Elucidating T Cell and B Cell Responses to SARS-CoV-2 in Humans: Gaining Insights into Protective Immunity and Immunopathology인간의 SARS-CoV-2에 대한 T 세포 및 B 세포 반응 설명: 보호 면역 및 면역 병리학에 대한 통찰력 확보Review Published on 2021-12-272022-09-12 Journal: Cells [Category] SARS, 진단, [키워드] attribute B cell response B cells breadth COVID-19 Critical Effect effective immune response Immunological memory immunopathology insight magnitude memory mitigate neutralizing antibody Neutralizing antibody response outbreak pandemic recognize response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic Scientific community Spread T cells tested Vaccine virus virus-specific T cell [DOI] 10.3390/cells11010067 PMC 바로가기 [Article Type] Review
The immunology and immunotherapy for COVID-19Review Published on 2021-12-172024-09-02 Journal: Expert reviews in molecular medicine [Category] 대상포진, [키워드] cellular exhaustion COVID-19 Cytokine storm immunopathology Immunotherapy SARS-CoV-2 [DOI] 10.1017/erm.2021.30 PMC 바로가기 [Article Type] Review
Vascular Damage, Thromboinflammation, Plasmablast Activation, T-Cell Dysregulation and Pathological Histiocytic Response in Pulmonary Draining Lymph Nodes of COVID-19COVID-19의 폐 배수 림프절에서 혈관 손상, 혈전 염증, 원형질모세포 활성화, T-세포 조절 장애 및 병리학적 조직구 반응Immunology Published on 2021-12-132022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료기술, [키워드] accumulation Activation alveolar damage Analysis Autopsy bronchoalveolar lavage sample bronchoalveolar lavage samples CD105 CD36 collected Control COVID-19 COVID-19 case DAD damage demonstrated Depletion Diffuse alveolar damage downregulation Draining draining lymph node dysfunction dysregulated immune response dysregulation EBV enrolled Epstein Barr virus evidence of evidenced expression profiling FIBRIN FLT1 follicular follicular hyperplasia FOXP3 Gene expression profiling germinal centers herpes Herpes virus herpes viruses histology HLH immunohistochemical staining immunological immunopathology incidence infectious mononucleosis initial LEF1 lymph Lymph node lymph nodes Macrophage macrophage activation marker maturation Microarray microthrombi Migration mounted node Panel pathological pathway peribronchial Peripheral blood phenotype plasmablast plasmablasts positive PROCR provided pulmonary Reactivation response responsible Sample SARS-CoV-2 selected severe COVID-19 staining T-cell T-cell dysregulation T-cells TEK Thromboinflammation thrombosis tissue tracheal upregulation viruses vWF was performed widespread [DOI] 10.3389/fimmu.2021.763098 PMC 바로가기 [Article Type] Immunology
Antiviral Immunity in SARS-CoV-2 Infection: From Protective to Deleterious ResponsesReview Published on 2021-12-132022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] antibodies Antiviral caused cellular cellular and molecular coronavirus COVID-19 pandemic Diagnosis effective highly pathogenic Human immune response Immunity immunopathology Inflammation intrinsically involved Lymphocytes MERS produced question Respiratory illness response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants the SARS-CoV-2 therapeutic approaches zoonotic origin [DOI] 10.3390/microorganisms9122578 PMC 바로가기 [Article Type] Review
Acute respiratory distress syndrome in COVID-19: possible mechanisms and therapeutic managementReview Published on 2021-12-062022-10-28 Journal: Pneumonia [Category] COVID-19, [키워드] acute respiratory distress syndrome adverse effects approved ARDS ARDS patients clinical trial COVID-19 COVID-19 pandemic COVID-19 patients COVID-19 vaccination distress Effect effective Efficacy evaluated experimental drug FDA help ICU immunopathology intensive care Lung disease lung failure management mechanism Multiple Pandemics patients patients with COVID-19 Potential treatment Probably SARS-CoV-2 sick syndrome therapeutic therapy Treatment treatment strategy [DOI] 10.1186/s41479-021-00092-9 PMC 바로가기 [Article Type] Review
