Inactivated SARS-CoV-2 vaccines elicit immunogenicity and T-cell responses in people living with HIV비활성화된 SARS-CoV-2 백신은 HIV에 감염된 사람들에게 면역원성과 T 세포 반응을 유발합니다Clinical Trial Published on 2022-01-012022-09-12 Journal: International immunopharmacology [Category] MERS, SARS, 임상, 진단, [키워드] Adenovirus Analysis antibody B cells booster dose caused CD4 CD45RO CD8 Community comparable COVID-19 cytokine determine dose Effect elicit ELISA Enumeration evaluated exhibited expression flow cytometry healthy donor HIV HIV-positive individual IFN-γ IL-2 inactivated individuals influences on Laboratory lymphocyte magnitude memory T cell Messenger RNA mRNA neutralization Neutralization antibody Neutralizing antibodies neutralizing antibody Pearson correlation Peripheral blood PLWH positive rate positive rates recruited required response SARS-2-S SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 vaccines. Spearman Spike protein staining T-cell Response Th1 Th17 Th17 response Th2 TNF-α Treg Vaccine Vaccines was used with HIV [DOI] 10.1016/j.intimp.2021.108383 PMC 바로가기 [Article Type] Clinical Trial
Longitudinal dynamics of SARS-CoV-2-specific cellular and humoral immunity after natural infection or BNT162b2 vaccination자연 감염 또는 BNT162b2 백신 접종 후 SARS-CoV-2 특이적 세포 및 체액성 면역의 종적 역학Research Article Published on 2021-12-282022-09-12 Journal: PLoS Pathogens [Category] Coronavirus, SARS, 진단, [키워드] acute COVID-19 adaptive addition age and gender analysed anti-S anti-SARS-CoV-2 vaccination antibody BNT162b2 cellular Cellular and humoral responses cellular immunity cellular response characterized Clinical outcome comparable COVID-19 COVID-19 recovered patients declined description disease Early detection elicited emergency room healthy controls hospital humoral humoral immune response Humoral immunity Humoral response IFN-γ IL-2 immune response immune responses Immunity independent Infection information longitudinal longitudinal study Mild mild patients moderate natural infection neutralization capacity Neutralizing antibodies neutralizing antibody outcome Patient patients performed Post-infection Predictive Prognosis Prognostic value protective factor protective response provide public health recommendations robust SARS-CoV-2 SARS-COV-2 infection Seven severe COVID-19 severe patients severity subjects T cell T cell response T cells the patient uninfected vaccination [DOI] 10.1371/journal.ppat.1010211 PMC 바로가기 [Article Type] Research Article
Off-the-Shelf Partial HLA Matching SARS-CoV-2 Antigen Specific T Cell Therapy: A New Possibility for COVID-19 Treatment기성품 부분 HLA 매칭 SARS-CoV-2 항원 특이적 T 세포 요법: COVID-19 치료를 위한 새로운 가능성Immunology Published on 2021-12-232022-09-11 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료법, [키워드] adoptive transfer Antigen approach assays both groups CD4+ T cell CD56 CD8+ Cell Characteristics COVID-19 COVID-19 patient COVID-19 patients COVID19 Culture cytokine cytotoxicity determined by donors effector memory ELISPOT feature Final functional generate groups HLA HLA sharing hyperinflammation IL-2 Immunity immunophenotype in both group individual intracellular cytokine lymphopenia matching membrane mononuclear cell mononuclear cells New Nucleocapsid proteins Partial peptide Peripheral blood Peripheral blood mononuclear cells profiles rationale reduced respond Result SARS-CoV-2 SARS-CoV-2 antigen severe COVID-19 patient severe COVID-19 patients Specific specificity stimulated subset T cell T cell responses T cell therapy T cells transfer treat Treatment viral immunity virus specific T cells was determined [DOI] 10.3389/fimmu.2021.751869 PMC 바로가기 [Article Type] Immunology
