Comparison of two T-cell assays to evaluate T-cell responses to SARS-CoV-2 following vaccination in naïve and convalescent healthcare workers미경험 및 회복기 의료 종사자를 대상으로 백신 접종 후 SARS-CoV-2에 대한 T 세포 반응을 평가하기 위한 두 가지 T 세포 분석 비교Comparative Study Published on 2022-07-222022-09-11 Journal: Clinical and experimental immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] acquisition antibody Antibody responses AZD1222 Blood BNT162b ChAdOx1 ChAdOx1 nCoV-19 characterized complex convalescent correlated strongly correlation dose ELISPOT ELISpot assay evaluate HCWs healthcare worker implication Infection less magnitude measure membrane moderate naïve Nucleocapsid proteins Oxford Panel pathway patient population peptides Pfizer Pfizer/BioNTech processing proportion protocol Region reported Reporting representing Research response responses SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein seasonal coronaviruses significantly lower Spike protein Spike-specific T-cell responses Standardization T cell T-cell T-cell assay T-cell Response T-cell responses vaccination Vaccine vaccinees virus [DOI] 10.1093/cei/uxac042 PMC 바로가기 [Article Type] Comparative Study
Heterologous saRNA Prime, DNA Dual-Antigen Boost SARS-CoV-2 Vaccination Elicits Robust Cellular Immunogenicity and Cross-Variant Neutralizing Antibodies이종 saRNA 프라임, DNA 이중 항원 부스트 SARS-CoV-2 백신 접종으로 강력한 세포 면역원성과 교차 변형 중화 항체 유도Article Published on 2022-07-152022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] Adenovirus animal model animal models B.1.617.2 Beta boost CD4+ CD8+ T-cell combinations COVID-19 D614G mutation Delta distribution DNA dual dual antigen ENCODE enhanced expression followed by furin furin cleavage region Glutamine Heterologous highest homologous homologous or heterologous Humoral response humoral responses IgG immune response immune responses immunogenicity lipid carrier MHC class I MHC class I and II mice motif N antigen Neutralizing nucleic acid nucleocapsid omicron peptide peptides prefusion conformation prime proline prolines protease pseudovirus receiving regimen regimens Region response RNA vaccine SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant self-amplifying RNA sequence sera serotype spike Stimulation strain Strains Support T-cell T-cell responses vaccination Vaccine Vaccines variant wild type Wuhan [DOI] 10.3389/fimmu.2022.910136 PMC 바로가기 [Article Type] Article
Peptide-Antibody Fusions Engineered by Phage Display Exhibit an Ultrapotent and Broad Neutralization of SARS-CoV-2 Variants파지 디스플레이가 조작한 펩티드-항체 융합은 SARS-CoV-2 변이체의 초강력 및 광범위한 중화를 나타냅니다Article Published on 2022-07-152022-09-11 Journal: ACS chemical biology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] affinities affinity approach approved B.1.1.529 Bivalent bivalent IgG breadth clinically Coverage COVID-19 demonstrated display domain dominant ENhance exacerbated fused fusion fusions generate implicated IMPROVE Infection infection assay low potency Mutation N-terminal domain N-terminus NAb NAbs naïve neutralization neutralization potency neutralize neutralizing antibody NTD omicron peptide peptides phage RBD RBD mutation RBD mutations S-protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spike protein spread of COVID-19 tetravalent the RBD the spike protein therapeutic Therapeutics trimer variant variants variants of concern vulnerability [DOI] 10.1021/acschembio.2c00411 PMC 바로가기 [Article Type] Article
Novel Engineered SARS-CoV-2 HR1 Trimer Exhibits Improved Potency and Broad-Spectrum Activity against SARS-CoV-2 and Its Variants신규 설계된 SARS-CoV-2 HR1 삼량체, SARS-CoV-2 및 그 변이체에 대해 향상된 효능 및 광범위한 활성을 나타냄Article Published on 2022-07-132022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] activities activity adopted affinity antibodies binding affinity C terminus caused cell-cell fusion develop domain effective Effectiveness foldon foundation fusing fusion fusion inhibitor global public health HR1 HR1 domain Improved increased the risk information inhibit inhibit SARS-CoV-2 inhibitor inhibitors inhibitory inhibitory activity limit MERS MERS-CoV MERS-CoV pseudoviruses motif much higher Multiple NAbs Neutralizing antibodies neutralizing antibody novel pandemic of COVID-19 peptide Peptide inhibitor Peptide Inhibitors peptides potency provide pseudoviruses reported S protein SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants shown significantly Spread the S protein the SARS-CoV-2 theory treating SARS-CoV-2 infection trimer trimeric Vaccine variants viral infection viral S protein viral variant Viral variants VOCs [DOI] 10.1128/jvi.00681-22 PMC 바로가기 [Article Type] Article
SARS-Arena: Sequence and Structure-Guided Selection of Conserved Peptides from SARS-related Coronaviruses for Novel Vaccine DevelopmentSARS-Arena: 새로운 백신 개발을 위한 SARS 관련 코로나바이러스에서 보존된 펩티드의 서열 및 구조 유도 선택Article Published on 2022-07-122022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] 3D structure affected against SARS-CoV agent Analysis approach can be used case study caused CD8 computational method Computational methods conserved contribute coronavirus COVID-19 disease cross-reactive database development envelope proteins help HLA HLA-Arena HLA-B7 Human human leukocyte antigen humoral Humoral response immune response less leukocyte mitigate MOST Multiple sequence alignment N protein Notebook novel nucleocapsid nucleocapsid protein pandemic peptide peptides pHLA scoring Practitioner practitioners Prevent Protein protein regions protein sequence protein sequence alignment protein sequences Proteins Region related viruses responsible SARS-CoV SARS-CoV viruses SARS-CoV-2 SARS-CoV-2 virus Selection selection pressure Sequence alignment Spike protein structural modeling. susceptible T-cell T-cells target the disease the N protein the SARS-CoV-2 virus the spike protein therapy Vaccine development Vaccines variants viral envelope protein viral strains viruses widespread [DOI] 10.3389/fimmu.2022.931155 PMC 바로가기 [Article Type] Article
