US201 Study: A Phase 2, Randomized Proof-of-Concept Trial of Favipiravir for the Treatment of COVID-19Major Articles Published on 2021-12-072022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] acute respiratory syndrome Administered adverse event Analysis antiviral activity coronavirus coronavirus disease COVID-19 Critical disease disease severity enrolled Favipiravir Follow-up groups Hospitalized Human Influenza median time Mild moderate disease multicenter Neutralizing Open-label Patient PCR-negative PCR-positive performed Phase 2 polymerase chain primary end point randomization Randomized Result SARS-CoV-2 severe disease Standard of care stratified subgroup of patient treat Treatment Trial viral clearance with COVID-19 [DOI] 10.1093/ofid/ofab563 PMC 바로가기 [Article Type] Major Articles
Randomized, Double-Blinded, Placebo-Controlled Phase 2 Trial of an Inactivated Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine in Healthy Adults건강한 성인을 대상으로 한 비활성화된 중증 급성 호흡기 증후군 코로나바이러스 2 백신에 대한 무작위, 이중 맹검, 위약 대조 2상 시험Clinical Trial Published on 2021-12-062022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 임상, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adverse reaction Adverse reactions anti-N antibodies anti-N antibody anti-S antibody clinical Controlled trial coronavirus coronavirus 2 dose double-blinded enrolled evaluated geometric mean geometric mean titer geometric mean titers GMT GMTs groups HD group healthy High dose immunization immunogenicity inactivated Inactivated SARS-CoV-2 vaccine medium dose neutralizing antibody Phase 2 phase 2 trial Randomized respiratory Safety safety analysis SARS-CoV-2 SARS-CoV-2 vaccine Serious Adverse Event Serious Adverse Events seroconversion rate seroconversion rates study period subject the vaccine Trial Vaccine [DOI] 10.1093/cid/ciaa1703 PMC 바로가기 [Article Type] Clinical Trial
Improving precision and power in randomized trials for COVID-19 treatments using covariate adjustment, for binary, ordinal, and time-to-event outcomes공변량 조정을 사용하여 이항, 순서 및 사건 발생까지의 시간 결과에 대한 COVID-19 치료에 대한 무작위 시험의 정밀도 및 검정력 향상Article Published on 2021-12-012022-09-11 Journal: Biometrics [Category] SARS, 임상, [키워드] added Analysis approach center clinical trials ClinicalTrials Control covariate covariate adjustment COVID-19 COVID-19 treatment disease control distribution drug Drug administration essence European Medicines Agency food hypothetical implementation IMPROVE Improving Inference Longitudinal data Medicine New York ordinal outcomes outcome Participants patients hospitalized Phase 2 Precision prevention prevention of COVID-19 Primary outcome R package Randomized randomized clinical trial randomized trial randomized trials recommendation reduce reductions in Registered required Sample size sample sizes Standard of care statistical analysis survival survival analysis targets time Treatment treatment trials treatments for COVID-19 Trial trials Two-arm U.S. Food and Drug Administration variety [DOI] 10.1111/biom.13377 PMC 바로가기 [Article Type] Article
Acute estradiol and progesterone therapy in hospitalised adults to reduce COVID-19 severity: a randomised control trialRandomized Controlled Trial Published on 2021-11-302022-10-05 Journal: BMJ Open [Category] SARS, 임상, [키워드] addition Admission adverse events Anti-inflammatory antibody production approved drug Biology center clinically Corticosteroids COVID-19 death determine disease severity double blind drug Efficacy Ethical approval Ethics evaluate food general endocrinology Hospital stay hospitalised Hospitalised patients HRT HRT. immune response immune tolerance include Infectious diseases Inflammatory biomarker intramuscular mechanical ventilation Medicine mitigate New New Orleans Occurrence Oestradiol outcome Participants Patient peer-reviewed Phase 2 Placebo placebo-controlled primary endpoint Primary outcome progesterone proportion randomised readmission reduce reducing Result Sample size secondary Sex sex steroids & Sponsor Standard of care steroid subjects submitted the WHO therapeutic option therapy Trial university USA was obtained WHO ordinal scale [DOI] 10.1136/bmjopen-2021-053684 PMC 바로가기 [Article Type] Randomized Controlled Trial
Scoping Review of Antimalarial Drug Candidates in Phase I and II Drug Development말라리아 치료제 후보에 대한 1상 및 2상 약물 개발의 범위 검토Article Published on 2021-11-292024-08-08 Journal: Med Instrum [Category] 말라리아, [키워드] antimalarial Drug development malaria Phase 1 Phase 2 [DOI] 10.1128/aac.01659-21 PMC 바로가기
