Disease activity and humoral response in patients with inflammatory rheumatic diseases after two doses of the Pfizer mRNA vaccine against SARS-CoV-2SARS-CoV-2에 대한 Pfizer mRNA 백신 2회 접종 후 염증성 류마티스 질환 환자의 질병 활성 및 체액 반응Article Published on 2021-10-012022-09-11 Journal: Annals of the rheumatic diseases [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] (Abbott Abbott administration age antirheumatic agents Autoimmune Autoimmune diseases biological therapy blood sample Blood samples consecutive patients COVID-19 disease dose humoral Humoral response IgG IgG antibodies IgG antibody immunomodulating drug immunomodulating drugs immunomodulatory therapy Inflammatory majority Messenger RNA mounted mRNA mRNA vaccine Patient patients patients treated Pfizer receiving recruited remained reported rheumatic disease Rheumatic diseases rheumatology SARS-CoV-2 SARS-CoV-2 virus second dose second dose of vaccine second vaccination serology Side effect the SARS-CoV-2 the vaccine treated Trial vaccination Vaccine [DOI] 10.1136/annrheumdis-2021-220503 PMC 바로가기 [Article Type] Article
Serologic Responses following a Single Dose of SARS-Cov-2 Vaccination in Allogeneic Stem Cell Transplantation Recipients동종 줄기 세포 이식 환자에서 SARS-Cov-2 백신 1회 접종 후 혈청학적 반응Article Published on 2021-10-012022-09-12 Journal: Transplantation and cellular therapy [Category] MERS, SARS, 진단, [키워드] Administered Allogeneic Allogeneic stem cell transplantation Antibody Response AstraZeneca AZ vaccine Cell cell transplantation Cohort COVID COVID vaccination healthy Hematologic malignancy highlight immunogenic Immunosuppression Immunosuppressive medication individual lack measure mounted mRNA vaccines Older age Patient patient groups patients Pfizer-BioNTech PROTECT recipient recipients response SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antibody response. SARS-CoV-2 vaccine serologic significantly single dose solid organ transplantation STEM transplantation Trial vaccination Vaccine [DOI] 10.1016/j.jtct.2021.07.011 PMC 바로가기 [Article Type] Article
Humoral and T-cell responses to SARS-CoV-2 vaccination in patients receiving immunosuppression면역 억제를 받는 환자에서 SARS-CoV-2 백신 접종에 대한 체액 및 T 세포 반응Article Published on 2021-10-012022-09-11 Journal: Annals of the rheumatic diseases [Category] MERS, SARS, 진단, 치료기술, [키워드] antibody Antibody Response assays Autoimmune Autoimmune diseases B-cell B-lymphocytes BNT162b2 BNT162b2 mRNA ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccines Combination COVID-19 detectable Diseases Efficacy Evidence evidence of failure glomerular glomerular diseases healthy individuals immune responses immunogenic immunogenicity Immunological response Immunosuppression immunosuppressive immunosuppressive therapies immunosuppressive therapy impair induce investigated Lymphocytes mounted non-responder participant Patient preserved receiving responders response responses rituximab robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines Seroconversion seroconvert seroconverted serological serology T-cell ELISpot T-cell Response T-cell responses tacrolimus therapy vaccination Vaccine vaccine dose Vaccines were used [DOI] 10.1136/annrheumdis-2021-220626 PMC 바로가기 [Article Type] Article
SARS-CoV-2 vaccination in rituximab-treated patients: B cells promote humoral immune responses in the presence of T-cell-mediated immunity리툭시맙 치료 환자에서 SARS-CoV-2 백신 접종: T 세포 매개 면역이 있는 경우 B 세포가 체액성 면역 반응을 촉진합니다Article Published on 2021-10-012022-09-11 Journal: Annals of the rheumatic diseases [Category] MERS, SARS, 진단, 치료기술, [키워드] Affect antibody assays B cell B cells BNT162b2 CD19 controls correlated COVID-19 detectable develop Elecsy enzyme enzyme-linked immunosorbent except for healthy control healthy individual healthy individuals humoral humoral immune response humoral immune responses IFN-γ immune response immune responses