PBMC – Page 7 – Communicable Diseases Research

Selection and T-cell antigenicity of synthetic long peptides derived from SARS-CoV-2

Animal

Published on 2022-01-112022-10-30
Journal: The Journal of General Virology [Category] COVID-19,

Cardiovascular Risk After SARS-CoV-2 Infection Is Mediated by IL18/IL18R1/HIF-1 Signaling Pathway Axis

SARS-CoV-2 감염 후 심혈관 위험은 IL18/IL18R1/HIF-1 신호 경로 축에 의해 매개됩니다

Immunology

Published on 2022-01-052022-09-11
Journal: Frontiers in Immunology [Category] 유전자 메커니즘, 치료기술, 치료제,

[키워드] activate activated Activation Algorithm Analysis Aneurysm aneurysms Atherosclerosis axis cardiovascular cardiovascular risk Cell cell types changes in characterized choice Compound COVID-19 COVID-19 infection detect Epigenetic expected functional gene co-expression network HIF-1 HIF-1 signaling pathway HIF1a hypoxia identify IL-18 IL18 IL18R1 Infection Inference Intercellular communication interleukin locus Macrophage macrophages MAP2K1 mechanism Mediated MEK inhibitor Methylation NF-κB nucleus objective pathway Pathways PBMC phenotype phenotypic Potential promote promoted Proteins Proteomic analysis Regulation Regulatory Regulon Result SARS-CoV-2 SARS-COV-2 infection scRNA-seq Signaling signaling pathway smooth muscle therapeutic compound therapeutic target Treatment type I interferon type I interferon pathway vascular smooth muscle vascular smooth muscle cells VIPER was used WGCNA with COVID-19
[DOI] 10.3389/fimmu.2021.780804 PMC 바로가기 [Article Type] Immunology

Serum level of testosterone predicts disease severity of male COVID-19 patients and is related to T-cell immune modulation by transcriptome analysis

테스토스테론의 혈청 수준은 남성 COVID-19 환자의 질병 중증도를 예측하고 전사체 분석을 통해 T 세포 면역 조절과 관련이 있습니다

Article

Published on 2022-01-012022-09-11
Journal: Clinica chimica acta; international journal of cli [Category] SARS, 유전자 메커니즘, 진단, 치료기술,

[키워드] Activation addition Admission Affiliated Hospital Analysis CD28 changes in Clinical treatment collected correlated correlation COVID-19 COVID-19 patient diagnostic value disease disease severity effective enrolled female patient Female patients ICU immune activation immune modulation immune response independent risk factor Inositol INPP4B lymphocyte male mechanism Medicine Mortality non-ICU occur Patient patients PBMC Pneumonia positively correlated predict progression Regulation remained ROC Curve School serum serum sample serum samples severe disease severity severity of COVID-19 significantly significantly lower Stage T cell T cell activation T-cell Testosterone the disease the patient Transcriptome transcriptome analysis Type university was performed Zhejiang
[DOI] 10.1016/j.cca.2021.11.006 PMC 바로가기 [Article Type] Article

Coordinated cellular and humoral immune responses after two-dose SARS-CoV2 mRNA vaccination in liver transplant recipients

간 이식 환자에서 SARS-CoV2 mRNA 2회 접종 후 조정된 세포 및 체액 면역 반응

Article

Published on 2022-01-012022-09-12
Journal: Liver international : official journal of the Inte [Category] MERS, SARS, 진단,

Cross-reactive and mono-reactive SARS-CoV-2 CD4+ T cells in prepandemic and COVID-19 convalescent individuals

전염병 및 COVID-19 회복기 개인의 교차 반응성 및 단일 반응성 SARS-CoV-2 CD4+ T 세포

Research Article

Published on 2021-12-292022-09-10
Journal: PLoS Pathogens [Category] SARS, 치료기술, 치료법,

[키워드] Activation allele Amino acid amino acid sequence Amino acid sequences Analysis assays Author CD4+ T cell class common cold common cold coronavirus common cold Coronaviruses common cold virus common cold viruses contributed convalescent convalescent individual convalescent individuals coronavirus COVID-19 cross-react cross-reactive cross-reactivity defined demonstrated Direct dominant epitope DPB1 elicit elicited Endemic epitope Epitopes Ex vivo frequencies Frequency functional HLA-DP HLA-DR identify immunodominant low frequency marker membrane MHC-II naïve individuals nucleocapsid Nucleocapsid proteins overlapping PBMC peptide peptides Potential prevalent Previous studies previous study proportion protective immunity Protein reactive reagent recognizing SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 epitope SARS-CoV-2 epitopes sequence identity shown spike staining stratified subjects suggested T cell T cell epitope T cell epitopes T cell response T cell responses T cells the Spike to define unlikely viruses was used were used world population
[DOI] 10.1371/journal.ppat.1010203 PMC 바로가기 [Article Type] Research Article

High CD169 Monocyte/Lymphocyte Ratio Reflects Immunophenotype Disruption and Oxygen Need in COVID-19 Patients

