A family cluster of diagnosed coronavirus disease 2019 (COVID‐19) kidney transplant recipient in ThailandOriginal Research Published on 2020-08-082022-10-30 Journal: Immunity, Inflammation and Disease [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome antiviral therapy carried case sery cause clinical Clinical course Cluster coronavirus coronavirus disease COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 described develop diagnosed Family cluster Immune status immunocompromised condition immunosuppressants individual intensive care kidney transplant management Mild outbreak Pneumonia post kidney transplant receiving recipient recipients Respiratory illness respiratory specimen Result SARS‐CoV‐2 severe disease severity solid organ transplant Support Transmission [DOI] 10.1002/iid3.337 PMC 바로가기 [Article Type] Original Research
Development and Evaluation of Novel and Highly Sensitive Single-Tube Nested Real-Time RT-PCR Assays for SARS-CoV-2 DetectionArticle Published on 2020-08-072022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, [키워드] Algorithm assays coronavirus disease COVID-19 COVID-19 patient COVID-19 patients COVID-19 testing Critical cross detection development Diagnosis evaluate evaluated Evaluation Follow-up human coronavirus initial limit of detection Molecular assay N genes novel offer positive real-time RT-PCR respiratory specimen respiratory viruses RT-PCR Saliva SARS-CoV-2 SARS-CoV-2 detection sensitive sensitivity single-tube nested specimen specimens tested while [DOI] 10.3390/ijms21165674 PMC 바로가기 [Article Type] Article
Investigation and Serologic Follow-Up of Contacts of an Early Confirmed Case-Patient with COVID-19, Washington, USASynopsis Published on 2020-08-012022-10-31 Journal: Emerging Infectious Diseases [Category] COVID-19, MERS, SARS, [키워드] 2019 novel coronavirus disease acute respiratory syndrome antibody caused collected Confirmed Contact Contact tracing coronavirus coronavirus disease COVID-19 detectable ELISA face-to-face interaction Interaction investigation performed reported respiratory infections respiratory specimen reverse transcription PCR rRT-PCR SARS-CoV-2 SARS-COV-2 infection secondary transmission serologic serology serum sample severe acute respiratory syndrome coronavirus 2 Symptoms tested The United States USA viruses Washington with COVID-19 zoonoses [DOI] 10.3201/eid2608.201423 PMC 바로가기 [Article Type] Synopsis
Evaluation of SARS-CoV-2 viral RNA in fecal samplesShort Report Published on 2020-06-302022-10-28 Journal: Virology Journal [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Complete coronavirus COVID-19 diagnostic diagnostic protocol ENhance fecal Fecal sample Fecal specimens first positive Infection Infectious disease Initially knowledge Mild novel coronavirus disease Novel coronavirus disease 19 (COVID-19) offer Patient positive qRT-PCR assay remained respiratory specimen respiratory specimens respiratory tract samples returned SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 viral RNA selected specimen specimens Symptom virus RNA [DOI] 10.1186/s12985-020-01359-1 PMC 바로가기 [Article Type] Short Report
Disposition of patients with coronavirus disease 2019 (COVID-19) whose respiratory specimens remain positive for severe acute respiratory coronavirus virus 2 (SARS-CoV-2) by polymerase chain reaction assay (PCR)Commentary Published on 2020-06-102022-10-30 Journal: Infection Control and Hospital Epidemiology [Category] COVID-19, SARS, [키워드] coronavirus disease COVID-19 disposition Patient PCR polymerase chain positive Respiratory Coronavirus respiratory specimen SARS-CoV-2 virus [DOI] 10.1017/ice.2020.286 PMC 바로가기 [Article Type] Commentary
Efficacy and safety of Anluohuaxian in the treatment of patients with severe Coronavirus disease 2019- a multicenter, open label, randomized controlled study: a structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-06-082022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] 6-minute walking distance actual Alpha analyst Anluohuaxian antiviral drugs brand bronchial asthma Care change changes Chinese Chinese herbal medicines chronic obstructive Colchicine Combined completion Compliance composed computer tomography Confirmed connective tissue control group Coronavirus disease 2019 COVID-19 criteria Cyclophosphamide cytokine diagnosed dissemination distribution drug Efficacy and safety element Endocrine enrolled Estimated evaluate expected experimental group explained facilitate fibrosis glucocorticoid groups hepatic fibrosis High-resolution history Hormones HRCT Huoshenshan Hospital Imatinib include indicate interferon-γ interstitial Interstitial lung disease investigators involved IWRS Kidney disease lactating liver lobular lung maximum Mental Disorders minimum multicenter Nasopharyngeal swab Necrosis negative neurologic Nintedanib nodule not blinded nucleic acid test number objective open label outcome outcome assessors participant Participants Pathogenesis pathway Patient pharmaceutical pill professional proportion protocol provided pulmonary pulmonary disease pulmonary fibrosis random randomised randomised controlled trial randomization randomization system Randomized Randomized controlled trial randomly divided RCT recruitment Research research drug respiratory specimen Sample size Science second selected severe COVID-19 sputum statistical status Study protocol subject technology therapeutic drug Tongji Hospital treated Treatment treatment group Trial Union Hospital university variety website West Wuhan Year [DOI] 10.1186/s13063-020-04399-8 PMC 바로가기 [Article Type] Letter
