Effects of Coronavirus Disease 2019 (COVID-19) on Peripheral Blood Lymphocytes and Their Subsets in Children: Imbalanced CD4 + /CD8 + T Cell Ratio and Disease SeverityPediatrics Published on 2021-04-142022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] abnormality acute respiratory syndrome Analysis analyzed CD4 CD4+/CD8+ lymphocytes CD8 center children complete blood count coronavirus COVID-19 cytokine described disease Effect group hematological hospitalized patient Hyper-inflammatory responses immune response immune system laboratory feature lymphocyte lymphocyte subpopulation Lymphocyte subset lymphopenia Medical Sciences Mild Pathogenesis pathology Patient Pediatric patient peripheral Pneumonia Ratio real-time RT-PCR reported Sample size SARS-CoV-2 SARS-COV-2 infection Seven Severe case severe COVID-19 severe group severe pneumonia subject subset T cell Tehran the disease university while [DOI] 10.3389/fped.2021.643299 PMC 바로가기 [Article Type] Pediatrics
Downregulation of type III interferons in patients with severe COVID‐19Observational Study Published on 2021-04-132022-10-04 Journal: Journal of medical virology [Category] MERS, SARS, 바이오마커, 임상, [키워드] Admission alteration C‐reactive protein Characteristics chemokine conducted Coronavirus disease 2019 COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 cytokine disease disease severity ferritin fibrinogen group hospital IFN‐lambda indicated Japan knowledge labor lactate dehydrogenase Mild Ministry of Health pathophysiology Patient Protein reduced SARS‐CoV‐2 serum serum cytokine severe group severity significantly higher significantly lower single center the disease the patient two groups type III interferon Welfare [DOI] 10.1002/jmv.26993 PMC 바로가기 [Article Type] Observational Study
Krebs Von den Lungen-6 as a predictive indicator for the risk of secondary pulmonary fibrosis and its reversibility in COVID-19 patientsKrebs Von den Lungen-6은 COVID-19 환자에서 이차성 폐섬유증의 위험과 가역성에 대한 예측 지표입니다.Research Paper Published on 2021-04-102022-08-31 Journal: International Journal of Biological Sciences [Category] MERS, SARS, 바이오마커, 치료기술, [키워드] Analysis AUC clinical clinical information collected Coronavirus disease 2019 COVID-19 COVID-19 patient diagnose dysregulated immune response Efficacy evaluate fibrosis focus hospital Hospital stay immune response Inflammation information Krebs von den Lungen-6 lung Lung function marker moderate nucleic acid nucleic acid test Occurrence Patient predict Predictive pulmonary fibrosis radiological receiver operating characteristic recorded reflect risk ROC SARS-COV-2 infection severe group severity severity of COVID-19 severity of illness survival curve Survival curves [DOI] 10.7150/ijbs.58825 PMC 바로가기 [Article Type] Research Paper
Relationship between changes in the course of COVID-19 and ratio of neutrophils-to-lymphocytes and related parameters in patients with severe vs . common diseaseOriginal Paper Published on 2021-03-292022-11-01 Journal: Epidemiology and Infection [Category] COVID-19, [키워드] accompanied Admission analysed changes in characteristic clinical Clinical characteristics common disease coronavirus disease Course COVID-19 COVID-19 disease severity COVID-19 patient cut-off value Cutoff diagnosed discharged FIVE generate hospitalisation increases in indicated Laboratory lymphocyte Moderate COVID-19 monocyte Neutrophil-to-lymphocyte ratio Neutrophils NLR parameter Patient patients PCT positive correlation procalcitonin relationship SARS-CoV-2 selected sensitivity severe group Severe patient severity severity of COVID-19 significant difference specificity statistically significant Symptoms treated White blood cells [DOI] 10.1017/S0950268821000674 PMC 바로가기 [Article Type] Original Paper
Analysis of Ovarian Injury Associated With COVID-19 Disease in Reproductive-Aged Women in Wuhan, China: An Observational StudyMedicine Published on 2021-03-192022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] accounted adjusted age age-matched control AMH baseline clinical Clinical characteristics conditions COVID-19 COVID-19 disease COVID-19 patient declined diagnosed disorder dysmenorrhea eight Endocrine follicle-stimulating hormone healthy Hierarchical identify increase in independent risk factor Infectious disease Injury Linear regression analysis Luteinizing Hormone marker menstrual observational study ovarian Ovarian injury Ovarian reserve pandemic Patient performed PRL progesterone Randomly recruited reproductive reproductive health risk factor selected serum severe COVID-19 severe group sex hormone Sex hormones Significant significant difference significantly tested Tongji Hospital Variation Volume were recorded with COVID-19 women Wuhan [DOI] 10.3389/fmed.2021.635255 PMC 바로가기 [Article Type] Medicine
