Combination of Angiotensin (1-7) Agonists and Convalescent Plasma as a New Strategy to Overcome Angiotensin Converting Enzyme 2 (ACE2) Inhibition for the Treatment of COVID-19Medicine Published on 2021-03-182022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] ACE2 ACE2 antibody ACE2 expression acute respiratory syndrome agonist alleviate Ang II angiotensin Angiotensin (1-7 Angiotensin 1-7 (Ang1-7) angiotensin-converting enzyme 2 antibodies appear approach ARBs AT1R binding block viral entry blocker cardiovascular pathology caused Cell circulating combination therapy concerning convalescent plasma Convalescent plasma (CP) coronavirus correlated COVID-19 COVID-19 patients detrimental effect differential expression Effect elicit expected Health infect Inflammatory response inhibition inhibitor Level lung Lung pathology modulation neutralize neutralizing capacity New pandemic pathogenesis of COVID-19 pathology pharmacological positive cells pro-fibrotic pro-inflammatory protective effect Protective effects receptor recovered patient reduced regimen risk SARS-CoV-2 Spread Strategy Symptoms therapeutic therapy Treatment upregulation viral entry viral infection virus [DOI] 10.3389/fmed.2021.620990 PMC 바로가기 [Article Type] Medicine
COVID-19 Confinement and Sexual Activity in Spain: A Cross-Sectional StudyArticle Published on 2021-03-042022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] 95% CI activity adjusted age alcohol analyses of variance average Complete control variable COVID-19 detrimental effect disease effective female group health habits Iberian Peninsula lifestyle Logistic regression analysis males media Population Prevalence promote reported restriction sexual sexual intercourse significant difference smoking social isolation Spain Spanish spread of COVID-19 subgroups submitted were used women [DOI] 10.3390/ijerph18052559 PMC 바로가기 [Article Type] Article
Sociodemographic and Psychological Risk Factors for Anxiety and Depression: Findings from the Covid-19 Health and Adherence Research in Scotland on Mental Health (CHARIS-MH) Cross-sectional SurveyFull Length Manuscript Published on 2021-03-032022-10-29 Journal: International Journal of Behavioral Medicine [Category] COVID-19, SARS, [키워드] adherence Adults age amplified Anxiety association coronavirus COVID-19 decile Depression Deprivation determine detrimental effect Effect exacerbated example Factor female finding Gender group Health identify illness representations investigation lack loneliness median age mental health offer pandemic poor mental health prevalence rate Psychological psychological risk public mental health Result risk simple linear regression Social support Sociodemographic sociodemographic factors Support survey thought Threat perception variable were used women [DOI] 10.1007/s12529-021-09967-z PMC 바로가기 [Article Type] Full Length Manuscript
SARS-CoV-2 Nonstructural Proteins 1 and 13 Suppress Caspase-1 and the NLRP3 Inflammasome ActivationArticle Published on 2021-02-262022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] activate Activation activation of inflammasome amino acid residue antagonist antiviral immune response caspase-1 cDNA cells complementary complexes coronavirus disease Coronaviruses detrimental effect DNA domain dysregulated Effect Effector mechanism evade Helicase Host IL-1β implicated induce Inflammasome inflammasome activation inhibit inhibited involved MERS-CoV NLRP3 NLRP3 inflammasome nonstructural protein nsp1 Open reading frame ORFs Pathogenesis positive promote reduced Replication responsible SARS-CoV SARS-CoV-2 SARS-CoV-2 NSP1 Screening secretion severe acute respiratory syndrome coronavirus 2 severity significantly THP-1 translation viral clearance viral replication virus [DOI] 10.3390/microorganisms9030494 PMC 바로가기 [Article Type] Article
The Balance of Neutrophil Extracellular Trap Formation and Nuclease Degradation: an Unknown Role of Bacterial Coinfections in COVID-19 Patients?Perspective Published on 2021-02-162022-10-29 Journal: mBio [Category] COVID-19, MERS, [키워드] accumulate acute respiratory distress acute respiratory syndrome Bacterial coinfection balance boost Coinfection Contact contribute coronavirus COVID-19 COVID-19 patient Defense Degradation degrade described detrimental effect DNase Evidence extracellular DNA fiber Formation Host humans immunothrombosis Infection NET NETs neutrophil Neutrophil extracellular trap Neutrophils Nuclease Pathogenesis peptides public health released role SARS-CoV-2 severe COVID-19 severe SARS-CoV-2 severity syndrome the disease therapeutic strategy Treatment treatment strategy Unknown Vascular [DOI] 10.1128/mBio.03304-20 PMC 바로가기 [Article Type] Perspective