Post-mortem lung tissue: the fossil record of the pathophysiology and immunopathology of severe COVID-19Review article Published on 2021-12-032022-10-05 Journal: The Lancet. Respiratory Medicine [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] affected assumption cause Cell classic COVID-19 death Diffuse alveolar damage disease heterogeneity histology immunopathology Inflammatory lung Lung disease lung tissue management occur pathology pathophysiological pathophysiology Patient phenotype Post-mortem post-mortem lung progression provide severe COVID-19 severe disease tissue Treatment strategies [DOI] 10.1016/S2213-2600(21)00408-2 [Article Type] Review article
Genome-Wide B-Cell, CD4 + and CD8 + T-Cell Epitopes, that are Highly Conserved Between Human and Animal Coronaviruses, Identified from SARS-CoV-2 as Targets for Pre-Emptive Pan-Coronavirus VaccinesArticle Published on 2021-11-252023-07-01 Journal: Journal of immunology (Baltimore, Md. : 1950) [Category] SARS, [키워드] antibodies CD4+ T cells CD8+ T cells COVID-19 Epitopes Immunity immunopathology pan-coronavirus SARS-CoV-2 SL-CoVs Vaccine [DOI] 10.4049/jimmunol.2001438 PMC 바로가기 [Article Type] Article
Critically Ill Coronavirus Disease 2019 Patients Exhibit Hyperactive Cytokine Responses Associated With Effector Exhausted Senescent T Cells in Acute InfectionArticle Published on 2021-11-222022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 바이오마커, [키워드] CD4+ T-cell cells Coronavirus disease 2019 COVID-19 cytokine level cytokine response Cytokines death demonstrated deregulation effector events excessive inflammation exhausted/senescent T cells expression Frequency hallmark Ill immune system immunodeficiency immunopathology infected patient mechanism phenotype Reinfection Respiratory failure response SARS-CoV-2 severe pneumonia significantly increased susceptibility T cell T-cell T-cell exhaustion the cytokine storm [DOI] 10.1093/infdis/jiab425 PMC 바로가기
Waning antibodies from inactivated SARS-CoV-2 vaccination offer protection against infection without antibody-enhanced immunopathology in rhesus macaque pneumonia models비활성화된 SARS-CoV-2 백신 접종으로 인한 항체 약화는 붉은털 원숭이 폐렴 모델에서 항체 강화 면역병리학 없이 감염에 대한 보호를 제공합니다Letter Published on 2021-11-212022-09-10 Journal: Emerging Microbes & Infections [Category] Coronavirus, SARS, 진단, 치료기술, [키워드] absence acute phase acute respiratory syndrome acute respiratory syndrome coronavirus ADE alveolar anti-SARS-CoV-2 anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG antibody Antibody Response Antibody-dependent enhancement bronchioles Bronchoalveolar lavage Bronchoalveolar lavage fluid Cell cellular immunity clinical trial control group coronavirus Coronaviruses elevated epithelial Evidence evidence of humans IL-33 IL-8 immunology immunopathology inactivated Inactivated Vaccines Infection initial MCP-1 MERS-CoV Middle East Middle East respiratory syndrome Coronavirus Mild mild to moderate moderate Mucus murine neutralizing antibody NHP no evidence of observation offer passive transfer Pneumonia polyclonal antibodies polyclonal antibody postvaccination preclinical studies preclinical study pulmonary immunopathology reported respiratory Respiratory disease respiratory diseases respiratory syndrome coronavirus rhesus SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines severe acute respiratory syndrome Coronavirus subneutralizing antibodies supported transfer Typical vaccination Vaccine virus virus infection [DOI] 10.1080/22221751.2021.2002670 PMC 바로가기 [Article Type] Letter
Myeloid dysregulation and therapeutic intervention in COVID-19Review Published on 2021-11-092023-07-02 Journal: Seminars in Immunology [Category] SARS, [키워드] COVID-19 Hyperactivation immunopathology Immunotherapy myeloid cell Pathogenesis SARS-CoV-2 [DOI] 10.1016/j.smim.2021.101524 PMC 바로가기 [Article Type] Review