small molecule – Page 7 – Communicable Diseases Research

Identification of potent small molecule inhibitors of SARS-CoV-2 entry

SARS-CoV-2 진입의 강력한 소분자 억제제의 식별

Article

Published on 2022-01-012022-09-11
Journal: SLAS discovery : advancing life sciences R & D [Category] SARS, 변종, 신약개발, 치료제,

The Landscape of COVID-19 Research in the United States: a Cross-sectional Study of Randomized Trials Registered on ClinicalTrials.Gov

미국의 COVID-19 연구 환경: ClinicalTrials.Gov에 등록된 무작위 시험의 횡단면 연구

Article

Published on 2022-01-012022-09-11
Journal: Journal of General Internal Medicine [Category] SARS, 임상, 치료기술,

[키워드] antiviral medication Antiviral medications antivirals capita Characteristics Chloroquine chloroquine/hydroxychloroquine clinical endpoint clinical trial clinical trials Composite conducted Controlled trial COVID-19 cross-sectional cross-sectional study deaths Descriptive statistics detect diagnosed with COVID-19 distribution effective evaluate excluded followed by Geographic distribution greater highest highlighting Hydroxychloroquine identify immunomodulator Intervention IQR landscape less lowest measure monoclonal antibodies monoclonal antibody Mortality National ongoing trials pandemic participant pathogen people with COVID-19 Phase 3 power Prevent Primary outcome Randomized Randomized controlled trial Randomized controlled trials randomized trial randomized trials reduction in mortality Registered Relative risk resulting risk reduction Sample size SARS-CoV-2 setting severity single trial single-center small molecule Statistical power the median the United State Treatment treatments for COVID-19 Trial trials United States Vaccine Variability Ventilation
[DOI] 10.1007/s11606-021-07167-9 PMC 바로가기 [Article Type] Article

Discovery of Highly Potent Fusion Inhibitors with Potential Pan-Coronavirus Activity That Effectively Inhibit Major COVID-19 Variants of Concern (VOCs) in Pseudovirus-Based Assays

Article

Published on 2021-12-312022-10-28
Journal: Viruses [Category] COVID-19, SARS,

[키워드] activities activity acute respiratory syndrome ADME African Analysis B.1.1.7 B.1.351 B.1.617.2 bind Candidates Compound concern coronavirus COVID-19 Cytopathic effect delta variant demonstrated distribution facilitate fusion fusion inhibitor half-maximal inhibitory concentration in vivo India inhibited inhibitor inhibitors inhibitory lowest Major MERS-CoV metabolism Middle East Middle East respiratory syndrome (MERS) oral bioavailability pan-coronavirus potent Potential prefusion prevented respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein Severe acute respiratory syndrome (SARS) small molecule South SPR surface plasmon resonance trimer variant variants of concern VOCs
[DOI] 10.3390/v14010069 PMC 바로가기 [Article Type] Article

Compound screen identifies the small molecule Q34 as an inhibitor of SARS-CoV-2 infection

Article

Published on 2021-12-242022-10-30
Journal: iScience [Category] COVID-19,

Inhibition of SARS-CoV-2 by Targeting Conserved Viral RNA Structures and Sequences

Chemistry

Published on 2021-12-232022-10-31
Journal: Frontiers in Chemistry [Category] COVID-19,

Activation of the SARS-CoV-2 NSP14 3′–5′ exoribonuclease by NSP10 and response to antiviral inhibitors

Research Article

Published on 2021-12-202022-10-30
Journal: The Journal of Biological Chemistry [Category] COVID-19, SARS,

