Communication Pattern Changes Along With Declined IGF1 of Immune Cells in COVID-19 Patients During Disease Progression질병 진행 중 COVID-19 환자의 면역 세포 IGF1 감소와 함께 의사 소통 패턴 변화Immunology Published on 2022-01-142022-09-11 Journal: Frontiers in Immunology [Category] 치료기술, 치료제, [키워드] activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis analyzed cause Cell change changed chemokine chemokines communication communication pattern Contact coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 Crosstalk Cytokines described feature growth factor IGF1 Immune cell immune cells immune response immune system Inflammatory Inflammatory cytokine Inflammatory cytokines insulin-like growth factor less mononuclear cell Most patient Most patients Negative conversion pandemic Patient pattern PBMC Peripheral blood Regulatory respiratory reveal SARS-CoV-2 SARS-CoV-2 RNA Serum level serum levels severe acute respiratory syndrome Coronavirus Signal transduction single-cell sequencing stages status Symptoms T cell T cells therapeutic target therapeutic targets [DOI] 10.3389/fimmu.2021.729990 PMC 바로가기 [Article Type] Immunology
Selection and T-cell antigenicity of synthetic long peptides derived from SARS-CoV-2Animal Published on 2022-01-112022-10-30 Journal: The Journal of General Virology [Category] COVID-19, [키워드] activate Activation Alpha Antigen antigenicity approach autologous beta coronavirus caused CD4+ CD8+ T cell Cluster conserved coronavirus demonstrated dendritic cell effective vaccine epitope HLA class I immunogenic in vitro individual induce leucocyte mononuclear cell other coronavirus outbreak pandemic PBMC peptide Peripheral blood Protein proteome Region SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 peptide SARS-CoV-2 peptides Selection T-cell T-cell Response T-cells the SARS-CoV-2 the Spike Vaccine variants of SARS-CoV-2 virus [DOI] 10.1099/jgv.0.001698 PMC 바로가기 [Article Type] Animal
Long non-coding RNAs (lncRNAs) NEAT1 and MALAT1 are differentially expressed in severe COVID-19 patients: An integrated single-cell analysis긴 비 코딩 RNA (LNCRNA) NEAT1 및 MALAT1은 심각한 COVID-19 환자에서 차등 적으로 발현됩니다. 통합 된 단일 세포 분석Research Article Published on 2022-01-102022-09-10 Journal: PLoS ONE [Category] 유전자 메커니즘, 치료기술, 치료제, [키워드] Analysis analyzed Apoptosis applied BAL Bronchoalveolar lavage Cell cell population cell stress cell types cellular stress response component coronavirus disease Coronavirus disease 2019 COVID-19 damage diagnostic differentially expressed differentiator disease severity dysregulation focus foster hallmark immune dysregulation immunomodulatory Inflammation Inflammatory involved lncRNA Long long non-coding RNA MALAT1 measure Mild mononuclear cell mononuclear cells NEAT1 non-coding RNA Patient PBMCs Peripheral blood Peripheral blood mononuclear cells pro-inflammatory function pro-inflammatory functions Regulation sequenced severe COVID-19 Severe patient severity single-cell single-cell RNA-seq dataset single-cell transcriptomic analysis stress response target targets therapy with COVID-19 [DOI] 10.1371/journal.pone.0261242 PMC 바로가기 [Article Type] Research Article
Single-Cell Analysis Reveals the Immune Characteristics of Myeloid Cells and Memory T Cells in Recovered COVID-19 Patients With Different SeveritiesImmunology Published on 2022-01-032022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] accompanied addition Analysis Antigen antigen processing B-cell CD14 CD69 CD83 collected Coronavirus disease 2019 COVID-19 CXCR4 dataset datasets dendritic cell dendritic cells disease severity downregulated downregulation exhibited FOS healthy controls HLA HLA class II HLA-DRA HLA-DRB1 IGHV3-21 immune Immune cell immune characteristics immune disorder Immunoglobulin JUN leukocyte memory T memory T cells monocyte mononuclear cell myeloid myeloid cells pathway Patient PBMCs performed Peripheral blood peripheral immune response plasmacytoid dendritic cell progression stage proportion recovered recovered COVID-19 patient Recovered COVID-19 patients recovered patient recovered patients Regulation reported severe symptom single-cell Single-cell RNA sequencing symptom onset T-cell differentiation upregulated upregulation [DOI] 10.3389/fimmu.2021.781432 PMC 바로가기 [Article Type] Immunology