The Mechanism and Clinical Outcome of patients with Corona Virus Disease 2019 Whose Nucleic Acid Test has changed from negative to positive, and the therapeutic efficacy of Favipiravir: A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-06-052022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] 24 hours acid Administered Affect analyst Anti-viral anticipated Beijing block block randomization Blood Body Capital cardiovascular system Care center changed Chinese clinical clinical manifestation Clinical outcome Clinical studies clinical trial college Complete condition Consent control group Corona Corona virus cough COVID-19 criteria curative Diagnosis discharge discharged disease Diseases dissemination dose drug Ebola virus element eligibility criteria enrolled expected experimental group Favipiravir female Follow-up form hepatology history hospital include Including Infection Infectious disease Informed inhibit investigators kidney lack lactating women life-threatening liver Loss male Measures mechanism Medicine Mental Disorders Nasopharyngeal swab nasopharyngeal swabs not blinded nucleic acid nucleic acid test number objective open label oral administration outcome outcome assessors Oxygen therapy parallel group participant Participants Patient plan poor compliance positive protocol Public pulmonary randomised randomised controlled trial randomization system Randomized controlled trial Randomly recruited recruitment reduced Regular Reinfection Research researcher respiratory specimen response returned RNA-dependent RNA polymerase routine screening visit second secondary severe adverse events severity severity of symptoms Shenzhen specimens sputum status Study protocol subject Symptom Symptoms System temperature Test tested therapeutic efficacy throat swabs Traditional Treatment treatment for COVID-19 treatment group Trial uncontrolled university variety viral nucleic acid virus Web website Withdrawal Wuhan [DOI] 10.1186/s13063-020-04430-y PMC 바로가기 [Article Type] Letter
Challenges in Laboratory Diagnosis of the Novel Coronavirus SARS-CoV-2Review Published on 2020-05-262022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] Asymptomatic challenge Characteristics China Clinical treatment comprehensive strategy Coronavirus disease 2019 Coronavirus infection COVID-19 Critical Diagnosis diagnosis of COVID-19 diagnostic diagnostic challenges diagnostics gold standard highlight immunoassay Isolation Laboratory majority molecular testing novel outbreak Pandemics PCR performed POC point-of-care technology Research respiratory specimen rRT-PCR SARS-CoV-2 Sensitivity and specificity serology Spread Surveillance symptomatic patient Vaccines viral shedding virus viruses with COVID-19 Wuhan [DOI] 10.3390/v12060582 PMC 바로가기 [Article Type] Review
Molecular Evolution and Structural Mapping of N-Terminal Domain in Spike Gene of Middle East Respiratory Syndrome Coronavirus (MERS-CoV)Article Published on 2020-05-022022-10-28 Journal: Viruses [Category] COVID-19, MERS, [키워드] adaptive amino acid change amino acid substitutions Analysis Anti-viral treatment Arabian Peninsula changes in circulating Concentration eight Evolution heptad repeat highlight Human IMPROVE investigated Lineage lineages mapping MERS MERS-CoV MERS-CoV RNA Middle East Middle East respiratory syndrome Coronavirus N-terminal domain pathogen Pathogenesis Patient peaked Positive selection provide recombination event residue respiratory respiratory specimen Saudi Arabia selected sequence homology significantly spike spike gene spike gene sequence strain Strains suggested Surveillance Topology Vaccine Viral load virus zoonotic [DOI] 10.3390/v12050502 PMC 바로가기 [Article Type] Article
A RT-PCR assay for the detection of coronaviruses from four generaArticle Published on 2020-04-302022-11-01 Journal: Journal of Clinical Virology [Category] COVID-19, SARS, [키워드] Amplicon can be used coronavirus CoV COVID-19 COVID-19 patients CoVs cross-reactivity detect diagnostic emerging Epidemics evaluate evaluated genetic diversity genome sequence help Host identify Infectious diseases International Limits of detection mitigate molecular morbidity Novel coronavirus objective Orthocoronavirinae patients performed Pneumonia ranged respiratory specimen respiratory virus respiratory viruses Result reverse transcription RT-PCR assay Sanger sequencing SARS-CoV-2 secretion Sequencing specimen specimens tested Threats [DOI] 10.1016/j.jcv.2020.104391 PMC 바로가기 [Article Type] Article