High-resolution within-sewer SARS-CoV-2 surveillance facilitates informed intervention고해상도 하수도 내 SARS-CoV-2 감시는 정보에 입각한 개입을 용이하게 합니다.Article Published on 2021-10-012022-09-11 Journal: Water research [Category] SARS, 치료기술, [키워드] approach assist biological replicates Boulder Building-scale monitoring Campus collected Composite Composite sampler Concentration COVID-19 Critical Decision making Epidemiology facilitate Guidance health guidance house individual Intervention normalization normalized pandemic polymerase chain reaction Population Prevalence Prevent public health qPCR quantified Quantitative reflected replicate reverse transcription RT-qPCR RT-qPCRs SARS-CoV-2 SARS-CoV-2 surveillance Supply chain Surveillance Temporal resolution the SARS-CoV-2 university utility utilization wastewater wastewater surveillance Wastewater-based epidemiology withdrawn [DOI] 10.1016/j.watres.2021.117613 PMC 바로가기 [Article Type] Article
Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate InhibitorsSAM 경쟁 억제제를 사용한 시험관 내 SARS-CoV-2 Nsp14의 SAM 결합 부위 조사 선택적 이중 기질 억제제 개발 가이드Article Published on 2021-10-012022-09-11 Journal: SLAS discovery : advancing life sciences R & D [Category] SARS, 유전자 메커니즘, 치료제, [키워드] adenosylmethionine Antiviral binding cause competitive inhibitor Consequences coronavirus COVID-19 COVID-19 pandemic Developing DNA evade Guanosine guide Healthcare system Healthcare systems house Human immune system inhibited inhibitor library lysine mechanism of action Methylation methyltransferase NSP nsp14 Nsps optimization other coronaviruses path Probing Protein provided RNA SAM SARS-CoV-2 SARS-CoV-2 virus selective significant difference significant differences Site the disease these compound these compounds Viral RNA [DOI] 10.1177/24725552211026261 PMC 바로가기 [Article Type] Article
An evaluation of a FluoroSpot assay as a diagnostic tool to determine SARS-CoV-2 specific T cell responsesSARS-COV-2 특이 적 T 세포 반응을 결정하기위한 진단 도구로서 플루오 스팟 분석의 평가Research Article Published on 2021-09-302022-09-10 Journal: PLoS ONE [Category] SARS, 진단, 치료법, [키워드] addition Affect aligning Amino acid appear assays blood sample Blood samples calculated cellular Cellular immune response cellular immune responses cellular response Chain Reaction Cohort COVID-19 patients cross-reactive determine diagnostic diagnostic value dual endemic HCoVs evaluated HCoVs HCW healthcare worker Healthcare workers hospitalized COVID-19 patient house human coronavirus human coronaviruses IFN-γ IgG immune response immune responses individuals less nucleocapsid Numerous peptide peptide pool peptide pools polymerase chain polymerase chain reaction post infection reference standard Release repeated Research SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike sensitivity Seroconversion serological serological assays serology seronegative Specificities specificity T cell T cell response [DOI] 10.1371/journal.pone.0258041 PMC 바로가기 [Article Type] Research Article
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence: Navigating the absence of a gold standard심한 급성 호흡기 증후군 코로나 바이러스 2 (SARS-COV-2) 혈청 유병률 : 금 표준의 부재를 탐색Research Article Published on 2021-09-232022-09-10 Journal: PLoS ONE [Category] SARS, 진단, 치료기술, 치료법, 치료제, [키워드] Abbott absence acute respiratory syndrome acute respiratory syndrome coronavirus anti-SARS-CoV-2 assays Bayesian Blood donors can be used Canada Characteristics class conducted coronavirus COVID-19 pandemic credible interval CrI cross-sectional cross-sectional study diagnostic First wave gold gold standard healthy blood donor highest house IgG IgG antibody IgG ELISA immunoassay Latent Model nucleocapsid pandemic plasma sample plasma samples positive predicted Receptor binding domain reference standard Reference standards respiratory Result SARS-CoV-2 sensitivity Seroprevalence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike spike glycoprotein unique waned was tested while [DOI] 10.1371/journal.pone.0257743 PMC 바로가기 [Article Type] Research Article
COVID-19 mRNA vaccine and antibody response in lactating women: a prospective cohort study수유 여성의 COVID-19 mRNA 백신 및 항체 반응 : 전향 적 코호트 연구Clinical Trial Published on 2021-09-172022-08-09 Journal: BMC Pregnancy and Childbirth [Category] SARS, 바이오마커, 임상, 진단, [키워드] antibodies in breastmilk antibodies transfer via breastmilk antibody antibody quantification Antibody Response antibody transfer association Blood BNT162b2 BNT162b2 Pfizer vaccine Breastfeeding breastmilk change clinical Clinical data clinical trial conducted convenience homogenous sample COVID-19 COVID-19 vaccination dominant dominant serum antibody response enrolled evidence of healthcare worker house human milk IgA IgG IgG antibodies IgM immunity after vaccination immunization immunological characteristics immunological profile in-house ELISA lactating lactating women lactation levels of antibody moderate mother mRNA vaccination mRNA vaccine positive post vaccination presence of antibody prospective cohort study quantified questionnaire Registered reported Result SARS- CoV-2 SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 trimeric spike protein serum antibody response shown Spike protein titer titers titers of IgG transfer Trimeric spike protein vaccination was performed women [DOI] 10.1186/s12884-021-04051-6 PMC 바로가기 [Article Type] Clinical Trial
