Inhaled route and anti-inflammatory action of ivermectin: Do they hold promise in fighting against COVID-19?이버멕틴의 흡입 경로 및 항염 작용: COVID-19와의 싸움에서 약속이 있습니까?Article Published on 2021-01-012022-08-31 Journal: Medical Hypotheses [Category] SARS, 신약개발, 치료법, 치료제, [키워드] Administered administration anti-inflammatory action antiviral activity approved broad spectrum Clinical studies clinically coronavirus COVID-19 demonstrated DNA and RNA dose doses drug Drug repurposing effective effort global pandemic hypothesise hypothesised IC50 In-vitro Inhaled interfere Ivermectin lung Lungs nucleus oral administration prevention of COVID-19 Protein repurposing respiratory Respiratory illness RNA viruses SARS-CoV-2 SARS-CoV-2 nucleocapsid Scientific community severe respiratory illness Transport Treatment treatment strategy virus viruses [DOI] 10.1016/j.mehy.2020.110364 PMC 바로가기 [Article Type] Article
Safety and immunogenicity of INO-4800 DNA vaccine against SARS-CoV-2: A preliminary report of an open-label, Phase 1 clinical trialResearch article Published on 2020-12-242022-10-05 Journal: EClinicalMedicine [Category] Coronavirus, 비임상, [키워드] administration adverse event Antigen binding binding antibody CD8+ T cell cellular cellular immune responses CEPI clinical trial Coalition COVID-19 Cytometry demonstrated described DNA vaccine ELISA ELISpot assay evaluated finding Flow Frequency full length funding geometric geometric mean titer Grade 1 groups humoral humoral immune response IC50 IL-4 immunogenic increase in Innovation INO-4800 median age men neutralizing antibody Open-label participant Participants PBMC Phase 1 preliminary report PRNT receiving reported response Safety SARS-CoV-2 second dose Serious Adverse Event seroconverted SFU subject T cell response the median TNF-α Tolerability Trial two group urgency Vaccine [DOI] 10.1016/j.eclinm.2020.100689 [Article Type] Research article
Development of a Minimal Physiologically-Based Pharmacokinetic Model to Simulate Lung Exposure in Humans Following Oral Administration of Ivermectin for COVID-19 Drug RepurposingShort communication Published on 2020-12-012022-10-05 Journal: Journal of pharmaceutical sciences [Category] SARS, 신약개발, 치료제, [키워드] ACE2 receptor Antiviral antiviral activity cellular Combination Concentration COVID-19 described determine develop development doses drug Efficacy exposure geometric host cell Human human lung humans IC50 Importins in vitro Inhaled inhibiting Ivermectin Kinetics less lung lung tissue mechanism Minimal physiologically-based pharmacokinetic model Model nuclei oral pharmacokinetic Pharmacokinetic/pharmacodynamic (PK/PD) modeling pharmacokinetics Pharmacometrics Physiologically based pharmacokinetic modeling plasma plasma concentration profile reached reported repurposing SARS-CoV-2 shown subunit therapeutic potential were used [DOI] 10.1016/j.xphs.2020.08.024 [Article Type] Short communication
Bovine Interferon Lambda Is a Potent Antiviral Against SARS-CoV-2 Infection in vitroVeterinary Science Published on 2020-11-062022-11-01 Journal: Frontiers in Veterinary Science [Category] COVID-19, [키워드] absence Adaptive immune response Against Antiviral antivirals biotherapeutic agent bovine bovine IFN-λ Cell cells circulating COVID-19 demonstrated effective epithelial expressed Health HEK-293 cell higher affinity Human human PBMC IC50 identity IFN IFN-λ in silico in vitro inhibitory concentration Interaction lack Lambda lung mucosal surfaces non-specific other respiratory virus polymorphism potent produced proinflammatory receptor reduce reduced respiratory viral infections respiratory viruses SARS-CoV-2 SARS-COV-2 infection tested therapeutic therapy These cells Toxicity Transmission Type I IFN type I IFNs variants viral infections virus [DOI] 10.3389/fvets.2020.603622 PMC 바로가기 [Article Type] Veterinary Science
Drug repurposing: Discovery of troxipide analogs as potent antitumor agentsResearch article Published on 2020-09-012022-10-05 Journal: European journal of medicinal chemistry [Category] 신약개발, [키워드] 4] triazolo[1 5-a] pyrimidines 1 activating anti-apoptotic Antiproliferative activity antitumor agent Apoptosis apoptotic signaling Bax BCL-2 Bioactivity cancer cell line caspase Cell Cell migration cells cleaved Compound death down-regulated drug Drug repurposing drugs evaluated exhibited expression extrinsic pathway feasibility IC50 indicated inhibit inhibited intrinsic pathway MCF-7 PARP pathway PC3 pro-apoptotic reported researcher significantly increased suppressed up-regulated [DOI] 10.1016/j.ejmech.2020.112471 [Article Type] Research article
