Necrosis – Page 7 – Communicable Diseases Research

Identifying Immunological and Clinical Predictors of COVID-19 Severity and Sequelae by Mathematical Modeling

수학적 모델링을 통한 COVID-19 심각도 및 후유증의 면역학적 및 임상적 예측인자 식별

Article

Published on 2022-04-202022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단,

Inflammation and Mortality in COVID-19 Hospitalized Patients With and Without Type 2 Diabetes

제2형 당뇨병이 있거나 없는 COVID-19 입원 환자의 염증 및 사망률

Article

Published on 2022-04-192022-09-11
Journal: The Journal of Clinical Endocrinology and Metaboli [Category] Coronavirus, COVID19(2023년), SARS, 바이오마커,

[키워드] 95% CI adjusted odds ratio association benefit Case-control center chemokine chemokines Columbia University Columbia University Irving Medical Center components conducted COVID-19 COVID-19 mortality COVID-19 patient CXCL10 CXCL8 cytokine Cytokine storm Cytokines death determine diabete diabetes elevated hospitalized patient hospitalized patients Hypothesis IFN-γ IL-1β IL-6 IL-6 inhibitor IL-8 immunoassays Inflammation inflammatory chemokine inflammatory chemokines Inflammatory cytokine Inflammatory marker inflammatory markers innate immune pathway Innate immunity interferon interleukin Intervention IP10 log-transformed logistic regression models marker Mortality Necrosis patients with diabetes positive Principal component principal components Protein quantified Regression model SARS-CoV-2 serum Serum level Significant significantly similarities similarity stratified TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor α Type type 2 diabete type 2 diabetes were used with COVID-19
[DOI] 10.1210/clinem/dgac003 PMC 바로가기 [Article Type] Article

A randomized, double-blind, placebo-controlled trial of intravenous alpha-1 antitrypsin for ARDS secondary to COVID-19

Clinical Trial

Published on 2022-04-082022-10-05
Journal: Med (New York, N.Y.) [Category] 바이오마커, 임상,

[키워드] accelerated acute respiratory distress acute respiratory distress syndrome addition alpha-1 antitrypsin Anti-inflammatory ARDS biochemically changes in circulating Clinical outcome clinical trial Concentration coronavirus COVID-19 Cytokines develop double-blind EudraCT feasible febrile Grifols groups IL-10 IL-1β IL-6 IL-8 Inflammation interleukin-6 intravenous moderate Mortality multicenter Necrosis patients patients receiving placebo patients with COVID-19 phase 3 trial Placebo placebo-controlled trial plasma primary endpoint pro-inflammatory progression Randomized randomized control trial randomized control trial. receive receptor reduce Safe Secondary endpoints severe ARDS severe coronavirus disease Support syndrome the placebo group therapeutic Tolerability Treatment treatment group Trial ventilator ventilator-free day was increased were assessed
[DOI] 10.1016/j.medj.2022.03.001 PMC 바로가기 [Article Type] Clinical Trial

Biotin-thiamine responsive basal ganglia disease in the era of COVID-19 outbreak diagnosis not to be missed: A case report

코로나19 발병 진단에서 놓쳐서는 안 될 비오틴-티아민 반응성 기저핵 질환: 증례 보고

Case Reports

Published on 2022-04-012022-09-11
Journal: Brain & development [Category] COVID19(2023년), SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Analysis autosomal recessive basal ganglia Biotin Biotin-thiamine responsive basal ganglia disease Case report caused central necrosis characteristic characterized chromosome Coronavirus-2 COVID-19 COVID-19 outbreak death diagnosed Diagnosis disability disease disorder Encephalomyelitis Encephalopathy episode febrile illness Fever ganglia genetic analysis high signal male male child MRI Mutation Necrosis Neurometabolic Patient presenting SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severity SLC19A3 suspicion Thiamine Transporter 2 treatable treated triggered viral infection virus infection
[DOI] 10.1016/j.braindev.2021.12.003 PMC 바로가기 [Article Type] Case Reports

Association of TNF-α G-308 a Promoter Polymorphism with the Course and Outcome of COVID-19 Patients

TNF-α G-308 프로모터 다형성과 COVID-19 환자의 경과 및 결과와의 연관성

Article

Published on 2022-04-012022-09-11
Journal: Immunological investigations [Category] 유전자 메커니즘,

Amyloid processing in COVID-19-associated neurological syndromes

COVID-19 관련 신경 증후군에서 아밀로이드 처리

Article

Published on 2022-04-012022-09-11
Journal: Journal of neurochemistry [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단,

[키워드] Activation Acute disseminated encephalomyelitis Altered Alzheimer's disease amyloid amyloid precursor protein amyloid processing app Beta beta amyloid. Biomarker Central pain central pain syndrome cerebrospinal fluid cohort study controls correlated COVID-19 COVID-19 negative cross-sectional CSF Cytokines described Disseminated encephalomyelitis Encephalitis Encephalopathy exploratory GFAp greater Guillain-barrè syndrome healthy hypertension IL-1β IL-8 impairment Infection Injury interleukin Intracranial Hypertension mechanism Necrosis nervous system Neuroinflammation neurological neurological manifestation neuronal Pain Patient patients with COVID-19 pilot study positively correlated Proinflammatory cytokine proinflammatory cytokines raise reduced SARS-CoV-2 SARS-COV-2 infection sensitivity analysis serum biomarker serum biomarkers significantly significantly increased syndrome tissue with COVID-19
[DOI] 10.1111/jnc.15585 PMC 바로가기 [Article Type] Article