Collateral impact of COVID-19: why should children continue to suffer?Short Communication Published on 2021-02-132022-10-31 Journal: European journal of pediatrics [Category] COVID-19, MERS, SARS, [키워드] Adults affected appear caused children Children and young people Collateral COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 vaccine detrimental effect Effect Efficacy evaluate Evidence globe highlight Hospital admission Impact Infection Influenza initiated mental health mitigate new strain positive Prevalence public health measure reduce reduced reduction in respiratory syncytial virus risk RSV RSV infection severe disease Significant Transmissibility Vaccine vaccine trial virus [DOI] 10.1007/s00431-021-03963-x PMC 바로가기 [Article Type] Short Communication
A longitudinal study on the COVID-19 pandemic and its divergent effects on social participation and mental health across different study groups with and without mental disordersOriginal Paper Published on 2021-02-102022-10-28 Journal: Social psychiatry and psychiatric epidemiology [Category] COVID-19, MERS, SARS, [키워드] assessment BSI-18 changes in chronic coronavirus COVID-19 COVID-19 pandemic detrimental effect disorder Effect effort Germany impairment IMPROVE Inclusion index initial inventory investigated lockdown lockdown restriction lockdown restrictions measure Mental Mental disorder mental health pandemic participant Participation physical distancing Psychological well-being Resilience Result Social participation spread of COVID-19 study group supplementary material were assessed [DOI] 10.1007/s00127-021-02025-9 PMC 바로가기 [Article Type] Original Paper
Exposure and risk factors for COVID-19 and the impact of staying home on Michigan residentsResearch Article Published on 2021-02-082022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] African American African Americans Chronic diseases clinical care COVID-19 COVID-19 case detrimental effect diagnosed with COVID-19 effort essential worker exposure Fever Health higher risk Hospitalization less lowest Medicine outcomes pandemic participant positive positive COVID-19 reported rhinorrhea risk factor significantly higher state women worsening [DOI] 10.1371/journal.pone.0246447 PMC 바로가기 [Article Type] Research Article
The psychological impact of COVID-19 pandemic lockdowns: a review and meta-analysis of longitudinal studies and natural experimentsReview Article Published on 2021-01-132022-10-29 Journal: Psychological Medicine [Category] COVID-19, MERS, [키워드] 95% CI Affect age analyzed Anxiety conducted coronavirus disease COVID-19 COVID-19 pandemic Cross-sectional studies death rate Depression detrimental effect distress Effect effect size Effects experiment Gender heterogeneity heterogeneous indicated lockdown loneliness longitudinal study magnitude mental health Meta-analysis meta-regression analysis Multivariate analysis not significant participant positive Psychological psychological Impact psychologically quarantine random effect risk SARS-CoV-2 Spread Study design Support Symptoms Well-being [DOI] 10.1017/S0033291721000015 PMC 바로가기 [Article Type] Review Article
SARS-CoV-2-specific antibody rearrangements in prepandemic immune repertoires of risk cohorts and patients with COVID-19코로나19 위험 집단과 환자의 전염병 전 면역 레퍼토리에서 SARS-CoV-2 특이 항체 재배열Clinical Trial Published on 2021-01-042022-09-12 Journal: The Journal of Clinical Investigation [Category] MERS, 임상, 진단, [키워드] acute respiratory syndrome Adaptive immunity age antibodies antibody antibody sequence B cell B cell receptor B cell response biochemical Blood Cancer Clinical course Cohort coronavirus coronavirus disease courses COVID-19 detrimental effect disease severity element explain fraction Future groups healthy individual healthy individuals immune immunoglobulins immunology individual less memory Neutralizing neutralizing antibody occurred pandemic Patient patients with COVID-19 receptor recognize reflect resulting retrieved risk SARS-CoV-2 SARS-CoV-2 antibody sequence serological data solid cancer validation cohorts while [DOI] 10.1172/JCI142966 PMC 바로가기 [Article Type] Clinical Trial