Factors Associated with Pneumocystis jirovecii Pneumonia in Patients with Rheumatoid Arthritis Receiving Methotrexate: A Single-center Retrospective StudyOriginal Article Published on 2021-09-112024-09-04 Journal: Internal medicine (Tokyo, Japan) [Category] 대상포진, [키워드] Disease-modifying anti-rheumatic drugs methotrexate pneumocystis pneumonia rheumatoid arthritis [DOI] 10.2169/internalmedicine.8205-21 PMC 바로가기 [Article Type] Original Article
The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models엽산 길항제 메토트렉세이트는 코로나바이러스 SARS-CoV-2의 복제를 감소시키고 세포 배양 모델에서 렘데시비르의 항바이러스 효능을 향상시킵니다Article Published on 2021-09-012022-09-11 Journal: Virus research [Category] SARS, 신약개발, 유전자 메커니즘, 치료법, 치료제, [키워드] aberrant inflammatory response Aberrant inflammatory responses addition Antiviral antiviral activity antiviral agent antiviral efficacy benefit calu-3 cells Cancer therapy Cell culture Combination Concentration coronavirus coronavirus SARS-CoV-2 COVID-19 cultured cells decrease described dihydrofolate Dihydrofolate reductase diminishe dissemination distress drug Efficacy ENhance enzyme Enzymes Folic acid Folinic acid Frame host cell Immunosuppression impairment induce Infection inhibit inhibited Inosine Leucovorin limit mechanism methotrexate MTX nucleocapsid nucleotide nucleotides Organisms Perspective progeny protein synthesis purine Purine synthesis raise reduce reductions in released Remdesivir Replication replication of SARS-CoV-2 required rescued respiratory distress RNA RNA replication SARS-CoV-2 SARS-CoV-2 infections spike structural protein structural proteins synergistic synthesis tested therapeutic therapy Toxicity treating COVID-19 treating SARS-CoV-2 infection Vero Vero E6 virus virus replication virus RNA [DOI] 10.1016/j.virusres.2021.198469 PMC 바로가기 [Article Type] Article
COVID-19 vaccination and antirheumatic therapyReview Published on 2021-08-122022-10-28 Journal: Rheumatology (Oxford, England) [Category] COVID-19, MERS, SARS, [키워드] biologics coronavirus disease COVID-19 COVID-19 vaccination COVID-19 vaccine decision DMARDs Evidence hepatitis B humoral Humoral response immunosuppressive impair IMPROVE indicate Inflammatory arthritis Influenza inhibit management methotrexate MTX NHS Other Patient patients pneumococcal Pragmatic response responses rituximab shown therapy translate vaccination Vaccine vaccine response Vaccines [DOI] 10.1093/rheumatology/keab223 PMC 바로가기 [Article Type] Review
Impact of Low-Dose Methotrexate–Adalimumab Combination Therapy on the Antibody Response Induced by the mRNA-1273 SARS-CoV-2 Vaccine: Case of an Elderly Patient with Rheumatoid ArthritisCase Report Published on 2021-08-092022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] adalimumab anti-S Antibody Response Case report combination therapy doses drug drugs elderly elderly patients IgG immune response Impact induced low-dose methotrexate mRNA-1273 mRNA1273 mRNA1273 vaccine Neutralizing antibody response Patient patients treated reported response Rheumatoid rheumatoid arthritis SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines therapy treated Vaccine vaccine administration [DOI] 10.3390/vaccines9080883 PMC 바로가기 [Article Type] Case Report
Application of an evidence-based, out-patient treatment strategy for COVID-19: Multidisciplinary medical practice principles to prevent severe diseaseCOVID-19에 대한 증거 기반 외래 환자 치료 전략의 적용: 중증 질환을 예방하기 위한 다학제 진료 원칙Review Published on 2021-07-152022-09-12 Journal: Journal of the neurological sciences [Category] MERS, SARS, 변종, 진단, 치료법, [키워드] alveoli application Bronchiole Budesonide COVID-19 COVID-19 pandemic Dexamethasone driven by early treatment entire spectrum Evolution Expectorate form Gas exchange human physiology individuals Inflammation Intervention L-albuterol methotrexate microbe molecular Mucus Mucus clearance oxygen saturation Postural percussion Prevent pulmonary Pulmonary hygiene pulse oximetry question raise respiratory muscle Respiratory muscle training risk SARS virus SARS-CoV-2 severe disease target tissues Treatment Vaccine Vaccine development Vibratory sonication viral family Vitamin D [DOI] 10.1016/j.jns.2021.117463 PMC 바로가기 [Article Type] Review