[키워드] activate acute respiratory syndrome Analysis antiviral inhibitor antiviral therapeutics biochemical C-terminal complex coronavirus COVID-19 COVID-19, Coronavirus disease 2019 CV, column volume DDEE, residues forming the active site aspartic acid (D) and glutamic acid (E) DMSO, dimethyl sulfoxide DSF, differential scanning fluorimetry ENhance enzyme enzyme kinetics Escherichia coli exonuclease exonucleases Exoribonuclease expression Factor FL, full-length highlight increase in inhibit inhibitor methyltransferase monophosphate MP, monophosphate MTase, methyltransferase N-terminal Ni, nickel nonstructural protein 14 NP-40, Nonidet-P40 nsp10 nsp14 NSP14, nonstructural protein 14 NTA, nitrilotriacetic acid observé producing Protein protein complex protein drug interaction Protein purification protein stability protein–protein interaction Proteins protocol provide purification Remdesivir Replication required RMP, remdesivir monophosphate SAH, S-adenosylhomocysteine SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SEC, size-exclusion chromatography small molecule TCEP, Tris(2-carboxyethyl)phosphine the SARS-CoV-2 the SARS-CoV-2 genome Treatment understanding viral proofreading Viral protein
[DOI] 10.1016/j.jbc.2021.101518 PMC 바로가기 [Article Type] Research Article

Enhancing the Antiviral Potency of Nucleobases for Potential Broad-Spectrum Antiviral Therapies

Article

Published on 2021-12-142022-10-28
Journal: Viruses [Category] COVID-19,

Coronavirus Infection-Associated Cell Death Signaling and Potential Therapeutic Targets

코로나바이러스 감염 관련 세포 사멸 신호 및 잠재적 치료 표적

Review

Published on 2021-12-092022-09-10
Journal: Molecules [Category] SARS, 치료제,

[키워드] (RdRp 3CLpro ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-apoptotic Anti-inflammatory antiviral properties Apoptosis assembly autophagy BCL-2 can be used caused celastrol cell death cell death pathways Chloroquine chloroquine/hydroxychloroquine Compound coronavirus CoV infection COVID-19 COVID-19 treatment Critical Curcumin cysteine Cytokines death deaths Effect Efficacy enzyme expression FIVE flavonoids Frame group Helicase host cell Hydroxychloroquine induce Infection Inflammation inhibiting inhibitor Inhibitory effects interactions involved L-cysteine life cycle mechanism mitigate modify molecular target molecules MPro name natural natural compounds necroptosis NF-κB NF-κB signaling NLRP3 inflammasome non-structural protein nonstructural protein 1 nsp1 Nsp12 occurred Open reading frame ORF7a outcomes Papain play roles PLPro Potential progression proliferation promote Propagation protease Protein proteinase pyroptosis RdRP Regulated cell death Replication responsible RNA RNA dependent RNA polymerase RNA polymerase SARS-CoV infection SARS-CoV-2 SARS-CoV-2-infected patients Serine serine 2 severe acute respiratory syndrome Coronavirus Signaling small molecule specific inhibitor spike Spike protein survival target targeted therapy the disease therapeutic targeting TMPRSS2 TNF transmembrane transmembrane protease serine 2 Treatment variety Viral viral entry viral infection viral life cycle virions XIAP yielding
[DOI] 10.3390/molecules26247459 PMC 바로가기 [Article Type] Review

Metabolites with SARS-CoV-2 Inhibitory Activity Identified from Human Microbiome Commensals

Research Article

Published on 2021-12-012022-10-30
Journal: mSphere [Category] COVID-19, SARS,

[키워드] activity Anti-SARS-CoV-2 Activity Antiviral antiviral activities antiviral activity antiviral property antivirals Bacteria bacterial metabolite Bioactivity Biochemistry biological activities clinically commensal complement Compound COVID-19 COVID-19 pandemic Culture drug Evidence examined fraction functional host receptor Human Identified identify in vitro inhibit SARS-CoV-2 inhibiting inhibitory concentration Isolation ligands metabolite Microbiome Molecular biology natural antiviral phylogenetically platform prevalence of COVID-19 Prevent produced receptor reported SARS-CoV-2 SARS-COV-2 infection screened similarity small molecule Therapies Treatment variant viral infections Virology
[DOI] 10.1128/mSphere.00711-21 PMC 바로가기 [Article Type] Research Article

dockECR: Open consensus docking and ranking protocol for virtual screening of small molecules

dockECR: 소분자의 가상 스크리닝을 위한 개방형 합의 도킹 및 순위 지정 프로토콜

Article

Published on 2021-12-012022-09-11
Journal: Journal of molecular graphics & modelling [Category] SARS, 치료기술, 치료제,