Genome‐wide screening of SARS‐CoV‐2 infection‐related genes based on the blood leukocytes sequencing data set of patients with COVID‐19Research Article Published on 2021-05-282022-11-01 Journal: Journal of medical virology [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome adverse effect Analysis analyzed AUC AUC value bioinformatics blood leukocyte calculated caused contribute coronavirus Coronavirus disease 2019 COVID‐19 COVID‐19 patient COVID‐19 CTSB CTSL DEGs Diagnosis diagnostic differentially expressed gene disease enrichment analysis Epidemic EPSTI1 expressed expression function Gene ontology GEO database Health IFI27 IFIT3 leukocyte Logistic regression analysis mechanism OASL Patient positively correlated Protein–protein interaction risk ROC Curve SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 screened sequencing data therapeutic therapeutic target TMPRSS2 Treatment USP18 virus XAF1 [DOI] 10.1002/jmv.27093 PMC 바로가기 [Article Type] Research Article
The relationship between cytokine and neutrophil gene network distinguishes SARS-CoV-2–infected patients by sex and age사이토카인과 호중구 유전자 네트워크 사이의 관계는 SARS-CoV-2 감염 환자를 성별과 연령으로 구분합니다Research Article Published on 2021-05-242022-09-10 Journal: JCI Insight [Category] SARS, 유전자 메커니즘, [키워드] age approach association chemokine chemokines correlated COVID-19 CXCL8 CXCR1 CXCR2 cytokine Cytokine storm Cytokines data set data sets DBNL DEGs differentially expressed gene Differentially expressed genes downregulated Elderly patient elderly patients exhibited Fatality rate female female patient Female patients gene network Genes IL-1 IL-1 β immune modulation increasingly infected with SARS-CoV-2 Inflammation Inflammatory ITGAM leukocytes male modulation Molecular genetics Nasopharyngeal swab nasopharyngeal swabs neutrophil neutrophil activation Neutrophils outcome pathological role pathway Patient patients patients with SARS-CoV-2 Peripheral blood peripheral blood leukocyte peripheral blood leukocytes Protective provide receptor reduced S100A9 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2–infected patient Sex subjects transcriptional transcriptional level upregulated [DOI] 10.1172/jci.insight.147535 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Infection Induces Psoriatic Arthritis Flares and Enthesis Resident Plasmacytoid Dendritic Cell Type-1 Interferon Inhibition by JAK Antagonism Offer Novel Spondyloarthritis Pathogenesis InsightsSARS-CoV-2 감염은 JAK 길항 작용에 의한 건선성 관절염 발적 및 유착 상주 형질세포양 수지상 세포 유형-1 인터페론 억제를 유도하여 새로운 척추관절염 발병 통찰력 제공Immunology Published on 2021-04-152022-09-11 Journal: Frontiers in Immunology [Category] MERS, 유전자 메커니즘, [키워드] activated Activation antagonism Arthritis arthropathy Blood CD45 CD45+ cells characterized COVID-19 COVID-19 infection CpG DEGs dendritic dendritic cell dendritic cells differentially expressed gene Elevation enthesis evaluate evaluated flare Gene Expression IFNα imiquimod Infection inhibition insight interferon Interferon alpha interferon response investigated Jak JAK/STAT signaling pathway maturation mechanism microbe microbes modulation NF-κB NF-κB signaling normal novel objective occurred Pathway analysis pDC pDCs plasmacytoid dendritic cell plasmacytoid dendritic cells Protein psoriatic arthritis resident Result RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 SARS-CoV2 infection Signaling significantly spondyloarthritis STAT stimulated suppressed therapeutic TLR-7 TNF Tofacitinib Toll-like receptor toll-like receptor signaling Trigger triggered triggers upregulated Viral viral infection was performed [DOI] 10.3389/fimmu.2021.635018 PMC 바로가기 [Article Type] Immunology
