7150/thno.59293 PMC 바로가기 [Article Type] Review