COVID-19 generates hyaluronan fragments that directly induce endothelial barrier dysfunctionCOVID-19는 내피 장벽 기능 장애를 직접 유도하는 히알루로난 단편을 생성합니다Research Article Published on 2021-09-082022-09-12 Journal: JCI Insight [Category] 진단, [키워드] activity analyzed CD44 circulating circulation Clinical severity Complication contributing to coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical Critical illness damaged Degradation degrade disease dysfunction dysregulated endothelial Endothelial cell enzyme Enzymes Evidence exacerbating Extracellular matrix functions generate glycobiology glycocalyx glycosaminoglycan Hyaluronan hyaluronidase induce Inflammatory cytokine Injury moderate moderate to severe morbidity Organ failure pathologic pathology patients with COVID-19 plasma Protective provide pulmonary regulate released Sepsis Severity of disease significantly Vascular Vascular Biology Vascular injury [DOI] 10.1172/jci.insight.147472 PMC 바로가기 [Article Type] Research Article
The relationship between serum 25-hydroxyvitamin D levels and the severity of COVID-19 disease and its mortalityArticle Published on 2021-09-022022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] Admitted Patient age albumin Analysis analyzed Biochemistry calcium Characteristics Comorbidity Coronavirus disease 2019 correlation COVID-19 creatinine Critical cross-sectional disease Diseases endocrinology evaluated hospitalized patient ICU ICU admission immunology intensive care male Medical research Mild moderate Mortality mortality rate multivariate logistic regression negative correlation participant Patient positive correlation quartile radiologic reduce risk Risk factors serum serum 25-hydroxyvitamin D Serum level severe disease severity severity of COVID-19 Severity of disease significantly Viral pneumonia were measured with COVID-19 [DOI] 10.1038/s41598-021-97017-9 PMC 바로가기 [Article Type] Article
SARS-CoV-2 antibody persistence in COVID-19 convalescent plasma donors: Dependency on assay format and applicability to serosurveillanceCOVID-19 회복기 혈장 기증자에서 SARS-CoV-2 항체 지속성: 분석 형식 및 혈청 감시에 대한 적용 가능성에 대한 의존성Article Published on 2021-09-012022-09-11 Journal: Transfusion [Category] MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] Abbott acute respiratory syndrome addition Algorithm Algorithms antibody antibody waning Antigen applicability association best binding Broad Institute contribute convalescent plasma coronavirus COVID-19 declining demonstrated dependency disease severity Donor greater help heterogeneous IgG include Infection levels of antibody Live virus maximum natural infection neutralization Neutralization assay neutralization assays nucleocapsid persistence PRNT pseudovirus Receptor binding domain reduce reporter Research resolution of symptoms respiratory response response duration Roche SARS-CoV-2 SARS-CoV-2 antibody screened Seven Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Severity of disease stability target tested These data total Ig variety Viral viral particle Vitalant was collected [DOI] 10.1111/trf.16555 PMC 바로가기 [Article Type] Article
What GI Physicians Need to Know During COVID-19 PandemicCOVID-19 팬데믹 동안 소화기 의사가 알아야 할 사항Review Published on 2021-09-012022-09-11 Journal: Digestive diseases and sciences [Category] SARS, 치료기술, [키워드] abnormality ACE-2 receptor anorexia appear caused cell line clearance confounding factor COVID-19 detected in stool diarrhea elevated enzyme Evidence General population GI symptom GI symptoms GI Tract host cells hypoxia infection rate infection rates involved liver Liver disease liver enzyme liver enzymes Liver manifestations: GI symptoms Loss of Smell management medications Mild morbidity and mortality Mortality nausea Patient patients patients with COVID-19 pharyngeal physician proportion recommendation Respiratory illness RNA SARS-CoV-2 Sepsis severe disease Severity of disease Stool Transmission Viral RNA virus vomiting worldwide pandemic [DOI] 10.1007/s10620-020-06625-4 PMC 바로가기 [Article Type] Review
Frailty Assessment in the Emergency Department for Risk Stratification of COVID-19 Patients Aged ≥80 YearsObservational Study Published on 2021-09-012022-10-05 Journal: Journal of the American Medical Directors Associat [Category] SARS, 임상, [키워드] 95% CI 95% confidence interval activities Admission Adults age approach assessment association clinical Clinical characteristics Clinical frailty scale clinical risk Clinical severity Cognitive impairment Cohort Comorbidities Comorbidity conducted COVID-19 Cox regression analysis delirium Dementia Department disease Emergency enrolled evaluate evaluated frailty functional hospital identify In-hospital death independent risk factor interquartile range Italy male Male sex Multimorbidity Older Older adults older patient outcomes overlapping parameter Patient patients with COVID-19 predict presence of comorbidity prospective observational cohort risk stratification scale setting Severity of disease variable was used with COVID-19 Year [DOI] 10.1016/j.jamda.2021.07.005 PMC 바로가기 [Article Type] Observational Study
