Combined Role of Troponin and Natriuretic Peptides Measurements in Patients With Covid-19 (from the Cardio-COVID-Italy Multicenter Study)Research article Published on 2022-03-012022-10-05 Journal: The American journal of cardiology [Category] SARS, 바이오마커, [키워드] 95% confidence interval Acute heart failure Admission age available data Biomarker Chronic kidney disease Combined concerning consecutive patient coronary syndrome COVID-19 patients Cox regression analysis death defined Diagnosis died elevated evaluate follow-up period Gender greater hazard ratio higher risk hospitalized COVID-19 patients limit measurement median men multicenter study Natriuretic oxygen saturation Patient patients with COVID-19 peptide Predictive prognostic Prognostic value provided recruited remained risk stratification role troponin troponin level were excluded with COVID-19 worse prognosis [DOI] 10.1016/j.amjcard.2021.11.054 [Article Type] Research article
Computed tomography findings and prognosis in older COVID-19 patientsResearch Published on 2022-03-012022-10-27 Journal: BMC Geriatrics [Category] COVID-19, [키워드] 95%CI Affect age calculated Chest CT chest CT scan chronic condition Cluster Clusters Computed tomography confounders consolidation COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity CT finding CT findings enrolled GGO hazard ratio hierarchical clustering hospitalized COVID-19 patients identify implication independent Mortality multicenter multivariable model Old Older older patient older patients Oldest patients Pleural pleural effusion Pneumonia Prevalence prevalent Prognosis prognostic Prognostic marker reflect Result risk of death SARS-CoV-2 severity stratified supplementary material the patient tomography Validity was performed X-ray computed [DOI] 10.1186/s12877-022-02837-7 PMC 바로가기 [Article Type] Research
Computed tomography findings and prognosis in older COVID-19 patientsResearch Published on 2022-03-012022-10-27 Journal: BMC Geriatrics [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] 95%CI Affect age calculated Chest CT chest CT scan chronic condition Cluster Clusters Computed tomography confounders consolidation COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity CT finding CT findings enrolled GGO hazard ratio hierarchical clustering hospitalized COVID-19 patients identify implication independent Mortality multicenter multivariable model Old Older older patient older patients Oldest patients Pleural pleural effusion Pneumonia Prevalence prevalent Prognosis prognostic Prognostic marker reflect Result risk of death SARS-CoV-2 severity stratified supplementary material the patient tomography Validity was performed X-ray computed [DOI] 10.1186/s12877-022-02837-7 PMC 바로가기 [Article Type] Research
Tocilizumab treatment in severe COVID-19: a multicenter retrospective study with matched controls중증 COVID-19에서의 토실리주맙 치료: 대조 대조군을 사용한 다기관 후향적 연구Multicenter Study Published on 2022-03-012022-09-11 Journal: Rheumatology International [Category] 진단, 치료제, [키워드] Activation acute respiratory distress acute respiratory distress syndrome Analysis anti-IL-6R approach ARDS Arm ARMS carried case-control study collected Control coronavirus coronavirus disease COVID-19 criteria Critical cytokine Cytokine storm death develop distress effective Efficacy evaluate feature ferritin Gender hospitalized COVID-19 patients IL-6 in some interleukin interleukin-6 Interleukin-6 (IL-6) intubation logistic regression models Macrophage macrophage activation syndrome multicenter Multiple no significant difference outcome parameters Patient patients Pneumonia Primary outcome procalcitonin progression provided reduced reduction in Regression model reported respiratory distress Respiratory distress syndrome retrospective retrospective cohort Retrospective study SAS severe disease shown significantly Standard of care study population subset syndrome Tocilizumab Treatment was reduced was used [DOI] 10.1007/s00296-021-04965-6 PMC 바로가기 [Article Type] Multicenter Study
Nasopharyngeal Microbiota as an early severity biomarker in COVID-19 hospitalised patientsCOVID-19 입원 환자의 초기 중증도 바이오마커로서의 비인두 미생물총Article Published on 2022-03-012022-09-11 Journal: The Journal of Infection [Category] MERS, SARS, 바이오마커, [키워드] 16S rRNA Actinobacillus adjusted age all-cause mortality analysed Analysis association Biomarker Chroococcidiopsis clinical evolution Clinical outcome Clustering Comorbidity COVID-19 determine Diversity Gender hospitalised patient hospitalized COVID-19 patients hospitalized patients IMV Invasive mechanical ventilation Logistic regression microbiota multiple logistic regression multivariate adjustment nasopharyngeal outcome Patient patients processed Prognosis reduction retrospective cohort rRNA SARS-CoV-2 sequence Sequencing severity with COVID-19 [DOI] 10.1016/j.jinf.2021.12.030 PMC 바로가기 [Article Type] Article
Prognostic Markers in Hospitalized COVID-19 Patients: The Role of IP-10 and C-Reactive Protein입원한 COVID-19 환자의 예후 마커: IP-10 및 C-반응성 단백질의 역할Observational Study Published on 2022-02-282022-09-10 Journal: Disease Markers [Category] MERS, 바이오마커, 임상, [키워드] Admission Analysis analyzed Asymptomatic AUC baseline baseline characteristics Biomarker C-reactive protein C-reactive protein (CRP characteristic chemokine clinical condition clinical conditions clinical decision clinically cohort study Concentration Course COVID-19 CRP cytokine death discharge disease disease onset disease severity driving enrolled Evolution expected growth factor heterogeneous Hospital stay Hospitalization Hospitalized hospitalized COVID-19 patients identify immunological independent predictor independent predictors intensive care intensive care unit IP-10 Italy Laboratory Laboratory tests majority Manifestations moderate moderate to severe Multivariate analysis outcome pandemic Patient performed predict prospective cohort study responsible Result ROC role SARS-CoV-2 SARS-CoV-2 positive patient sensitivity serum serum concentrations specificity Stratification trajectory worsening [DOI] 10.1155/2022/3528312 PMC 바로가기 [Article Type] Observational Study
