Motivation to COVID-19 Vaccination and Reasons for Hesitancy in Employees of a Czech Tertiary Care Hospital: A Cross-Sectional SurveyArticle Published on 2021-08-052022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] 95% CI 95% confidence interval age Care Coverage COVID-19 COVID-19 pandemic determine Efficacy effort employee females HCWs healthcare worker Hesitancy hospital Influenza motivation Odds ratio predictor PROTECT questionnaire raise reason Sex Side effect Significant survey Tertiary vaccination Vaccine vaccine efficacy vaccine safety [DOI] 10.3390/vaccines9080863 PMC 바로가기 [Article Type] Article
Incidentally Detected SARS-COV-2 Among Hospitalized Patients in Los Angeles County, August to October 20202020년 8월부터 10월까지 로스앤젤레스 카운티 입원 환자 중 우연히 SARS-COV-2 발견Article Published on 2021-08-012022-09-11 Journal: Journal of hospital medicine [Category] SARS, 치료기술, [키워드] Adjusting Clinical diagnosis COVID-19 determine discharge help hospital hospital discharge Hospitalization IMPROVE incidentally detected limit Los Angele Los Angeles medical record medical records positive Public public health Randomly reason reason for reported resource SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 test selected test result [DOI] 10.12788/jhm.3641 PMC 바로가기 [Article Type] Article
Molecular docking, binding mode analysis, molecular dynamics, and prediction of ADMET/toxicity properties of selective potential antiviral agents against SARS-CoV-2 main protease: an effort toward drug repurposing to combat COVID-19분자 도킹, 결합 모드 분석, 분자 역학 및 SARS-COV-2 주요 프로테아제에 대한 선택적 전위 항 바이러스제의 ADMET/독성 특성의 예측 : CovID-19에 대항하기위한 약물 용도를 향한 노력Article Published on 2021-08-012022-08-31 Journal: Molecular diversity [Category] SARS, 신약개발, 치료제, [키워드] active site Amino acid amino acid residue amino acid residues Analysis Antiviral antiviral agent Antiviral agents antiviral drug antiviral molecules ARB Arbidol AutoDock binding carried Chloroquine complex COVID-19 crystal structure Cys145 digestion direction docking Docking studies docking study drug design Drug discovery drug target Dynamics/simulation study effort enzyme exhibited FDA-approved drug FDA-approved drugs Glu166 glycyrrhizin GS441524 HCQ HIS163 Hydroxychloroquine in silico indicated inhibitory Interaction lead Ligand M pro mechanism molecular molecular docking molecular docking studies Molecular docking study molecular dynamics molecules MPro not need polyprotein Potential Potential antiviral agents present protease Protein provide RDV reason reason for Remdesivir RMSD SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 main protease (Mpro). selected selective stability starting point starting points suggested tested Toxicity Viral [DOI] 10.1007/s11030-021-10188-5 PMC 바로가기 [Article Type] Article
Comprehensive virtual screening of 4.8 k flavonoids reveals novel insights into allosteric inhibition of SARS-CoV-2 M PRO4.8K 플라보노이드의 포괄적 인 가상 스크리닝Article Published on 2021-07-292022-09-10 Journal: Scientific Reports [Category] SARS, 변종, 치료제, [키워드] absence active site affected Analysis antiviral activity AutoDock AutoDock vina Comprehensive Computational biology and bioinformatics Coronaviruses criteria curated database docking Drug discovery flavonoid flavonoids hinge movement in silico inactive inhibit inhibition assay Inhibition assays inhibitors Interpretation lack limitation mechanism molecular molecular dynamics mutant Pathways plasticity protease reason reported reveal robust SARS-CoV SARS-CoV-2 SARS-CoV-2 main protease structural biology triggered Usage Virtual screening [DOI] 10.1038/s41598-021-94951-6 PMC 바로가기 [Article Type] Article
Impact of COVID-19 on Dental Care during a National Lockdown: A Retrospective Observational StudyObservational Study Published on 2021-07-282022-10-04 Journal: International Journal of Environmental Research an [Category] SARS, 임상, [키워드] accounted Administered Care complete recovery conditions Conservative coronavirus disease COVID-19 COVID-19 infection COVID-19 infections dental Dental health dentistry Department dropped Germany Health Impact infection risk lack Local lockdown measure Measures Munich pandemic Patient Periodontology Personal protective equipment PPE provided reason recorded Regulatory Safe Treatment university urgent dental care while [DOI] 10.3390/ijerph18157963 PMC 바로가기 [Article Type] Observational Study
