The Importance of RNA-Based Vaccines in the Fight against COVID-19: An OverviewReview Published on 2021-11-172022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] absence applied approach Cancer cell cultures COVID-19 COVID-19 pandemic Diseases effective example generate humoral immune response immunogenic Importance IMPROVE induce Messenger RNA mRNA mRNA stability mRNA vaccines non-infectious platform powerful tool Prophylaxis Protein Research RNA RNA vaccines Safe saRNA vaccines SARS-CoV-2 targets Treatment Vaccine Vaccine development Vaccines [DOI] 10.3390/vaccines9111345 PMC 바로가기 [Article Type] Review
Differences in IgG Antibody Responses following BNT162b2 and mRNA-1273 SARS-CoV-2 VaccinesResearch Article Published on 2021-11-102022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, [키워드] age and gender antibodies antibody antibody kinetics Antibody Response average binding domain BNT162b2 BNT162b2 vaccine changes in clinically clinician Cohort COVID-19 COVID-19 pandemic defined difference dosage dose regimen elicited first dose Follow-up human cell IgG IgG antibody IgG response immune system immunization immunosuppressive drugs linear Moderna mRNA mRNA platform mRNA vaccine mRNA-1273 mRNA-1273 vaccine overcome participant peaked Pfizer/BioNTech powerful tool Prospective regimens regression modeling remained response S-protein SARS-CoV-2 SARS-CoV-2 vaccine second dose seroconverted serological Serologically seronegative participants significantly higher Spike protein the SARS-CoV-2 the vaccine titer translated vaccination Vaccine Vaccines virus spike protein was used were measured [DOI] 10.1128/Spectrum.01162-21 PMC 바로가기 [Article Type] Research Article
Clinical features of Danon disease and insights gained from LAMP-2 deficiency modelsReview article Published on 2021-11-012022-10-05 Journal: Trends in cardiovascular medicine [Category] 비임상, [키워드] absence animal model autophagic cardiac cells characterized clinical clinical feature clinical trial contribute deficiency demonstrated disease disorder drug dysfunction Effect effective Evidence feature Gene therapy humans hypertrophic cardiomyopathy impairment in vitro in vivo isoform LAMP2 mechanism Mental mimicking molecular Mutation pathology Patient phenotype pluripotent stem cell potential therapy powerful tool Protein provided Research resulting Skeletal muscle Symptom therapeutic Treatment weakness while X-linked [DOI] 10.1016/j.tcm.2021.10.012 [Article Type] Review article
Evaluation of a surrogate virus neutralization test for high-throughput serosurveillance of SARS-CoV-2SARS-CoV-2의 고처리량 혈청감시를 위한 대리바이러스 중화시험 평가Article Published on 2021-11-012022-09-11 Journal: Journal of virological methods [Category] MERS, SARS, 진단, 치료기술, [키워드] antibody Antibody test Antibody titer Belgium biosafety level Biosafety Level 3 Cell culture Cohort correlation COVID-19 case cPass. cPass™ cVNT Democratic Republic detect Efficacy Genscript gold gold standard healthcare worker Hospitalized immune immunoassay independent involved less level 3 Live virus Luminex MIA Mild multiplex Neutralising Antibodies neutralising antibody neutralization neutralization test Neutralizing antibodies neutralizing antibody Neutralizing antibody test performed population studies powerful tool SARS-CoV-2 screening programs sensitivity sera serological test Serological tests Serosurveillance sub-Saharan Africa surrogate virus neutralization test sVNT technique Vaccine virus neutralization test [DOI] 10.1016/j.jviromet.2021.114228 PMC 바로가기 [Article Type] Article
Applications of Blockchain in the Medical Field: Narrative ReviewReview Published on 2021-10-282022-10-30 Journal: Journal of Medical Internet Research [Category] Coronavirus, MERS, SARS, [키워드] addition analyzed application Blockchain Care Characteristics Combination COVID-19 database determine Efficiency Electronic health records for inclusion Health Health care health data IMPROVE literature review mechanism narrative objective offer outbreak Patient care Perspective powerful tool previous study provide Regulatory Research Result review searched secure smart health care systematic review unique variety [DOI] 10.2196/28613 PMC 바로가기 [Article Type] Review
