Impairment in selenocysteine synthesis as a candidate mechanism of inducible coagulopathy in COVID-19 patientsCOVID-19 환자에서 유도성 응고병증의 후보 기전으로서 셀레노시스테인 합성 장애Article Published on 2021-02-012022-09-11 Journal: Medical Hypotheses [Category] SARS, 유전자 메커니즘, [키워드] Coagulopathy complication of COVID-19 COVID 19 patient COVID 19 patients COVID-19 patient Critical Critical illness endothelial Endothelium epidemiological Evidence homeostasis immune response impairment latency mechanism Perturbation perturbations physiological functions platelet activation Platelets SARS-CoV-2 Selenium selenocysteine Taking transcriptomic [DOI] 10.1016/j.mehy.2020.110475 PMC 바로가기 [Article Type] Article
Could Perturbation of Gut Microbiota Possibly Exacerbate the Severity of COVID-19 via Cytokine Storm?Immunology Published on 2021-01-252022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] COVID-19 COVID-19 and gut microbiome COVID-19 inflammation cytokine storm in SARS-CoV-2 gut dysbiosis in COVID-19 microbial translocation in COVID-19 microbiome and cytokine storm Perturbation severe acute respiratory syndrome coronavirus-2 [DOI] 10.3389/fimmu.2020.607734 PMC 바로가기 [Article Type] Immunology
Adaptation and resilience of commercial fishers in the Northeast United States during the early stages of the COVID-19 pandemicResearch Article Published on 2020-12-172022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] adaptation adaptive affecting Characteristics collected COVID-19 pandemic demonstrated driven by early stage Effect Fisher Government Impact indicated landing majority outcomes pandemic Perturbation remained reported Research Resilience response resulting switching United State United States was reduced [DOI] 10.1371/journal.pone.0243886 PMC 바로가기 [Article Type] Research Article
Protein-Driven Mechanism of Multiorgan Damage in COVID-19Research article Published on 2020-12-012022-10-05 Journal: Medicine in Drug Discovery [Category] 신약개발, [키워드] activate biological networks candidate Combination COVID-19 damage damaged drug drug-drug interaction ellagic acid Endocrine Exosomes expressed Extracellular extracellular vesicle Extracellular vesicles eyes identify Lungs mathematical mechanism Multiorgan Multiorgan damage Musculoskeletal neurologic organ Perturbation predict Protein protein-protein interaction Proteins SARS-CoV-2 SARS-CoV-2 proteins severe COVID-19 patients Subdiffusion the lungs a treat [DOI] 10.1016/j.medidd.2020.100069 [Article Type] Research article
The potential impact of the COVID-19 response related lockdown on TB incidence and mortality in India인도의 결핵 발병률 및 사망률에 대한 COVID-19 대응 관련 잠금의 잠재적 영향Review Published on 2020-12-012022-09-11 Journal: The Indian journal of tuberculosis [Category] SARS, 치료기술, [키워드] BMI body mass body mass index case finding coronavirus COVID-19 death decrease distribution effort Epidemiology exacerbated food insecurity group highest implication Impoverishment incidence increase in India lockdown management migrant workers Mortality National notification nutrition nutritional status occur Perturbation poverty Prevent progression pulse reduction in Referral risk severe disease shown social groups systematic review transfer Transmission Tuberculosis Tuberculosis epidemiology. undernutrition weight loss [DOI] 10.1016/j.ijtb.2020.07.004 PMC 바로가기 [Article Type] Review
Overlapping host pathways between SARS-CoV-2 and its potential copathogens: An in silico analysisSARS-CoV-2와 잠재적 copathogens 간의 중복 호스트 경로: 실리코 분석Article Published on 2020-12-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] analyses bacterial pathogen Biomarker candidate Candidates Coinfection COVID-19 cohort COVID-19 phenotypes detect determinant determine drug design EBV enrichment analysis Enrichr epithelial false discovery rate FDR Gene Expression Gene Expression Omnibus gene network gene set enrichment analysis GEO GSEA HIV1 Host host gene IAV immune cells in silico analysis increasingly Infection infections Interaction involved material Meta-analysis overlap pathogen Pathogens pathway Peripheral blood Perturbation platform provide reported RSV SARS-CoV-2 SARS-COV-2 infection significantly statistically significant System Systems biology transcriptomic transcriptomics Viral viral infection were used [DOI] 10.1016/j.meegid.2020.104602 PMC 바로가기 [Article Type] Article