immunisation immunoassay independent independent of induce levels of antibody mounted mRNA mRNA-1273 n=36 neutralisation neutralisation tests Neutralising Antibodies neutralising antibody one patient Patient patients peripheral B cell peripheral B cells promote protective effect Protective effects quantified RBD Receptor-binding domain responses rituximab RTX SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 vaccination SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells SARS-CoV-2-specific T-cell response SARS-CoV-2-specific T-cell responses seroconverted significantly specific antibodies Spike protein T cells T-cell responses T-cell-mediated immunity the patient the receptor-binding domain the SARS-CoV-2 the spike protein therapy Treatment vaccination [DOI] 10.1136/annrheumdis-2021-220781 PMC 바로가기 [Article Type] Article
Clinical Course of SARS-CoV-2 Infection in Adults with ESKD Receiving Outpatient Hemodialysis외래 혈액투석을 받는 성인 ESKD에서 SARS-CoV-2 감염의 임상 경과Article Published on 2021-09-222022-09-11 Journal: Kidney360 [Category] SARS, 진단, 치료기술, [키워드] Antibody Response Atlanta Blood blood specimens chronic kidney failure clinical Clinical course collected COVID-19 COVID-19 symptom COVID-19 symptoms Culture Diagnosis dialysis eight End-stage renal disease enrolled ESRD higher risk Infection infections Infectious virus infectiousness Infectivity interquartile range kidney Kidney failure median age MOST mounted nasal Neutralizing antibodies neutralizing antibody Outpatient outpatients participant Participants Patient PCR tests positive positive RT-PCR receive remained renal renal disease Replication replication-competent virus RT-PCR RT-PCRs Saliva SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 RNA SARS-CoV-2 RT-PCR test SARS-CoV-2-specific antibodies Seroconversion Serologic response serology severe SARS severe SARS-CoV-2 specific antibodies specimen specimens symptom onset symptoms onset tested Viral viral culture was measured [DOI] 10.34067/KID.0004372021 PMC 바로가기 [Article Type] Article
Challenges and Lessons Learned From COVID-19 Trials: Should We Be Doing Clinical Trials Differently?COVID-19 시험에서 배운 도전과 교훈: 우리는 임상 시험을 다르게 해야 합니까?Review Published on 2021-09-012022-09-11 Journal: The Canadian journal of cardiology [Category] SARS, 신약개발, 임상, [키워드] accelerated adaptive administration adopted Analysis challenge clinical clinical care Clinical research clinical trial Consent COVID-19 COVID-19 crisis database diffusion dissemination diver English Evidence facilitate French integration Intervention large trial lesson meta-analyses Meta-analysis MOST mounted nonrandomized observation pragmatism pressure producing promotion provided randomized trial randomized trials recruitment Registered regulatory agencies regulatory agency Research Sample size Structure structures systematic review systematic reviews Trial trials [DOI] 10.1016/j.cjca.2021.05.009 PMC 바로가기 [Article Type] Review
Preliminary evidence of blunted humoral response to SARS-CoV-2 mRNA vaccine in multiple sclerosis patients treated with ocrelizumab오크렐리주맙으로 치료받은 다발성 경화증 환자에서 SARS-CoV-2 mRNA 백신에 대한 체액 반응 둔화의 예비 증거Article Published on 2021-09-012022-09-11 Journal: Neurological Sciences [Category] MERS, SARS, 진단, 치료기술, [키워드] all subject all subjects Anti-spike anti-Spike IgG Antibody Units baseline BAU binding antibody units BNT162b2 Case series case sery collected COVID-19 COVID-19 infection develop DiaSorin disease expand first dose geometric geometric mean health-care healthy subject healthy subjects humoral Humoral response IgG antibodies IgG antibody immunogenicity Infection International international standard majority mounted mRNA mRNA vaccine Multiple multiple sclerosis Ocrelizumab patients treated preliminary evidence relapsing SARS-CoV-2 SARS-CoV-2 mRNA vaccine SARS-CoV-2 spike protein SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARSCoV-2 second dose second dose of vaccine sera serum sample serum samples Spike protein tested Therapies treated unit Vaccine were expressed [DOI] 10.1007/s10072-021-05397-7 PMC 바로가기 [Article Type] Article
