Study on SARS-CoV-2 strains in Iran reveals potential contribution of co-infection with and recombination between different strains to the emergence of new strains이란의 SARS-CoV-2 균주에 대한 연구는 새로운 균주의 출현에 대한 다른 균주와의 공동 감염 및 재조합의 잠재적 기여를 보여줍니다Article Published on 2021-10-012022-09-11 Journal: Virology [Category] SARS, 변종, [키워드] addition circulating clade Co-infection contribute FIVE Genome genotyped genotyping Haplotype haplotypes individuals Infection Iran isolate isolates mutations new SARS-CoV-2 new strain nine nucleotide partner passage PCR amplicons prevalent random recombinant Recombinant genomes Recombination reveal RNA SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains significantly single nucleotide strain Strains Tag Tag nucleotide genotyping. variant variants virus [DOI] 10.1016/j.virol.2021.06.004 PMC 바로가기 [Article Type] Article
Bacterial and fungal ventilator associated pneumonia in critically ill COVID-19 patients during the second wave2차 유행 동안 중환자 COVID-19 환자의 박테리아 및 곰팡이 인공 호흡기 관련 폐렴Article Published on 2021-10-012022-09-11 Journal: Journal of infection and public health [Category] SARS, 치료기술, [키워드] 95% CI 95% confidence interval Acinetobacter admitted to ICU antimicrobial antimicrobial resistance antimicrobial susceptibility Aspergillus Bacteria Bacterial Bacterial infections Candida caused Chest collected coronavirus disease Corticosteroid Corticosteroids COVID-19 COVID-19 patient Critical Critically ill critically ill COVID-19 patients Culture diabetes Diabetes Mellitus diagnosed disease element followed by fungal fungi Hypothyroidism ICUs identify intensive care unit intensive care units isolate isolates Klebsiella pneumoniae MDR mechanical ventilation Mucor multi outcomes pandemic Patient PDR Pneumonia pneumoniae positive respiratory Respiratory samples risk factor Risk factors SARS-CoV2 second wave specimen specimens subsequent susceptibility Tocilizumab Treatment VAP ventilator Ventilator associated pneumonia [DOI] 10.1016/j.jiph.2021.08.003 PMC 바로가기 [Article Type] Article
Quantifying bacterial evolution in the wild: A birthday problem for Campylobacter lineages야생에서 박테리아 진화를 정량화 : 캄 필로 박터 계통의 생일 문제Research Article Published on 2021-09-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate Accuracy addition alteration Analysis approach approaches Bacteria Bacterial bacterium birthday problem Campylobacter Campylobacter jejuni clinical isolates CLOCK clock rate dataset DNA replication ecological effective estimates estimation event Evolution focus gastroenteritis gene transfer Genome genomic growth help horizontal gene Horizontal gene transfer Host humans identifying infect information introduced isolates lead Lineage lineages maintenance molecular molecular evolution Non-synonymous not applicable nucleotide nucleotide change nucleotide changes nucleotide sequence organism outbreak pathogen pathogenic bacteria pathogenic strains Pathogens Population Probability provide reducing reflect Region reproduction robust sampling selected Spread strain Strains synonymous toolkit transfer Transmission turnover Variation [DOI] 10.1371/journal.pgen.1009829 PMC 바로가기 [Article Type] Research Article
Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants교차 중화 항체는 SARS-CoV-2 잠복 부위에 결합하고 순환 변이체에 저항합니다Article Published on 2021-09-272022-09-10 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] affinity antibodies antibody Antibody therapeutics causative agent circulating SARS-CoV-2 variants circulating variant conserved COVID-19 COVID-19 pandemic cross-neutralizing antibody crystal structure crystal structures disrupt domain epitope Epitopes global effort global efforts isolates Mutation N-terminal domain neutralize Neutralizing antibodies public health RBD Receptor-binding domain recognize sarbecovirus SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variants several variant several variants the RBD the receptor-binding domain Vaccines variants of SARS-CoV-2 Viral viral infection viral spike virus variants X-ray crystallography [DOI] 10.1038/s41467-021-25997-3 PMC 바로가기 [Article Type] Article
Co-infection of ST2 IP carbapenem-resistant Acinetobacter baumannii with SARS-CoV-2 in the patients admitted to a Tehran tertiary referral hospitalResearch Published on 2021-09-082022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, [키워드] oxa23 oxa24 oxa58 Acinetobacter age antibiotic Antibiotic resistance carbapenem Carbapenem-resistant Acinetobacter baumannii (CRAB) carried caused clinical sample clone Co-infection concerning COVID-19 COVID-19 case COVID-19 pandemic COVID-19 patient COVID-19 patients demonstrated dissemination Genetic Gram-negative bacteria HAI high mortality hospital ICU identify Infection infection control isolate isolates Multiplex PCR outbreak outcome PCR performed recognize resistance gene Result SARS-CoV-2 screened sequence Sequence type ST2 susceptibility Tehran TEM tertiary referral hospital the mean the patient underlying disease was determined was recorded [DOI] 10.1186/s12879-021-06642-2 PMC 바로가기 [Article Type] Research
