Single-cell RNA sequencing reveals immunological rewiring at the maternal-fetal interface following asymptomatic/mild SARS-CoV-2 infection단일 세포 RNA 시퀀싱은 무증상/경증 SARS-CoV-2 감염 후 모체-태아 경계면에서 면역학적 재배선을 밝힙니다.Article Published on 2022-06-142022-09-12 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated acute respiratory syndrome adverse outcome Antigen presentation Blood CD4/CD8 coronavirus Coronavirus 2019 COVID-19 CP: Immunology CP: Microbiology decidua disease Frequency IFN immune activation immunological Infection macrophages observation offspring Placenta Pregnancy pregnant women Regulatory T cell response reveal RNA sequencing SARS-CoV-2 SARS-COV-2 infection Signaling signaling pathways T cell T cell receptor T cells TCR Type I IFN type I interferon upregulated while [DOI] 10.1016/j.celrep.2022.110938 PMC 바로가기 [Article Type] Article
Histopathology of Third Trimester Placenta from SARS-CoV-2-Positive WomenArticle Published on 2022-06-012023-07-06 Journal: Fetal and pediatric pathology [Category] SARS, [키워드] COVID-19 pathology Placenta Third trimester. [DOI] 10.1080/15513815.2020.1828517
Clinical and genomic data of sars-cov-2 detected in maternal-fetal interface during the first wave of infection in Brazil브라질의 첫 번째 감염 파동 동안 산모-태아 경계면에서 검출된 sars-cov-2의 임상 및 게놈 데이터Article Published on 2022-06-012022-09-11 Journal: Microbes and infection [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] abortion Americas Apoptosis B.1.1.28 B.1.1.33 Brazil circulating clinical Clinical virology contribute coronavirus fetal Fetal placenta First wave FIVE genomes genomic data gestation Ground-glass opacities ground-glass opacity highest hospital hospital discharge IgM Illumina Miseq in viral indicate induction of apoptosis Infection interferon involved Lineage Lungs Maternal Mild molecular virology mother Mutation Neonatal infection Newborn nonsynonymous mutation Nonsynonymous mutations Nsp12 Nsp3 ORF3 ORF7b outcome Pathways Phylogeny Placenta pregnant women Preterm birth preterm births Protein qPCR Replication reported RT-qPCR SARS-CoV-2 SARS-COV-2 infection secretion Sequencing South spontaneous abortion state stillborn symptomatic symptomatic cases tested treated umbilical Umbilical cord vertical transmission viral replication Virological virus women [DOI] 10.1016/j.micinf.2022.104949 PMC 바로가기 [Article Type] Article
Impact of Gestational COVID-19 on Neonatal Outcomes: Is Vertical Infection Possible?신생아 결과에 대한 임신성 COVID-19의 영향: 수직 감염이 가능합니까?Observational Study Published on 2022-06-012022-09-11 Journal: The Pediatric Infectious Disease Journal [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] acute infection analyzed Asymptomatic biological sample Blood breast milk Chain Reaction Characteristics Clinical characteristics Cohort conditions Cord blood Coronavirus-2 COVID-19 demographic demographic and clinical characteristics evaluated Follow-up hospital Impact in urine Infant Infants Infection life maternal blood meconium microbiologically Mild symptom mild symptoms MOST mother Nasopharyngeal swab nasopharyngeal swabs Neonatal Neonatal infection neonatal period Newborn no difference no differences Placenta polymerase chain reaction Pregnancy pregnant women remained reverse transcriptase reverse transcriptase-polymerase chain reaction SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral load SARS-CoV2 severe acute respiratory coronavirus Severe acute respiratory coronavirus-2 Spanish susceptibility tested Transmission transmission of SARS-CoV-2 Urine vertical vertical transmission Viral load viral loads women [DOI] 10.1097/INF.0000000000003518 PMC 바로가기 [Article Type] Observational Study
Stillbirth due to SARS-CoV-2 placentitis without evidence of intrauterine transmission to fetus: association with maternal risk factors태아에 대한 자궁내 전파의 증거가 없는 SARS-CoV-2 태반염으로 인한 사산: 산모 위험 인자와의 연관성Multicenter Study Published on 2022-06-012022-09-11 Journal: Ultrasound in obstetrics & gynecology : the offici [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected affecting Analysis asphyctic association Asymptomatic Autopsy carried caused Chain Reaction characterized Clinical characteristics Combination coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 diagnosis death demise diagnosed electron microscopy Evidence evidence of examined Factor Factors fetal fetal death fetal infection fetus FGR Greece Gross growth Gynecology histological histological change histopathological identify immunostaining independent Infection Inflammatory intervillous space intrauterine