A multicenter randomized open-label clinical trial for convalescent plasma in patients hospitalized with COVID-19 pneumoniaRandomized Controlled Trial Published on 2021-10-152022-10-04 Journal: The Journal of Clinical Investigation [Category] SARS, 임상, [키워드] 1:1 350 patient 95% CI addition Analysis assigned benefit category clinical trial conducted control arm control group Controlled clinical trial convalescent plasma COVID-19 CP group death ECMO extracorporeal membrane oxygenation greater High-flow oxygen hospital Immunotherapy intention-to-treat Invasive mechanical ventilation multicenter Noninvasive ventilation on mechanical ventilation Open-label Patient patients hospitalized Pneumonia Potential treatment primary endpoint progression proportion Randomized Randomly receiving Spain Standard of care statistical significance statistically survival symptom onset Treatment was performed with COVID-19 [DOI] 10.1172/JCI152740 PMC 바로가기 [Article Type] Randomized Controlled Trial
Medical Significance of Uterine Corpus Endometrial Carcinoma Patients Infected With SARS-CoV-2 and Pharmacological Characteristics of PlumbaginSARS-CoV-2에 감염된 자궁체부 자궁내막암 환자의 의학적 의의 및 Plumbagin의 약리학적 특성Endocrinology Published on 2021-10-122022-09-11 Journal: Frontiers in Endocrinology [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis Anti-inflammation Anti-inflammatory Apoptosis bioinformatics Cancer candidate clinical Clinical characteristics conducted coronavirus coronavirus disease corpus COVID-19 COVID-19 in patient cytotoxicity disease Effect Endometrial Carcinoma Evidence functions Genes Health identify immunomodulating immunomodulation in silico in silico analysis In silico method infected with SARS-CoV-2 inhibitor MAPK3 mechanism mechanism and characterization mitogen mitogen-activated protein kinase modulation molecular molecular docking molecular docking analysis Necrosis network network pharmacology pathway Patient pharmacologic (drug) therapy pharmacological PLAU Plumbagin Potential treatment prognostic proliferation Protein protein kinase respiratory Result risk SARS-CoV-2 Screen severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Significance survival rate target targets TNF Treatment Tumor tumor necrosis tumor necrosis factor Urokinase-Type Plasminogen Activator uterine [DOI] 10.3389/fendo.2021.714909 PMC 바로가기 [Article Type] Endocrinology
Focusing Treatment on Pregnant Women With COVID DiseaseGlobal Women's Health Published on 2021-10-112022-10-31 Journal: Frontiers in Global Women's Health [Category] COVID-19, [키워드] China concerning coronavirus COVID COVID-19 COVID-19 infection COVID-19 vaccine drug Focusing Healthcare system Infection information management morbidity and mortality Novel coronavirus populations positive Potential treatment Pregnancy pregnant patients pregnant women Prevent provided resource SARS-CoV-2 Treatment Trial Vaccine [DOI] 10.3389/fgwh.2021.590945 PMC 바로가기 [Article Type] Global Women's Health
Hydroxychloroquine and mortality in COVID-19 patients: a systematic review and a meta-analysis of observational studies and randomized controlled trialsCOVID-19 환자의 하이드록시클로로퀸과 사망률: 관찰 연구 및 무작위 대조 시험에 대한 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-10-012022-09-11 Journal: Pathogens and global health [Category] SARS, 임상, 치료제, [키워드] article association Azithromycin certainty certainty of evidence clinical trials Cohort studies cohort study COVID-19 COVID-19 patient COVID-19 patients debate Evidence evidence of HCQ help Hydroxychloroquine lower dose lower mortality risk Meta-analysis Mortality observational studies observational study patients Potential treatment randomized clinical trial Randomized controlled trial RCT RCTs reduction retrieved risk risk ratio SARS-CoV-2 Seven severe adverse event severe adverse events systematic review total mortality were used [DOI] 10.1080/20477724.2021.1936818 PMC 바로가기 [Article Type] Meta-Analysis
Calcifediol Treatment and COVID-19-Related OutcomesObservational Study Published on 2021-09-272022-10-05 Journal: The Journal of Clinical Endocrinology and Metaboli [Category] SARS, 임상, [키워드] 25-hydroxyvitamin D 95% CI adjusted Admission age Analysis Barcelona baseline calcifediol calcifediol treatment Comorbidity conducted COVID-19 died Health healthy individuals Hospital admission ICU ICU admission intensive care unit intention-to-treat intention-to-treat analysis Mortality mortality risk Observational cohort study Odds ratio outcome measure outcomes Participants Patient patients hospitalized patients treated patients with COVID-19 Potential treatment reduce reduced reduced risk required severity Sex significantly Spain the disease treated treated patient Treatment Vitamin D were excluded with COVID-19 [DOI] 10.1210/clinem/dgab405 PMC 바로가기 [Article Type] Observational Study
Inhibitory activity of FDA-approved drugs cetilistat, abiraterone, diiodohydroxyquinoline, bexarotene, remdesivir, and hydroxychloroquine on COVID-19 main protease and human ACE2 receptor: A comparative in silico approachResearch article Published on 2021-09-222022-10-05 Journal: Informatics in Medicine Unlocked [Category] 신약개발, 치료제, [키워드] ACE2 ACE2 receptor animal models claimed clinical trials COVID-19 Culture demonstrated drug drugs Dynamic simulation effective inhibitor Ex vivo FDA-approved drug host cell human ACE2 Hydroxychloroquine in silico Approach Infection inhibit inhibitor inhibitors investigated main protease MD simulation molecular molecular docking organ organoids Patient Potential treatment protease Protein Proteins Remdesivir respiratory virus SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 main protease specific treatment systemic effect tested the SARS-CoV-2 virus were used [DOI] 10.1016/j.imu.2021.100745 [Article Type] Research article
