Drug repurposing for coronavirus (SARS-CoV-2) based on gene co-expression network analysis유전자 공동 발현 네트워크 분석에 기초한 코로나 바이러스 (SARS-COV-2)에 대한 약물 재생Article Published on 2021-11-082022-08-31 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 신약개발, 유전자 메커니즘, 치료기술, 치료제, [키워드] acute respiratory syndrome analyses Analysis applied approach Asia candidate drug candidate drugs cisplatin co-expression Computational models contagious coronavirus Cyclophosphamide database disease drug Drug repurposing Drug screening drugs drugs targeting effective drug effective drugs FIVE FLUOROURACIL gene co-expression network Gene ontology Genes Genome Interaction list METHYLDOPA Microarrays miRNA miRNAs reconstructed respiratory Respiratory illness retrieved SARS-CoV SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 disease Severe acute respiratory syndrome Sirolimus Systems biology target gene the SARS-CoV-2 transcription factor transcription factors treat Treatment Viral viral respiratory virus [DOI] 10.1038/s41598-021-01410-3 PMC 바로가기 [Article Type] Article
Sclerosing Encapsulating Peritonitis Following Recovery From COVID-19 PneumoniaEmergency Medicine Published on 2021-11-062022-10-31 Journal: Cureus [Category] COVID-19, [키워드] abdomen abdominal cocoon abdominal pain acute respiratory syndrome bowel Case report Computed tomography coronavirus Coronavirus disease 2019 COVID-19 Critical demonstrated diagnosed Diagnosis Endotracheal intubation gastrointestinal involvement Injury intensive care manifestation Measures mechanical ventilation membrane Pain Patient patients with COVID-19 peritonitis Pneumonia positive remained reported Resection Respiratory illness Respiratory system RT-PCR SARS-CoV-2 Sclerosing sclerosing encapsulating peritonitis Seven Severe COVID-19 pneumonia the disease the SARS-CoV-2 virus was performed with COVID-19 [DOI] 10.7759/cureus.19306 PMC 바로가기 [Article Type] Emergency Medicine
Neurokinin-1 Receptor as a potential drug target for COVID-19 treatmentCOVID-19 치료를 위한 잠재적인 약물 표적으로서의 뉴로키닌-1 수용체Review Published on 2021-11-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, 신약개발, 치료법, 치료제, [키워드] alleviate antagonist aprepitant biomedical scientist boost Brainstem clinical Clinical studies conducted Coronavirus infection Coronavirus treatment COVID-19 COVID-19 infection Cytokine storm Dexamethasone directions disease drug drug target Economy etiology hour immune system Infection Infectious disease Inflammation Neurokinin-1 Receptor antagonist neuromodulator neurotransmitter nociception novel Novel coronavirus Novel coronavirus infection pandemic Perspective receptor antagonist released respiratory Respiratory illness responsible substance substance P Substance P/ Neurokinin-1 Receptor antagonist. Symptom the disease therapeutic intervention Treatment Treatment strategies treatment strategy trigeminal nerve [DOI] 10.1016/j.biopha.2021.112159 PMC 바로가기 [Article Type] Review
Comparison of SARS-CoV-2 Receptors Expression in Primary Endothelial Cells and Retinoic Acid-Differentiated Human Neuronal Cells1차 내피 세포와 레티노산 분화 인간 신경 세포에서 SARS-CoV-2 수용체 발현의 비교Comparative Study Published on 2021-10-302022-09-12 Journal: Viruses [Category] MERS, SARS, 진단, [키워드] absence ACE-2 ACE2 acute respiratory syndrome coronavirus Brain Cell cell subpopulation cells cellular cellular receptors characterized coronavirus 2 coronavirus disease COVID-19 Diagnosis differentiation disease dysfunction Dyspnea dysregulation endothelial Endothelial cell endothelial cells epithelial cells Express expressed Fever help Human infect Infection Interaction Lung epithelial cells majority Manifestations mode neurological neurological manifestations neuronal neuronal cells NRP1 Patient patients problem promote Protein protein expression pseudovirus pseudoviruses receptor receptors regulated replicate reported respiratory Respiratory illness respiratory syndrome coronavirus 2 responsible retinoic acid RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 receptors SARS-CoV-2 spike protein SARS-receptors severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 SH-SY5Y shown spike Spike protein subjects surface molecule target the SARS-CoV-2 the Spike these cell These cells TMPRSS2 treated Treatment umbilical umbilical vein Vascular viral entry Viral protein [DOI] 10.3390/v13112193 PMC 바로가기 [Article Type] Comparative Study
