Repurposing Immunomodulatory Therapies against Coronavirus Disease 2019 (COVID-19) in the Era of Cardiac Vigilance: A Systematic ReviewReview Published on 2020-09-112022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] animal models Anti-inflammatory benefit building Cancer Cancer therapy cardiac cardio-oncology clinical outcomes clinical trial coronavirus 2019 (COVID-19) coronavirus disease COVID-19 COVID-19 infection COVID-19 therapy Cytokine release syndrome decrease drug Efficacy effort Evidence Human hyper-inflammatory phase identify Immunomodulatory therapies Immunotherapy Inflammation Intervention low dose dexamethasone mechanism Microvascular thrombosis outcomes pandemic physician potential therapy proliferation recovery Repurposed drug repurposing review safety profile screened therapeutic therapy Trial vascular permeability Volume [DOI] 10.3390/jcm9092935 PMC 바로가기 [Article Type] Review
C-C chemokine receptor type 5 links COVID-19, rheumatoid arthritis, and Hydroxychloroquine: in silico analysisResearch Published on 2020-09-092022-10-29 Journal: Translational Medicine Communications [Category] COVID-19, [키워드] activated addition can be used CCL11 CCL4 CCL8 CCR5 cells Chemokine receptor chemotactic coronavirus disease COVID-19 COVID-19 infection Critical disease drug Effects explain Factors HCQ highlight identify immune cell population immune cell recruitment in silico analysis in silico Approach increased risk interfere lack lung tissue Lungs mechanism methotrexate Mild molecular molecular mechanisms monotherapy natural killer pathway Patient patient group potential therapy RA synovium receptor reduced Research rheumatic disease rheumatoid arthritis significantly susceptible therapy transcriptomic profile treat upregulated upregulation [DOI] 10.1186/s41231-020-00066-x PMC 바로가기 [Article Type] Research
Cross-neutralization activity against SARS-CoV-2 is present in currently available intravenous immunoglobulinsShort Communication Published on 2020-09-092022-10-31 Journal: Immunotherapy [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome antibody Cell culture coronavirus CoV COVID-19 COVID-19 pandemic cross-neutralization human coronavirus in vitro Infectivity Intravenous immunoglobulin material MERS-CoV Middle East neutralization neutralization activity Neutralizing activity plaque-forming unit potential therapy produced quantified reduction in reported SARS-CoV SARS-CoV-2 SARS-CoV-2 isolates syndrome tested virus [DOI] 10.2217/imt-2020-0220 PMC 바로가기 [Article Type] Short Communication
The C-C Chemokine Receptor Type 4 Is an Immunomodulatory Target of HydroxychloroquinePharmacology Published on 2020-08-282022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute respiratory syndrome antagonist approach autoimmune conditions binding CCR4 Characteristics characterized Chemokine receptor China clinical trial coronavirus COVID-19 COVID-19 patient COVID-19 treatment death demonstrated FDA-approved drug global pandemic Hydroxychloroquine immunomodulation immunomodulatory immunomodulatory activity in silico in vitro Inflammatory interact International involved Ligand malaria Molecular docking study patients potential therapy public health QT prolongation reported Result rheumatoid arthritis risk SARS-CoV-2 SEA similarity subject target therapeutic use Treatment Type Vaccine was selected World Health Organization [DOI] 10.3389/fphar.2020.01253 PMC 바로가기 [Article Type] Pharmacology
Cardiovascular Considerations in Coronavirus Disease 2019 with a Special Focus on ArrhythmiaResearch Review Published on 2020-08-152022-10-30 Journal: Arquivos Brasileiros de Cardiologia [Category] COVID-19, [키워드] Abnormalities abnormality acute respiratory syndrome angiotensin-converting enzyme 2 arrhythmia cardiovascular conduction coronavirus coronavirus disease COVID-19 COVID-19 patient Critically ill described elevated focus hospitalized patient Hydroxychloroquine Manifestations myocarditis occur outcome pandemic Patient potential therapy raised reported responsible SARS-CoV-2 suggested troponin levels ventricular Wuhan, China [DOI] 10.19102/icrm.2020.110804 PMC 바로가기 [Article Type] Research Review
