Variant to function mapping at single-cell resolution through network propagation Research Published on 2022-06-062022-10-05 Journal: Nature biotechnology [Category] 유전자 메커니즘, [키워드] Algorithm Analysis approach association Blood causal variant cell types cellular Combination COVID-19 developmental epigenomic Genetic variation help Hematopoiesis human genetic variation identify Inference leukemia lymphocyte mechanism monocyte network propagation overcome provide risk single-cell single-cell genomic Stage subset trajectory [DOI] 10.1038/s41587-022-01341-y [Article Type] Research
A systems biology approach identifies candidate drugs to reduce mortality in severely ill patients with COVID-19시스템 생물학 접근 방식으로 COVID-19 중증 환자의 사망률을 줄이기 위한 후보 약물 식별Article Published on 2022-06-032022-09-11 Journal: Science Advances [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus applied approach attribute candidate candidate drug caused coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID-19 Critically ill Critically ill patient critically ill patients drug target drug treatment effective Epigenetic Hospital admission host response identify interferon interferon signaling lack Messenger RNA metabolism monocyte Mortality Nintedanib Ordinal Scale pathway Pathways Patient patients hospitalized reduce mortality RNA splicing SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severely ill patient severely ill patients Systems biology tacrolimus therapeutic transcriptomic Treatment Vaccines with COVID-19 Zotatifin [DOI] 10.1126/sciadv.abm2510 PMC 바로가기 [Article Type] Article
Opposing roles for sMAdCAM and IL-15 in COVID-19 associated cellular immune pathologyCOVID-19 관련 세포 면역 병리학에서 sMAdCAM 및 IL-15의 반대 역할Article Published on 2022-06-012022-09-11 Journal: Journal of leukocyte biology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Activation Adhesion Molecule association Asymptomatic Asymptomatic cases CD4+ CD8 Cell cell adhesion molecule cellular characterized circulating Cohort correlated COVID COVID-19 COVID-19 pathology cytokine disease Disease progression duration of hospitalization dysfunction dysregulation effector memory ELISA evaluated Factors flow cytometry Frequency healthy control healthy controls homeostasis homeostatic hypoxemic IL-15 IL-6 IL-6 level IL-6 levels immune increase in India infected individuals Inflammatory factor inflammatory factors intermediate monocytes involved lymphocyte lymphopenia marker Mild moderate moderate to severe monocyte Monocytes mucosal multiparametric flow cytometry Mumbai Pathogenesis pathology plasma profiles quantified recruited regulatory T cells SARS-CoV-2 SARS-CoV-2 infected individual SARS-CoV-2 infected individuals severe disease sMAdCAM. Stage subset symptomatic individual symptomatic individuals symptomatic infection T cells was used while [DOI] 10.1002/JLB.3COVBCR0621-300R PMC 바로가기 [Article Type] Article
Baricitinib attenuates the proinflammatory phase of COVID-19 driven by lung-infiltrating monocytesResearch article Published on 2022-05-252022-10-05 Journal: Cell Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory distress airway airways antiviral signaling Asymptomatic attenuate Baricitinib blood monocyte Bronchoalveolar lavage fluid Combined COVID-19 COVID-19 pathogenesis CP: Immunology CP: Microbiology driven by ENhance epithelial cell Express expression Gene Expression highlight immunopathology in vivo Infection Inflammation inflammatory mediator Inflammatory mediators inhibitor initial Janus kinase lung epithelium monocyte Monocytes mRNA proinflammatory Remdesivir SARS-CoV-2 secretion severe COVID-19 patients subject syndrome therapeutic target transcripts viral burden viral clearance viral replication virus [DOI] 10.1016/j.celrep.2022.110945 [Article Type] Research article
Dysregulated Immune Responses in SARS-CoV-2-Infected Patients: A Comprehensive OverviewSARS-CoV-2 감염 환자의 조절되지 않은 면역 반응: 종합 개요Review Published on 2022-05-182022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute phase acute respiratory syndrome acute respiratory syndrome coronavirus adaptive alteration Antigen antigen-presenting cell antiviral immune responses B cell subset Biomarker caused CD8+ CD8+ T cell cellular cellular immunity complications of COVID-19 Comprehensive comprehensive analysis coronavirus country COVID-19 COVID-19 patients disease effective evade follicular follicular Th cell help Host Human humoral Humoral immunity identify immune responses Immunity IMPROVE Infection Inflammatory information innate and adaptive immunity involved knowledge mechanism molecular mechanism monocyte new virus outcomes pathological change pathological changes Phenotypes Post-COVID-19 syndrome predict recognize Research response SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity Symptom syndrome T cell Th cell Th cell subsets Th17 the SARS-CoV-2 variety [DOI] 10.3390/v14051082 PMC 바로가기 [Article Type] Review
