Teleworking, Work Engagement, and Intention to Quit during the COVID-19 Pandemic: Same Storm, Different Boats?Article Published on 2022-01-242022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] Analysis Characteristics condition conducted COVID-19 COVID-19 pandemic cross-sectional decrease emotional intelligence engage Engagement indirect effect individual characteristics Intention intention to quit Intervention key consideration labor shortage medium organization organizational characteristics organizations pandemic pathway Recognition storm teleworking use of emotion work Work engagement [DOI] 10.3390/ijerph19031267 PMC 바로가기 [Article Type] Article
Mental Health Intent Recognition for Arabic-Speaking Patients Using the Mini International Neuropsychiatric Interview (MINI) and BERT ModelArticle Published on 2022-01-232022-10-29 Journal: Sensors (Basel, Switzerland) [Category] Coronavirus, SARS, [키워드] Accuracy addition BERT model bidirectional Care claimed collected conducted COVID-19 pandemic dataset Depression diagnose Diagnosis disorder evaluated FIVE healthcare help hidden intent recognition interview limits literature review machine learning mental health mental health disorders MINI Model natural language processing Panic disorder Patient Precision provided psychiatry recall Recognition Result seeking suffered transformer treated patient Treatment Tunis was tested [DOI] 10.3390/s22030846 PMC 바로가기 [Article Type] Article
Pandemic preparedness systems and diverging COVID-19 responses within similar public health regimes: a comparative study of expert perceptions of pandemic response in Denmark, Norway, and SwedenResearch Published on 2022-01-212022-11-01 Journal: Globalization and Health [Category] Coronavirus, SARS, [키워드] Characteristics Comparative analysis component country COVID-19 COVID-19 pandemic Denmark disciplinary distribution dominant Evidence Expertise Factor First wave global public health groups highlight International Health Regulations National Norway pandemic pandemic preparedness Policy studies preference public health question raised Recognition response Result second significant difference supplementary material Support trajectory Variation World Health Organization’ [DOI] 10.1186/s12992-022-00799-4 PMC 바로가기 [Article Type] Research
The Prognostic Role of Metabolic and Endocrine Parameters for the Clinical Severity of COVID-19COVID-19의 임상 중증도에 대한 대사 및 내분비 매개변수의 예후 역할Research Article Published on 2022-01-202022-09-10 Journal: Disease Markers [Category] 바이오마커, 진단, [키워드] Admission albumin blood cell blood count blood glucose C-reactive protein calcium clinical clinical study complete blood count coronavirus coronavirus disease Coronavirus disease-19 cortisol count COVID-19 COVID-19 patients creatinine Critical Critical illness cross-sectional duration of hospitalization Endocrine enrolled estimation Glucose Hormones ICU admission rates independent predictor independent predictors intensive care International laboratory result Laboratory results Lactate lactate dehydrogenase liver enzymes Magnesium material metabolic morbidity and mortality Mortality mortality rate Multivariate analysis nonsurvivor nonsurvivors objective outbreak outcome parameter Patient patients with COVID-19 phosphate poor prognosis profiles Prognosis Prognostic factor Prognostic factors public health emergency Recognition Result risk risk factor Risk factors role Serum level serum levels severe COVID-19 severity and prognosis significantly higher Spread survivor Thyroid Thyroid hormones Univariate analysis Vitamin D WBC WBC count were recorded White blood cell [DOI] 10.1155/2022/5106342 PMC 바로가기 [Article Type] Research Article
Extended ensemble simulations of a SARS-CoV-2 nsp1–5’-UTR complexSARS-COV-2 NSP1–5'-UTR 복합체의 확장 된 앙상블 시뮬레이션Research Article Published on 2022-01-192022-09-10 Journal: PLoS Computational Biology [Category] SARS, 유전자 메커니즘, [키워드] 5’-untranslated region acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Author bind binding block C-terminal causative pathogen characteristic cluster analysis complex Consistency coronavirus COVID-19 cryo cryo-EM Efficiency electron density ENCODE evade experimental evidence experiments Extended flexible Host host cells host immunity host mRNA human cell increase infected cells interactions intrinsically investigated involved mechanism modulate molecular dynamics Molecular dynamics simulation molecular mechanism mutant N-terminal nonstructural protein 1 nsp1 open pandemic of COVID-19 performed predicted Protein Recognition recognize reported residue residues respiratory ribosome RNA SARS-CoV-1 SARS-CoV-2 SARS-CoV-2-infected cells selective severe acute respiratory syndrome Coronavirus Simulation solvent suggested the SARS-CoV-2 translate translation Viral Viral RNA virus X-ray crystallographic structure [DOI] 10.1371/journal.pcbi.1009804 PMC 바로가기 [Article Type] Research Article