Comparable endemic coronavirus nucleoprotein-specific antibodies in mild and severe Covid-19 patients경증 및 중증 Covid-19 환자에서 유사한 풍토성 코로나바이러스 핵단백질 특이적 항체Article Published on 2021-09-012022-09-12 Journal: Journal of medical virology [Category] SARS, 진단, [키워드] antibodies antibody Asymptomatic comparable contribute coronavirus COVID-19 Critical cross-reactive immune response death disease disease severity Endemic Endemic coronaviruses healthy Immunity Infection Mild nucleoprotein-specific antibodies. Patient Potential Respiratory disease SARS-CoV-2 SARS-COV-2 infection sera severe symptoms severity Severity of disease subjects Variability [DOI] 10.1002/jmv.27038 PMC 바로가기 [Article Type] Article
Robust Antibody Responses to the BNT162b2 mRNA Vaccine Occur Within a Week After the First Dose in Previously Infected Individuals and After the Second Dose in Uninfected IndividualsBNT162b2 mRNA 백신에 대한 강력한 항체 반응은 이전에 감염된 개인의 경우 첫 번째 접종 후 일주일 이내에, 감염되지 않은 개인의 경우 두 번째 접종 후 발생Immunology Published on 2021-08-262022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료법, [키워드] acquired immunity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Analysis Anti-nucleocapsid antibodies anti-nucleocapsid antibody Anti-spike anti-spike and anti-nucleocapsid antibodies antibody Antibody Response Antibody responses Antibody titre antibody titres Blood blood sample Blood samples BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine collected conducted coronavirus coronavirus disease COVID-19 exposure to first dose FIVE genders HCW HCWs Health care Health care worker immunisation Immunity increase in Incubation period individual infected individuals Kinetics mRNA vaccine occurred offer pandemic path Patient respiratory response restrict viral replication Result robust SARS-CoV-2 second second dose second vaccination serological analysis severe acute respiratory syndrome Coronavirus Severity of disease Spike protein the spike protein titre Trigger vaccinated individual vaccinated individuals vaccination Viral viral replication virus was performed Week [DOI] 10.3389/fimmu.2021.722766 PMC 바로가기 [Article Type] Immunology
The Importance of miRNA Identification During Respiratory Viral InfectionsArticle Published on 2021-08-212022-10-30 Journal: Journal of cellular immunology [Category] COVID-19, [키워드] acute respiratory syndrome Adenovirus AdV cells Coronavirus-2 Critical downregulation expression Factor globe Health highlight HMPV host response hRSV IAV identification immune immune response implicated Importance include Infection infections influenza A virus métapneumovirus miRNA miRNAs modulation non-coding RNA Non-coding RNAs non-immune Pathogenesis regulate reported respiratory respiratory syncytial virus respiratory tract respiratory viral infection respiratory virus respiratory viruses RSV SARS-CoV-2 Severity of disease upregulation viral infection viral replication [DOI] 10.33696/immunology.3.101 PMC 바로가기 [Article Type] Article
No difference in biomarkers of ischemic heart injury and heart failure in patients with COVID-19 who received treatment with chloroquine phosphate and those who did notResearch Article Published on 2021-08-162022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] age average benefit biochemical analysis Biomarker C-reactive protein Chloroquine Chloroquine phosphate clinical trial comparable Control control group controls country COVID-19 creatinine demographics Effectiveness electrocardiogram Electrocardiograms elevated Evidence FIVE group heart failure Heart injury increased risk Laboratory lack median MOST NT-proBNP pandemic Patient patients with COVID-19 promoted receiving Result risk severe adverse events Severity of disease statistically significant difference the study group therapeutic Thrombocytes treat treated Treatment [DOI] 10.1371/journal.pone.0256035 PMC 바로가기 [Article Type] Research Article
Risk factors for mortality in patients over 70 years old with COVID-19 in Wuhan at the early break: retrospective case seriesResearch Article Published on 2021-08-162022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, MERS, SARS, [키워드] Admission Blood urea nitrogen case sery clinical Clinical characteristics Clinical data Clinical outcome collected COVID-19 Critical death early stage elderly Elderly patient enrolled evaluate Factor Fatality rate greater groups help hospitalized patient identify independent risk factor Laboratory Mild moderate Mortality multivariable Cox regression non-survivor outcome Patient patients with COVID-19 physician Renmin Hospital Result retrospective Retrospective study risk factor Risk factors risk of death Severity of disease shown subtype Subtypes supplementary material survivor two groups university urea nitrogen were used with COVID-19 Wuhan [DOI] 10.1186/s12879-021-06450-8 PMC 바로가기 [Article Type] Research Article