Community predictors of COVID‐19 cases and deaths in Massachusetts: Evaluating changes over time using geospatially refined dataOriginal Article Published on 2021-11-102022-10-30 Journal: Influenza and Other Respiratory Viruses [Category] COVID-19, MERS, SARS, [키워드] age Analysis association autocorrelation black Care census tract change Community COVID‐19 COVID‐19 death disease Disparities elevated essential worker Essential workers Evaluating exclusion geocoding granular heterogeneity identify incidence incidence rate individual Intervention Latinx less Local Massachusett mortality data pandemic Patient phase Phase 1 Phase 2 Population predictor proportion PROTECT race/ethnicity Result risk risk factor SARS‐CoV‐2 Sociodemographic subgroups survey [DOI] 10.1111/irv.12926 PMC 바로가기 [Article Type] Original Article
Design, content, and fieldwork procedures of the COVID‐19 Psychological Research Consortium (C19PRC) Study – Wave 4Original Article Published on 2021-11-052022-10-29 Journal: International Journal of Methods in Psychiatric Research [Category] COVID-19, MERS, SARS, [키워드] Algorithm Analysis Anxiety baseline calculated Characteristics COVID‐19 COVID‐19 Depression estimate facilitate General population Ireland longitudinal Mental health disorder objective offer pandemic Phase 1 Phase 2 Population Posttraumatic Stress provided Psychological public health question recruited Research respondent Result robust sample characteristics selected stimulate study outcomes survey methodology unique Wave weight [DOI] 10.1002/mpr.1899 PMC 바로가기 [Article Type] Original Article
Ongoing and future COVID-19 vaccine clinical trials: challenges and opportunities진행 중인 및 미래의 COVID-19 백신 임상 시험: 도전과 기회Review Published on 2021-11-012022-09-11 Journal: The Lancet. Infectious Diseases [Category] SARS, 임상, [키워드] Affect benefit candidate Candidates commitment Community Council country COVID-19 vaccine COVID-19 vaccines double-blind Host immune response International organizations knowledge Medical Science Medical Sciences non-inferiority older population organization Phase 2 phase 3 trial placebo-controlled placebo-controlled trial proportion randomised Research SARS-CoV-2 vaccine Sponsor Trial trial participant trial participants vaccine candidate vaccine candidates Vaccines WHO [DOI] 10.1016/S1473-3099(21)00263-2 PMC 바로가기 [Article Type] Review
Spatiotemporal distribution of COVID-19 during the first 7 months of the epidemic in Vietnam베트남 전염병의 첫 7 개월 동안 Covid-19의 시공간 분포Research Published on 2021-10-302022-09-10 Journal: BMC Infectious Diseases [Category] MERS, SARS, 치료기술, [키워드] age age distribution calculation Cluster Clustering collected contribute contributed COVID-19 COVID-19 case COVID-19 cases COVID-19 pandemic diagnosed disease Disease clustering distribution elevated Emerging infectious disease Emerging infectious diseases epidemic wave geographical distribution Government Health Organization implementation incidence Infectious disease Infectious diseases Local measure Measures median age men middle Ministry of Health Nosocomial infection Nosocomial infections observation period occurred Occurrence occurrence of COVID-19 outbreak pandemic phase Phase 1 Phase 2 phase 4 quarantine Relative risk Result risk severe COVID-19 spatiotemporal Spatiotemporal analysis supplementary material Temporal temporal distribution the epidemic the median timelines Transmission transmission classification understanding Vinh Phuc Province Wave were assessed World Health Organization [DOI] 10.1186/s12879-021-06822-0 PMC 바로가기 [Article Type] Research
Longitudinal humoral antibody response to SARS-CoV-2 infection among healthcare workers in a New York City hospital뉴욕시 병원의 의료 종사자들 사이에서 SARS-CoV-2 감염에 대한 세로 체액성 항체 반응Article Published on 2021-10-262022-09-11 Journal: BMJ Open [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] addition age anti-S anti-S antibody antibodies antibody Antibody Response Asymptomatic clinical symptom Clinical symptoms completion conducted correlation COVID-19 COVID-19 symptom COVID-19 symptoms decay detect Diseases domain duration of symptom Dynamics ELISA evaluate faster Fever followed by full-length S Gastrointestinal symptom gastrointestinal symptoms HCW HCWs healthcare worker Healthcare workers hospital humoral humoral immune response humoral immune responses Humoral response immune responses immunology Infection Infectious diseases initial longitudinal longitudinal study Mount Sinai New York New York City outcome participant participated Phase 1 Phase 2 positive positive correlation Protein Quantitative reactive Receptor-binding domain S protein SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV-2 nucleocapsid SARS-CoV-2 PCR serology testing Significant South subject subsequent symptomatic System titre Viral was performed [DOI] 10.1136/bmjopen-2021-051045 PMC 바로가기 [Article Type] Article