The effect of methotrexate and targeted immunosuppression on humoral and cellular immune responses to the COVID-19 vaccine BNT162b2: a cohort studyArticles Published on 2021-07-082022-10-29 Journal: The Lancet Rheumatology [Category] COVID-19, [키워드] 95% CI All participant B.1.1.7 variant BNT162b2 BNT162b2 vaccine Cellular immune response cellular response clinical effectiveness Cohort cohort study consecutive patient Control controls Coverage COVID-19 vaccine COVID-19 vaccine trials defined determine Diagnosis Dilution East eligible England evaluate evaluated extended interval females finding first dose foundation funding groups healthy control healthy controls humoral Humoral immunity IL-17 IL-2 IL-21 IL-23 immune response Immune-mediated inflammatory disease immunogenicity Immunosuppressant Immunosuppression individual inhibitors inhibitory interferon-γ IQR London lowest males median median age methotrexate monotherapy Necrosis neutralising antibody response Neutralising titre NHS of BNT162b2 participant Participants Patient Pfizer-BioNTech preserved Primary outcome receive receiving recruited Seven significantly lower single dose South spike glycoprotein spike-specific T-cell response study population the healthy the SARS-CoV-2 therapeutic Therapies Thoma TNF Trust vaccination vaccine immunogenicity Volunteer were excluded white wild-type SARS-CoV-2 [DOI] 10.1016/S2665-9913(21)00212-5 PMC 바로가기 [Article Type] Articles
Factors associated with COVID-19-related death in people with rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance physician-reported registry류마티스 질환이 있는 사람의 COVID-19 관련 사망과 관련된 요인: COVID-19 Global Rheumatology Alliance 의사 보고 레지스트리의 결과Article Published on 2021-07-012022-09-12 Journal: Annals of the rheumatic diseases [Category] Fulltext, SARS, 진단, [키워드] 1.26 95% CI age Alliance antirheumatic agents association Autoimmune Autoimmune diseases cardiovascular disease caution Comorbidities covariate COVID-19 COVID-19-related death Cyclophosphamide death determine died disease Disease activity Disease diagnosis dosage dosages Epidemiology Factor female glucocorticoid Glucocorticoids Health Health care higher odd highlight hypertension Immunosuppressant immunosuppressants Lung disease Male sex medication medications methotrexate monotherapy multivariable logistic regression Older age Other outcome outcome assessment Patient Primary outcome receiving required Rheumatic diseases rituximab Sex smoking status stratified sulfasalazine [DOI] 10.1136/annrheumdis-2020-219498 PMC 바로가기 [Article Type] Article
TBK1 and TNFRSF13B mutations and an autoinflammatory disease in a child with lethal COVID-19Case Report Published on 2021-07-012022-10-04 Journal: NPJ Genomic Medicine [Category] 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome autoinflammatory disease Autoinflammatory syndrome cardiac insufficiency children Combination coronavirus coronavirus disease COVID-19 CVID death Deleterious disorder etiology Exome Factor Genetic testing homozygous homozygous missense variant immunodeficiency Infection methotrexate Mild Mutation nonspecific occurred parent Prednisolone SARS-CoV-2 Seizure Sequencing severe COVID-19 Symptoms TBK1 TNFRSF13B treated Treatment variant variants viral infection [DOI] 10.1038/s41525-021-00220-w PMC 바로가기 [Article Type] Case Report
A Comprehensive Review of Sarcoidosis Treatment for PulmonologistsReview Published on 2021-06-182024-09-04 Journal: Pulmonary Therapy [Category] 대상포진, [키워드] adalimumab anti-TNF azathioprine Corticosteroids infliximab methotrexate sarcoidosis Treatment [DOI] 10.1007/s41030-021-00160-x PMC 바로가기 [Article Type] Review
Does methotrexate influence COVID-19 infection? Case series and mechanistic dataResearch Article Published on 2021-06-102022-10-28 Journal: Arthritis Research & Therapy [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 expression acute respiratory syndrome addition Affect Angiotensin-converting enzyme anti-SARS-CoV-2 IgG Case series case sery clinical assessment coronavirus coronavirus disease coronavirus disease 19 COVID-19 downregulating Follow-up healthy Infection initial intestinal epithelium Intestinal Organoids joint lung mechanistic data methotrexate mice mRNA Organoid protective effect protein expression receiving receptor remained Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA Seven significantly susceptibility Symptoms the SARS-CoV-2 treated Treatment women [DOI] 10.1186/s13075-021-02464-4 PMC 바로가기 [Article Type] Research Article