Transchromosomic bovines-derived broadly neutralizing antibodies as potent biotherapeutics to counter important emerging viral pathogens with a special focus on SARS-CoV-2, MERS-CoV, Ebola, Zika, HIV-1, and influenza A virusSARS-CoV-2, MERS-CoV, 에볼라, 지카, HIV-1 및 인플루엔자 A 바이러스에 특히 중점을 두고 중요한 신흥 바이러스 병원체에 대응하는 강력한 생물 치료제로서의 형질전환 소 유래 광범위 중화 항체Review Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adjuvant adjuvants Alpha animals antibody antibody-based therapies Antiviral approach approved assist Beta Biotherapeutics blocked bovine bovine-derived biotherapeutics Clinical studies colostrum convalescent coronavirus creating Delta disease Donor E484K Ebola effective Efficiency emerging viruses Epsilon Gamma highlight HIV-1 Human Human immunodeficiency virus human immunodeficiency virus type 1 human infection human infections hyperimmunization immune immunoreactivity Immunotherapy Influenza influenza A influenza A virus Iota K417N L452R Lambda MERS MERS-CoV Middle East Middle East respiratory syndrome Coronavirus mutations N501Y neutralization neutralized Neutralizing Neutralizing activity neutralizing antibody omicron Omicron variants outbreak P681R Pandemics platform polyclonal antibodies polyclonal antibody produced Protective respiratory respiratory syndrome coronavirus robust Safe SARS-CoV-2 serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown T478K therapeutic option transchromosomic bovines. Vaccine variant variants variants of concern variants of interest Viral viral infection viral infections viral pathogen VOCs VOIs Zika [DOI] 10.1002/jmv.27907 PMC 바로가기 [Article Type] Review
AuNP-based biosensors for the diagnosis of pathogenic human coronaviruses: COVID-19 pandemic developmentsArticle Published on 2022-10-012022-11-15 Journal: Analytical and bioanalytical chemistry [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy Antigen Asymptomatic carrier AuNP AuNPs biofluid Biomarker CoV COVID-19 epidemic COVID-19 pandemic CoVs CRISPR Diagnosis Diagnostic method Early detection example gold helping higher risk highlight highly pathogenic CoV Human human coronavirus human coronaviruses identify Laboratory MERS-CoV nanobiosensors nucleic acids optical outbreak pathogenic Pathogenic. platform point-of-care Probability Protein provided RT-PCR SARS-CoV-1 SARS-CoV-2 Spread the disease the SARS-CoV-2 Transmission treatment intervention virus viruses [DOI] 10.1007/s00216-022-04193-2 PMC 바로가기
Characteristics of animal models for COVID-19Article Published on 2022-10-012022-11-16 Journal: Animal models and experimental medicine [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome animal model animal models applied blueprint Characteristics coronavirus coronavirus disease COVID-19 develop disease establishment. Genome group hamsters Health Infection Infection route manifestation MERS-CoV mice Mutation pandemic Pandemics pathogen resource SARS-CoV SARS-CoV-2 SARS-CoV-2 pandemic transmission route unique variants of concern World Health Organization [DOI] 10.1002/ame2.12278 PMC 바로가기
Structural Basis for the Inhibition of Coronaviral Main Proteases by a Benzothiazole-Based InhibitorArticle Published on 2022-09-182022-11-15 Journal: Viruses [Category] SARS, 변종, 치료제, [키워드] acute respiratory syndrome Analysis Antiviral antivirals Basis binding caused consequence coronavirus Coronavirus-2 Coronaviruses COVID-19 crystal structure defined determinant effective effective inhibitor enzyme Health inhibition inhibitor M pro main protease maturation mechanism MERS-CoV molecular other coronaviruses promote protease provide required SARS-CoV SARS-CoV-2 Spread Treatment unique Vaccine variant viral replication warhead. YH-53 [DOI] 10.3390/v14092075 PMC 바로가기
Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivationArticle Published on 2022-09-142022-11-16 Journal: Signal Transduction and Targeted Therapy [Category] SARS, 유전자 메커니즘, [키워드] activated Activation acute respiratory syndrome Adenovirus aggravate Aggravated alleviate complement Complement pathway contribute coronavirus Coronaviruses expressing highly pathogenic human coronaviruses Hyperactivation in vitro in vivo Inflammation inflammatory lung injury Inflammatory response Interaction lectin pathway Lung injury MASP-2 mechanism MERS-CoV mice N protein Pathogenesis pathogenic coronavirus Pneumonia respiratory syndrome coronavirus resulting SARS-CoV SARS-CoV-2 SARS-CoV-2-infected patients serine protease significantly suggested the N protein Therapeutic approach These data [DOI] 10.1038/s41392-022-01133-5 PMC 바로가기
Longitudinal Analysis of Memory T-Cell Responses in Survivors of Middle East Respiratory SyndromeArticle Published on 2022-09-102023-06-20 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Fulltext, MERS, [키워드] longitudinal analysis memory T cells MERS-CoV [DOI] 10.1093/cid/ciab1019 PMC 바로가기
Rhinovirus/enterovirus was the most common respiratory virus detected in adults with severe acute respiratory infections pre-COVID-19 in Kuala Lumpur, MalaysiaArticle Published on 2022-09-022022-11-15 Journal: PLoS ONE [Category] 치료기술, [키워드] Acute respiratory infection aetiology Analysis Asia Bacterial bacterial pathogen Blood contribute COVID-19 pandemic Critical disease Culture determine diagnostic effective Gender increased risk Influenza virus investigated lack Lung disease Malaysia male MERS-CoV Molecular assay Neurological disease Patient PCR positive predictor Prevalence qPCR assays respiratory pathogen Respiratory pathogens respiratory virus SARS-CoV sore throat Surveillance Treatment strategies virus was performed [DOI] 10.1371/journal.pone.0273697 PMC 바로가기
A non-invasive ultrasensitive diagnostic approach for COVID-19 infection using salivary label-free SERS fingerprinting and artificial intelligenceResearch article Published on 2022-09-012022-10-05 Journal: Journal of photochemistry and photobiology. B, Bio [Category] SARS, 바이오마커, 변종, 진단, 치료기술, [키워드] Accuracy approach artificial intelligence biochemical change Classifier clinical COVID-19 COVID-19 infected patient COVID-19 infection COVID-19 outbreak demonstrated Diagnosis diagnostic diagnostics Efficiency false-negative genetic diversity global healthcare gold standard healthy healthy control high accuracy invasive Label-free limit Machine learning algorithms management MERS-CoV Mutation Nasopharyngeal swab Non-invasive Patient Population screening positive predicted reagents risk Saliva salivary SARS-CoV SARS-CoV-2 SARS-COV-2 infection scattering sensitivity specificity Stage subjects Support surface enhanced Raman spectroscopy SVM the patient virus virus spike protein [DOI] 10.1016/j.jphotobiol.2022.112545 [Article Type] Research article
Ecology of Middle East respiratory syndrome coronavirus, 2012-2020: A machine learning modelling analysisArticle Published on 2022-09-012023-07-08 Journal: Transboundary and emerging diseases [Category] COVID19(2023년), [키워드] machine learning MERS-CoV Middle East respiratory syndrome predicted map Risk factors [DOI] 10.1111/tbed.14548 PMC 바로가기
Impact of SARS-CoV-2 Spike Mutations on Its Activation by TMPRSS2 and the Alternative TMPRSS13 ProteaseArticle Published on 2022-08-302022-11-16 Journal: mBio [Category] SARS, 변종, 치료기술, [키워드] 229E Activation acute respiratory syndrome affected airway being benefit Calu-3 cell change changes in cleavage conserved coronavirus creating Critical Delta dibasic experiment favor functional fusion peptide had no help host cell human coronavirus 229E humans immune evasion immunogenic Impact influence less MERS-CoV Middle East motif mutant Mutation mutations new SARS-CoV-2 no difference omicron pathogenic protease Proteases Protein pseudovirus pseudovirus entry reduced remained residue residues respiratory syndrome coronavirus reverse effect SARS-CoV-2 SARS-CoV-2 spike sequence shown spike spike functioning Spike protein Surveillance the SARS-CoV-2 TMPRSS13 TMPRSS13 protease TMPRSS2 Tolerance variant variants Variation virus entry Wuhan-Hu-1 [DOI] 10.1128/mbio.01376-22 PMC 바로가기