Occurrence of COVID-19 Symptoms During SARS-CoV-2 Infection Defines Waning of Humoral ImmunitySARS-CoV-2 감염 중 COVID-19 증상의 발생은 체액 면역 약화를 정의합니다Immunology Published on 2021-08-162022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, [키워드] age antibody Antibody Response Antibody responses Antigen Asymptomatic asymptomatic individual Asymptomatic individuals asymptomatic infections body weight both groups collective/herd immunity correlated COVID-19 COVID-19 patients declined detectable Endemic enrolled Humoral immunity IgG IgG antibodies IgG response IgG responses IgM IgM response IgM responses Immunity immunization Immunoglobulin Immunoglobulin G implication in both groups individual Infection mounted neutralizing capacity nucleoprotein occur Plasma level Plasma levels Prevalence question raising SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2-specific IgG Sex side specific IgG antibodies subsequent Surveillance symptomatic symptomatic and asymptomatic symptomatic patient Symptomatic patients Symptoms the SARS-CoV-2 Viral viral spike Wuhan Wuhan, China [DOI] 10.3389/fimmu.2021.722027 PMC 바로가기 [Article Type] Immunology
Effect of COVID-19 pandemic on provision of sexual and reproductive health services in primary health facilities in Nigeria: a cross-sectional studyResearch Published on 2021-08-042022-10-29 Journal: Reproductive Health [Category] COVID-19, MERS, SARS, [키워드] Administered adolescent health affected agency analysed Antenatal Area assistant Care caused conducted contraceptive contract the virus country COVID-19 COVID-19 pandemic cross-sectional drug Effect effort elicited equipment field Frequency Government Health Health Service Health services health worker identify information Kruskal–Wallis test lockdown lockdowns Maternal and Child Health mounted Nigeria offered pandemic Primary Health Facilities proportion Protective provided questionnaire raised reduced reduction in Region reported representing reproductive reproductive health Resilience resource Result state supplementary material symptoms of COVID-19 temperature the disease Travel Variation was used while [DOI] 10.1186/s12978-021-01217-5 PMC 바로가기 [Article Type] Research
Antibody Responses After mRNA-Based COVID-19 Vaccination in Residential Older Adults: Implications for Reopening거주 노인에서 mRNA 기반 COVID-19 백신 접종 후 항체 반응: 재개방에 대한 시사점Article Published on 2021-08-012022-09-11 Journal: Journal of the American Medical Directors Associat [Category] SARS, 치료기술, [키워드] adaptive Adults advanced age All participant All participants Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibody antibody level antibody levels Antibody Response assisted living B.1.1.7 Beckman Coulter blinded calculated Care coefficients collected Community condition conducted correlated correlation COVID-19 COVID-19 vaccines criteria cross-sectional Descriptive statistics detectable evaluated Factor greater IgG immune response immune responses Immunity Immunoglobulin Impact impair independent independent living Long-term care magnitude males mounted mRNA mRNA-based mRNA-based COVID-19 vaccine Multiple linear regression multiple linear regression analysis neutralization titer neutralization titers nursing homes Older older adult participant Pearson correlation personal care personal care living Pittsburgh protective effect Protective effects provide pseudovirus pseudovirus neutralization titers. Quality improvement reflex reopening response risk SARS-CoV-2 SARS-CoV-2 pseudovirus sera setting Spearman Steroids use of steroids vaccination Variation [DOI] 10.1016/j.jamda.2021.06.006 PMC 바로가기 [Article Type] Article