S2 subunit – Page 7 – Communicable Diseases Research

Spike S2 Subunit: The Dark Horse in the Race for Prophylactic and Therapeutic Interventions against SARS-CoV-2

Review

Published on 2021-02-202022-10-28
Journal: Vaccines [Category] COVID-19,

Mapping major SARS-CoV-2 drug targets and assessment of druggability using computational fragment screening: Identification of an allosteric small-molecule binding site on the Nsp13 helicase

전산 단편 스크리닝을 사용한 주요 SARS-CoV-2 약물 표적 매핑 및 약물 가능성 평가: Nsp13 헬리카제의 알로스테릭 소분자 결합 부위 식별

Research Article

Published on 2021-02-172022-09-10
Journal: PLoS ONE [Category] MERS, 신약개발, 치료제,

[키워드] accelerate acting Antiviral benzene binding binding domain binding site calculated complex conformation conformational state conformational states drug target effective Efficiency effort FIVE free energy Free energy calculation Free energy calculations functional Helicase identification identify Impact information life Ligand ligand binding site mapping mechanism methyltransferase N-terminal Nsp12 nsp13 Protein protein-protein interaction recent replication-transcription complex RNA-dependent RNA polymerase S2 subunit SARS-CoV-2 SARS-CoV-2 drug small molecule Society solvent spike Spike protein Structural analysis target target protein the Spike was used Zinc
[DOI] 10.1371/journal.pone.0246181 PMC 바로가기 [Article Type] Research Article

Human Milk Antibodies against S1 and S2 Subunits from SARS-CoV-2, HCoV-OC43, and HCoV-229E in Mothers with a Confirmed COVID-19 PCR, Viral SYMPTOMS, and Unexposed Mothers

COVID-19 PCR, 바이러스성 증상 및 노출되지 않은 산모에서 SARS-CoV-2, HCoV-OC43 및 HCoV-229E의 S1 및 S2 소단위체에 대한 모유 항체

Article

Published on 2021-02-092022-09-10
Journal: International Journal of Molecular Sciences [Category] MERS, 진단, 치료기술,

[키워드] β-coronaviruses antibodies antibody Antigen antigens breast milk Breastfeeding Confirmed control group COVID-19 COVID-19 group COVID-19 pandemic COVID-19 PCR test cross-reactive cross-reactive antibodies cross-reactive antibody ELISA evaluate group groups HCoV HCoV-229E HCoV-OC43 HCoVs Human human milk IgG IgG levels IgM Immunity immunoglobulins Infectious diseases milk mother Neonates not differ OC43 passive immunity PCR PCR test polyreactive antibody positive correlation positive correlations Preexisting immunity reactive S1 and S2 S2 subunit SARS-CoV-2 SARS-CoV-2 IgG secretory antibodies secretory IgA SIgA subunit Symptom Symptoms Viral were measured α-coronaviruses
[DOI] 10.3390/ijms22041749 PMC 바로가기 [Article Type] Article

Cryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynamic prefusion conformational changes

Article

Published on 2021-01-082022-10-29
Journal: Nature Communications [Category] Coronavirus, MERS,

COVID-19 variants that escape vaccine immunity: Global and Indian context-are more vaccines needed?

백신 면역을 벗어나는 COVID-19 변종: 전 세계 및 인도 상황에서 더 많은 백신이 필요합니까?

Review

Published on 2021-01-012022-09-11
Journal: Journal of biosciences [Category] MERS, 변종, 진단,

Biochemical and antigenic characterization of the structural proteins and their post-translational modifications in purified SARS-CoV-2 virions of an inactivated vaccine candidate

Original Article

Published on 2020-12-142022-10-31
Journal: Emerging Microbes & Infections [Category] COVID-19, SARS,

[키워드] Analysis anti-SARS-CoV-2 vaccines Antibody Response antibody response against antigenic antigenicity Antisera caused cleavage cleaved clinical trial convalescent convalescent serum COVID-19 pandemic demonstrated elicit facilitate FIVE form forms full-length S glycoprotein glycosylated immunization immunized immunogenic inactivated Inactivated vaccine membrane Modification modifications natural infection Neutralizing antibodies pathogenesis of SARS-CoV-2 post-translational modification protease Protein purified Quality control S glycoprotein S protein S1 and S2 S1/S2 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 virion sera shown stimulated structural protein structural proteins subunit subunits the vaccine vaccination Vaccine vaccine candidate Vero virion virions
[DOI] 10.1080/22221751.2020.1855945 PMC 바로가기 [Article Type] Original Article

Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

인간의 SARS-CoV-2에 대한 기존 및 새로운 체액 면역

Report

Published on 2020-12-112022-09-10
Journal: Science (New York, N.y.) [Category] Fulltext, MERS, SARS, 조류인플루엔자, 진단, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adults age age distribution anti-S2 antibody antibody repertoire children circulating Cohort contribute coronavirus Course COVID-19 patient COVID-19 patients COVID-19 susceptibility Critical cross-protection cross-react de novo detectable distinguishing distribution Donor exhibited explain flow cytometry HCoV HCoVs Human human coronavirus humans Humoral immunity IgA IgA antibodies IgG IgG antibody IgM IgM antibodies IgM antibody Immunity Immunoglobulin Immunoglobulin G Immunological memory in some individual individuals Infection infection rate memory much higher Neutralizing activity Neutralizing antibodies Novel coronavirus novel coronaviruses observation period Patient Perspective positive Preexisting immunity prevalent proportion recognizing respiratory S1 and S2 S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 proteins SARS-CoV-2 S SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike protein Science sera severe acute respiratory syndrome Coronavirus spike glycoprotein Spike protein subunits susceptibility the SARS-CoV-2 uninfected Wilson Zoonotic introduction
[DOI] 10.1126/science.abe1107 PMC 바로가기 [Article Type] Report

In Silico Discovery of Antimicrobial Peptides as an Alternative to Control SARS-CoV-2

SARS-CoV-2를 제어하는 대안으로서 항균성 펩티드의 실리코 발견

Article

Published on 2020-11-252022-09-10
Journal: Molecules [Category] SARS, 치료제,

[키워드] ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 AMP AMPs Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antimicrobial antimicrobial peptide antimicrobial peptides antiviral properties antiviral property caused cellular receptor Control coronavirus database docking docking analysis drug effective Effectiveness experimental validation highest affinity host cell in silico in viral Infection Interaction investigated pandemic pathogenicity peptide peptides performed physicochemical Protein receptors respiratory S2 subunit SARS-CoV-2 screened selected severe acute respiratory syndrome Coronavirus Spike protein structural protein structural proteins subunit the SARS-CoV-2 therapeutic therapeutic strategy treat Viral Viral protein was reduced
[DOI] 10.3390/molecules25235535 PMC 바로가기 [Article Type] Article

Conservation analysis of SARS-CoV-2 spike suggests complicated viral adaptation history from bat to human

Original Research Article

Published on 2020-11-052022-11-01
Journal: Evolution, Medicine, and Public Health [Category] COVID-19,

[키워드] acute respiratory syndrome analyses Analysis analyzed bat coronavirus RaTG13 carried caused conservation conservation analysis Contact coronavirus coronavirus disease coronavirus strains CoV COVID-19 domain GISAID groups Host identify Multiple sequence alignment N-terminal domain NCBI pandemic pangolin coronavirus pangolin CoV Phylogenetic plague public health emergency RaTG13 RBD Receptor-binding domain recombination event recombine Result reveal S2 subunit SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 spike sequence similarity spike strain Strains Transmission Variation viral adaptation virus was used whole-genome
[DOI] 10.1093/emph/eoaa041 PMC 바로가기 [Article Type] Original Research Article

S1 Subunit and Host Proteases as Potential Therapeutic Avenues for the Treatment of COVID-19

COVID-19 치료를 위한 잠재적인 치료 수단으로서의 S1 소단위 및 숙주 단백질 분해효소

Review

Published on 2020-10-012022-09-11
Journal: Archives of medical research [Category] SARS, 신약개발, 치료법, 치료제,

[키워드] acute respiratory syndrome angiotensin angiotensin converting enzyme Angiotensin converting enzyme-2 binding cause Cell cell membrane China cleaving COVID-19 COVID-19 treatment disease drug Drug development drugs effective FIVE FUSE globe host cell host cell protease host cell proteases host protease host proteases inactivation lack novel corona virus pandemic Potential protease Proteases receptor reported respiratory S1 subunit S2 subunit SARS-CoV SARS-CoV-2 Severe acute respiratory syndrome spike Spike (S) transmembrane glycoprotein. Spread target cell therapeutic therapeutic target therapeutic targets transmembrane glycoprotein Treatment Viral virus WHO Wuhan
[DOI] 10.1016/j.arcmed.2020.05.013 PMC 바로가기 [Article Type] Review