Dysregulation of RNA interference components in COVID-19 patientsCOVID-19 환자에서 RNA 간섭 성분의 조절 조절Research Note Published on 2021-10-292022-09-10 Journal: BMC Research Notes [Category] 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Ago2 Antiviral China component coronavirus COVID-19 COVID-19 patient COVID-19 patients COVID-19patient COVID-19patients Defense defense mechanisms demonstrated DGCR8 Dicer Drosha dysregulated expression expression level Health healthy individuals healthy subjects inhibiting mechanism mRNA mRNAs Novel coronavirus objective Post-transcriptional gene silencing respiratory Respiratory illness Result RNA interference RNAi SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 severe respiratory illness statistically suggested supplementary material Viral Viral proteins virus virus replication Wuhan [DOI] 10.1186/s13104-021-05816-0 PMC 바로가기 [Article Type] Research Note
BCG vaccination to reduce the impact of COVID-19 in healthcare workers: Protocol for a randomised controlled trial (BRACE trial)의료 종사자에서 Covid-19의 영향을 줄이기위한 BCG 예방 접종 : 무작위 대조 시험을위한 프로토콜 (Brace Trial)Infectious Diseases Published on 2021-10-272022-09-10 Journal: BMJ Open [Category] Fulltext, MERS, SARS, 임상, [키워드] 1:1 Analysis approval BCG BCG vaccination Blood Blood samples Brazil changes in ClinicalTrials collected control group Controlled trial COVID-19 database determine dissemination episode of Ethics evaluated Factor febrile Final group HCW HCWs healthcare healthcare worker Healthcare workers identify immune response immune responses immune system Immunological analyses immunology incidence infections Infectious diseases International Intervention Microbiology modulate multicentre Netherlands outcomes participant Pathogens peer-reviewed questionnaire Questionnaires randomised controlled trial reduce Repository respiratory Respiratory illness Result safety profile SARS-CoV-2 SARS-COV-2 infection Secondary objectives severe COVID-19 severity Spain susceptibility symptomatic tested Trial Trial registration vaccination Virology [DOI] 10.1136/bmjopen-2021-052101 PMC 바로가기 [Article Type] Infectious Diseases
Contribution of Nanotechnologies to Vaccine Development and Drug Delivery against Respiratory VirusesReview Article Published on 2021-10-272022-10-29 Journal: PPAR Research [Category] COVID-19, [키워드] Adenovirus antiviral drug cause CDC center contribute contributed Control coronavirus disease Critical death delivery Depression development drug Epidemics evaluated Evidence humans Influenza Lipid nanoparticle morbidity Mortality Nanotechnology Pandemics Particle prevention respiratory Respiratory illness respiratory infections respiratory syncytial virus respiratory viral illness respiratory viruses SARS-CoV-2 Treatment Vaccine virus [DOI] 10.1155/2021/6741290 PMC 바로가기 [Article Type] Review Article
A case of humidifier lung with a difficult differential diagnosis from COVID-19Case Report Published on 2021-10-262022-10-28 Journal: Oxford Medical Case Reports [Category] COVID-19, [키워드] Atypical centrilobular nodule Chest computed tomography chest CT scan coronavirus disease COVID-19 CT findings Diagnosis differential diagnosis Dyspnea GGO GGOs ground-glass opacity High-resolution CT HRCT hypersensitivity pneumonitis Interpretation lung offer other disease phenotype Respiratory illness Symptom [DOI] 10.1093/omcr/omab100 PMC 바로가기 [Article Type] Case Report
Fatal large-vessel cerebrovascular infarct presenting with severe coronavirus disease 2019 in a 39-year-old patient: a case reportCase Report Published on 2021-10-262022-10-30 Journal: Journal of Medical Case Reports [Category] COVID-19, MERS, SARS, [키워드] anticoagulation benefit blood test carotid Case report Coagulopathy coronavirus disease COVID-19 Critical diabete died Doppler ultrasound Evidence healthy highlight Interaction male Malignant stroke Patient patients presenting Research Respiratory illness risk factor serious complication severe coronavirus disease severity stroke the patient thrombosis unique Vascular younger patient [DOI] 10.1186/s13256-021-02991-3 PMC 바로가기 [Article Type] Case Report
Role of Gut Microbiome in COVID-19: An Insight Into Pathogenesis and Therapeutic PotentialImmunology Published on 2021-10-142022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome available data Bacterial Biomarker caused circulatory system coronavirus Coronavirus disease 2019 COVID-19 cytokine Cytokine release syndrome direct infection Dysbiosis dysregulated immune response Evidence exacerbate Gut gut microbiome gut–lung axis immunological insight intestinal permeability leaky gut Local microbial community Microbiome multi-organ dysfunction Potential progression Respiratory illness respiratory tract role SARS-CoV-2 systemic inflammatory systemic inflammatory response therapeutic target toxin [DOI] 10.3389/fimmu.2021.765965 PMC 바로가기 [Article Type] Immunology