intranasal – Page 7 – Communicable Diseases Research

Survival analysis of COVID-19 patients in Ethiopia: A hospital-based study

Observational Study

Published on 2022-05-092022-10-05
Journal: PLoS ONE [Category] 임상,

[키워드] Admission admitted to ICU age analyzed Care carried chronic chronic kidney diseases chronic obstructive Clinical characteristics close monitoring confidence COVID-19 COVID-19 case COVID-19 disease COVID-19 patient Cox regression analysis death deaths Final global public health hazard high mortality higher risk HIV/AIDS Hospitalization Hospitalized hospitalized patient independent risk factor interval intranasal Kidney disease laboratory-confirmed majority median medical record Mortality mortality rate nine Observational cohort study occurred Older oxygen Patient patients hospitalized performed predictor Probability pulmonary disease Ratio retrospective risk risk of death Sociodemographic survival survival analysis the patient those with comorbidity treated Treatment zone
[DOI] 10.1371/journal.pone.0268280 PMC 바로가기 [Article Type] Observational Study

Adenovirus type 5 SARS-CoV-2 vaccines delivered orally or intranasally reduced disease severity and transmission in a hamster model

Research Article

Published on 2022-05-052022-10-04
Journal: Science Translational Medicine [Category] SARS, 임상, 진단, 치료법,

[키워드] acute respiratory syndrome Adenovirus clinical symptom clinical trial coronavirus coronavirus disease COVID-19 cross-reactive cross-reactive antibody decrease demonstrated description disease disease severity elicited exhibited expresse hamster IgA response immunization Infection Infectious virus intranasal intranasal route intranasally less lung Lung pathology mucosal nasal swab nucleocapsid protein oral platform PROTECT reduced responses robust SARS-CoV-2 SARS-CoV-2 disease SARS-CoV-2 vaccine SARS-CoV-2-infected hamster Spread the SARS-CoV-2 the spike protein Transmission Viral RNA Viral transmission
[DOI] 10.1126/scitranslmed.abn6868 PMC 바로가기 [Article Type] Research Article

Human inhalable antibody fragments neutralizing SARS-CoV-2 variants for COVID-19 therapy

COVID-19 치료를 위한 SARS-CoV-2 변이체를 중화하는 인간 흡입 가능한 항체 단편

Article

Published on 2022-05-042022-09-11
Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration aerosol aerosol therapy animal models anti-COVID-19 antibody antibody antibody fragment caused cell-cell fusion cells coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 pathology COVID-19 therapy Critical delta variant Efficiency epitope Human human single-chain antibody Immune status independent Infection inhalation inhibit Intervention intranasal intranasal administration nebulization neutralize Neutralizing other variant other variants phage display Resilience respiratory SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variant neutralization scFv severe acute respiratory syndrome Coronavirus single-chain variable fragment Spike protein stability subject the SARS-CoV-2 therapy
[DOI] 10.1016/j.ymthe.2022.02.013 PMC 바로가기 [Article Type] Article

Ex vivo and in vivo suppression of SARS-CoV-2 with combinatorial AAV/RNAi expression vectors

조합 AAV/RNAi 발현 벡터를 사용한 SARS-CoV-2의 생체외 및 생체내 억제

Article

Published on 2022-05-042022-09-11
Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 변종, 치료제,

[키워드] AAV acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition adeno-associated virus Antiviral Antiviral agents antiviral RNAi Cell clinically cocktail complement coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease symptom effective escape mutant escape mutants experiment expression vector flexible Genetic global effort Gut hACE2 in vivo infected cell infected cells intestinal cells intranasal mice mutational escape. N gene N genes organoids pandemic prevented RdRP RNA RNAi SARS virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RdRp SARS-CoV-2 strains severe acute respiratory syndrome Coronavirus suppressed the SARS-CoV-2 therapeutic translation triggers Vaccine vector vectors viral adaptation Viral load viral loads virus wild-type
[DOI] 10.1016/j.ymthe.2022.01.024 PMC 바로가기 [Article Type] Article

Control of CDH1/E-Cadherin Gene Expression and Release of a Soluble Form of E-Cadherin in SARS-CoV-2 Infected Caco-2 Intestinal Cells: Physiopathological Consequences for the Intestinal Forms of COVID-19

SARS-CoV-2에 감염된 Caco-2 장 세포에서 CDH1/E-Cadherin 유전자 발현 및 가용성 형태의 E-Cadherin 방출 제어: COVID-19의 장 형태에 대한 생리병리학적 결과

Article

Published on 2022-05-042022-09-11
Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료기술, 치료제,

[키워드] 24 hour 24 hours 48 hour 48 hours ACE2 ACE2 mRNA Affect AT1 Caco-2 Caco-2 cell Caco-2 cells cadherin CDH1 Cell cell line cells Co-receptor connexin consequence contributing to Control COVID-19 Culture culture supernatant diarrhoea diarrhoea) digestive tract Disruption dissemination down-regulated dysregulation E-cadherin ENCODE epithelial exposure to expresse expression form Gastrointestinal symptom gastrointestinal symptoms gastrointestinal tract HCoV HCoV-OC43 HLA class I human ACE2 illnesses in viral induce infected with SARS-CoV-2 Infection intestinal Intestinal barrier intestinal cells intestinal tissue intranasal involved JAMA junctions leads membrane mRNA mRNA expression OC43 occludin pandemic Patient Physiopathological Post-infection Protein receptor receptor ACE2 Release remained reported respiratory respiratory tract SARS-CoV-2 SARS-COV-2 infection significant increase significantly lower Symptom the disease these symptoms TMPRSS2 Transcription transgenic mice Trigger Viral viral entry virus
[DOI] 10.3389/fcimb.2022.798767 PMC 바로가기 [Article Type] Article