Energetics and IC50 based epitope screening in SARS CoV-2 (COVID 19) spike protein by immunoinformatic analysis implicating for a suitable vaccine developmentResearch Published on 2020-07-102022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, SARS, [키워드] ACE-2 receptor protein ACE2 Analysis antigenicity binding conserved COVID 19 database develop domain Effect Effects energetics epitope Epitope designing and screening extreme genetic material glycoprotein glycosylation Health Host IC50 inhibitor manifested MERS-CoV MHC II motif mutations Ontology outbreak PyMol reactivity regimen Region Result SARS CoV SARS CoV-2 SARS CoV-2 (COVID 19) SARS-CoV SARS-CoV-2 screened selected server Severe global outbreak-Dec 2019 spike glycoprotein Spike protein stability the SARS-CoV-2 therapeutic Topology vaccination Vaccination strategy Vaccine Vaccine development viral spike virulence ZDOCK [DOI] 10.1186/s12967-020-02435-4 PMC 바로가기 [Article Type] Research
Interaction of certain monoterpenoid hydrocarbons with the receptor binding domain of 2019 novel coronavirus (2019-nCoV), transmembrane serine protease 2 (TMPRSS2), cathepsin B, and cathepsin L (CatB/L) and their pharmacokinetic propertiesArticle Published on 2020-06-212022-10-29 Journal: Turkish Journal of Biology [Category] COVID-19, [키워드] 2019 novel coronavirus 2019-nCoV ACE2 addition Analysis binding binding energy cathepsin cathepsin B cathepsin L caused cellular protease coronavirus coronavirus disease COVID-19 cross death docking dose drug-likeness effective evaluated IC50 inhibit Interaction liver cells molecular interaction monoterpene P-glycoprotein pharmacokinetic predicted Receptor binding domain serine protease Spike protein target target protein TMPRSS2 toxic effect transmembrane serine protease [DOI] 10.3906/biy-2005-46 PMC 바로가기 [Article Type] Article
Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusionArticle Published on 2020-03-302022-10-04 Journal: Cell Research [Category] MERS, SARS, 치료제, [키워드] amino acid residue caused circulating coronavirus coronavirus disease COVID-19 defined develop domain effective electron microscopy examined global public health HCoV-OC43 HR1 domain human coronavirus IC50 Infection inhibit inhibited inhibition inhibitor Interaction membrane fusion MERS-CoV mice molecular mechanism mutated outbreak peptide plasma membrane pseudovirus pseudovirus infection Replication S protein S2 subunit SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S SARS-CoV-2 spike SARSr-CoVs Spike protein tested the SARS-CoV-2 Treatment viral infection Wuhan, China X-ray [DOI] 10.1038/s41422-020-0305-x PMC 바로가기 [Article Type] Article
Correlation between in vitro and in vivo antimalarial activity of compounds using CQ-sensitive and CQ-resistant strains of Plasmodium falciparum and CQ-resistant strain of P. yoeliiarticle Published on 2017-07-312024-09-01 Journal: Parasitology Research [Category] 말라리아, [키워드] 3D7 strain Discriminant function analysis IC50 IC90 K1 strain MIC STATISTICA 7.1 [Article Type] article
Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike proteinArticle Published on 2006-04-172022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] affected Anti-viral antiviral activity Asia Atypical cell cytotoxicity Class I viral fusion protein Concentration concentrations coronavirus CoV domain dose-dependent Effect Europe fusion peptide fusion protein glycoprotein heptad repeat hydrophobicity IC50 identify inhibited inhibition inhibitor membrane membrane fusion MHV murine hepatitis virus N-terminus North America peptide Peptide inhibitor Pneumonia provide recent Receptor binding Region regions responsible S2 subunit SARS-CoV severe Severe acute respiratory syndrome-associated coronavirus six-helix bundle tested the S protein viral infectivity viral spike viral spike protein was used white [DOI] 10.1016/j.virusres.2006.03.001 PMC 바로가기 [Article Type] Article