Impaired immunogenicity of BNT162b2 anti-SARS-CoV-2 vaccine in patients treated for solid tumors고형 종양 치료를 받은 환자에서 BNT162b2 항-SARS-CoV-2 백신의 면역원성 손상Article Published on 2021-08-012022-09-12 Journal: Annals of oncology : official journal of the Europ [Category] Fulltext, MERS, 진단, [키워드] anti-SARS-CoV-2 Impaired of BNT162b2 patients treated solid tumor Vaccine [DOI] 10.1016/j.annonc.2021.04.019 PMC 바로가기 [Article Type] Article
Non-RBM Mutations Impaired SARS-CoV-2 Spike Protein Regulated to the ACE2 Receptor Based on Molecular Dynamic SimulationMolecular Biosciences Published on 2021-07-272022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] ACE2 ACE2 receptor ACE2-RBD binding addition angiotensin-converting enzyme 2 bind binding binding free energy change changes conducted coronavirus Deterioration domain dynamic electrostatic interaction experiment higher affinity host cell hydrophobic interactions Impaired Infection interact Interaction looser molecular dynamic simulation molecular dynamics mutant Mutation mutations non-RBM mutations Novel coronavirus pathogenicity performed polar positive Protein random RBD RBM RBM region receptor Receptor binding domain receptor-binding motif Region Research residue SARS-CoV-2 SARS-CoV-2 mutation selected shown significantly Simulation spike Spike protein the epidemic the RBD V367F weakened wild-type [DOI] 10.3389/fmolb.2021.614443 PMC 바로가기 [Article Type] Molecular Biosciences
Comparison of Brain Activation Patterns during Olfactory Stimuli between Recovered COVID-19 Patients and Healthy Controls: A Functional Near-Infrared Spectroscopy (fNIRS) StudyCase Report Published on 2021-07-232022-10-28 Journal: Brain Sciences [Category] COVID-19, [키워드] addition AUC Case report changes in COVID-19 COVID-19 infection fraction functional functional near-infrared spectroscopy (fNIRS) healthy control Impaired Infection investigated near-infrared spectroscopy no difference not affect occur olfactory olfactory function olfactory stimuli Patient patients with COVID-19 pattern recovered recruited relative sense of smell sniffin’ sticks 12-identification test Spectroscopy [DOI] 10.3390/brainsci11080968 PMC 바로가기 [Article Type] Case Report
Impaired humoral and cellular immunity after SARS-CoV-2 BNT162b2 (tozinameran) prime-boost vaccination in kidney transplant recipients신장 이식 환자에서 SARS-CoV-2 BNT162b2(토지나메란) 프라임-부스트 백신 접종 후 체액 및 세포 면역 손상Article Published on 2021-07-152022-09-12 Journal: The Journal of Clinical Investigation [Category] SARS, 진단, [키워드] accompanied Adaptive immunity Affect age analyzed antibody approach BNT162b2 booster caused CD4+ CD8+ T cell cellular immunity cellular response change combating Control COVID-19 cytokine production dialysis dose Frequency global pandemic healthy healthy control Hemodialysis humoral IgA IgG immune immunization immunology immunosuppressed patients Immunosuppressive medication Impaired impairment individual kidney transplant recipient less majority memory mounted mRNA-based vaccine novel organ transplantation Patient patients powerful tool promotion reduced rejection renal response responses risk SARS-CoV-2 SARS-CoV-2 BNT162b2 second vaccination Seroconversion severe COVID-19 significantly Still T cells T helper cell transplantation undetectable vaccination Vaccine-induced immunity vaccinee [DOI] 10.1172/JCI150175 PMC 바로가기 [Article Type] Article
