Sub-optimal neutralisation of omicron (B.1.1.529) variant by antibodies induced by vaccine alone or SARS-CoV-2 Infection plus vaccine (hybrid immunity) post 6-months6개월 후 백신 단독 또는 SARS-CoV-2 감염 + 백신(하이브리드 면역)에 의해 유도된 항체에 의한 오미크론(B.1.1.529) 변이체의 차선 중화Article Published on 2022-04-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI Against Anti-RBD IgG antibody B.1.1.529 BBV152 Biotechnology ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine correlation Covaxin Covishield cross-sectional cross-sectional study demonstrated Department exhibited explain foundation four group four groups geometric mean geometric mean titre GMT group groups hybrid Hybrid immunity Immune escape Immunity inactivated India individual Infection limit Live virus Live-virus neutralisation Melinda Gate Melinda Gates moderate natural infection nCoV neutralisation neutralisation assay neutralisation test neutralisation titre Neutralisation titres neutralise neutralising ability omicron Omicron variant outcome Primary outcome quantification Rapid reduction reduction in SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 variant serum Significant Spread subjects tested titre USA vaccinated individual vaccinated individuals vaccination Vaccine variant virus Virus neutralisation [DOI] 10.1016/j.ebiom.2022.103938 PMC 바로가기 [Article Type] Article
The ViReflow pipeline enables user friendly large scale viral consensus genome reconstructionViReflow 파이프라인은 사용자 친화적인 대규모 바이러스 합의 게놈 재구성을 가능하게 합니다.Article Published on 2022-03-242022-09-11 Journal: Scientific Reports [Category] SARS, 변종, [키워드] administration Analysis Cluster computation configuration consensus genome consensus sequence consensus sequences COVID-19 pandemic dataset effort epidemiological flexibility hands information Intervention molecular platform Prevent provided public health resource resources SARS-CoV-2 SARS-CoV-2 strain scalability sequence Sequencing service Spread Surveillance variants viral pathogen virus Web [DOI] 10.1038/s41598-022-09035-w PMC 바로가기 [Article Type] Article
Omicron: What Makes the Latest SARS-CoV-2 Variant of Concern So Concerning?Omicron: 최신 SARS-CoV-2 변종을 우려하게 만드는 요인은 무엇입니까?Review Published on 2022-03-232022-09-11 Journal: Journal of Virology [Category] SARS, 변종, [키워드] accumulating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 BA.1 BA.2 causative agent changes changes in concern coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Delta VOC Efficiency Evidence functional consequences Genome immune evasion less Mutation Neutralizing antibodies omicron pandemic pathogenic Protein resulting SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus South Africa spike Spike protein strain Transmission variants variants of concern Viral protein Viral proteins viral spike protein VoC VOCs [DOI] 10.1128/jvi.02077-21 PMC 바로가기 [Article Type] Review
Mutations and Evolution of the SARS-CoV-2 Spike ProteinSARS-CoV-2 스파이크 단백질의 돌연변이와 진화Review Published on 2022-03-192022-09-11 Journal: Viruses [Category] SARS, 변종, 유전자 메커니즘, [키워드] Alpha Alter alterations arising Beta binding can be used cellular entry COVID-19 Critical Delta Effect ENhance Evolution FIVE functions Gamma genesis Health Organization immune Immune escape Infectivity mechanism Mutation new SARS-CoV-2 occur omicron potential mechanism potential mechanisms protein structure SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 spike protein SARS-CoV-2 strain SARS-CoV-2 variants Scientific community spike Spike protein strain the SARS-CoV-2 the spike protein variant variants viral infection Virus neutralization World Health Organization [DOI] 10.3390/v14030640 PMC 바로가기 [Article Type] Review
OraSure InteliSwab ™ Rapid Antigen Test Performance with the SARS-CoV-2 Variants of Concern-Alpha, Beta, Gamma, Delta, and Omicron알파, 베타, 감마, 델타, 오미크론의 SARS-CoV-2 변종을 사용한 OraSure InteliSwab ™ 신속한 항원 테스트 성능Article Published on 2022-03-062022-09-11 Journal: Viruses [Category] SARS, 변종, 치료기술, 치료법, 치료제, [키워드] Alpha Beta cell culture medium comparable COVID-19 COVID-19 pandemic culture medium Delta diagnostic tests dilution series dilution sery evaluate evaluated FDA function Gamma human population inoculated investigated Lateral flow device limit of detection Limits of detection Lineage no decrease nucleocapsid protein omicron oropharyngeal swab oropharyngeal swabs performance Rapid rapid antigen-detecting test Rapid test Recombinant nucleocapsid protein recorded resulting RNA RNA copies SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 strain sensitivity strain Syrian golden hamster Syrian Golden hamsters Test the SARS-CoV-2 variant variants variants of concern VoC VOCs was determined [DOI] 10.3390/v14030543 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Virus-Like