Differential susceptibility of SARS‐CoV‐2 in animals: Evidence of ACE2 host receptor distribution in companion animals, livestock and wildlife by immunohistochemical characterisation동물에서 SARS-CoV-2의 감수성: 면역조직화학적 특성화에 의한 반려동물, 가축 및 야생동물에서 ACE2 숙주 수용체 분포의 증거Original Article Published on 2021-07-262022-09-10 Journal: Transboundary and emerging diseases [Category] COVID19(2023년), MERS, SARS, 치료기술, [키워드] absence ACE2 ACE2 expression Acinonyx addition anatomical angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 binding bronchiolar cats cattle characterisation cheetah coronavirus distribution Enterocyte enterocytes enzyme Eptesicus European badger Evidence evidence of felids Felis ferret ferrets gastrointestinal tracts histological Host host cell host cell membrane host receptor host susceptibility humans IHC immunohistochemistry in some indicated information intestine limit lion Lower respiratory tract lung Lungs Mesocricetus microvillus mink mustelids nasal nasal mucosa nasal turbinate Neovison Ovis primates Protein receptor respiratory respiratory and gastrointestinal tracts respiratory tract respiratory tracts SARS Coronavirus SARS coronaviruses SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 serotine bat sheep species susceptibility tiger tissue tissue tropism Trachea Viral viral infection zoonoses [DOI] 10.1111/tbed.14232 PMC 바로가기 [Article Type] Original Article
Interference of Polydatin/Resveratrol in the ACE2:Spike Recognition during COVID-19 Infection. A Focus on Their Potential Mechanism of Action through Computational and Biochemical AssaysArticle Published on 2021-07-162022-10-28 Journal: Biomolecules [Category] COVID-19, SARS, [키워드] ACE2 ACE2:Spike binding-inhibition Action Angiotensin-converting enzyme appear binding biochemical assay cell type complex Compound COVID-19 evidenced focus host cells host receptor inhibitory activity Interaction Interference investigated molecular docking Polydatin Potential protein-binding Recognition respiratory epithelial cells resveratrol SARS-CoV-2 spike targets therapeutic strategy Viral protein virus entry [DOI] 10.3390/biom11071048 PMC 바로가기 [Article Type] Article
Structural and Dynamical Differences in the Spike Protein RBD in the SARS-CoV-2 Variants B.1.1.7 and B.1.351SARS-CoV-2 변이체 B.1.1.7 및 B.1.351에서 스파이크 단백질 RBD의 구조 및 동적 차이Article Published on 2021-07-082022-09-11 Journal: The journal of physical chemistry. B [Category] SARS, 변종, [키워드] 501Y.V2 ACE2 B.1.1.7 B.1.351 B.1.351 variant complex contributing to difference Factor flexible host receptor hydrogen Hydrogen bond hydrogen bond network Interaction investigated molecular dynamics Molecular dynamics simulation molecular dynamics simulations mutated variants Mutation mutations new strain Novel coronavirus pandemic performed RBD RBD-ACE2 Receptor binding domain residue responsible SARS-CoV-2 Spike protein stability stable complex the RBD the SARS-CoV-2 the Spike transmissivity Vaccine variant variants virus virus spike protein wild-type [DOI] 10.1021/acs.jpcb.1c01626 PMC 바로가기 [Article Type] Article
Long-chain polyphosphates impair SARS-CoV-2 infection and replicationResearch Article Published on 2021-07-062022-10-04 Journal: Science Signaling [Category] SARS, 변종, 치료제, [키워드] ACE2 acute respiratory syndrome addition amino acid residue analyses Analysis angiotensin-converting enzyme 2 antiviral activities antiviral activity B.1.1.7 SARS-CoV-2 variant binding Blood Caco2 cell Cell composed conserved coronavirus delivery docking Effect ELISA facilitate functional genomic HIV-1 infection host receptor impair impairing in viral in vitro incubated Infection Inflammatory response inhibit SARS-CoV-2 inorganic Interaction investigated involved linear polymer mapped molecular docking Nasal Epithelial cells nebulized phosphate polymerase polyphosphate positive-sense presenting proinflammatory cytokines proteasomal degradation Protein RdRP reduced repeated Replication required resulting RNA transcript RNA-dependent RNA polymerase SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RdRp SARS-CoV-2 replication site-directed mutagenesis structural proteins subgenomic RNAs tested therapeutic use Toxicity Vero E6 viral entry Viral RNA virus virus entry [DOI] 10.1126/scisignal.abe5040 PMC 바로가기 [Article Type] Research Article
Meta-Analysis and Structural Dynamics of the Emergence of Genetic Variants of SARS-CoV-2Microbiology Published on 2021-06-292022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome analyzed B.1.1.7 B.1.1.7 variant B.1.351 B1.351 variant Betacoronavirus binding Brazil complex consensus sequence coronavirus COVID-19 COVID-19 pandemic Deleterious driving Dynamics Effect emergence error Evolution Factor feature genetic modification Genetic variant genetic variants Genome genome replication host receptor identify immune Immune escape Mutation Neutral neutralizing antibody new SARS-CoV-2 new virus offer P.1 P.1 variant pathogenicity polymerase positive positive-sense single-stranded RNA Prevalence Proofreading replicate RNA genome SARS-CoV-2 SARS-CoV-2 gene South Africa spike glycoprotein structural property the SARS-CoV-2 genome trajectory Transmissibility United Kingdom Vaccines variant variants variants of concern virulence virus VoC Wuhan, China [DOI] 10.3389/fmicb.2021.676314 PMC 바로가기 [Article Type] Microbiology