T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective cohort study이전에 감염된 SARS-CoV-2-naive 영국 의료 종사자의 첫 BNT162b2 백신 투여에 대한 T 세포 및 항체 반응: 다기관 전향적 코호트 연구Multicenter Study Published on 2022-01-012022-09-10 Journal: The Lancet. Microbe [Category] MERS, SARS, 변종, 진단, 치료법, [키워드] Affect All participants Analysis anti-SARS-CoV-2 antibodies antibody Antibody Response antibody unit Antibody Units applied benefit blood sample Blood samples BNT162b2 BNT162b2 vaccine collected coronavirus cryopreserved PBMCs Department determine determined by dose doses enrolled enzyme-linked immunospot assay exclusion criteria finding first dose fresh peripheral blood mononuclear cells funding Future greater health-care hospital IgG antibodies IgG antibody immune response immune responses individual individuals infected individual Infection infection with SARS-CoV-2 interferon interferon-γ IQR magnitude median median time mononuclear cell mononuclear cells mRNA vaccine multicentre naïve individuals nucleocapsid Older Oxford participant PBMCs Peripheral blood Peripheral blood mononuclear cells Pfizer–BioNTech positive prospective cohort study quantified receiving response RT-PCR SARS-COV-2 infection SARS-CoV-2 vaccine second dose single dose specific IgG antibodies Specific T-cell response spike-specific IgG spike-specific IgG antibodies spike-specific T-cell response spot spot-forming unit spot-forming units T-cell T-cell Response T-cell responses the median the SARS-CoV-2 vaccination Vaccine vaccine dose vaccine doses variants variants of concern was determined [DOI] 10.1016/S2666-5247(21)00275-5 PMC 바로가기 [Article Type] Multicenter Study
Systems Biology and Bioinformatics approach to Identify blood based signatures molecules and drug targets of patient with COVID-19Research article Published on 2021-12-302022-10-05 Journal: Informatics in Medicine Unlocked [Category] 바이오마커, [키워드] acute respiratory syndrome approach association AURKB bioinformatics Biology Biomarker Biomarker signatures Blood blood cell Blood cells Blood common gene BUB1B CCNB1 Cell connection contagious Coronavirus-2 COVID-19 dataset DEGs diagnose differentially expressed gene Differentially expressed genes disease DLGAP5 drug target effective Gene Expression Gene ontology HJURP hub protein Identified identify infected with SARS-CoV-2 Infection KIF11 Microarray molecular MONITOR mononuclear cell NCAPG New coronavirus Ontology pathophysiology pathway patient with COVID-19 patients with COVID-19 PBMCs PBMCs cell performed Peripheral blood prevalence of COVID-19 progression Research SARS-CoV-2 signaling pathways subjects System therapeutic intervention TOP2A TPX2 transcript transcriptomic Treatment TTK with COVID-19 [DOI] 10.1016/j.imu.2021.100840 [Article Type] Research article
Postmortem Biopsies of the Lung, Heart, Liver, and Spleen of COVID-19 PatientsRadiology Published on 2021-12-272022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acquisition alteration autopsy studies biopsies biopsy Case series Characteristics Chest computed tomography collected Complete coronavirus disease correlated COVID-19 died Diffuse alveolar damage evaluate examined feasible FIVE Ground-glass opacities heart heart tissue histopathologic histopathological infiltration liver lung lung biopsy Lungs material Microscope mononuclear cell Necrosis neutrophil infiltration nonspecific objective Patient patients performed Postmortem Result SARS-CoV-2 specimens spleen spleen tissue Splenic steatosis the patient tissue Treatment underlying disease were stained [DOI] 10.7759/cureus.20734 PMC 바로가기 [Article Type] Radiology
