The Salmonella Effector SteD Mediates MARCH8-Dependent Ubiquitination of MHC II Molecules and Inhibits T Cell Activation살모넬라 효과 인자 SteD는 MARCH8 의존적인 MHC II 분자의 유비퀴틴화를 매개하고 T 세포 활성화를 억제한다.Article Published on 2016-11-092024-08-19 Journal: Cell Host & Microbe [Category] 살모넬라증, [키워드] dendritic cells effector Ligase major histocompatibility complex Salmonella ubiquitin [DOI] 10.1016/j.chom.2016.10.007 PMC 바로가기 [Article Type] Article
Suppression of Virulent Porcine Epidemic Diarrhea Virus Proliferation by the PI3K/Akt/GSK-3α/β PathwayResearch Article Published on 2016-08-252022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] activated caused cellular pathway downstream effector epidemic diarrhea function high mortality Infection inhibiting intracellular signaling late stage pathway Pathways PEDV phosphatidylinositol 3-kinase PI3K regulated Replication required shown signaling pathway subsequent suppression upstream Vero Cell Vero cells viral infection virus virus replication [DOI] 10.1371/journal.pone.0161508 PMC 바로가기 [Article Type] Research Article
Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity비복제 Toxoplasma gondii Uracil Auxotrophs에 의한 Rhoptry 및 Dense Granule Effector 단백질의 분비는 항종양 면역의 발달을 제어합니다Research Article Published on 2016-07-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abrogated activate activated acute infection Auxotroph auxotrophic mutants axis CD4 CD8 Cell Nucleus Cell signaling cellular signaling pathway cellular signaling pathways conjunction Control deleted Deletion dendritic cells Dense development effective effective therapy effector effector molecule effector molecules effector protein effector proteins function Granule GTPase GTPases Host host cell host cell nucleus host cell response Host immune response host immune responses host innate immunity host response host responses identify IFN-γ immune responses Immune suppression Immunity independent Infection interferon Invasion latent infection mammalian cell mechanism membrane mice mutant not affect nucleus ovarian cancer parasite pathway Pathways Protein required responses rhoptry Safe secreted secretion shown Signaling solid tumor solid tumors survival T cell T cells target therapeutic These data Toxoplasma gondii transcriptional Trigger Tumor tumor microenvironment tumors type I uracil vaccination vaccine strain virulence [DOI] 10.1371/journal.pgen.1006189 PMC 바로가기 [Article Type] Research Article
A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to NeuroinflammationT 세포 수용체 신호 분자 Vav1의 천연 변이체는 이펙터 T 세포 기능과 신경 염증에 대한 감수성을 모두 감소시킵니다Research Article Published on 2016-07-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation Affect alteration Antigen antigen receptor Autoimmune candidate gene CD4 T cell CD4 T cells changes in chromosome 9 Control cytokine cytokine production Cytokines Diseases effector effector T cell effector T cells FOXP3 function functions Genetic genetic study GM-CSF guanine highlight IFN-γ IL-17 immune system immunization Inflammatory cytokine Inflammatory cytokines intrinsic leads locus mechanism mice MOG molecule natural Neuroinflammation Non-synonymous normal enzymatic activity nucleotide peptide phenotype physiological polymorphism Polymorphisms proportion Quantitative receptor reduce reduced Regulatory T cell regulatory T cells Signaling susceptibility T cell T cell receptor T cells Th1/Th17 These data transducing Treg variant Vav1 [DOI] 10.1371/journal.pgen.1006185 PMC 바로가기 [Article Type] Research Article
Crystal structure of the substrate-recognition domain of theShigellaE3 ligase IpaH9.8시겔라 E3 리가제 IpaH9.8의 기질 인식 도메인의 결정 구조journal-article Published on 2016-04-012024-07-30 Journal: Acta Crystallographica Section F Structural Biology Communications [Category] 세균성이질, [키워드] E3 ligase effector IpaH9.8 leucine-rich repeats. Shigella flexneri [DOI] 10.1107/S2053230X16002715 [Article Type] journal-article