The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variantsSARS-CoV-2 베타에 대한 항체 반응은 다른 변이체와의 항원 거리를 강조합니다Article Published on 2022-01-122022-09-10 Journal: Cell Host & Microbe [Category] MERS, SARS, 변종, 진단, [키워드] Abstract Alter Analysis antibody Antibody Response antigenic antigenic structure Beta Beta variant binding conserved COVID-19 Delta E484K epitope escape Express immune responses include individual infected with SARS-CoV-2 K417N mAb mAbs multiple mutation multiple mutations mutated Mutation N-terminal domain N501Y neutralization neutralize Neutralizing Neutralizing antibodies neutralizing antibody NTD other variant pandemic Patient performed RBD Receptor-binding domain Recognition recognize residue residues SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 SARS-CoV-2 strain separated sequence serum Spike protein Structure structure-function the receptor-binding domain the SARS-CoV-2 the spike protein Vaccine Vaccine-induced immunity variant variants of SARS-CoV-2 viruses [DOI] 10.1016/j.chom.2021.11.013 PMC 바로가기 [Article Type] Article
Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors공공 및 민간 T 세포 수용체가 인식하는 HLA-A2 제한 SARS-CoV-2 스파이크 에피토프의 구조적 평가Article Published on 2022-01-102022-09-10 Journal: Nature Communications [Category] 변종, 유전자 메커니즘, [키워드] antibody B-cell cellular immunity complex conserved Convalescent patients COVID-19 convalescent patient Critical determine effort elicit epitope Epitopes germline gene homologous epitope homologous epitopes immune response Immunity immunodominant immunology infective agent information less long-term memory mechanism Memory responses Neutralizing antibodies neutralizing antibody receptors Recognition recognize SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein seasonal coronaviruses Spike protein Structure structures T cell T cell receptors T cells T-cell receptor T-Cell Receptors target targeted epitope TCR TCRs Vaccine variant X-ray crystallography [DOI] 10.1038/s41467-021-27669-8 PMC 바로가기 [Article Type] Article
Deep mutational engineering of broadly-neutralizing nanobodies accommodating SARS-CoV-1 and 2 antigenic driftSARS-CoV-1 및 2 항원 드리프트를 수용하는 광범위 중화 나노바디의 심층 돌연변이 공학Article Published on 2022-01-012022-09-11 Journal: mAbs [Category] SARS, 변종, 진단, [키워드] ACE2 amino acids antibody antibody engineering antigenic applied binding contribute cross-reactivity deep deep mutational scanning Efficiency epitope high affinity immunodominant Interaction molecular motif nanobodies nanobody neutralize Neutralizing Pathogens RBD Receptor-binding domain Recognition regions sarbecovirus SARS-CoV-1 SARS-CoV-1 and 2 SARS-CoV-1 RBD SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 RBD screened specificity Substitution variant VHH72 virus yeast yeast surface display. [DOI] 10.1080/19420862.2022.2076775 PMC 바로가기 [Article Type] Article
Murine monoclonal antibodies against RBD of the SARS-CoV-2 spike protein as useful analytical tools for subunit vaccine development and clinical trials소단위 백신 개발 및 임상 시험을 위한 유용한 분석 도구로서 SARS-CoV-2 스파이크 단백질의 RBD에 대한 뮤린 모노클로날 항체Article Published on 2022-01-012022-09-11 Journal: Journal of Immunological Methods [Category] MERS, SARS, 비임상, 임상, 진단, [키워드] ACE2-RBD binding Additivity index affinities affinity Alpha Anti-RBD antibodies antibody Antigen Beta binding breath characterization clinical trial COVID-19 D614G demonstrated determine Epitopes FIVE high affinity hybridoma technology infect mAbs monoclonal monoclonal antibodies monoclonal antibody murine neutralized Neutralizing neutralizing capacity neutralizing monoclonal antibodies nine pandemic pharmacokinetic purified RBD Receptor binding domain Recognition recombinant antigens sandwich ELISA SARS-CoV-2 SARS-CoV-2 spike protein solution Spike protein stability strain subunit Subunit vaccine subunit vaccines the RBD the SARS-CoV-2 trials Vaccine development Vero cells virus was used [DOI] 10.1016/j.jim.2021.113195 PMC 바로가기 [Article Type] Article
Canadian College of Medical Geneticists (CCMG) points to consider: resuming genetic services in a pandemic-a summaryCanadian College of Medical Geneticists(CCMG)는 다음 사항을 고려해야 합니다. 전염병에 대한 유전 서비스 재개-요약Article Published on 2022-01-012022-09-11 Journal: Journal of medical genetics [Category] 유전자 메커니즘, [키워드] affected asked Canada Care clinical care clinics college competing COVID-19 pandemic Decision-making Diagnosis effort Factors Genetic Geneticist genetics Health Health care health care facilities help highlight Laboratory manpower medical Patient Population public health Recognition services Variation Virtual care while [DOI] 10.1136/jmedgenet-2020-107394 PMC 바로가기 [Article Type] Article