COVID-19 Vaccine Acceptability and Its Determinants in Mozambique: An Online SurveyArticle Published on 2021-07-272022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acceptability chronic disease collected Community Coverage COVID-19 COVID-19 pandemic COVID-19 test determinant effective Efficacy General population Health healthcare healthcare worker Logistic regression male Mozambique Older age online survey positive reason SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine Side effect significantly lower survey tested the SARS-CoV-2 the vaccine vaccinated against COVID-19 vaccination Vaccine vaccine acceptability Vaccine hesitancy [DOI] 10.3390/vaccines9080828 PMC 바로가기 [Article Type] Article
Association Between Air Pollution and Acute Coronary Syndromes During Lockdown for COVID-19: Results From the Terni Hub CenterCOVID-19에 대한 폐쇄 기간 동안 대기 오염과 급성 관상 동맥 증후군 사이의 연관성: Terni Hub Center의 결과Public Health Published on 2021-06-242022-09-11 Journal: Frontiers in Public Health [Category] MERS, SARS, 치료기술, [키워드] Acute coronary syndrome acute coronary syndromes Air pollution analyzed association average catheterization center changes in comparable Concentration coronary syndrome COVID-19 decrease demonstrated drop event explain fixed Hospital admission Hospital admissions Hypothesis invasive invasive procedures Italy Laboratory lack lockdown monitoring network Particulate matter Pollution reason recorded reduced reduction in reductions reductions in Result Support university [DOI] 10.3389/fpubh.2021.683683 PMC 바로가기 [Article Type] Public Health
Assessment of Successful qRT-PCR of SARS-CoV-2 Assay in Pool Screening Using Isopropyl Alcohol Purification Step in RNA ExtractionRNA 추출에서 이소 프로필 알코올 정제 단계를 이용한 풀 스크리닝에서 SARS-COV-2 분석의 성공적인 QRT-PCR 평가Research Article Published on 2021-06-082022-09-10 Journal: BioMed Research International [Category] 바이오마커, [키워드] alcohol analysed assessment average average value best checked Concentration Council COVID-19 determinant E gene E-gene evaluate extracted RNA extraction followed by group ICMR Isopropyl isopropyl alcohol Medical research molecular Nanodrop parameter pool positive protocol purification purified purified RNA purity qRT-PCR reagents real-time RT-PCR reason reason for Research RNA RNA purification RNAseP RT-PCR SARS-CoV-2 Screening second set selected sensitivity Sensitivity and specificity significantly increased specificity specimen specimens spectrophotometer step suggested treated Treatment was tested [DOI] 10.1155/2021/6653950 PMC 바로가기 [Article Type] Research Article
Epidemiological profiles and associated risk factors of SARS-CoV-2 positive patients based on a high-throughput testing facility in India인도의 고처리량 검사 시설을 기반으로 한 SARS-CoV-2 양성 환자의 역학 프로필 및 관련 위험 요소Research Published on 2021-06-022022-09-10 Journal: Open Biology [Category] MERS, 변종, 진단, [키워드] accelerate age Analysis Asymptomatic Care Chain Reaction Characteristics clinical profile co-morbidities co-morbidity collected cough COVID-19 Descriptive analysis determine disease disease spread epidemiological exhibiting Fever Follow-up Government Increasing increasing age India individual Infection International Isolation less Logistic regression analysis male Male sex men and women morbidities morbidity Multivariable logistic regression analysis North Odds ratio participant performed positive presenting profile proportion reason regions resource retrospective risk risk factor Risk factors RT-PCR Sample SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 positive patient SARS-CoV-2 test SARS-CoV-2 testing second wave Symptom symptom status symptomatic symptomatic individual Symptoms tested trajectory Travel Vaccine variant [DOI] 10.1098/rsob.200288 PMC 바로가기 [Article Type] Research
Transcriptomic Signature Differences Between SARS-CoV-2 and Influenza Virus Infected PatientsSARS-CoV-2와 인플루엔자 바이러스 감염 환자 간의 전사 서명 차이Observational Study Published on 2021-05-312022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 임상, [키워드] adverse outcome adverse outcomes B cell blood cell Blood cells Cell cell cycle Complete Complication COVID-19 COVID-19 pathogenesis COVID-19 severity degranulation develop difference distress dramatic increase dysregulated dysregulation dysregulation of T cells Evidence feature gene expression pattern group healthy host response IFN immune profiling immune signature Immunoglobulin Increasing individuals individuals with COVID-19 infected individuals infected with SARS-CoV-2 Influenza influenza viruses involved life-threatening metabolism Neutrophils NK cells over-expression Patient provided reason reduction respiratory distress responses RNA-sequencing SARS-CoV-2 SARS-COV-2 infection severity signature Symptom T cells Toxicity transcriptomic transcriptomic profile transcriptomic profiles website whole blood transcriptome [DOI] 10.3389/fimmu.2021.666163 PMC 바로가기 [Article Type] Observational Study