Shigella IpaH Family Effectors as a Versatile Model for Studying Pathogenic Bacteria시겔라 IpaH 가족 효과기를 병원성 세균 연구를 위한 다재다능한 모델로 사용하기Article Published on 2016-01-062024-07-30 Journal: Frontiers in Cellular and Infection Microbiology [Category] 세균성이질, [키워드] E3 ligase effector NF-kB Shigella ubiquitin [DOI] 10.3389/fcimb.2015.00100 PMC 바로가기
The Nuclear Immune Receptor RPS4 Is Required for RRS1 SLH1 -Dependent Constitutive Defense Activation in Arabidopsis thaliana핵 면역 수용체 RPS4는 Arabidopsis thaliana에서 RRS1 SLH1 -의존적 구성 방어 활성화에 필요합니다Research Article Published on 2014-10-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence activate Activation Agrobacterium allele Amino acid Analysis Arabidopsis Arabidopsis thaliana Bacterial C-terminal Cell complex conducted Defense disease DNA binding domain dominant downstream effector effectors ENCODE function Genes Genetic genetic screen growth hypotheses identify Immune receptor immune receptors immune responses Immunity inactive insertion leucine loss-of-function mutation loss-of-function mutations mammalian mechanism motif mutant mutants Mutation NLR NLRs nuclear nucleotide overlap pathogen performed plant plants Protein Pseudomona Pseudomonas R genes receptor Recognition recognize required rescued responses RRS1 secretion Signaling significantly temperature transcribed transcriptional transcriptional activation transcriptional change Trigger triggers type III wild type [DOI] 10.1371/journal.pgen.1004655 PMC 바로가기 [Article Type] Research Article
Regulation of p53 and Rb Links the Alternative NF-κB Pathway to EZH2 Expression and Cell Senescencep53 및 Rb의 조절은 대체 NF-κB 경로를 EZH2 발현 및 세포 노화에 연결합니다Research Article Published on 2014-09-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated Activation alternative NF-κB pathway Analysis ANAPC1 c-Rel cancer cell Cancer cells CD40 CD40 ligand CD40L CDK4 CDK6 Cell cell cycle cell senescence cellular senescence ChIP chromatin immunoprecipitation chronic chronic lymphocytic leukemia classical complexes Crosstalk de-repression defined Degradation DEK dependent on Effect effector effectors expression EZH2 fibroblasts Hematological malignancies Hematological malignancy IKK IKKα induce inhibit investigated IκB IκBα knockdown leads Loss Lymphocytic leukemia mechanism microarray analysis microenvironment NEMO NF-κB NF-κB inducing kinase NF-κB pathway NF-κB2 NIK or canonical oxygen p100 p21WAF1 p52 p53 pathway patients phenotype Phosphorylation polycomb protein promote protein stability provide PSMA5 quantitative PCR RacGAP1 reactive oxygen species reactive oxygen specy regulate Regulation regulatory subunit RELA RelB repression retinoblastoma retinoblastoma protein ROS SASP senescence senescent siRNA solid tumors stability stimulated subset subunit subunits suppress suppression target gene Target genes the cell Tumor tumor suppressor tumorigenesis tumors tumour suppressor turn western blot Western blot analyses Western blot analysis wild type [DOI] 10.1371/journal.pgen.1004642 PMC 바로가기 [Article Type] Research Article
SptP106–136 plays a role in the complex formation with SptP-specific chaperone SicPSptP106–136은 SptP 특이적 샤페론 SicP와의 복합체 형성에 역할을 한다.journal-article Published on 2014-09-022024-07-30 Journal: Bioscience, Biotechnology, and Biochemistry [Category] 살모넬라증, [키워드] chaperone effector Salmonella type III secretion system urea [DOI] 10.1080/09168451.2014.921552 [Article Type] journal-article
Impact of Inflammatory Cytokines on Effector and Memory CD8+ T CellsArticle Published on 2014-05-122023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] CD8 T cells Cytokines effector memory resident memory signal 3 [DOI] 10.3389/fimmu.2014.00295 PMC 바로가기