Intranasal Delivery of Thermostable Subunit Vaccine for Cross-Reactive Mucosal and Systemic Antibody Responses Against SARS-CoV-2

SARS-CoV-2에 대한 교차 반응성 점막 및 전신 항체 반응을 위한 열안정성 소단위 백신의 비강내 전달

Article

Published on 2022-05-032022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] ACE2 addition Against Alpha angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-RBD Anti-RBD antibody antibody Antibody Response Antibody responses Antibody titer Antibody titers approved Beta binding binding domain Breakthrough infection breakthrough infections chitosan circulation COVID-19 COVID-19 vaccines CpG cross-reactive delivery Delta variants domain Efficacy effort enzyme exclusion FIVE genetic material help Hesitancy IgA antibodies IgG1 IgG2a IL-12 Immunity immunization IMPROVE induce inhibited interleukin interleukin-12 intranasal intranasal vaccination intranasally isotype Laboratory mice mucosal mucosal immunity mutant oligonucleotide polypeptide Prevent PROTECT RBD RBD-specific antibodies RBD-specific antibody receptor Receptor binding domain receptor binding domain (RBD) reduce respiratory respiratory viruses response responses room temperature SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants specific antibodies stability subcutaneous vaccination subunit Subunit vaccine systemic temperature the vaccine thermostable upper respiratory tract vaccination Vaccine Vaccine development Vaccine hesitancy vaccine platform variants virus
[DOI] 10.3389/fimmu.2022.858904 PMC 바로가기 [Article Type] Article

Furin and TMPRSS2 Resistant Spike Induces Robust Humoral and Cellular Immunity Against SARS-CoV-2 Lethal Infection

푸린 및 TMPRSS2 내성 스파이크는 SARS-CoV-2 치명적인 감염에 대한 강력한 체액 및 세포 면역을 유도합니다

Article

Published on 2022-05-022022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2 ACE2 transgenic mice Against Amino acid antibody response against blocked C-terminal CD8 cleavage site clone clones COVID-19 vaccine effective Express furin furin cleavage furin cleavage site hamsters identify in some induce intranasal lethal Mutation mutations produced protective immunity Protein pseudotype Replication replication-competent. Resistant robust S antigen S protein S1/S2 cleavage S1/S2 cleavage site SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variant single dose spike Spike protein T cell T cell response the SARS-CoV-2 TMPRSS2 transgenic unmet need vaccination Vaccine Vaccine design variant vesicular stomatitis vesicular stomatitis virus virus VSV was used
[DOI] 10.3389/fimmu.2022.872047 PMC 바로가기 [Article Type] Article

Intranasal delivery of SARS-CoV-2 spike protein is sufficient to cause olfactory damage, inflammation and olfactory dysfunction in zebrafish

SARS-CoV-2 스파이크 단백질의 비강 내 전달은 제브라피쉬에서 후각 손상, 염증 및 후각 기능 장애를 유발하기에 충분합니다

Article

Published on 2022-05-012022-09-11
Journal: Brain, behavior, and immunity [Category] COVID19(2023년), SARS, 치료기술,

[키워드] animal animal models animals Anosmia bind cause Cell characterized cilia Cluster Combined damage Danio direct infection driven by edema endothelial EOG explained expression fish food functional hemorrhage hemorrhages Histopathology implication indicated Infection Inflammation Inflammatory response Inflammatory responses intranasal intranasally Loss of Smell mechanism myeloid cell nasal epithelium non-neuronal cell non-neuronal cells olfactory Olfactory damage olfactory dysfunction olfactory function Olfactory organ olfactory receptor Olfactory receptor expression organ prevalent Protein RBD receptor reduced response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S SARS-CoV-2 spike SARS-CoV-2 spike protein sensory neuron spike Spike protein Symptom treated Vaccine Viral protein Viral proteins widespread zebrafish Zebrafish (Danio rerio).
[DOI] 10.1016/j.bbi.2022.03.006 PMC 바로가기 [Article Type] Article

A single intranasal dose of human parainfluenza virus type 3-vectored vaccine induces effective antibody and memory T cell response in the lungs and protects hamsters against SARS-CoV-2

Research

Published on 2022-04-252022-10-05
Journal: NPJ Vaccines [Category] 유전자 메커니즘,

Development of an Intranasal Gel for the Delivery of a Broadly Acting Subunit Influenza Vaccine

Article

Published on 2022-04-112023-06-23
Journal: ACS Biomaterials Science & Engineering [Category] 신종인플루엔자,

[키워드] hemagglutinin Influenza intranasal mucosal subunit Vaccine
[DOI] 10.1021/acsbiomaterials.2c00015 PMC 바로가기