Characterization of SARS-CoV-2-Specific Humoral and Cellular Immune Responses Induced by Inactivated COVID-19 Vaccines in a Real-World SettingImmunology Published on 2021-12-222022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] acute respiratory syndrome binding domain CD4+ CD4+ T cell CD8+ T cell cellular cellular immune responses characterization characterized clinical trials Concentration concerning conditions coronavirus coronavirus disease COVID-19 COVID-19 vaccine COVID-19 vaccines COVID‐19 cytokine demonstrated detectable dose dosing interval elicited Evidence Frequency humoral humoral immune response humoral immune responses IFN-γ IgG IgG response IL-2 immune response Immunity inactivated Inactivated vaccine individual individuals induced longitudinal analysis majority male membrane neutralizing antibody nucleocapsid parameter participant peptide pool Protein raised recognizing response S-RBD SARS-CoV-2 SARS‐CoV‐2 second dose second vaccination setting significantly higher single vaccine sustained the SARS-CoV-2 TNF-α vaccination Vaccine vaccinees waned while [DOI] 10.3389/fimmu.2021.802858 PMC 바로가기 [Article Type] Immunology
Toward finding the difference between untreated celiac disease and COVID-19 infected patients in terms of CD4, CD25 (IL-2 Rα), FOXP3 and IL-6 expressions as genes affecting immune homeostasisResearch Published on 2021-12-112022-10-27 Journal: BMC Gastroenterology [Category] COVID-19, [키워드] accompanied acute respiratory syndrome affecting Analysis Anti-inflammatory Autoimmune carried caused CD25 CD4 cDNA synthesis celiac disease collected Control control group coronavirus Coronavirus disease 2019 COVID-19 COVID-19 infected patient COVID-19 patient defined diagnosed disease Diseases expression expression level FOXP3 fresh whole blood Gene Expression GraphPad greater healthy subject IL-2 IL-6 IL-6 expression Immune homeostasis in both group Increased increased expression increased risk infected with COVID-19 Infectious disease Inflammation interleukin interleukin-6 marker median age Multiorgan Patient patients Peripheral blood Prism Quantitative recruited reducing Regulatory Result risk risk of infection RNA expression RT-PCR SARS-CoV-2 SARS-CoV-2 virus severe COVID-19 severe COVID-19 patient severe COVID-19 patients severity of COVID-19 SPSS subjects T-lymphocytes total RNA viral illnesses viral infections was obtained was performed were assessed while [DOI] 10.1186/s12876-021-02056-1 PMC 바로가기 [Article Type] Research
Toward finding the difference between untreated celiac disease and COVID-19 infected patients in terms of CD4, CD25 (IL-2 Rα), FOXP3 and IL-6 expressions as genes affecting immune homeostasisResearch Published on 2021-12-112022-10-27 Journal: BMC Gastroenterology [Category] Coronavirus, COVID-19, Fulltext, [키워드] accompanied acute respiratory syndrome affecting Analysis Anti-inflammatory Autoimmune carried caused CD25 CD4 cDNA synthesis celiac disease collected Control control group coronavirus Coronavirus disease 2019 COVID-19 COVID-19 infected patient COVID-19 patient defined diagnosed disease Diseases expression expression level FOXP3 fresh whole blood Gene Expression GraphPad greater healthy subject IL-2 IL-6 IL-6 expression Immune homeostasis in both group Increased increased expression increased risk infected with COVID-19 Infectious disease Inflammation interleukin interleukin-6 marker median age Multiorgan Patient patients Peripheral blood Prism Quantitative recruited reducing Regulatory Result risk risk of infection RNA expression RT-PCR SARS-CoV-2 SARS-CoV-2 virus severe COVID-19 severe COVID-19 patient severe COVID-19 patients severity of COVID-19 SPSS subjects T-lymphocytes total RNA viral illnesses viral infections was obtained was performed were assessed while [DOI] 10.1186/s12876-021-02056-1 PMC 바로가기 [Article Type] Research