Particle Neutralizing Capacity in Blood Donors Depends on Serological Profile and Donor-Declared SARS-CoV-2 Vaccination History혈액 기증자의 SARS-CoV-2 바이러스 유사 입자 중화 능력은 혈청학적 프로필과 기증자가 선언한 SARS-CoV-2 예방 접종 이력에 따라 다릅니다.Research Article Published on 2022-02-162022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha analyzed anti-RBD anti-receptor-binding domain anti-S Anti-spike antibody approach B.1.1.7 B.1.351 B.1.617.2 Beta Blood blood donor Blood donors breadth Canadian Capacity characterized coronavirus cross-sectional cross-sectional design Delta Donor elevated Evidence evidence of Gamma groups history humoral indicate initial initial stages less neutralization neutralization assays neutralization capacity Neutralizing Neutralizing antibodies neutralizing antibody neutralizing capacity Neutralizing titer neutralizing titers nucleocapsid Particle plasma presence or absence profile Protein Pseudotyped virus random Receptor-binding domain reduced repeated respiratory SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 vaccine SARS-CoV-2 variant second dose second dose of vaccine service severe acute respiratory syndrome Coronavirus signal significantly specimen spike Stage stratified subset unlikely vaccination Vaccine variant variants of concern virus-like particles VLP VLPs VoC VOCs was used wild type wild-type [DOI] 10.1128/spectrum.02262-21 PMC 바로가기 [Article Type] Research Article
Design of a mutation-integrated trimeric RBD with broad protection against SARS-CoV-2Article Published on 2022-02-152022-10-04 Journal: Cell Discovery [Category] 변종, [키워드] analyses Antigen Beta Biological techniques Delta demonstrated Heterologous highlight hotspot immune response immunology in vivo Live virus mice Mutation Neutralization assay Neutralizing activity Neutralizing antibody titer Protective provided RBD SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants selected significantly higher spike receptor-binding domain strain tested the SARS-CoV-2 Trial trimeric trimeric RBD Vaccine vaccine candidate variants [DOI] 10.1038/s41421-022-00383-5 PMC 바로가기 [Article Type] Article
SARS-CoV-2 prolonged infection during advanced HIV disease evolves extensive immune escapeBrief Report Published on 2022-02-092022-10-31 Journal: Cell Host & Microbe [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] Abstract advanced HIV disease antibody Beta Beta variant BNT162b2 convalescent plasma Delta delta variant elicited escaped Evolution example help HIV HIV disease hosts Immune escape Immunity implication infections mapped Mutation neutralization omicron other variants Pfizer predict Prolonged infection regions SARS-CoV-2 SARS-CoV-2 evolution SARS-COV-2 infection SARS-CoV-2 strain serological South tested Vaccine variant variants variants of concern virus [DOI] 10.1016/j.chom.2022.01.005 PMC 바로가기 [Article Type] Brief Report
Immunodominant Linear B-Cell Epitopes of SARS-CoV-2 Spike, Identified by Sera from K18-hACE2 Mice Infected with the WT or Variant VirusesArticle Published on 2022-02-072022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Analysis anti-viral antibody approach B-cell epitope B.1.1.7 B.1.351 Beta collected contribute COVID-19 COVID-19 vaccine cross-protective diagnostic Efficacy epitope epitope mapping examined Frequency Genetic variant host cell humoral Identified immune immunodominant immunogenic immunological Immunotherapy implication in vitro experiment Infection K18-hACE2 linear epitope linear epitopes mice neutralization tests SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 strain SARS-CoV-2 variants serum sample serum samples spike Spike protein targets the SARS-CoV-2 the spike protein transgenic viral entry virus variant [DOI] 10.3390/vaccines10020251 PMC 바로가기 [Article Type] Article
Structural Comparison and Drug Screening of Spike Proteins of Ten SARS-CoV-2 VariantsResearch Article Published on 2022-02-012022-10-29 Journal: Research [Category] COVID-19, [키워드] ACE2-RBD acute respiratory syndrome Analysis anti-SARS-CoV-2 antibody Beta Cell Characteristics Cluster Clustering analysis complexes Compound contribute coronavirus Delta delta variant drug Endemic Epsilon experimental validation feature Gamma immune evasion in vitro in vivo induce Infection Iota knowledge Lambda Medicines Mutation NTD pandemic pathophysiology potential therapy predicted Protein protein sequence provided RBD SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants Screening similarity spike Spike protein Strains Structure structures the binding affinity the epidemic the SARS-CoV-2 the spike protein understanding unique variant variants Virtual screening ZINC database [DOI] 10.34133/2022/9781758 PMC 바로가기 [Article Type] Research Article