senescence – Page 7 – Communicable Diseases Research

The role of senescent T cells in immunopathology

Review

Published on 2020-11-092022-10-28
Journal: Aging Cell [Category] Coronavirus, MERS, SARS,

Companion animals likely do not spread COVID-19 but may get infected themselves

Review

Published on 2020-10-012023-05-31
Journal: GeroScience [Category] SARS, 조류인플루엔자,

[키워드] aging SARS-CoV-2 senescence
[DOI] 10.1007/s11357-020-00248-3 PMC 바로가기 [Article Type] Review

Cellular senescence as a potential mediator of COVID‐19 severity in the elderly

Review

Published on 2020-09-212022-10-28
Journal: Aging Cell [Category] COVID-19, MERS, SARS,

[키워드] accumulate advanced age alleviate association Biomarker cellular cellular senescence characterized complex Consequences contribute coronavirus disease COVID‐19 COVID‐19 patient Cytokine storm detrimental disease disease severity distress early phase Efficacy evaluate Factor functional growth Health identifying IMPROVE individual infect inflammatory reaction limit Lower respiratory tract lung failure mechanism novel Betacoronavirus Older Pathogenesis Prevent promote rising mortality risk SARS‐CoV‐2 SARS‐CoV‐2 infection second senescence senescent cell severe complication severity syndrome the disease therapy tissue damage Vaccinations Vaccine vaccine response
[DOI] 10.1111/acel.13237 PMC 바로가기 [Article Type] Review

Single-cell transcriptomic atlas of primate cardiopulmonary aging

Article

Published on 2020-09-102022-10-04
Journal: Cell Research [Category] MERS, SARS, 신약개발, 진단, 치료제,

Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis

Pharmacology

Published on 2020-09-092022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] acute respiratory syndrome age aging alteration Analysis analyzed assessment association attrition axis CDKN1C cellular senescence chronic obstructive chronic obstructive pulmonary diseases contribute COPD coronavirus COVID-19 COX10 COX18 differentially expressed DNA damage DPP4 ERCC1 Factor FEN1 FIS1 furin GADD45A GADD45B Gene Expression HAT1 HSPD1 Human human lung tissue Idiopathic pulmonary fibrosis immunoblot Infection Infectious disease Inflammatory IPF lung Lung diseases mechanism Mitochondria mitochondrial Mitochondrial function NBN NFATC1 NOX4 Older PARP1 Patient patients PCNA pharmacological target platform processed progression protease Protein PTEN pulmonary disease pulmonary fibrosis Quality control RAD17 receptor ACE2 regulate Result RHOT2 RNA SARS-CoV-2 senescence SIRT6 slight increase SLX4 Smokers subject subjects target gene Target genes telomere TERT the SARS-CoV-2 TMPRSS2 TNKS2 Total Transcription UCP2
[DOI] 10.3389/fphar.2020.584637 PMC 바로가기 [Article Type] Pharmacology

Age influences the thermal suitability of Plasmodium falciparum transmission in the Asian malaria vector Anopheles stephensi

연령은 아시아 말라리아 매개체인 Anopheles stephensi에서 Plasmodium falciparum 전파의 열적 적합성에 영향을 미친다.

Article

Published on 2020-07-292024-08-11
Journal: Proceedings of the Royal Society B: Biological Sciences [Category] 말라리아,

[키워드] Anopheles life history malaria senescence temperature Transmission
[DOI] 10.1098/rspb.2020.1093 PMC 바로가기

Silibinin and SARS-CoV-2: Dual Targeting of Host Cytokine Storm and Virus Replication Machinery for Clinical Management of COVID-19 Patients

Perspective

Published on 2020-06-072022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

[키워드] acute respiratory distress caused clinical clinical setting clinical testing clinical trial coronavirus COVID-19 Cytokine storm drug candidate effective evaluate expected function global pandemic global public health Host IL-6 immune Infection Inflammatory cytokine inhibitor interferon Jak limit lymphopenia mechanism monoclonal antibody novel coronavirus SARS-CoV-2 Open-label Patient predicted provide Randomized reduce Remdesivir replication/transcription machinery responses RNA-dependent RNA polymerase senescence severe COVID-19 Signaling silibinin Spain STAT3 storm syndrome T-cell targeting the cytokine storm therapeutic efficacy Viral load virus replication
[DOI] 10.3390/jcm9061770 PMC 바로가기 [Article Type] Perspective

COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?

Research Perspective

Published on 2020-04-302022-10-28
Journal: Aging (Albany NY) [Category] COVID-19, MERS, SARS,

[키워드] ACE-2 age aging angiotensin-converting enzyme 2 antibiotic Antibiotics association Azithromycin Beta-galactosidase CD26 cellular China clinical trial Compound Corona virus COVID-19 COVID-19 disease COVID-19 infection disease doxycycline drug Drug repurposing FDA-approved drugs functional host receptor Hydroxy-chloroquine Hypothesis IL-6 inhibit inhibitor marker MERS Middle East mortality rate Other pandemic Patient preventing the transmission prevention prevention of COVID-19 profiles protein synthesis quercetin question Rapamycin respiratory resulting SARS-CoV-2 SASP senescence senolytic drug therapy Side-effect Spread Treatment viral replication virus zoonotic
[DOI] 10.18632/aging.103001 PMC 바로가기 [Article Type] Research Perspective

Theory and strategy for Pneumococcal vaccines in the elderly

노인용 폐렴구균 백신에 대한 이론과 전략

Review

Published on 2016-02-252024-08-04
Journal: Human vaccines & immunotherapeutics [Category] 폐렴구균 감염증,

[키워드] aging elderly pneumococcal conjugate vaccine Pneumococcal diseases Pneumococcal polysaccharide vaccine pneumococcal vaccines senescence
[DOI] 10.1080/21645515.2015.1075678 PMC 바로가기 [Article Type] Review

Modelling Anopheles gambiae s.s. Population Dynamics with Temperature- and Age-Dependent Survival

온도 및 연령 의존 생존율을 고려한 Anopheles gambiae s.s. 개체군 동역학 모델링

Article

Published on 2015-05-282024-08-13
Journal: International Journal of Environmental Research and Public Health [Category] 말라리아,

[키워드] Anopheles gambiae s.s Climate change malaria Mathematical modelling mosquito population dynamics senescence vector-borne diseases
[DOI] 10.3390/ijerph120605975 PMC 바로가기 [Article Type] Article