Technical framework for wastewater-based epidemiology of SARS-CoV-2SARS-CoV-2의 폐수 기반 역학을 위한 기술 프레임워크Article Published on 2021-10-152022-09-11 Journal: The Science of the total environment [Category] SARS, 치료기술, [키워드] affecting Biomarker Community comparability Concentration COVID-19 decay Decay kinetics detect detectability dissemination Epidemiology estimation expected Factor HRT implementation include Infection modeling MONITOR powerful tool protocol qPCR quantification relative Relative quantification retention time RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA sewage virus virus abundance wastewater Wastewater-based epidemiology while [DOI] 10.1016/j.scitotenv.2021.148271 PMC 바로가기 [Article Type] Article
Early Prediction of Severe COVID-19 in Patients by a Novel Immune-Related Predictive Model새로운 면역 관련 예측 모델을 통한 환자의 중증 COVID-19 조기 예측Research Article Published on 2021-10-132022-09-10 Journal: mSphere [Category] MERS, 바이오마커, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 an area analyzed applied AUC can be used change characteristic clearance clinician collected Combination Consequences coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients develop diagnostic effective enrolled EOS eosinophil eosinophils evaluated event external validation identify IgA immune immune response independent predictors indicate Infection Inflammation inflammatory reaction Inflammatory response lead Logistic regression analysis Model neutrophil Neutrophils novel Patient powerful tool predict prediction Predictive Predictive model Prognostic marker Prognostic markers progression reaction receiver operating characteristic receiver operating characteristic curve regression analysis Research respiratory responsible SARS-CoV-2 screened Sensitivity and specificity serum severe acute respiratory syndrome Coronavirus severe COVID-19 severity of COVID-19 Severity of disease the disease threshold virus was performed [DOI] 10.1128/mSphere.00752-21 PMC 바로가기 [Article Type] Research Article
Orchestrating an Optimized Next-Generation Sequencing-Based Cloud Workflow for Robust Viral Identification during PandemicsArticle Published on 2021-10-112022-10-28 Journal: Biology [Category] COVID-19, [키워드] Accuracy acute respiratory syndrome Algorithm caused cloud cloud computing cloud workflow Complete coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 dataset evaluate events example flu H1N1 H1N1 subtype Healthcare professional Hopefully identification implementation Infectious disease influenza A virus Next-generation sequencing number of sample occurred outperform pandemic Pandemics platform powerful tool Result robust SARS-CoV-2 short-read sequencing simple swine flu was used while [DOI] 10.3390/biology10101023 PMC 바로가기 [Article Type] Article
Catalytic hairpin DNA assembly-based chemiluminescent assay for the detection of short SARS-CoV-2 target cDNA짧은 SARS-CoV-2 표적 cDNA 검출을 위한 촉매 헤어핀 DNA 어셈블리 기반 화학발광 분석Article Published on 2021-10-012022-09-11 Journal: Talanta [Category] SARS, 변종, 치료기술, 치료제, [키워드] amplify approach Biotin biotinylated catalytic Catalytic hairpin assembly cDNA challenge Chemiluminescent assay color change colorimetric detection Combination complex Concentration detect Detection limit Detection sensitivity diagnostics dimeric DNA DNA probe enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay equipment exhibit horseradish peroxidase IMPROVE interactions mutant mutant gene naked eye peroxidase powerful tool probe protocol resulting SARS-CoV-2 selective sensitivity sequence specificity target Target DNA. target gene Target genes [DOI] 10.1016/j.talanta.2021.122505 PMC 바로가기 [Article Type] Article
SARS-CoV-2 integral membrane proteins shape the serological responses of patients with COVID-19Article Published on 2021-09-292022-10-30 Journal: iScience [Category] COVID-19, [키워드] Abstract acute respiratory syndrome Anti-viral Antibody Response antigenicity binding compose coronavirus D614 variant develop Effectiveness elevated elicit elicited evaluated exhibited host cell host immune system Humoral response immune immune response immunogenic potential immunology Infection insertion Like M protein membrane membrane protein moderate N-glycosylation pandemic patients with COVID-19 patients with SARS-CoV-2 post-translational modification powerful tool Proteins reduced responses SARS-CoV-2 SARS-CoV-2 variant Scientific community serological response severe disease Severe patient transmembrane protein unique Vaccine Viral protein Virology with COVID-19 [DOI] 10.1016/j.isci.2021.103185 PMC 바로가기 [Article Type] Article