fetal death lesion less live birth Microscopy mild clinical symptom mild clinical symptoms molecular mother multicenter Multiple multiple sclerosis Neonates no evidence of obstetrics occurred organs pathology Placenta placental Placentas placentitis polymerase chain polymerase chain reaction positive potential risk predisposing factors pregnancies Pregnancy pregnant women prenatally ranged Regression regression analysis respiratory retrieved risk risk factor Risk factors SARS-CoV-2 SARS-CoV-2 placentitis SARS-CoV-2 spike protein Seven severe acute respiratory syndrome Coronavirus Society Spike protein Stillbirth stillborn Thrombophilia tissues Transmission Ultrasound Viral Viral transmission virion virions was performed was used [DOI] 10.1002/uog.24906 PMC 바로가기 [Article Type] Multicenter Study
Life After Amsterdam: Placental Pathology Consensus Recommendations and BeyondReview Published on 2022-06-012023-07-09 Journal: Surgical pathology clinics [Category] COVID19(2023년), [키워드] Amsterdam ascending infection chorioamnionitis fetal vascular malperfusion Maternal vascular malperfusion Placenta placenta accreta Villitis. [DOI] 10.1016/j.path.2022.02.001 [Article Type] Review
SARS-CoV-2 Immunohistochemistry In Placenta태반의 SARS-CoV-2 면역조직화학Article Published on 2022-06-012022-09-11 Journal: International journal of surgical pathology [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] COVID-19 delta variant diagnosing dominant electron microscopy immunohistochemistry Infection nucleocapsid nucleocapsid protein parental pathology Placenta placental Placental infection pregnant women Protein robust SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 virus Spike protein ultrastructure [DOI] 10.1177/10668969211067754 PMC 바로가기 [Article Type] Article
The clinical impact of maternal COVID-19 on mothers, their infants, and placentas with an analysis of vertical transfer of maternal SARS-CoV-2-specific IgG antibodies산모 SARS-CoV-2 특이 IgG 항체의 수직 이동 분석을 통한 산모 COVID-19가 산모, 아기 및 태반에 미치는 임상 영향Observational Study Published on 2022-06-012022-09-12 Journal: Placenta [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] Abnormalities Analysis antibody Asymptomatic C-section Chapel clinical impact Complication complications COVID-19 COVID-19 severity criteria diabete Diabetic had no hearing loss Hill histologic Infant Infants infected with SARS-CoV-2 Infection Injury intrauterine infection Maternal Maternal COVID-19 Maternal diabetes Maternal vascular malperfusion Mild moderate MOST mother NICU admission Observational cohort study occur pathology Placenta placental Placentas Pregnancy pregnant Premature recorded retrospective risk SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2-specific IgG severe COVID-19 severity subset survival survived Symptom Symptoms transfer Type Vascular [DOI] 10.1016/j.placenta.2022.04.006 PMC 바로가기 [Article Type] Observational Study
No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccinationCOVID-19 mRNA 백신 접종 후 태아 결함 또는 항-싱시틴-1 항체 유도의 증거 없음Article Published on 2022-05-242022-09-11 Journal: PLoS Biology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome coronavirus age anti-RBD anti-receptor-binding domain Anti-spike antibody antibody status birth defects circulating Cohort coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 mRNA Vaccination crown-rump length detect determine double-stranded RNA early pregnancy elevated ELISA Fertility fetal gestational age growth immunization impacted in utero incidence infertility injection intramuscular investigated lead levels of antibody maternal antibody mice mouse model mRNA mRNA vaccination murine Neonatal no evidence of observé outcomes Placenta placental poly(I:C poly(I:C) polyinosinic-polycytidylic acid Pregnancy Protein public interest reduced respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Stage term TLR3 Topic transfer vaccination Volunteer weight [DOI] 10.1371/journal.pbio.3001506 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection and COVID-19 vaccination in pregnancy임신 중 SARS-CoV-2 감염 및 COVID-19 예방 접종Review Published on 2022-05-012022-09-11 Journal: Nature reviews. Immunology [Category] COVID19(2023년), SARS, 변종, 임상, 치료기술, [키워드] COVID-19 vaccination determine during pregnancy Effect Effectiveness increased risk individual Infection omicron outcome Placenta Pregnancy pregnant Preterm birth Progress reduce risk SARS-CoV-2 SARS-COV-2 infection Stillbirth vaccination Vaccine Viral variants virus [DOI] 10.1038/s41577-022-00703-6 PMC 바로가기 [Article Type] Review