Ahead of the second wave: Early warning for COVID-19 by wastewater surveillance in Hungary두 번째 물결을 앞두고: 헝가리의 폐수 감시를 통한 COVID-19 조기 경보Article Published on 2021-09-102022-09-11 Journal: The Science of the total environment [Category] SARS, 치료기술, [키워드] average Budapest Capital comparable Concentration correlated correlation COVID-19 COVID-19 outbreak early warning effective Efficiency Environmental surveillance Epidemiology first positive First wave flat Frequency house Hungary indicated infections introduced low frequency membrane N gene outbreak pandemic plant quantified reproducibility RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA second wave sewage subsequent Surveillance Treatment Viral load Volume wastewater Wastewater-based epidemiology [DOI] 10.1016/j.scitotenv.2021.147398 PMC 바로가기 [Article Type] Article
Assessment of avidity related to IgG subclasses in SARS-CoV-2 Brazilian infected patientsSARS-COV-2 브라질 감염 환자의 IgG 서브 클래스와 관련된 열성 평가Clinical Trial Published on 2021-09-032022-08-13 Journal: Scientific Reports [Category] SARS, 임상, 진단, 치료기술, [키워드] analyzed anti-RBD Anti-RBD IgG anti-RBD IgG4 antibody Antibody avidity antibody levels Antibody Response Applied immunology assessment association avidity avidity range Brazil COVID-19 detectable Diagnostic markers died disease effort elicit ELISA exacerbated Follow-up form Health highlighting hospitalized patient hospitalized patients house IgG IgG antibody IgG subclasse IgG1 IgG3 IgG4 Immunological response Immunological techniques indicate infected patient Laboratory less life-threatening Mild Mild disease Most patients outcome Patient predict protective immunity RBD RBD IgG RBD IgG-ELISA RBD protein resulting reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RBD sensibility sera severe COVID-19 specificity study period symptomatic patient Symptomatic patients symptoms onset the disease Vaccine development with COVID-19 with mild disease [DOI] 10.1038/s41598-021-95045-z PMC 바로가기 [Article Type] Clinical Trial
Implementation of Sample Pooling Procedure Using a Rapid SARS-CoV-2 Diagnostic Real-Time PCR Test Performed Prior to Hospital Admission of People with Intellectual Disabilities지적 장애가 있는 사람의 입원 전에 수행된 신속한 SARS-CoV-2 진단 Real-Time PCR 테스트를 사용한 샘플 풀링 절차 구현Brief Report Published on 2021-09-032022-09-10 Journal: International Journal of Environmental Research an [Category] SARS, 치료기술, [키워드] Accuracy Community conditions consumables Dementia diagnostic diagnostic testing dimensions disability Health health maintenance helping Hospital admission house Intellectual intellectual disability management Nasopharyngeal swab nasopharyngeal swabs Oropharyngeal PCR performed pooling populations Prevalence procedure public health Rapid reduce reliability RT-PCR RT-PCR assay Sample sample collection Sample pooling SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection sensitivity significantly Spread Test the disease Timeliness tube Viral viral spread Vulnerable populations [DOI] 10.3390/ijerph18179317 PMC 바로가기 [Article Type] Brief Report
Clinical Evaluation of In-House-Produced 3D-Printed Nasopharyngeal Swabs for COVID-19 TestingCOVID-19 테스트를위한 사내 생성 된 3D 프린트 비 인두 면봉의 임상 평가Brief Report Published on 2021-09-022022-09-01 Journal: Viruses [Category] SARS, 진단, [키워드] 3D-printed nasopharyngeal swabs Accuracy anticipated autonomous clinical Community Concordance COVID-19 COVID-19 pandemic Diagnosis diagnostic Diagnostic accuracy head house knowledge nasopharyngeal Oropharyngeal PCR platform provided radiology replacement SARS-CoV-2 South standard flocked swab standard flocked swabs Swab swab sample swabs System Testing university validation was performed [DOI] 10.3390/v13091752 PMC 바로가기 [Article Type] Brief Report
Seroprevalence of SARS-CoV-2 among high-risk healthcare workers in a MERS-CoV endemic areaMERS-CoV 발병 지역의 고위험 의료 종사자 중 SARS-CoV-2의 혈청 유병률Article Published on 2021-09-012022-09-11 Journal: Journal of infection and public health [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibody blood sample body aches chain Chain Reaction collected Contact contact with coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus-2 cough country CoV antibodies COVID-19 COVID-19 patients cross-sectional cross-sectional study detectable dual ELISA endemic area enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Evidence expected exposure to Fever HCW HCWs headache healthcare worker Healthcare workers hospital house IgG IgG antibodies IgG antibody in-house ELISA Infection International Loss of Smell loss of smell and taste MERS MERS-CoV Middle East Middle East respiratory syndrome Coronavirus MOST neutralization activity participant Participants Patient PCR physically polymerase chain reaction positive positive sample Prevalence PROTECT reaction recruited reported respiratory respiratory syndrome coronavirus SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 seroprevalence Saudi Arabia seropositive seropositive sample Seropositivity Seroprevalence Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spike proteins Symptom Taste tested the SARS-CoV-2 the spike protein unique venous venous blood Viral Viral RNA with COVID-19 [DOI] 10.1016/j.jiph.2021.08.029 PMC 바로가기 [Article Type] Article