Development of rapid antigen test prototype for detection of SARS-CoV-2 in saliva samples타액 샘플에서 SARS-CoV-2 검출을 위한 신속 항원 검사 프로토타입 개발Original Article Published on 2022-02-252022-09-10 Journal: Upsala Journal of Medical Sciences [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-RBD anti-receptor-binding domain Anti-spike antibody Antigen antigen test Asymptomatic capture Chain Reaction clinical analysis Cohort Combination combinations coronavirus coronavirus disease COVID-19 demonstrated detect detection antibody development diagnostic Diagnostic accuracy Diagnostic method diagnostic methods domain early stage ELISA ENhance enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated exhibited followed by hospitalized COVID-19 patient hospitalized COVID-19 patients immunized improvement individual Infection interquartile range lateral flow lateral flow assay median time NPV onset of symptom pilot study point-of-care testing polyclonal antibodies polyclonal antibody polymerase chain reaction positive PPV RBD reference method respiratory Result reverse transcription Reverse transcription-polymerase chain reaction rRBD rRT-PCR Saliva saliva samples sample collection SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus sensitivity severe acute respiratory syndrome Coronavirus specificity Spike protein stratified symptomatic patient tested the median the SARS-CoV-2 validation study virus was used were used [DOI] 10.48101/ujms.v127.8207 PMC 바로가기 [Article Type] Original Article
Subcutaneous sarilumab for the treatment of hospitalized patients with moderate to severe COVID19 disease: A pragmatic, embedded randomized clinical trial중등도 내지 중증 CovID19 질병을 가진 입원 환자의 치료를위한 피하 Sarilumab : 실용적이고 임베디드 무작위 임상 시험Randomized Controlled Trial Published on 2022-02-252022-09-10 Journal: PLoS ONE [Category] 임상, 진단, 치료제, [키워드] adaptive added addition adopted anti-IL-6R Anti-inflammatory drugs antibody Antiviral Arm benefit clinical criteria Clinical management contribute Controlled trial COVID-19 COVID-19 disease COVID19 Data monitoring committee death Dexamethasone diagnostic diagnostic test dose Effectiveness EHR Electronic health record Eligible patients evaluated event Health health record hospitalized COVID-19 patients hospitalized patient IL-6R Importance include information initial Inpatient Inpatients intubation majority measure mechanical ventilation moderate moderate to severe numbers of patient occurred Open-label outcome participant Patient patients hospitalized positive Pragmatic primary endpoint Primary outcome Probability randomization Randomized randomized clinical trial randomized trial Remdesivir respiratory respiratory compromise Result sarilumab SARS-CoV-2 setting severe COVID-19 severe COVID-19 disease Standard of care Subcutaneous subcutaneous injection the primary endpoint Treatment Trial was increased [DOI] 10.1371/journal.pone.0263591 PMC 바로가기 [Article Type] Randomized Controlled Trial
Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection흡입형 렘데시비르는 SARS-CoV-2 감염의 비인간 영장류 모델에서 바이러스 부담을 줄입니다Article Published on 2022-02-232022-09-11 Journal: Science Translational Medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] Administered administration African green monkey African green monkeys AGM alternative route approved Bronchoalveolar lavage fluid clinical benefit clinical development comparable Concentration coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated disease dose Efficacy Emergency use evaluated followed by green hospitalized COVID-19 patients hours post-infection inhalation Inhaled intravenous investigated IV administration lower dose Lower respiratory tract metabolite nucleotide once daily Patient pharmacokinetics Placebo produced RDV reduce reductions reductions in relative Remdesivir repeated respiratory tract tissue respiratory tract tissues SARS-COV-2 infection Support tissues Treatment triphosphate upper respiratory tract US FDA viral burden viral replication [DOI] 10.1126/scitranslmed.abl8282 PMC 바로가기 [Article Type] Article
Retrospective modelling of hospital bed capacities associated with the administration of remdesivir during the first wave of COVID-19 in a German metropolitan city독일 대도시에서 COVID-19의 첫 번째 물결 동안 렘데시비르 투여와 관련된 병상 용량의 후향적 모델링Article Published on 2022-02-232022-09-11 Journal: Journal of Antimicrobial Chemotherapy [Category] COVID19(2023년), SARS, 치료기술, [키워드] addition administration contributed coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient death discharge Eligible patients EMA epidemiological evaluate Fewer patients First wave Germany Healthcare system Healthcare systems hospital Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient ICU admission medical resource Medical resources Novel coronavirus novel coronavirus disease pandemic Patient recorded reduced Remdesivir Treatment were used [DOI] 10.1093/jac/dkab432 PMC 바로가기 [Article Type] Article