Severe COVID-19 Is Characterized by an Impaired Type I Interferon Response and Elevated Levels of Arginase Producing Granulocytic Myeloid Derived Suppressor Cells심각한 COVID-19는 손상된 I형 인터페론 반응과 과립구 골수 유래 억제 세포를 생성하는 아르기나아제 수치 상승이 특징입니다Observational Study Published on 2021-07-142022-09-11 Journal: Frontiers in Immunology [Category] SARS, 임상, 치료제, [키워드] Arg arginase arginine association Asymptomatic asymptomatic patient asymptomatic patients cause Cell circulating coronavirus COVID 19 COVID-19 COVID-19 complications degranulation deplete determine develop died difference Endothelial cell explain expressing G-MDSC granulocyte IFN impair Impaired increase in Increased increased expression Inflammation Inflammatory response interferon Level lung Lung injury Lungs myeloid oxygen pathway Pathways Patient patients Protective pulmonary complications pulmonary damage reactive oxygen species recent Replenishment respiratory Respiratory complications response severe COVID-19 severity Stage suppressor suppressor cells T cell T cell receptor the disease Transcriptome Type Type I IFN type I interferon [DOI] 10.3389/fimmu.2021.695972 PMC 바로가기 [Article Type] Observational Study
Impaired Priming of SARS-CoV-2-Specific Naive CD8 + T Cells in Older SubjectsImmunology Published on 2021-07-132022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] Activation addition Adults advanced age age approach CD8 CD8+ T cells cellular immunity contribute COVID-19 Critical death Donor Epitopes groups healthy immune Immune aging Impaired in vitro individual magnitude Manifestations naïve T cells Older older subject pathogen primary responses priming Protective recognize SARS-CoV-2 SARS-COV-2 infection severe symptom shown T cell T cells T-cell T-cell Response T-cell responses the disease virus [DOI] 10.3389/fimmu.2021.693054 PMC 바로가기 [Article Type] Immunology
Impaired Immune Response to SARS-CoV-2 Vaccination in Dialysis Patients and in Kidney Transplant RecipientsMulticenter Study Published on 2021-07-132022-10-05 Journal: Kidney360 [Category] SARS, 임상, [키워드] Against age Analysis Antibody Response BNT162b2 chronic clinical clinical immunology cohort study Control controls COVID-19 COVID-19 mRNA vaccine Cutoff dialysis dose evaluated first vaccination high risk humoral humoral immune response IgG level immune immune response Immunity Impaired kidney Kidney failure kidney transplant recipient Kidney transplantation Modification MOST mRNA-1273 neutralization capacity neutralizing antibody Neutralizing antibody titer Patient Prophylaxis recipient renal renal insufficiency response SARS-CoV-2 SARS-CoV-2 specific antibody SARS-CoV-2 vaccination SARS-CoV-2-specific antibody SARS-CoV-2-specific IgG second vaccination Severe COVID-19 Infection significantly significantly lower Transplant transplantation undetectable vaccination Vaccination strategy Vaccine Virology were measured [DOI] 10.34067/KID.0003512021 PMC 바로가기 [Article Type] Multicenter Study
Impaired Consciousness in a Coronavirus Disease 2019 Patient Caused by Low Serum Sodium: A Case ReportCase Report Published on 2021-07-062022-10-30 Journal: JMA Journal [Category] COVID-19, [키워드] Abnormalities acute respiratory syndrome cerebrospinal fluid Cognitive impairment consciousness coronavirus COVID-19 CSF Department Emergency Encephalitis etiology Fever Impaired Meningitis Mild Nasopharyngeal swab neurological abnormality neurological manifestation patients with COVID-19 PCR positive recovered completely report RT-PCR SARS-CoV-2 serum sodium Spain vomiting [DOI] 10.31662/jmaj.2021-0023 PMC 바로가기 [Article Type] Case Report
Impaired antibody response to COVID‐19 vaccination in patients with chronic myeloid neoplasms만성 골수성 신 생물 환자에서 Covid -19 백신 접종에 대한 항체 반응 장애Clinical Trial Published on 2021-06-242022-08-13 Journal: British Journal of Haematology [Category] MERS, SARS, 임상, [키워드] Antibody Response COVID‐19 Impaired neoplasm Patient vaccination [DOI] 10.1111/bjh.17644 PMC 바로가기 [Article Type] Clinical Trial
Elevated Interleukin-10 Levels in COVID-19: Potentiation of Pro-Inflammatory Responses or Impaired Anti-Inflammatory Action?Immunology Published on 2021-06-212022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Cytokine storm diabetes immunometabolism Impaired Inflammation interleukin-10 Level potentiation response SARS – CoV – 2 [DOI] 10.3389/fimmu.2021.677008 PMC 바로가기 [Article Type] Immunology