Genomic analysis of early transmissibility assessment of the D614G mutant strain of SARS-CoV-2 in travelers returning to Taiwan from the United States of AmericaMicrobiology Published on 2021-09-022022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] acute respiratory syndrome America Analysis characterized circulation Cluster Comparative Continuous coronavirus COVID-19 D614G D614G mutation determine Direct epidemiological Evolution FIVE Genetic variation Genome genome sequence genomic genomic data GISAID global pandemic highlight imported case Infection isolate isolates mutant network analysis Outbreaks performed Phylogenetic analysis Result returned risk RT-PCR SARS-CoV-2 SARS-CoV-2 variant separated single-nucleotide specimen Surveillance Taiwan the SARS-CoV-2 genome the United State trajectory Transmissibility Transmission Travel USA Variation viral pathogenicity virus virus strain was performed whole-genome sequencing [DOI] 10.7717/peerj.11991 PMC 바로가기 [Article Type] Microbiology
The impact of spike N501Y mutation on neutralizing activity and RBD binding of SARS-CoV-2 convalescent serumSARS-CoV-2 회복기 혈청의 중화 활성 및 RBD 결합에 대한 스파이크 N501Y 돌연변이의 영향Article Published on 2021-09-012022-09-11 Journal: EBioMedicine [Category] MERS, SARS, 변종, 진단, [키워드] 95% CI Amino acid amino acids ANOVA Anti-RBD IgG Anti-S1 antibody Antibody binding assays B.1.1.7 B.1.351 binding binding domain clinician collected convalescent sera convalescent serum COVID-19 COVID-19 patient determine enzyme immunoassay evaluated geometric geometric mean geometric mean titer GMT Hong Kong IgG isolates K417N Lineage mean difference Michael microneutralization N501Y N501Y mutation neutralization Neutralizing activity neutralizing antibody Neutralizing antibody Spike protein receptor binding domain NSP2 one-way ANOVA Patient positive Protein RBD RBD binding Receptor binding Receptor binding domain recovered COVID-19 patient reduced Richard SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 lineage SARS-CoV-2 N501Y variant B.1.1.7 sensitivity sera serum service significantly spike Spike protein Spike receptor binding domain Spread statistically susceptibility symptom onset tested variant variants virus virus variant virus variants viruses VoC VOC. was determined wild-type [DOI] 10.1016/j.ebiom.2021.103544 PMC 바로가기 [Article Type] Article
Evolutionary insights into the furin cleavage sites of SARS-CoV-2 variants from humans and animals인간과 동물의 SARS-CoV-2 변이체의 푸린 절단 부위에 대한 진화론적 통찰력Article Published on 2021-09-012022-09-11 Journal: Archives of Virology [Category] SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] Affect Alter Amino acid Analysis analyzed B.1.1.7 B.1.1.7 isolate B.1.351 B.1.429 B.1.429 + B.1.427 B.1.525 binding cell tropism circulating variants cleavage database Deletion deletions Effect eight except for FCS Frequency furin furin cleavage site genetic polymorphisms GISAID GISAID initiative Human initiative investigated isolates Laboratory motif Multiple Mutation mutations P.1 P681H pathogenicity Point mutation predicted prevalent Q677H SARS-CoV-2 spike protein SARS-CoV-2 variant sequence Seven shown significantly spike Spike protein Spike protein sequence Surveillance Transmissibility USA variant variants virus transmissibility [DOI] 10.1007/s00705-021-05166-z PMC 바로가기 [Article Type] Article
Higher entropy observed in SARS-CoV-2 genomes from the first COVID-19 wave in Pakistan파키스탄의 첫 번째 코비드 -19 파에서 SARS-COV-2 게놈에서 관찰 된 더 높은 엔트로피Research Article Published on 2021-08-312022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 변종, [키워드] (RdRp 5’ UTR Analysis B.1 B.6 Capital change clade clades COVID-19 D614G Diversity Evolution except for exhibited Genetic Genome genome sequence genomes glycoprotein highest investigated isolates Laboratory lead material Mutation mutation rate Mutation rates not significant pandemic Phylogeny Q57H RdRP relative Result RNA RNA dependent RNA polymerase RNA polymerase SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 strain SARS-CoV-2 strains selection pressure sequence sequences Site spike spike glycoprotein stability strain Strains subsequent territory transmitted virus were used [DOI] 10.1371/journal.pone.0256451 PMC 바로가기 [Article Type] Research Article
Characterization of SARS-CoV-2 worldwide transmission based on evolutionary dynamics and specific viral mutations in the spike protein스파이크 단백질의 진화 역학 및 특정 바이러스 돌연변이를 기반으로 한 SARS-CoV-2 전 세계 전파 특성Research Article Published on 2021-08-212022-09-10 Journal: Infectious Diseases of Poverty [Category] MERS, SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome affinity angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antibody test antigenicity appear binding affinity caused characterization China clade Cluster Clustering composed coronavirus disease Coronavirus disease 2019 Coronavirus-2 country COVID-19 COVID-19 pandemic E484K early stage enzyme evolutionary dynamics facilitate followed by Frequency full-length GISAID database HEK293T cell HEK293T cells immune evasion independent information isolate isolates Italy Japan Malaysia mutants mutated Mutation neutralizing antibody pandemic predicted pseudovirus pseudoviruses R package Receptor-binding domain respiratory Result S477N SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 pseudovirus SARS-CoV-2 pseudoviruses SARS-CoV-2 strain SARS-CoV-2 strains sequence Severe acute respiratory syndrome Severe acute respiratory syndrome-related coronavirus Severe acute respiratory syndrome-related coronavirus-2 significantly Singapore Spike protein supplementary material tested the binding affinity the receptor-binding domain the spike protein Transmission transmission of SARS-CoV-2 USA V367F Viral viral infectivity viral mutation wild-type counterpart [DOI] 10.1186/s40249-021-00895-4 PMC 바로가기 [Article Type] Research Article