In Vitro SARS-CoV-2 Infection of Microvascular Endothelial Cells: Effect on Pro-Inflammatory Cytokine and Chemokine Release미세혈관 내피 세포의 시험관 내 SARS-CoV-2 감염: 염증성 사이토카인 및 케모카인 방출에 대한 영향Article Published on 2022-04-062022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 receptor Activation Analysis chemokine contribute coronavirus disease Coronavirus disease 2019 cytokine release Cytokines cytoplasm days post-infection dysfunction Effect electron ELISA endothelial Endothelial cell evaluated expressed expression Human Human Microvascular Endothelial Cells (HMEC-1) IFN-α IL-6 IL-6 level IL-6 levels IL-8 in vitro Inflammatory mediators mRNA mRNA expression pandemic pro-inflammatory cytokine pro-inflammatory cytokines pro-inflammatory mediators Release RT-PCR SARS-CoV-2 SARS-COV-2 infection significantly higher significantly lower supernatant supernatants susceptible TEM These data thrombotic Thrombotic events tissue Tissue Factor TNF-α transmission electron microscopy uninfected viral amplification Viral load virion virions western blot Western blot analysis [DOI] 10.3390/ijms23074063 PMC 바로가기 [Article Type] Article
Preclinical In Silico Evidence Indicates the Pharmacological Targets and Mechanisms of Mogroside V in Patients With Ovarian Cancer and Coronavirus Disease 20192019년 난소암 및 코로나바이러스 질환 환자에서 모그로사이드 V의 약리학적 표적 및 메커니즘을 나타내는 전임상 인 실리코 증거Article Published on 2022-04-062022-09-11 Journal: Frontiers in Endocrinology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anticancer biological processe China clinical clinical observations coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19-related death docking drug target Effects endothelial enrichment analysis growth factor Hsp90 HSP90AA1 IL2 indicated ingredient Injury mechanism medication Mitigation Mogroside mogroside V molecular docking network pharmacology observation ovarian ovarian cancer pathway Pathways Patient Preclinical preclinical report PRKCA PRKCB reduce remedial targets. reported SARS-CoV-2 Siraitia STAT3 suggested target target protein targets therapeutic therapeutic agent therapeutic efficacy TLR7 TLR9 Transmission Vaccine variant Vascular VEGFA with COVID-19 [DOI] 10.3389/fendo.2022.845404 PMC 바로가기 [Article Type] Article
BNT162b2 mRNA SARS-CoV-2 vaccination does not cause upregulation of endothelial activation markers or hypercoagulability: A prospective, single-arm, longitudinal studyBNT162b2 mRNA SARS-CoV-2 백신 접종은 내피 활성화 마커의 상향 조절 또는 과응고를 일으키지 않습니다: 전향적, 단일군, 종단 연구Article Published on 2022-04-012022-09-12 Journal: American journal of hematology [Category] COVID19(2023년), SARS, 진단, [키워드] Activation BNT162b2 mRNA endothelial marker SARS-CoV-2 vaccination single-arm upregulation [DOI] 10.1002/ajh.26462 PMC 바로가기 [Article Type] Article
The Influence of COVID-19 on the Stability of Patients with Neovascular Age-Related Macular Degeneration with Different Treatment Regimens다양한 치료 요법을 사용하는 신생혈관 연령 관련 황반변성 환자의 안정성에 대한 COVID-19의 영향Article Published on 2022-04-012022-09-12 Journal: Advances in therapy [Category] MERS, 진단, [키워드] addition Age-related macular degeneration Analysis analyzed anti-vascular Clinical characteristics CNV coronavirus disease COVID-19 COVID-19 pandemic degeneration E endothelial epithelial eye Features growth factor identify increasingly influence injection Injections Macular maintain multivariate logistic regression NAMD normalized Optical coherence tomography pandemic Patient predict PRN regimen receiving regimen Retrospective study second significantly stability T& the disease the patient therapy treat treated Treatment treatment regimen university VEGF visual acuity [DOI] 10.1007/s12325-021-01993-3 PMC 바로가기 [Article Type] Article
Stromal and endothelial herpes simplex virus keratitis reactivation in the convalescent period of COVID-19 – A case report코로나19 회복기에 간질 및 내피 단순포진 바이러스 각막염 재활성화 - 증례보고Case Reports Published on 2022-04-012022-09-11 Journal: Indian journal of ophthalmology [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acyclovir Anterior anterior chamber Case report Chain Reaction convalescent coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease Diagnosis edema endothelial examination fungal fungal keratitis herpes simplex herpes simplex virus herpetic keratitis Infection Inflammation keratitis knowledge left eye ocular ophthalmic pathogen PCR polymerase chain polymerase chain reaction reactivation of HSV keratitis redness reported SARS-CoV-2 severe acute respiratory syndrome Coronavirus steroid stromal and endothelial herpetic keratitis. treated viral infection virus White Spot [DOI] 10.4103/ijo.IJO_2838_21 PMC 바로가기 [Article Type] Case Reports
