Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balanceH3K9 메틸화 균형을 조절하여 H3K9 탈메틸화효소 Jmjd1a 결핍 마우스의 비정상적인 성 발달 구조Research Article Published on 2017-09-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activities activity administration approach balance biological function Cancer chromatin complex core histones deficiency demethylase demonstrated Diseases DNA Embryo embryonic enzyme Epigenetic eukaryotes expression Genetic hallmark heterochromatin heterozygous histone histone methylation Histones inhibitor initiate intellectual disability leads locus lysine mammals Methylation methyltransferase mice Modification modulating modulation molecular mechanism mutant Mutation pharmacological phenotype principle proof provide rescued reveal Sex Sex determination Therapeutic strategies therapeutic strategy transcriptional regulation transcriptionally tuning [DOI] 10.1371/journal.pgen.1007034 PMC 바로가기 [Article Type] Research Article
Report of novel H105R, D29N, V27A mutations in the methyltransferase region of the HEV genome in patients with acute liver failureArticle Published on 2017-06-012023-06-11 Journal: Journal of Clinical Virology [Category] E형 간염, [키워드] acute liver failure D29N H105R HEV methyltransferase V27A. [DOI] 10.1016/j.jcv.2017.03.017
Transposon Dysregulation Modulates dWnt4 Signaling to Control Germline Stem Cell Differentiation in Drosophila트랜스포존 조절 장애는 초파리에서 생식선 줄기 세포 분화를 제어하기 위해 dWnt4 신호를 조절합니다Research Article Published on 2016-03-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acts aging Cancer cancers Cell cell fate cell population cell types chromatin Control degenerative degenerative diseases differentiation differentiation defects disease downregulated Drosophila element elements encapsulation expression facilitate female Genetic Genome germline GSC independent insight lead Ligand Loss maintain mammary marker mechanism methyltransferase modulate multicellular multicellular organism mutants oogenesis organism Perspective progression promote Proteins regulate regulated repress required Signaling somatic cells STEM stem cell stem cells sustained therapeutic tissue tissues transposable elements transposon transposons upregulation virus while Wnt Wnt4 [DOI] 10.1371/journal.pgen.1005918 PMC 바로가기 [Article Type] Research Article
Molecular mechanisms of coronavirus RNA capping and methylationReview Published on 2016-02-022023-06-15 Journal: Virologica Sinica [Category] MERS, [키워드] cap structure coronavirus guanylyltransferase Methylation methyltransferase RNA capping triphosphatase [DOI] 10.1007/s12250-016-3726-4 PMC 바로가기 [Article Type] Review
Sequence analysis reveals a conserved extension in the capping enzyme of the alphavirus supergroup, and a homologous domain in nodavirusesResearch Published on 2015-04-112023-08-28 Journal: Biology Direct [Category] E형 간염, [키워드] alphavirus Amphipathic alpha-helix Bromovirus capping Chikungunya virus guanylyltransferase hepatitis E virus Homology detection methyltransferase nodavirus Protein sequence analysis Sindbis virus Viral replication factory [DOI] 10.1186/s13062-015-0050-0 PMC 바로가기 [Article Type] Research
Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirusArticle Published on 2014-10-162022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] activity Biochemistry capping complex coronavirus coronavirus RNA CoVs enzyme exonuclease Factors function Genome highlighting highly active highly pathogenic in vitro insight involved mechanism mechanisms MERS-CoV methyltransferase Middle East Molecular biology positive-sense Proofreading provided replicate Replication Research respiratory RNA RNA polymerase RNA synthesis RNA virus RNA-dependent RNA polymerase SARS Coronavirus SARS-coronavirus SARS-CoV single-stranded stimulated unique [DOI] 10.1016/j.virusres.2014.10.008 PMC 바로가기 [Article Type] Article
Biochemical and Structural Insights into the Mechanisms of SARS Coronavirus RNA Ribose 2′-O-Methylation by nsp16/nsp10 Protein ComplexResearch Article Published on 2011-10-132022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] Analysis antiviral drug assays Author biochemical canonical catalytic catalyzed cellular cofactor complex composed coronavirus demonstrated different Donor drug target drugs ENCODE eukaryotic eukaryotic virus found function Immune escape in viral indicated innate immune insight inter-molecular Interaction methylated methyltransferase modify mRNA mRNA stability mRNAs non-structural protein nsp14 promote protein translation required ribose ribosome RNA RNA stability RNAs S-adenosyl-L-methionine SAM SARS Coronavirus SARS-CoV shown stimulatory Structural analysis subunit subunits unique Viral RNA virus [DOI] 10.1371/journal.ppat.1002294 PMC 바로가기 [Article Type] Research Article
Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2′-O-Methyltransferase nsp10/nsp16 ComplexResearch Article Published on 2011-05-262022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] 2003 activating Activation antiviral drug assay association atomic resolution Author bind binding binding pocket CAP chromatin complex coronavirus crystal crystal structures disease enzyme etiological agent exhibit functional Genome Giant host cell identify inhibitor Innate immunity involved mechanism metabolism methyltransferase mRNA mutant non-structural protein Novel coronavirus nucleic acid performed Protein provide regulated Regulation replicate residue respiratory resulting RNA S-adenosylmethionine SAM severe Signal transduction stability Structure translation viruses [DOI] 10.1371/journal.ppat.1002059 PMC 바로가기 [Article Type] Research Article
In Vitro Reconstitution of SARS-Coronavirus mRNA Cap MethylationResearch Article Published on 2010-04-222022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] 2003 Activation activity acute respiratory syndrome addition Author CAP cellular mRNA Complete complex coronavirus Coronaviruses CoV Critical drug design enzyme etiological agent event expression generate Genome host cell in viral in vitro inactive include induce infected cell Influenza virus inhibition assay initiated involved membrane-bound methylated Methylation methyltransferase mRNA mRNAs Mutation non-structural protein nsp14 predicted produced Protein replicate ribosomes RNA RNA genome RNA synthesis RNA transcript S-adenosyl-L-methionine SARS-coronavirus SARS-CoV SARS-CoV infected cells selective sequence target translation variety viral mRNAs viral nonstructural proteins Viral protein virus [DOI] 10.1371/journal.ppat.1000863 PMC 바로가기 [Article Type] Research Article
16S rRNA Methyltransferase RmtC in Salmonella enterica Serovar Virchow살모넬라 엔테리카 비르초 혈청형의 16S rRNA 메틸트랜스퍼라제 RmtCDispatch Published on 2010-04-012024-08-02 Journal: Emerging Infectious Diseases [Category] 살모넬라증, [키워드] Aminoglycosides Bacteria dispatch drug resistance methyltransferase qnrB2 RmtC Salmonella enterica [DOI] 10.3201/eid1604.090736 PMC 바로가기 [Article Type] Dispatch