Metabolic Perturbations and Severe COVID-19 Disease: Implication of Molecular PathwaysReview Article Published on 2020-11-282022-10-30 Journal: International Journal of Endocrinology [Category] COVID-19, [키워드] absence ACE-2 receptor addition affected alteration association biological processe caused China Comorbidity conditions country COVID-19 COVID-19 severity deregulation described disease heterogeneous hyperglycemia hypertension immune system implication incidence Inflammatory response metabolic Metabolic diseases metabolic disorder modulation molecular mechanism outcomes pandemic Patient Perturbation Pneumonia Prognosis public health reported Respiratory failure Respiratory illness responsible SARS-COV-2 infection SARS-CoV-2 positive patients SARS-CoV-2 virus severe COVID-19 Spread Symptom Wuhan [DOI] 10.1155/2020/8896536 PMC 바로가기 [Article Type] Review Article
Retrospective cohort study of clinical characteristics of 2199 hospitalised patients with COVID-19 in New York City뉴욕시에서 COVID-19로 입원한 2199명의 환자의 임상 특성에 대한 후향적 코호트 연구Article Published on 2020-11-272022-09-12 Journal: BMJ Open [Category] SARS, 진단, [키워드] Admission age Analysis C reactive protein Care characteristic Clinical characteristics Clinical course Cohort cohort study condition Course COVID-19 COVID-19 pandemic D-dimer death demographic died discharged Electronic health records FIVE global public health greater had more hospital hospitalised hospitalised patient Hospitalised patients in-hospital mortality Infectious diseases Inflammatory marker intensive care internal medicine investigated lymphocyte median median age Mortality Mount Sinai New York City outcome overall mortality participant Patient patients with COVID-19 performed Perturbation procalcitonin public health remained required retrospective study period System USA with COVID-19 [DOI] 10.1136/bmjopen-2020-040736 PMC 바로가기 [Article Type] Article
Inhibiting the reproduction of SARS-CoV-2 through perturbations in human lung cell metabolic networkResearch Article Published on 2020-11-242022-10-30 Journal: Life Science Alliance [Category] COVID-19, SARS, [키워드] Amino acid Analysis approach can be used Cell cellular central metabolism demonstrated drugs enzyme gene knockout genomic highlight Host human lung human lung cells information inhibit inhibiting Interaction nucleic acid nucleotide offer Pathways Perturbation platform predict protein expression reaction RNA interference SARS-CoV-2 virus [DOI] 10.26508/lsa.202000869 PMC 바로가기 [Article Type] Research Article
COVID-19 infection in first trimester of pregnancy marked by a liver cytolysis in a woman previously treated by hydroxychloroquine for repeated implantation failure: a case reportCase Report Published on 2020-11-162022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, SARS, [키워드] absence aetiology assessment breathlessness Care Case report caused China clinical feature Comorbidities complications Comprehensive COVID-19 COVID-19 diagnosis COVID-19 infection digestive disease first trimester Foetus French Government gravid growth Hepatic cytolysis Hydroxychloroquine indicated liver monitoring Nasopharyngeal swab nausea Novel coronavirus Occurrence outcomes Patient Perturbation Pregnancy repeated required resolved respiratory symptom risk SARS-CoV-2 SARS-CoV-2 RNA severe symptoms spread to Symptom the patient Toxicity transaminase treated was tested were recorded with COVID-19 women [DOI] 10.1186/s12879-020-05551-0 PMC 바로가기 [Article Type] Case Report