SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model
형질전환 마우스 모델에서 항바이러스 활성을 갖는 SARS-CoV-2 M pro 억제제
Report
[키워드] acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus 2
antiviral activity
antiviral drug
antiviral drugs
antivirals
approved
assays
boceprevir
caused
Cell
cleaving
complex
Compound
compounds
coronavirus
COVID-19
COVID-19 pandemic
drug target
evade
experiments
functional
global public health
hepatitis C
hepatitis C virus
high potency
in viral
in vitro
in vivo
inhibited
inhibitor
inhibitory concentration
Interaction
lung lesions
lung viral load
M pro
mouse model
pharmacokinetic
polyprotein
precursor
protease
Protease inhibitor
protease inhibitors
RATs
reduced
Replication
required
respiratory
SARS-CoV-2
SARS-COV-2 infection
Science
selected
severe acute respiratory syndrome Coronavirus
significantly
targeting
telaprevir
the SARS-CoV-2
threat
Transgenic mouse
treat
Treatment
Vaccines
variant
variants
Viral
viral infection
Viral protein
Viral proteins
viral replication
[DOI] 10.1126/science.abf1611 PMC 바로가기 [Article Type] Report
[DOI] 10.1126/science.abf1611 PMC 바로가기 [Article Type] Report