Myocardial Damage by SARS-CoV-2: Emerging Mechanisms and TherapiesSARS-COV-2에 의한 심근 손상 : 신흥 메커니즘 및 요법Review Published on 2021-09-212022-09-01 Journal: Viruses [Category] SARS, 유전자 메커니즘, 진단, 치료법, [키워드] acting action potential acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Apoptosis arrhythmia ATP attack autophagy cause Cell cells coronavirus creating damage decrease direct infection docking drug early stage early stages Effect effective Endothelial cell endothelial cells energy energy metabolism evade heart host cell Host immune response Imbalance immune cells immune response immunosuppressive immunosuppressive therapy induce infect Inflammation inhibit ion homeostasis lead leads metabolism myocardial damage myocarditis necroptosis organ Potential treatment priming programmed cell death promote protease Protease inhibitor protease inhibitors Proteases pyroptosis receptor Replication respiratory RNA-dependent RNA polymerase ROS production SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus ssRNA stages therapy treatment of viral infection turn Vesicle Viral viral clearance viral docking viral entry viral replication viroporin [DOI] 10.3390/v13091880 PMC 바로가기 [Article Type] Review
Structural and kinetic analyses of holothurian sulfated glycans suggest potential treatment for SARS-CoV-2 infectionResearch Article Published on 2021-09-172022-10-30 Journal: The Journal of Biological Chemistry [Category] COVID-19, MERS, SARS, [키워드] ACE2, angiotensin converting enzyme 2 Analysis Anti-SARS-CoV-2 Activity Anticoagulant anticoagulation aPTT, activated partial thromboplastin time AT, antithrombin binding BoSG, sulfated galactan from the red alga Botryocladia occidentalis characterized chondroitin composed computational simulation conformational change CS, chondroitin sulfate cytotoxic effects demonstrated DMEM, Dulbecco's modified Eagle medium domain DS, dermatan sulfate Effect FDA, US Food and Drug Administration FucCS, fucosylated chondroitin sulfate fucosylated chondroitin sulfate GAG, glycosaminoglycan GlcA, D-glucuronic acid glycan glycans HS, heparan sulfate HSQC, heteronuclear single quantum coherence IbFucCS, FucCS isolated from Isostichopus badionotus IbSF, I. badionotus-derived sulfated fucan Interaction kinetic LvSF, sulfated fucan from the sea urchin Lytechinus variegatus MD, molecular dynamics Molecular modeling mutant N501Y NMR nuclear magnetic resonance occur oligosaccharide Potential treatment PpFucCS, FucCS from the sea cucumber Pentacta pygmaea RBD RBD binding RBD, receptor-binding domain S-protein SA, streptavidin SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SF, sulfated fucan SG, sulfated galactan SGP, spike glycoprotein SPR, surface plasmon resonance Structure sulfated surface plasmon resonance UFH, unfractionated heparin viral inhibition wildtype [DOI] 10.1016/j.jbc.2021.101207 PMC 바로가기 [Article Type] Research Article
Risk versus Benefit of Using Hydroxychloroquine to Treat Patients with COVID-19Review Article Published on 2021-09-152022-10-31 Journal: The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien des Maladies Infectieuses et de la Microbiologie Médicale [Category] COVID-19, [키워드] acute respiratory syndrome adverse event antiviral activity available data benefit China Chloroquine Clinical data Clinical improvement Combination coronavirus COVID-19 COVID-19 pandemic France HCQ hematologic hospitalized patient in vitro indicated malaria manifestation meta-analyses Mortality Neuropsychiatric patients with COVID-19 potential clinical benefit Potential treatment prevention of COVID-19 Prophylaxis provide Randomized controlled trials reported rheumatoid arthritis risk SARS-CoV-2 systematic review systemic lupus erythematosus the United State treated treating COVID-19 patient Treatment Trial viral load reduction with COVID-19 [DOI] 10.1155/2021/5942366 PMC 바로가기 [Article Type] Review Article
Ivermectin for Prophylaxis and Treatment of COVID-19: A Systematic Review and Meta-AnalysisSystematic Review Published on 2021-09-082022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] 95% CIs 95% confidence interval Admission adverse event Analysis baseline benefit CIs Clinical efficacy clinical trial registry Control control group COVID-19 decreased mortality Disease progression Evidence fine-tune Guidance include indicated indication intensive care Ivermectin likelihood mechanical ventilation Meta-analysis methodology Mild moderate disease Mortality negative RT-PCR no difference outcome Participants Patient patients Potential treatment Prophylaxis RCT recipient reported Repository review risk Risk of bias SARS-CoV-2 searched severe disease severe pneumonia significantly subjects Support systematic review Treatment treatment for COVID-19 Treatment protocol was used [DOI] 10.3390/diagnostics11091645 PMC 바로가기 [Article Type] Systematic Review