Bioinformatics and system biology approach to identify the influences of COVID-19 on cardiovascular and hypertensive comorbidities심혈관 및 고혈압 동반 질환에 대한 COVID-19의 영향을 식별하기 위한 생물정보학 및 시스템 생물학 접근Article Published on 2021-03-222022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 유전자 메커니즘, [키워드] ACE inhibitor ACE inhibitors ACE2 ACE2 gene acute respiratory syndrome acute respiratory syndrome coronavirus Affect aldosterone angiotensin angiotensin converting enzyme angiotensin I Angiotensin II approach bioinformatics blood pressure blood sample Blood samples Cancer cardiovascular cardiovascular comorbidities cardiovascular comorbidity cardiovascular disease cardiovascular diseases caused Cell cell signalling pathway and ontology cell stress cells chemical compound chemokines chronic heart failure Comorbidity condition convert coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cytokines DEGs diabetes differentially expressed differentially expressed gene Differentially expressed genes disease Diseases drug elevated enzyme expressed expression functions gene regulatory network Genetic heart heart failure help human tissues hypertension hypertensive hypertensive diseases identify immune response gene immune response genes infect infected individual infected individuals Infection influence Interaction interactions intestine kidneys Lung injury Lungs mechanism medication medications Messenger RNA Mortality ontologies Ontology pandemic Pathogenesis pathway Pathways Patient Peripheral blood peripheral blood cell peripheral blood cells receptor reduce Renin renin-angiotensin-aldosterone system Research risk SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 suggested susceptible System biology T cell target Testis Toll-like receptor Treatment type 2 diabete type 2 diabetes [DOI] 10.1093/bib/bbaa426 PMC 바로가기 [Article Type] Article
Exploration and validation of related hub gene expression during SARS-CoV-2 infection of human bronchial organoids인간 기관지 오르가노이드의 SARS-CoV-2 감염 중 관련 허브 유전자 발현의 탐색 및 검증Genome Database Published on 2021-03-162022-09-10 Journal: Human Genomics [Category] 유전자 메커니즘, [키워드] 3D structure model acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected analyzed Bioinformatics analysis bronchial organoid CCL2 CCL5 coronavirus COVID-19 CXCL1 CXCL10 CXCL8 Cytokines DEGs differentially expressed gene Differentially expressed genes downloaded downregulated gene EGF exploration expressed expression feasibility FGF2 FN1 Gene Expression Gene ontology Genes genomes GEO Health help high mortality hub genes Human bronchial organoids human bronchus ICAM1 identify IL1B IL6 immune response in vitro model Infection infection mechanism infection rate Interaction KEGG Kyoto Microarray MMP9 mRNA mRNA expression Novel coronavirus Novel coronavirus infection pandemic Pathogenesis pathway Pathways patients PBMC PBMCs Potential treatment PPI prognostic protein-protein interaction Protein–protein interaction R software respiratory Result SARS-CoV-2 SARS-COV-2 infection selected severe acute respiratory syndrome Coronavirus significantly suggested System three-dimensional structure Treatment upregulated gene were used [DOI] 10.1186/s40246-021-00316-5 PMC 바로가기 [Article Type] Genome Database
CSF3 Is a Potential Drug Target for the Treatment of COVID-19Physiology Published on 2021-01-222022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] A549 analyzed antiviral drug bronchial organoid bronchial organoids Calu3 cell line COVID-19 CSF3 cumulative dataset death DEGs differentially expressed gene docking downloaded drug drug target drugs targeting Elbasvir epithelial cell line exceeded expression flexible Genes GSE147507 help identify infected with SARS-CoV-2 Infection inhibited Interaction lung adenocarcinoma mechanism MOE NHBE pathogenic pathway Potential PPI Prevent protein expression Protein–protein interaction receptor Research residue respiratory infectious disease Ritonavir screened significantly target therapeutic treat uninfected upregulated Vaccines van der Waal virus [DOI] 10.3389/fphys.2020.605792 PMC 바로가기 [Article Type] Physiology