A COVID‐19 human viral challenge model. Learning from experienceInvited Review Article Published on 2020-08-122022-10-30 Journal: Influenza and Other Respiratory Viruses [Category] COVID-19, MERS, SARS, [키워드] accelerate clinical trial contagious Controlled human infection model COVID‐19 COVID‐19 determine develop effective Efficacy evaluate experience help human infection human viral challenge model infect Infection learning pathogenic potential benefit potential therapy respiratory syncytial virus RSV SARS‐CoV‐2 virus SARS‐CoV‐19 the vaccine Treatment Vaccine viral challenge virus volunteers [DOI] 10.1111/irv.12797 PMC 바로가기 [Article Type] Invited Review Article
COVID-19: The Immune Responses and Clinical Therapy CandidatesReview Published on 2020-08-032022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, [키워드] acute respiratory syndrome Adjunctive therapy anti-parasite Anti-viral approved candidate children clinical clinical trial coronavirus coronavirus disease COVID-19 drug effective Efficacy Emergency use FDA feature food Hospitalized immune Immunotherapy Infection infections inhibit SARS-CoV-2 laboratory-confirmed MERS-CoV Middle East molecular molecular immune response numbers of patient pandemic Pathogenesis pharmacological strategies potential therapy Remdesivir Replication Repurposed drug respiratory syndrome coronavirus response rising SARS-CoV SARS-CoV-2 therapy Vaccine [DOI] 10.3390/ijms21155559 PMC 바로가기 [Article Type] Review
Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cellsResearch Article Published on 2020-07-312022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] 24 hour acute respiratory syndrome Akt/mTOR/HIF-1 Analysis cellular cellular response Coronavirus-2 Course COVID-19 dose-dependent activation downstream effector molecule engage ErbB HIF-1 HIF-1α Host hpi Huh7 cell in vitro infected cell Infection inhibition inhibitor Innate immunity management MK-2206 modulated molecular mTOR signaling pathway Pathways patients performed post infection potential therapy proteomics reduction in required S6K1 SARS-CoV-2 SARS-CoV-2 infected cell severe coronavirus disease Signaling signaling pathways the SARS-CoV-2 TNF signaling transcriptomics virus virus production [DOI] 10.1080/22221751.2020.1799723 PMC 바로가기 [Article Type] Research Article
Treatment and research lines for the patient with COVID-19. What do we have and where are we going?Review Article Published on 2020-07-272022-10-29 Journal: International Brazilian Journal of Urology : official journal of the Brazilian Society of Urology [Category] COVID-19, SARS, [키워드] acute respiratory syndrome caused clinical trial coronavirus Coronavirus disease 2019 COVID-19 COVID-19 diagnostic testing [Supplementary Concept] COVID-19 pandemic effort Evidence global public health pandemic potential therapy Primary prevention quarantine Research resource SARS-CoV-2 the patient therapeutic strategy Treatment with COVID-19 [DOI] 10.1590/S1677-5538.IBJU.2020.S118 PMC 바로가기 [Article Type] Review Article
Pathogenesis of COVID-19 from the Perspective of the Damage-Response FrameworkMinireview Published on 2020-07-022022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Alter caused clinical manifestation Community coronavirus coronavirus disease COVID COVID-19 COVID-19 disease COVID-19 pathogenesis disease disparate explain flexible framework Host Immune-mediated manifestation mechanism microbial outcome pandemic Pathogenesis pathogenic Population potential therapy provide SARS-CoV-2 susceptibility viral pathogenesis virus [DOI] 10.1128/mBio.01175-20 PMC 바로가기 [Article Type] Minireview