The role of Monocyte Distribution Width (MDW) in the prognosis and monitoring of COVID-19 patientsCOVID-19 환자의 예후 및 모니터링에서 단핵구 분포 폭(MDW)의 역할Article Published on 2022-05-012022-09-11 Journal: Clinical biochemistry [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, [키워드] age AUC Beckman Coulter blood count blood sample calculated complete blood count correlated COVID-19 COVID-19 patient COVID-19 patients Critically ill Critically ill patient critically ill patients cut-off diagnostic distribution Efficacy enrolled form hospitalisation ICU less monocyte Monocyte Distribution Width (MDW) non-survivor not significant outcome parameter Patient patients procalcitonin Prognosis prognostic reported SARS-CoV-2-positive patient Sensitivity and specificity severe forms of COVID-19 shown significantly Standard deviation Support Surveillance Survivors the mean unfavourable prognosis was used width [DOI] 10.1016/j.clinbiochem.2022.02.007 PMC 바로가기 [Article Type] Article
Evaluation of patients with telogen effluvium during the pandemic: May the monocytes be responsible for post COVID-19 telogen effluvium?Observational Study Published on 2022-05-012022-10-04 Journal: Journal of cosmetic dermatology [Category] COVID19(2023년), SARS, 임상, [키워드] cause circulating monocyte Clinical characteristics conducted coronavirus disease COVID-19 COVID-19 diagnosis COVID-19-related complications demographic develop diagnosed with COVID-19 Diagnosis electronic medical records evaluate hair follicle hair follicles Hair loss incidence IQR laboratory parameter Macrophage mechanism mechanisms median Migration monocyte Monocytes Observational cohort study occurred pandemic Patient patients Peripheral blood Physical examination polymerase chain pro-inflammatory cytokine reported responsible RT-PCR SARS-CoV-2 suggested telogen effluvium the patient triggering factor was performed were recorded [DOI] 10.1111/jocd.14883 PMC 바로가기 [Article Type] Observational Study
The pandemic brain: Neuroinflammation in non-infected individuals during the COVID-19 pandemic대유행 뇌: COVID-19 대유행 동안 감염되지 않은 개인의 신경염Article Published on 2022-05-012022-09-11 Journal: Brain, behavior, and immunity [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] Activation aligned Brain Brain imaging change Combination control subject control subjects COVID-19 pandemic COVID-19 research dataset demonstrated Depression dysregulation Effect elevated enrolled examined explosion expression fatigue functions Future Health healthy individuals hippocampus increase in independent individual Inflammatory marker inflammatory markers interleukin interleukin-16 intraparietal sulcus involved kDa Magnetic resonance spectroscopy marker measure mechanism Mental mental fatigue mental health molecular monocyte monocyte chemoattractant protein-1 MRS multiple comparisons myoinositol negative test Neuroimaging Neuroinflammation non-infected pandemic pet physical positron emission Positron emission tomography precuneus preliminary findings Prevalence Protein Research SARS-CoV-2 antibodies serum Serum level serum levels several gene several genes statistical significance Stress Stressor subjects Symptom symptom burden Symptoms tomography transcriptomics TSPO uninfected virus while [DOI] 10.1016/j.bbi.2022.02.018 PMC 바로가기 [Article Type] Article
Recognition of Immune Cell Markers of COVID-19 Severity with Machine Learning Methods기계 학습 방법을 통한 COVID-19 심각도의 면역 세포 마커 인식Article Published on 2022-04-282022-09-11 Journal: BioMed Research International [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료기술, [키워드] Algorithms analyzed B cell best Biomarker Biomarkers CD4 CD8 Cell cell type classifiers COVID-19 COVID-19 disease COVID-19 disease severity CX3CR1 Decision tree determine disease Disease progression disease severity feature filtered Gene expression analysis gene expression profile Host IL1B Immune cell immune cells immune response Immunological response immunological responses Inflammatory involved ITK KEGG pathway machine learning molecular mechanism molecular mechanisms monocyte Mortality NK cell Numerous PRDM1 random Random forest Recognition Regulation resulting SARS-COV-2 infection single-cell these cell These cells TLR2 [DOI] 10.1155/2022/6089242 PMC 바로가기 [Article Type] Article
Intermediate Monocytes with PD-L1 and CD62L Expression as a Possible Player in Active SARS-CoV-2 InfectionArticle Published on 2022-04-152023-07-08 Journal: Viruses [Category] COVID19(2023년), [키워드] CD62 convalescent COVID-19 Intermediate monocyte monocyte non-classical monocyte. PD-L1 TIM-3 [DOI] 10.3390/v14040819 PMC 바로가기