Evidence of previous SARS-CoV-2 infection in seronegative patients with long COVID장기간 코로나바이러스에 감염된 혈청 음성 환자의 이전 SARS-CoV-2 감염의 증거Article Published on 2022-07-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute illness antibody assay Cambridge Cohort Consensus COVID COVID-19 illness Definition detectable Diagnosis diagnostic Evidence evidence of IFN-γ IL-2 Immunity infected with SARS-CoV-2 Innovation Long Long COVID Medical Research Council MRC NHSBT NIHR non-hospitalised Patient patients peptides positive PCR test Research reveal SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 peptide SARS-CoV-2 peptides seronegative patient seronegative patients supported Symptoms T cell T cell response T cell responses T cells tested Trust United Kingdom Wellcome Trust [DOI] 10.1016/j.ebiom.2022.104129 PMC 바로가기 [Article Type] Article
Self-derived peptides from the SARS-CoV-2 spike glycoprotein disrupting shaping and stability of the homotrimer unitSARS-CoV-2 스파이크 당단백질의 자가유래 펩타이드가 동종삼량체 단위의 형태와 안정성을 방해Article Published on 2022-07-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, [키워드] approach binding binding affinity blocker blockers conformation COVID dataset destabilized develop disrupting domain exhibited functional higher affinity homotrimer host cell host cell receptor instability linear Linear motif molecular molecular dynamics monomer motif mutated Mutation opposite peptide peptides Protein protein structure RBD Region regions responsible resulting S protein S1 and S2 S1 and S2 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 S Self-derived peptides shown spike spike glycoprotein stability Structural folding structure-based design subunit Support the S protein the SARS-CoV-2 Vaccine Vaccine design variant wild type β-coronavirus [DOI] 10.1016/j.biopha.2022.113190 PMC 바로가기 [Article Type] Article
Cellular and Humoral Immune Response to a Third Dose of BNT162b2 COVID-19 Vaccine – A Prospective Observational StudyBNT162b2 COVID-19 백신의 3차 접종에 대한 세포 및 체액 면역 반응 - 전향적 관찰 연구Observational Study Published on 2022-07-012022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, [키워드] addition administration All participant All participants anti-SARS-CoV-2 antibody binding binding antibody blood sample Blood samples BNT162b2 booster booster dose cellular Cellular immune response Combination COVID-19 detectable dose evaluate health-care humoral humoral and cellular immunity Humoral immunity immune response Immunity immunological infection rate infection rates interferon Interferon-gamma median Neutralizing antibodies neutralizing antibody observational study of BNT162b2 participant peptide peptides prime-boost regimen Prospective prospective observational study protocols provided quantitative assay questionnaire Questionnaires real-world data response SARS-CoV-2 second dose Seroprevalence significant increase significantly third dose vaccination Vaccine was measured were measured [DOI] 10.3389/fimmu.2022.896151 PMC 바로가기 [Article Type] Observational Study
Antimicrobial Activity of the Serum before and after Vaccination with EpiVacCoronaEpiVacCorona 백신 접종 전과 후 혈청의 항균 활성Article Published on 2022-07-012022-09-12 Journal: Bulletin of experimental biology and medicine [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activity antimicrobial antimicrobial activity antimicrobial peptide antimicrobial peptides Cell coronavirus correlated demonstrated EpiVacCorona evaluated expression expression of gene fraction initial inverse correlation Normal distribution PCR peptides reverse transcription SARS-CoV-2 antigen sera serum specific IgG antibodies specific IgG antibody Total vaccination Vaccine Volunteer was measured [DOI] 10.1007/s10517-022-05548-6 PMC 바로가기 [Article Type] Article
Inhibition of SARS-CoV-2 pathogenesis by potent peptides designed by the mutation of ACE2 binding regionACE2 결합 영역의 돌연변이에 의해 설계된 강력한 펩티드에 의한 SARS-CoV-2 발병 억제Article Published on 2022-07-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding allergenicity angiotensin Angiotensin-converting enzyme antiviral peptide binding energy complex Computational approaches COVID-19 COVID-19 treatment criteria deaths determined by Diagnosis docked domain Drug development effective inhibitor entry inhibitors Final host receptor identify information inhibition inhibitor inhibitory action initial Interaction mechanism molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations Mutation OSPREY outbreak pandemic peptide Peptide design Peptide inhibitor Peptide Inhibitors peptides provided RBD RBD binding RBD residue RBD residues RBD-ACE2 Receptor-binding domain residue residues SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 pathogenesis screened Spike protein spread of COVID-19 targeting Template the RBD Therapeutics Treatment vaccination variant Viral entry inhibitors. viral infection virus was determined [DOI] 10.1016/j.compbiomed.2022.105625 PMC 바로가기 [Article Type] Article