Molecular screening of glycyrrhizin-based inhibitors against ACE2 host receptor of SARS-CoV-2SARS-CoV-2의 ACE2 숙주 수용체에 대한 글리시리진 기반 억제제의 분자 스크리닝Article Published on 2021-06-242022-09-11 Journal: Journal of molecular modeling [Category] SARS, 신약개발, 치료제, [키워드] ACE-2 ACE2 ACE2 receptor analogue angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral approach aqueous solution AutoDock average binding binding energy binding free energy binding interactions binding pocket blind blockade complexes Compound compounds conformational change Consistency cut-off demonstrated deslanoside determine digitoxin digoxin docking docking result docking results DrugBank enzyme filtered glycyrrhizin high stability Host host receptor inhibitor Interaction Ligand MMGB/PBSA Molecular simulation molecular simulations performed predicted Protein remained reported RMSD SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein screened similarity Simulation spike Spike protein stability subsequent supported the SARS-CoV-2 Therapeutics these compounds Vaccine development Virtual screening was used [DOI] 10.1007/s00894-021-04816-y PMC 바로가기 [Article Type] Article
PNPLA3 and TLL-1 Polymorphisms as Potential Predictors of Disease Severity in Patients With COVID-19Cell and Developmental Biology Published on 2021-06-232022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] 95% CI absence ACE2 Admission Affect angiotensin-converting enzyme 2 binding characterized cleavage site Clinical course Comorbidity consecutive patient contribute Course COVID-19 death determinant disease course early phase Genetic polymorphism Genetic variant Genotype higher risk host cell host gene host receptor host’s cells IFNL3 immune stimulation in silico increased risk infect Infection Inflammation Intensive involved MERTK Mild nasopharyngeal swabs NLRP3 inflammasome nucleic acid older patient outcome pandemic Pathogenesis pathogenesis of COVID-19 pathway Patient PNPLA3 PNPLA3 I148M polymorphism Potential predicted Predictive Prognosis protease Protease activity Protein protein cleavage re-infect Reinfection risk SARS-CoV-2 SARS-COV-2 infection Severity of disease Sex significantly Specific spike subject subsequent Support the SARS-CoV-2 the Spike therapeutic approaches therapy tissue damage TLL-1 upregulation variant were assessed younger patient [DOI] 10.3389/fcell.2021.627914 PMC 바로가기 [Article Type] Cell and Developmental Biology
SARS-CoV-2 Infection and Significance of Oral Health Management in the Era of “the New Normal with COVID-19”Review Published on 2021-06-182022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome addition angiotensin-converting enzyme 2 Bacteria caused chronic obstructive Comorbidities Comorbidity comparable connection Contagion coronavirus coronavirus disease COVID-19 COVID-19 progression death rate diabete disease effective expected expressed greater Health host receptor hypothetical infective Inflammation involved Lower respiratory tract management mechanism Nasopharyngeal swab New normal oral oral bacteria oral health pandemic Pathogens Periodontitis pharyngeal Prevent proinflammatory protease pulmonary disease researcher respiratory epithelia responsible risk Saliva salivary SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission scrutiny shown Significance thought tongue vaccination Vaccine viral entry viral infection viral loads Viral RNA virus replication World Health Organization [DOI] 10.3390/ijms22126527 PMC 바로가기 [Article Type] Review
Phenolic compounds disrupt spike-mediated receptor-binding and entry of SARS-CoV-2 pseudo-virionsResearch Article Published on 2021-06-172022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] angiotensin-converting enzyme 2 anti-SARS-CoV-2 assays binding cathepsin L Cell cellular cellular entry cellular mechanism complex Compound Concentration decrease develop disrupt effective effective interventions Efficacy entry of SARS-CoV-2 experimental evidence expression greater highest host receptor human Angiotensin-converting enzyme infect inhibiting investigated involved pleiotropic Prevent protein level pursuit receptor reducing Replication SARS-COV-2 infection SARS-CoV-2 virions Spike protein targeting tested the receptor-binding domain the SARS-CoV-2 virus transmembrane serine protease virus [DOI] 10.1371/journal.pone.0253489 PMC 바로가기 [Article Type] Research Article
Possible inhibition of GM-CSF production by SARS-CoV-2 spike-based vaccinesSARS-CoV-2 스파이크 기반 백신에 의한 GM-CSF 생성 억제 가능성Perspective Published on 2021-05-222022-09-12 Journal: Molecular Medicine [Category] SARS, 진단, [키워드] ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-inflammatory effect antibodies antibody boost caused coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression elicit Evidence GM-CSF host receptor inhibiting Interaction Like mRNA pandemic protective antibodies Protective antibody RBM receptor-binding motif SARS-CoV SARS-CoV-2 SARS-like coronavirus Spike protein spike protein of SARS-CoV-2 Spike-based vaccine spike-based vaccines suggested the spike protein Vaccine viral entry [DOI] 10.1186/s10020-021-00313-3 PMC 바로가기 [Article Type] Perspective