SARS-CoV infection – Page 7 – Communicable Diseases Research

Identification of a novel conserved HLA-A*0201-restricted epitope from the spike protein of SARS-CoV

Research article

Published on 2009-12-032022-10-27
Journal: BMC Immunology [Category] Coronavirus,

Cleavage of the SARS Coronavirus Spike Glycoprotein by Airway Proteases Enhances Virus Entry into Human Bronchial Epithelial Cells In Vitro

Research Article

Published on 2009-11-172022-10-28
Journal: PLoS ONE [Category] Coronavirus,

[키워드] 16HBE ACE2 ACE2 binding Activation acute respiratory syndrome against SARS-CoV airway Amino acid Analysis arginine residue bronchial bronchial epithelial cell cell entry Chromatography cleavage cleaved coronavirus demonstrated dependent on different Efficacy Efficiency exhibited expand expressing expression Extracellular finding full-length glycoprotein host cell HPLC Human implication in vitro investigated lack liquid mechanism molecular basis mutant not affect performance potential therapeutic agent protease Proteases Protein R667 R797 Receptor binding regulate Respiratory system S-protein SARS-CoV SARS-CoV infection Sequencing shown spike susceptibility susceptible Treatment trimer trypsin viral entry viral envelope virus virus entry
[DOI] 10.1371/journal.pone.0007870 PMC 바로가기 [Article Type] Research Article

MicroRNome Analysis Unravels the Molecular Basis of SARS Infection in Bronchoalveolar Stem Cells

Research Article

Published on 2009-11-132022-10-28
Journal: PLoS ONE [Category] Coronavirus,

[키워드] ACE2 Activation acute infectious disease acute respiratory syndrome Basis bronchoalveolar caused CD45 Cell cellular miRNA complex interaction coronavirus SARS-CoV Data analysis Deterioration develop diagnostic Disease progression downregulated downregulation enrichment analysis epithelial evade Factors host cell host–virus interaction immune Infection inflammatory chemokines interact knowledge lung lung failure lung tissue marker microRNA miRNA miRNAs molecular mechanism Mortality observation pathway Protein target pulmonary fibrosis Replication reveal SARS-CoV SARS-CoV infection severe spike Stage STEM stem cell subset suppress target target cell the SARS epidemic Transmission viral genome Viral transmission virus
[DOI] 10.1371/journal.pone.0007837 PMC 바로가기 [Article Type] Research Article

MyD88 Is Required for Protection from Lethal Infection with a Mouse-Adapted SARS-CoV

Research Article

Published on 2008-12-122022-10-29
Journal: PLoS Pathogens [Category] Coronavirus, MERS,

[키워드] 2003 absence adapter addition animal model antiviral therapies Atypical Author BALB/c mice C57BL/6 caused Cell characterized chemokine Chemokine receptor chest X-ray China circulating Clinical course compared contribute coronavirus correlated Course CoV death disease disease pathogenesis early response exhibited expression Factor function Genetic greater Host host gene Host immune response humans identify immune immune system Infection Inflammatory Inflammatory response innate immune intranasal Laboratory lethal Lower respiratory tract lung Lung inflammation lung tissue Lungs mice monocyte monocytes/macrophage Mortality mouse-adapted SARS-CoV Pneumonia Post-infection Proinflammatory cytokine protection Protein provide Pulmonary pathology receptor recruitment Replication required respiratory virus respond SARS-CoV SARS-CoV infection severe lung pathology Signaling significantly higher Spread susceptible TLR Travel Viral load viral loads viral replication virus wild-type
[DOI] 10.1371/journal.ppat.1000240 PMC 바로가기 [Article Type] Research Article

Roles of TNF -α gene polymorphisms in the occurrence and progress of SARS-Cov infection: A case-control study

Research Article

Published on 2008-02-292022-10-28
Journal: BMC Infectious Diseases [Category] Coronavirus,

Functional Genomics Highlights Differential Induction of Antiviral Pathways in the Lungs of SARS-CoV–Infected Macaques

Research Article

Published on 2007-08-102022-10-29
Journal: PLoS Pathogens [Category] Coronavirus, MERS,