Rare variants in Toll-like receptor 7 results in functional impairment and downregulation of cytokine-mediated signaling in COVID-19 patientsToll-유사 수용체 7의 희귀 변이는 COVID-19 환자에서 기능 손상 및 사이토카인 매개 신호의 하향 조절을 초래합니다Brief Communication Published on 2021-12-242022-09-10 Journal: Genes and Immunity [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, [키워드] ACOD1 affected antiviral responses Cell Chronic diseases component COVID-19 patient CXCL10 Cytokines decrease downregulation failure functional Genes genetics hypomorphic IFIT2 IFN IFNα IFNγ imiquimod immune responses immunology impairment innate antiviral responses innate immune response innate immune responses interferons loss-of-function male men mononuclear cell mononuclear cells mRNA level mRNA levels Pathogens pathway Patient performed Peripheral blood Peripheral blood mononuclear cells pro-inflammatory cytokine pro-inflammatory cytokines recognize responses responsible RNA sequencing RSAD2 SARS-CoV-2 severe COVID-19 Signaling single-stranded RNA virus Stimulation TLR TLR7 TLRs Toll-like receptor toll-like receptor 7 Toll-like receptors Transcriptome triggering type I upregulation variant variants Variation variety viruses was performed [DOI] 10.1038/s41435-021-00157-1 PMC 바로가기 [Article Type] Brief Communication
Off-the-Shelf Partial HLA Matching SARS-CoV-2 Antigen Specific T Cell Therapy: A New Possibility for COVID-19 Treatment기성품 부분 HLA 매칭 SARS-CoV-2 항원 특이적 T 세포 요법: COVID-19 치료를 위한 새로운 가능성Immunology Published on 2021-12-232022-09-11 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료법, [키워드] adoptive transfer Antigen approach assays both groups CD4+ T cell CD56 CD8+ Cell Characteristics COVID-19 COVID-19 patient COVID-19 patients COVID19 Culture cytokine cytotoxicity determined by donors effector memory ELISPOT feature Final functional generate groups HLA HLA sharing hyperinflammation IL-2 Immunity immunophenotype in both group individual intracellular cytokine lymphopenia matching membrane mononuclear cell mononuclear cells New Nucleocapsid proteins Partial peptide Peripheral blood Peripheral blood mononuclear cells profiles rationale reduced respond Result SARS-CoV-2 SARS-CoV-2 antigen severe COVID-19 patient severe COVID-19 patients Specific specificity stimulated subset T cell T cell responses T cell therapy T cells transfer treat Treatment viral immunity virus specific T cells was determined [DOI] 10.3389/fimmu.2021.751869 PMC 바로가기 [Article Type] Immunology
Modulatory Effects of Physical Activity Levels on Immune Responses and General Clinical Functions in Adult Patients with Mild to Moderate SARS-CoV-2 Infections—A Protocol for an Observational Prospective Follow-Up Investigation: Fit-COVID-19 StudyProtocol Published on 2021-12-162022-10-04 Journal: International Journal of Environmental Research an [Category] SARS, 임상, [키워드] activity Adipose tissue analyzed approach baseline Biochemistry Blood blood sample body composition clinical collected conducted Control coronavirus coronavirus disease COVID-19 cytokine profile determine Effect evaluated Evidence exercise Exercise capacity explain expressed function functional healthy help homologous immune Immunity immunomodulatory in-vitro assay inactive individual Infection Inflammation Inflammatory information innate immune system knowledge Level long-COVID mechanism Mental mental health metabolic parameters metabolism Mild Moderate COVID-19 mononuclear cell obese participant Patient patients with COVID-19 PBMC PBMCs peripheral phenotypic physical physical activity physical activity level physically positive procedure Prospective prospective observational cohort provided Pulmonary function registry repeated-measures ANOVA Respiratory muscle strength respond response SARS-CoV-2 SARS-COV-2 infection Seahorse serum stimulated survival the SARS-CoV-2 virus the vaccine Trajectories treated vaccination venous viral infection virus [DOI] 10.3390/ijerph182413249 PMC 바로가기 [Article Type] Protocol