Article

Published on 2021-12-182022-10-28
Journal: Pathogens [Category] COVID-19,

[키워드] analyzed B-cell Biomarker Blood blood cell blood sample CD169 CD8 T-cell clinical outcomes correlated COVID-19 COVID-19 patient COVID-19 patients COVID-19 therapy cytokine Cytokine storm disease Disease progression Disruption dose-dependent manner Evidence flow cytometry fluorescence intensity healthy donor Hospitalization IL-10 IL-6 immune dysfunction immunophenotype in vitro Inflammation inflammatory markers lymphocyte marker maturation monocyte mRNA expression mRNA levels outcome overexpressed Patient PBMC Pneumonia Predictive pulmonary involvement Ratio Respiratory outcome SARS-CoV-2 severity sialoadhesin stimulated T-cell exhaustion the median the spike protein Transcription
[DOI] 10.3390/pathogens10121639 PMC 바로가기 [Article Type] Article

Modulatory Effects of Physical Activity Levels on Immune Responses and General Clinical Functions in Adult Patients with Mild to Moderate SARS-CoV-2 Infections—A Protocol for an Observational Prospective Follow-Up Investigation: Fit-COVID-19 Study

Protocol

Published on 2021-12-162022-10-04
Journal: International Journal of Environmental Research an [Category] SARS, 임상,

[키워드] activity Adipose tissue analyzed approach baseline Biochemistry Blood blood sample body composition clinical collected conducted Control coronavirus coronavirus disease COVID-19 cytokine profile determine Effect evaluated Evidence exercise Exercise capacity explain expressed function functional healthy help homologous immune Immunity immunomodulatory in-vitro assay inactive individual Infection Inflammation Inflammatory information innate immune system knowledge Level long-COVID mechanism Mental mental health metabolic parameters metabolism Mild Moderate COVID-19 mononuclear cell obese participant Patient patients with COVID-19 PBMC PBMCs peripheral phenotypic physical physical activity physical activity level physically positive procedure Prospective prospective observational cohort provided Pulmonary function registry repeated-measures ANOVA Respiratory muscle strength respond response SARS-CoV-2 SARS-COV-2 infection Seahorse serum stimulated survival the SARS-CoV-2 virus the vaccine Trajectories treated vaccination venous viral infection virus
[DOI] 10.3390/ijerph182413249 PMC 바로가기 [Article Type] Protocol

Impact of chemotherapy and immunotherapy on the composition and function of immune cells in COVID-19 convalescent with gynecological tumors

부인과 종양과 코비드 -19 회복기에서 면역 세포의 조성 및 기능에 대한 화학 요법 및 면역 요법의 영향

Research Paper

Published on 2021-12-152022-09-01
Journal: Aging (Albany NY) [Category] SARS, 진단,

[키워드] acute infection anti-viral activity B cells cancers caused Chemotherapy clonal expansion convalescent Convalescent patients coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CoVs effort ENhance facilitated functional phenotype healthy donor ICIs Immune cell immunological change Immunological memory Immunotherapy Impact molecular feature molecular features neutropenia NK cells pandemic Patient patients PBMC PBMCs performed Peripheral blood peripheral blood samples proportion PROTECT Reinfection resurgence SARS-CoV-2 virus single cell sequencing Single-cell RNA sequencing T and B cells T cell T cells Treatment Tumor tumors
[DOI] 10.18632/aging.203739 PMC 바로가기 [Article Type] Research Paper

Transcriptomic Profiles Reveal Downregulation of Low-Density Lipoprotein Particle Receptor Pathway Activity in Patients Surviving Severe COVID-19

심각한 COVID-19에서 생존한 환자의 저밀도 지단백질 입자 수용체 경로 활동의 하향 조절을 나타내는 전사체 프로필

Article

Published on 2021-12-102022-09-11
Journal: Cells [Category] SARS, 유전자 메커니즘,

[키워드] activity AnxA2 applied approach bioinformatics Biology cargo receptor activity CD36 characterized cholesterol cholesterol homeostasis COVID-19 COVID-19 infection died disease downregulation Endpoint expression Gene expression profiling generate GO ontology Infection intensive care unit ITGAV LDL LDL particle receptor activity leukocyte leukocyte differentiation lipoprotein low-density Low-density lipoprotein mononuclear cell mononuclear cells nonsurvivor nonsurvivors Particle pathway Patient patients who survived patients with COVID-19 patients with SARS-CoV-2 PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells PPARG profile Prognosis receptor reduced RNA-seq analysis Russia SARS-COV-2 infection severe COVID-19 STAB1 state surviving patient survivor transcriptional transcriptional response Transcriptome university virus
[DOI] 10.3390/cells10123495 PMC 바로가기 [Article Type] Article

Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients

Azvudine은 COVID-19 환자 치료에 효과적인 흉선 유도 항 SARS-CoV-2 약물입니다.

Article

Published on 2021-12-062022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 임상, 치료법, 치료제,

[키워드] (RdRp) active form agent anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Azvudine cells chest X-ray clinical trial compassionate use coronavirus COVID-19 COVID-19 patients cured Dizziness Drug development effective followed by Ground-glass opacities ground-glass opacity HCoV HCoV-OC43 HIV-1 hospital discharge rate Immunity Infectious diseases Inflammation inhibit inhibited lymphocyte mononuclear cell mononuclear cells monophosphate nausea Negative conversion nucleoside oral administration organ damage patients PBMC Peripheral blood Peripheral blood mononuclear cells phase profiles promoted promotion Randomized RATs RdRP reduced rhesus macaque rhesus macaques Ribonucleic acid RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 selective Sequencing Side-effect single-arm suggested thymus treating treating COVID-19 patient Trial triphosphate Viral Viral load viral ribonucleic acid virus viruses
[DOI] 10.1038/s41392-021-00835-6 PMC 바로가기 [Article Type] Article