Manifestations and Mechanism of SARS-CoV2 Mediated Cardiac Injury

SARS-CoV2 매개 심장 손상의 징후 및 메커니즘

Review

Published on 2022-03-282022-09-11
Journal: International Journal of Biological Sciences [Category] SARS, 치료기술,

[키워드] accompanied ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme arrhythmia Autopsy blood vessel blood vessels cardiac cardiac damage cardiac injury caused clinical manifestation clinical manifestations coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critically ill critically ill patients damaged edema evidenced global pandemic heart heart failure Heart injury heart tissue immune response Injury kidney liver lymphocyte Macrophage Macrophage infiltration manifestation mechanism Mediated membrane Mild morbidity and mortality Mortality Myocardial myocardial injury myocarditis Necrosis organs Patient Respiratory system SARS-CoV2 severe acute respiratory syndrome Coronavirus severe patients significantly Spike protein systemic inflammatory Takotsubo cardiomyopathy TCM the disease tissues Treatment virus virus RNA
[DOI] 10.7150/ijbs.69677 PMC 바로가기 [Article Type] Review

Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

인플릭시맙과 베돌리주맙으로 치료받은 염증성 장질환 환자에서 SARS-CoV-2 백신 2회 투여 후 항체 붕괴, T 세포 면역 및 돌발성 감염

Article

Published on 2022-03-162022-09-11
Journal: Nature Communications [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] anti-S anti-TNF antibody antibody concentration BNT162b2 Breakthrough infection breakthrough infections ChAdOx1 ChAdOx1 nCoV-19 Concentration dose drug geometric mean half-live immune responses Immunity impair induce Inflammatory bowel disease infliximab Influenza influenza vaccination integrin nCoV Necrosis of BNT162b2 p value Patient patients patients treated pneumococcal predicted protective immunity RBD required respiratory respiratory infection risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 vaccine sustained T cell T cell response treated treatment groups tumour necrosis factor U/mL vaccination vaccination schedule vaccine doses vaccine-induced immune response vedolizumab
[DOI] 10.1038/s41467-022-28517-z PMC 바로가기 [Article Type] Article

Effects of Resistance Training on C-Reactive Protein and Inflammatory Cytokines in Elderly Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

고령자의 C 반응성 단백질 및 염증성 사이토카인에 대한 저항 훈련의 효과: 무작위 대조 시험의 체계적인 검토 및 메타 분석

Review

Published on 2022-03-142022-09-11
Journal: International Journal of Environmental Research an [Category] MERS, 바이오마커, 임상,

[키워드] 95% confidence interval accompany Adults age aging Analysis C-reactive protein can be used chronic Chronic low-grade inflammation CINAHL Cochrane Library Controlled COVID-19 CRP Cytokines Effect effect size effective elderly evaluated Evidence exacerbate fixed Frequency Health Health status IL-10 IL-6 IMPROVE Inconclusive Infectious disease Inflammation intensity interleukin low-grade inflammation Necrosis outcome patients Random-effects models Randomized controlled trial reduce reduction resistance Resistance training review searched severity Subgroup analyses subgroup analysis The effect size TNF-α training Tumor tumor necrosis tumor necrosis factor was performed
[DOI] 10.3390/ijerph19063434 PMC 바로가기 [Article Type] Review

Adalimumab and Infliximab Impair SARS-CoV-2 Antibody Responses: Results from a Therapeutic Drug Monitoring Study in 11 422 Biologic-Treated Patients

아달리무맙과 인플릭시맙은 SARS-CoV-2 항체 반응을 손상시킨다: 생물학적 치료를 받은 11,422명의 환자를 대상으로 한 치료 약물 모니터링 연구의 결과

Article

Published on 2022-03-142022-09-11
Journal: Journal of Crohn's & colitis [Category] MERS, SARS, 진단, 치료기술, 치료법,

[키워드] adalimumab anti-TNF antibody reactivity Antibody Response Antibody testing attenuate biologic bowel causal relationship CLARITY combination therapy confounding factors COVID-19 cut-off detectable drug drug level drug levels drugs Immune-mediated inflammatory diseases immunomodulator Immunosuppression Inflammatory Inflammatory bowel disease Inflammatory diseases infliximab influence Laboratory magnitude median median age median time monitoring Necrosis Patient patients PCR testing PCR-confirmed positive Rate reactivity responses Result SARS-CoV-2 SARS-CoV-2 antibodies SARS-COV-2 infection SARS-CoV-2 nucleocapsid SARS-CoV-2 PCR seroconvert serological serological response seropositive Seropositivity Seroprevalence serum Support therapeutic drug Therapeutic Drug Monitoring treated Treatment treatment groups undetectable vaccination vedolizumab were measured
[DOI] 10.1093/ecco-jcc/jjab153 PMC 바로가기 [Article Type] Article