Gene Expression Profiling Reveals the Shared and Distinct Transcriptional Signatures in Human Lung Epithelial Cells Infected With SARS-CoV-2, MERS-CoV, or SARS-CoV: Potential Implications in Cardiovascular Complications of COVID-19Cardiovascular Medicine Published on 2021-01-152022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] acute inflammatory response acute respiratory syndrome Analysis Apoptosis cardiovasclar disease cardiovascular cardiovascular complication cellular response changes in Coagulation Complication contribute coronavirus coronavirus disease Coronaviruses COVID-19 COVID-19 and transcriptome analysis CSF2 CXCL1 CXCL3 dataset DEGs differentially expressed gene effort epithelial cell FOXO1 gene expression dataset Gene Expression Omnibus Genes global pandemic Human human lung IL1A IL32 infected with SARS-CoV-2 initial ITGB3 lower expression lung damage MERS MERS-CoV Middle East Mild NLRP1 NR2F2 NRP1 Potential Profiling prognostic PROS1 SARS-CoV SARS-CoV-2 SARS-COV-2 infection signature single-stranded RNA virus syndrome TCF4 TFPI2 therapeutic TNF TP53INP1 transcriptional transcriptional response transcriptomic TYMP unique upper respiratory tract Vascular function VAV3 viral replication virus [DOI] 10.3389/fcvm.2020.623012 PMC 바로가기 [Article Type] Cardiovascular Medicine
Mediators of SARS-CoV-2 entry are preferentially enriched in cardiomyocytesSARS-CoV-2 진입 매개체는 심근세포가 우선적으로 풍부합니다.Research Published on 2021-01-042022-09-10 Journal: Hereditas [Category] 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addition analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 binding cardiac conduction cardiac injury cardiac muscle cathepsin B cathepsin L Cell cellular coronavirus disease Coronavirus disease 2019 cough COVID-19 CTSB CTSL DEGs differentially expressed gene Differentially expressed genes embryonic enrichment analysis expression Fever Injury ion channel less mechanism mediator mitochondrial muscle contraction Patient patients with COVID-19 priming protease Regulation respiratory respiratory chain respiratory symptom respiratory symptoms Result RNA expression S protein SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2, COVID-19, ACE2, CTSB, CTSL, cardiac injury Serine serine protease Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Signaling single-cell Spread susceptible TMPRSS2 transmembrane serine protease ventricular Viral viral transcription [DOI] 10.1186/s41065-020-00168-4 PMC 바로가기 [Article Type] Research
C-reactive protein as a possible marker for severity and mortality of COVID-19 infectionOriginal Article Published on 2021-01-012022-10-31 Journal: Gastroenterology and Hepatology From Bed to Bench [Category] COVID-19, [키워드] added ALB analyzed bioinformatics Biomarker C-reactive protein candidate central node changed Clinical finding condition COVID-19 COVID-19 infection COVID-19 pandemic Critical CRP CXCL8 Cytoscape software database DEGs determine differentially expressed gene disease disease severity fatality Health IL6 Infection INS marker Mild Mortality MPO network analysis Patient prediction screened severity severity of COVID-19 TLR4 TNF TTR PMC 바로가기 [Article Type] Original Article
Molecular Basis of Cardiac and Vascular Injuries Associated With COVID-19Cardiovascular Medicine Published on 2020-11-032022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] absence Analysis Basis Blood cardiac cardiac and vascular injuries cardiac disease caused cellular response Clinical course core gene coronary syndrome Coronavirus disease 2019 COVID-19 dataset DEG (differentially expressed gene) analysis DEGs differentially expressed gene downregulated Endothelial cell Endothelium Evidence examined explain FIVE function Genetic predisposition genetic susceptibility healthy controls heart failure Immune cell indicate Injury likelihood lung tissue lung tissues material mechanism Microarray Migration molecular basis Mortality novel coronavirus SARS-CoV-2 Pathogenesis Pathways Patient patients with COVID-19 Regulation Risk factors SARS-CoV-2 Shock significantly specificity Stress transcriptomic upregulated Vascular Vascular injury Venous Thromboembolism viral respiratory [DOI] 10.3389/fcvm.2020.582399 PMC 바로가기 [Article Type] Cardiovascular Medicine