[키워드] activate activated acute phase acute respiratory distress acute respiratory syndrome Admission Adult against SARS-CoV analyzed Antiviral antiviral signaling Atypical Author cause Cell cells characterized chemokine genes chemokines circumvent Complication coronavirus Critical cynomolgus macaque cytokine demonstrated early IFN signaling Effect event examined functional gene expression profile gene signature Genomics highlight Host host response IFNs IL-8 immune response immunohistochemistry in vitro experiments individuals induction Infection innate immune response Innate immunity intensive care involved IP-10 lung Lung pathology macaque macaques nuclear translocation Pathogenesis pathogenic pathway phosphorylated Pneumonia protective immune response regulated required SARS patient SARS-CoV SARS-CoV infection SARS-CoV–infected cells severe shown Stat1 subset syndrome Transcription transcription factor type I interferon viral infection virus virus replication
[DOI] 10.1371/journal.ppat.0030112 PMC 바로가기 [Article Type] Research Article

SARS-CoV replication and pathogenesis in an in vitro model of the human conducting airway epithelium

Article

Published on 2007-04-232022-11-01
Journal: Virus research [Category] Coronavirus, MERS,

[키워드] addition airway airway epithelial cells airway epithelium Antisera apical surface Atypical Calu-3 Calu-3 cell Cell cells cellular Characteristics ciliated ciliated cell consequence coronavirus coronavirus pathogenesis Coronavirus replication Culture cultures detected develop did not reduce dry cough efficient enzyme Epidemics epithelial epithelial cell epithelial cell line Experimental result feature Fever fluorescent Frame GFP hACE2 HAE Human human airway epithelia human airway epithelial Human airway epithelium human lung human pathogen in vitro in vitro model in vivo Infection inoculated insertion late stage log Lower respiratory tract lung lung epithelial mechanism Morphological new strain onset of symptoms ORF Pathogenesis pathology physiological Pneumonia Post-infection primary cell progeny virion Protein provide reached receptor reduced replicate replicated Replication reported reservoir respiratory virus resulting SARS Coronavirus SARS-CoV SARS-CoV GFP SARS-CoV infection Support susceptible target tight junction Trachea Vero E6 viral infection viral replication viral titer virus wild type zoonotic
[DOI] 10.1016/j.virusres.2007.03.013 PMC 바로가기 [Article Type] Article

Using patient-collected clinical samples and sera to detect and quantify the severe acute respiratory syndrome coronavirus (SARS-CoV)

Research

Published on 2007-03-272022-10-28
Journal: Virology Journal [Category] Coronavirus,

Factors associated with nosocomial SARS-CoV transmission among healthcare workers in Hanoi, Vietnam, 2003

Research Article

Published on 2006-08-142022-10-28
Journal: BMC Public Health [Category] Coronavirus,

[키워드] 2003 95% confidence interval activity Analysis antibody assigned attack rate calculated Care Case-control category collected Community coronavirus cough detected disease Evidence Factor Fever group healthcare worker help highest highlight Hong Kong hospital implication increased risk individuals Infection Influenza lowest nosocomial Nurse occurred other respiratory infection outbreak Patient recommendation reported respiratory Result risk risk factor SARS-CoV SARS-CoV infection serologic serum severe specimen Spread subsequent Symptom the patient Transmission Univariate analysis was performed
[DOI] 10.1186/1471-2458-6-207 PMC 바로가기 [Article Type] Research Article

Human Monoclonal Antibody Combination against SARS Coronavirus: Synergy and Coverage of Escape Mutants

Research Article

Published on 2006-07-042022-10-29
Journal: PLoS Medicine [Category] Coronavirus,

[키워드] 2003 acute respiratory syndrome Administered affected against SARS-CoV Alter Amino acid anti-SARS-CoV antibody antibody antibody concentration Antigen antigens approach arising Bacteria binding blocked Blood breadth carried caused center China close contact close person-to-person contact Combination complementary Concentration Control convalescent SARS patient coronavirus Coverage CR3014 CR3022 died different disease disease severity dose Effect effective Epidemic Epidemics epitope escape experiment feasible ferret ferrets finding generate glycoprotein Guangdong Health healthy Hong Kong Human human cell human cells human macrophage Human monoclonal antibody humans immune Immune escape immunization immunize in vitro individual effects Infected infecting Infection infectious Infectious disease information interact Interaction International killing Laboratory less limit lung damage Lung pathology mAb mAbs measure monoclonal monoclonal antibody Mutation neutralization neutralized NO organism Patient pharyngeal Prevent prevented prevention producing Prophylaxis provided quarantine recognize recognizing reduce reduction repeated replicated required Research researcher residue responsible SARS epidemic SARS-CoV SARS-CoV infection screened shown sick Spread strain suppress synergistic synergistic fashion synergy tested the disease the receptor-binding domain Travel treat variant variants viral escape viral spread virus Virus neutralization virus strain virus-neutralizing viruses website Wikipedia World Health Organization
[DOI] 10.1371/journal.pmed.0030237 PMC 바로가기 [Article Type] Research Article