Atrial Arrhythmias in Patients with Severe COVID-19Research Article Published on 2021-03-122022-10-31 Journal: Cardiology Research and Practice [Category] COVID-19, [키워드] arrhythmia Bacterial cardiac troponin China city CKMB collected Comorbidity comparison confirmed COVID-19 case COVID-19 COVID-19 patient Critical Critical disease death demographic determine disease Diseases had more Infection information Mortality Myoglobin Occurrence Older Patient patients with COVID-19 plasma Pneumonia positively correlated Prospective Study severe COVID-19 severe group significantly Symptoms Tachycardia temporary treated with COVID-19 Wuhan younger patients [DOI] 10.1155/2021/8874450 PMC 바로가기 [Article Type] Research Article
Clinical features of hypertensive patients with COVID-19 compared with a normotensive group: Single-center experience in ChinaResearch Article Published on 2021-03-032022-10-28 Journal: Open Medicine [Category] COVID-19, [키워드] ACEi/ARB age analyzed Angiotensin-converting enzyme Antibiotic therapy antihypertensive drugs antiviral therapy blocker C-reactive protein China clinical Clinical features Clinical outcome collected Combination common Community Computed tomography conducted Corticosteroid cough COVID-19 COVID-19 patient COVID-19 patients CRP D-dimer demonstrated effective enrolled Epidemiology fatigue feature Fever Gender general treatment greater Ground glass opacity groups Health hospital hypertension hypertensive hypertensive patient IL-6 increased risk Inflammatory response initial International laboratory data lung median age Mild mild case morbidity and mortality no significant difference normotensive patchy Patient patients plasma receptor reported Result Safe SARS-CoV-2 severe cases severe COVID-19 severe group severe viral pneumonia significantly Spread statistically significant Symptom the median therapy treated Treatment Viral pneumonia was used with COVID-19 Wuhan [DOI] 10.1515/med-2021-0225 PMC 바로가기 [Article Type] Research Article
An Interpretable Model-Based Prediction of Severity and Crucial Factors in Patients with COVID-19COVID-19 환자의 심각도 및 중요한 요인에 대한 해석 가능한 모델 기반 예측Research Article Published on 2021-03-012022-09-12 Journal: BioMed Research International [Category] 진단, [키워드] Additive Admission age AUC Chest computed tomography Chest CT clinical clinical information collected Computed tomography coronavirus disease Coronavirus disease 2019 COVID-19 Deterioration distribution early stage enrolled explained Factor Factors groups help IMPROVE information Intervention Laboratory tests lung abnormalities lung involvement lymphocyte machine learning model Mild neutrophil neutrophil count Neutrophil-to-lymphocyte ratio parameter Patient predict prediction Prognosis radiologist reduce mortality sensitivity severe group severity severity of COVID-19 specificity temperature total score with COVID-19 [DOI] 10.1155/2021/8840835 PMC 바로가기 [Article Type] Research Article
An Interpretable Model-Based Prediction of Severity and Crucial Factors in Patients with COVID-19Research Article Published on 2021-03-012022-10-27 Journal: BioMed Research International [Category] COVID-19, MERS, [키워드] Additive Admission age AUC Chest computed tomography Chest CT clinical collected coronavirus disease COVID-19 Deterioration distribution early stage enrolled explained Factor Factors groups help IMPROVE information Intervention Laboratory tests lung abnormalities lung involvement machine learning model Mild neutrophil count Neutrophil-to-lymphocyte ratio parameter Patient predict prediction Prognosis radiologist reduce mortality sensitivity severe group severity severity of COVID-19 specificity temperature total score with COVID-19 [DOI] 10.1155/2021/8840835 PMC 바로가기 [Article Type] Research Article
The Epidemiological and Mechanistic Understanding of the Neurological Manifestations of COVID-19: A Comprehensive Meta-Analysis and a Network Medicine ObservationNeuroscience Published on 2021-02-242022-10-31 Journal: Frontiers in Neuroscience [Category] COVID-19, [키워드] 95% CI acute respiratory syndrome adhesion molecules Analysis C-reactive protein Cell Cerebrovascular disease Clinical characteristics clinical study Coagulation Comprehensive coronavirus coronavirus disease Coronavirus disease 2019 (COVID-19) COVID-19 CRP D-dimer dataset Effect elevated epidemiological host gene infected patient Infection Inflammatory Inflammatory response Inflammatory responses Intensive leukocyte manifestation mean difference mechanism Medicine Meta-analysis nervous system network network medicine neurological manifestation neurological manifestations non-severe group patients with COVID-19 PCT performed populations Prevalence procoagulant procoagulant pathways protein-protein interactome RNA-sequencing SARS-CoV-2 severe COVID-19 severe group stroke the SARS-CoV-2 understanding vascular cell adhesion molecule 1 (VCAM-1) VCAM-1 Via [DOI] 10.3389/fnins.2021.606926 PMC 바로가기 [Article Type] Neuroscience