Single-Cell and Bulk RNASeq Profiling of COVID-19 Patients Reveal Immune and Inflammatory Mechanisms of Infection-Induced Organ DamageCOVID-19 환자의 단일 세포 및 벌크 RNaseQ 프로파일 링은 감염에 의한 장기 손상의 면역 및 염증 메커니즘을 나타냅니다.Article Published on 2021-12-022022-09-10 Journal: Viruses [Category] SARS, 유전자 메커니즘, [키워드] accounted Analysis analyzed cardiac hypertrophy correlated COVID-19 COVID-19 infection COVID-19 organ damage COVID-19 patients gene expression Critical Cytokines damage deleterious effect determine downregulated downstream Effect effective Effectiveness eIF2 eukaryotic eukaryotic initiation factor 2 fibrosis Host host protein host proteins hypercytokinemia hypertrophy IL-17A IL-2 IL-6 IL-8 immune and inflammatory mechanisms of COVID-19 imperative induce Inflammation Inflammatory inflammatory genes inhibitors inhibitory initiation factor innate immune response Interaction interleukin investigation lead lung Lungs mechanism Mild moderate multiple organ failure NF-κB organ Organ failure organ injury organs overactive pathway Pathways patients peptide peptides potential therapeutic target potential therapeutic targets pro-inflammatory cytokine pro-inflammatory cytokines Profiling reduced RNAseq SARS-CoV-2 SARS-CoV-2 virus severe and critical patients severely infected patients Severity of infection single and bulk RNASeq cell profiling and analysis single-cell Stimulation suppress suppression therapeutic targets tissues translation Treatment upregulation Viral viral infection Viral protein Viral proteins viral-host protein was increased [DOI] 10.3390/v13122418 PMC 바로가기 [Article Type] Article
Humoral and Cell-Mediated Immune Response in Colostrum from Women Diagnosed Positive for SARS-CoV-2Clinical Research Published on 2021-12-012022-10-28 Journal: Breastfeeding medicine : the official journal of t [Category] COVID-19, MERS, [키워드] 48 hour acute respiratory syndrome addition antibody Asymptomatic COVID-19 Bilateral breast milk Breastfeeding collected colostrum comparable conducted controls coronavirus COVID-19 cytokine cytokine response disease elevated enzyme-linked immunosorbent evaluate Evolution exhibited humoral immune response IFN-γ IgA IgG IgM IL-10 IL-12 IL-13 IL-2 IL-4 IL-6 IL-8 immune response Inflammatory cytokine Inflammatory marker measure mother multiplex positive provided RBD reactivity Receptor binding domain response SARS-CoV-2 SARS-CoV-2-specific antibody Spike protein statistically significant symptomatic tested the antibody response the SARS-CoV-2 tumor necrosis factor-alpha validation study virus was used were infected were used women [DOI] 10.1089/bfm.2021.0082 PMC 바로가기 [Article Type] Clinical Research
Phenylalanine and COVID-19: Tracking disease severity markers페닐알라닌 및 COVID-19: 질병 중증도 마커 추적Article Published on 2021-12-012022-09-11 Journal: International immunopharmacology [Category] MERS, 바이오마커, [키워드] addition adjusted Amino acid amino acids analyzed association Clinical and laboratory data confounder confounders COVID-19 cytokine Cytokines disease disease onset disease severity Flow flow cytometry groups Hospital admission ICU admission IFN-γ IL-10 IL-2 IL-4 IL-6 independent independent of Inflammation Inflammatory cytokines Inflammatory marker inflammatory markers inflammatory state investigated laboratory data Linear regression model linear regression models magnitude marker metabolomic Mild mild case mild cases Mild disease moderate mortality rate mortality rates Non-COVID-19 patients nuclear magnetic resonance onset of symptom pathway Phenylalanine predictor SARS-CoV-2 serum Serum level serum levels severity significantly lower SOFA scores TNF-α tyrosine Tyrosine. with COVID-19 [DOI] 10.1016/j.intimp.2021.108313 PMC 바로가기 [Article Type] Article
Interleukin-10-Mediated Lymphopenia Caused by Acute Infection with Foot-and-Mouth Disease Virus in MiceArticle Published on 2021-11-242022-10-28 Journal: Viruses [Category] COVID-19, [키워드] addition Analysis Apoptosis B cells C57BL/6 CD4 CD8 characterized clinical symptom Clinical symptoms co-inhibitory molecules contribute correlated CTLA-4 CXCL1 disease severity downregulating elevated ENhance expression FMDV foot-and-mouth disease foot-and-mouth disease virus IFN-α/β IL-10 IL-17 IL-18 IL-1β IL-2 IL-6 Immune suppression in vivo Infection interleukin-10 LAG-3 lymphocyte Lymphocyte count lymphopenia mechanism mice Mild NK cell occurred Peripheral blood Prevent reduced serotype serum Signaling Support survival T cell T cells TGF-β Therapeutic approach TIGIT TNF-α Trafficking upregulated [DOI] 10.3390/v13122358 PMC 바로가기 [Article Type] Article