Endothelial dysfunction and altered endothelial biomarkers in patients with post-COVID-19 syndrome and chronic fatigue syndrome (ME/CFS)코로나19 이후 증후군 및 만성 피로 증후군(ME/CFS) 환자의 내피 기능 장애 및 변경된 내피 바이오마커Article Published on 2022-03-222022-09-11 Journal: Journal of Translational Medicine [Category] MERS, SARS, 바이오마커, [키워드] ACE ACE2 age analysed angiopoietin angiotensin Angiotensin-converting enzyme association Biomarker Biomarkers blood pressure BMI chronic fatigue syndrome clinical parameter Clinical parameters cohort of patient Concentration criteria defined Diagnostic Criteria dysfunction elevated Encephalomyelitis endocan endothelial endothelial cells Endothelial dysfunction endothelial function Endotheliitis Endothelin Endothelin-1 Endothelium ET-1 Evidence exhibited fatigue fatigue syndrome FIVE HCs healthy control hyperaemia IL-8 infect investigated malaise Myalgic encephalomyelitis/chronic fatigue syndrome paradoxical Pathomechanism Patient patients peripheral positive correlation post-COVID syndrome profile reactive Reactive hyperaemia index. SARS-CoV-2 seronegative serum Sex shown significantly subgroups subset Symptom syndrome [DOI] 10.1186/s12967-022-03346-2 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Spike Protein 1 Activates Microvascular Endothelial Cells and Complement System Leading to Platelet AggregationSARS-CoV-2 스파이크 단백질 1은 미세혈관 내피 세포 및 보체 시스템을 활성화하여 혈소판 응집을 유도합니다Article Published on 2022-03-072022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료기술, [키워드] ACE2 Activation addition adhesive molecule aggregate aggregation AMPK amplified Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 antibody blockade blocking antibody Blot C3a C5a circulating complement Complement activation complement inhibitors complement system complexity conditions coronavirus disease Coronavirus disease 2019 COVID-19 detection element ELISA endothelial Endothelial cell endothelial cells endothelial damage Endothelial dysfunction enzyme evaluated Exocytosis experiment expression human host immunofluorescence incubated induce infect Inflammation Inflammatory inhibitors investigated leading leukocyte lung Microvascular thrombosis microvasculature Mortality multiorgan failure P-selectin performed phenotype Platelet platelet aggregation pro-inflammatory recruitment replicate robust S1 protein SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 spike protein 1 selectin sera severe COVID-19 patient severe COVID-19 patients significant level spike Spike protein System thromboembolic thromboembolic complication thromboembolic complications thrombomodulin thrombosis thrombotic thrombotic complication Thrombotic complications viral infection von Willebrand factor were assessed western blot Western blot analysis [DOI] 10.3389/fimmu.2022.827146 PMC 바로가기 [Article Type] Article
Cardiopulmonary Exercise Performance and Endothelial Function in Convalescent COVID-19 PatientsArticle Published on 2022-03-072022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Analysis association cardiopulmonary exercise testing cardiovascular diseases chronic disease circulation coronavirus disease correlation COVID-19 disability dysfunction Efficiency end-tidal endothelial Endothelial dysfunction endothelial function exercise Exercise capacity exhibited function independent Linear regressions manifestation mechanism occupational medicine outcome parameters pathogenic Patient performance pharmacological preserved reduced rehabilitation reported SARS-CoV-2 significantly higher significantly lower standardized protocols study population survivor Survivors tension therapeutic option ventilatory [DOI] 10.3390/jcm11051452 PMC 바로가기 [Article Type] Article
Effect of a single high dose of vitamin D3 on cytokines, chemokines, and growth factor in patients with moderate to severe COVID-19Randomized Controlled Trial Published on 2022-03-042022-10-05 Journal: The American journal of clinical nutrition [Category] SARS, 임상, [키워드] 25-hydroxyvitamin D acute-phase reactants age assigned BMI Brazil chemokines Concentration COVID-19 cytokine Cytokines dose double-blind Effect endothelial estimating equation exploratory Exploratory analysis Generalized GM-CSF growth factor High dose hospital hospitalized patient IFN-γ IL-10 IL-12p70 IL-17A IL-1β IL-4 IL-6 IL-8 immune immune response Inflammation Inflammatory interaction effect IP-10 leukocyte Macrophage male MCP-1 MIP-1β moderate modulating monocyte chemoattractant protein-1 multicenter not significant outcomes Patient patients with moderate Placebo placebo-controlled postintervention Primary outcome randomized clinical trial Randomly randomly assigned patients receive recruited Registered repeated measures SARS-CoV-2 secondary outcome serum severe coronavirus disease severe COVID-19 significant effect single dose Support TNF-α Trial Vascular VEGF Vitamin D were assessed were used [DOI] 10.1093/ajcn/nqab426 PMC 바로가기 [Article Type] Randomized Controlled Trial
Alveolar, Endothelial, and Organ Injury Marker Dynamics in Severe COVID-19심각한 COVID-19의 폐포, 내피 및 장기 손상 마커 역학Observational Study Published on 2022-03-012022-09-11 Journal: American Journal of Respiratory and Critical Care [Category] MERS, SARS, 바이오마커, 임상, [키워드] 95% CI 95% confidence interval alveolar alveolar epithelial cells alveolar injury angiopoietin angiotensin association Biomarker Biomarkers calculated cardiac change changes in contribute coronavirus coronavirus disease COVID-19 COVID-19 severity Day Disease progression distress Dynamics emergency department endothelial endothelial injury endothelial marker Endothelial markers Endothelium enrolled epithelial epithelial cells Health Organization Injury intubated patients invasive ventilation Kidney injury marker measurement multivariable observational study outcome outcomes Patient patients patients with COVID-19 RAGE rationale receptor renal Renin renin-angiotensin system respiratory respiratory distress Respiratory distress syndrome Respiratory Support severe COVID-19 severity significantly single-center syndrome troponin Troponin-I ventilated patient Ventilation ventilatory with COVID-19 World Health Organization [DOI] 10.1164/rccm.202106-1514OC PMC 바로가기 [Article Type] Observational Study