Mutations in the B.1.1.7 SARS-CoV-2 Spike Protein Reduce Receptor-Binding Affinity and Induce a Flexible Link to the Fusion PeptideArticle Published on 2021-05-082022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] A570D ACE2 ACE2 binding Affect affected affinity Analysis B.1.1.7 B.1.1.7 variant binding affinity biochemical Cell consequence Contact COVID-19 D614G D614G mutation fusion fusion peptide Interaction interface region linear molecular Molecular dynamics simulation Mutation N501Y N501Y mutation Patient RBD Receptor binding reduced Salt Bridge SARS-CoV-2 significantly spike Spike protein stability starting point structural flexibility The B.1.1.7 the RBD the receptor-binding domain the SARS-CoV-2 the SARS-CoV-2 virus the spike protein trimer variant virus wild type [DOI] 10.3390/biomedicines9050525 PMC 바로가기 [Article Type] Article
Priority Given to Technology in Government-Based Mental Health and Addictions Vision and Strategy Documents: Systematic Policy ReviewReview Published on 2021-05-052022-10-30 Journal: Journal of Medical Internet Research [Category] Coronavirus, SARS, [키워드] Addiction Addictions addressed Analysis baseline Care category conducted COVID-19 COVID-19 pandemic described Digital health digital mental health E-health E-mental health English Evidence French Frequency highest highlighting indicate information knowledge less mental health mental health service mHealth MONITOR objective Policy priority researchers Result review searched starting point Strategy technology tele translation Virtual care vision [DOI] 10.2196/25547 PMC 바로가기 [Article Type] Review
Ethical considerations and patient safety concerns for cancelling non-urgent surgeries during the COVID-19 pandemic: a reviewReview Published on 2021-04-292022-10-28 Journal: Patient Safety in Surgery [Category] COVID-19, [키워드] Algorithm Analysis analyzed Autonomy Care Clinicians concerning condition cosmetic COVID-19 COVID-19 pandemic cumulative death decrease downstream Elective surgery Ethics global pandemic Health implication Local measure Non-urgent surgery pandemic Patient patient safety Predictive protocol reduce resource risk starting point Stressor surgical the patient transfer treat unique [DOI] 10.1186/s13037-021-00293-7 PMC 바로가기 [Article Type] Review
Metal-Promoted Heterocyclization: A Heterosynthetic Approach to Face a Pandemic Crisis금속 촉진 이형 고리화: 팬데믹 위기에 직면하기 위한 이형 합성 접근법Review Published on 2021-04-292022-09-10 Journal: Molecules [Category] MERS, SARS, 치료제, [키워드] administration Anti-inflammatory anticancer Antiviral approved drugs battle Bioactivity can not changed construction coronavirus crisis drug drugs targeting effective response everyday life face focus heterocyclization life metal-promoted mitigate outbreak pharmaceutical industry pharmacological plethora SARS-CoV-2 SARS-CoV-2 coronavirus Scientific community skeleton starting point Vaccine virus [DOI] 10.3390/molecules26092620 PMC 바로가기 [Article Type] Review
Mindfulness and Other Simple Neuroscience-Based Proposals to Promote the Learning Performance and Mental Health of Students during the COVID-19 PandemicReview Published on 2021-04-272022-10-28 Journal: Brain Sciences [Category] COVID-19, [키워드] adverse effect Anxiety association cognitive COVID-19 COVID-19 pandemic decrease education Effect effective hypothese impairment information learning loneliness memory mental health mindfulness neuroscience Other pandemic performance physical activity positive Psychological well-being recommendation reported Research shown simple starting point Stress student tested [DOI] 10.3390/brainsci11050552 PMC 바로가기 [Article Type] Review
Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking결정학적 스크리닝 및 컴퓨터 도킹을 통해 확인된 SARS-CoV-2의 Nsp3 매크로도메인에 대한 단편 결합Research Article Published on 2021-04-142022-08-13 Journal: Science Advances [Category] Biochemistry, COVID-19, SARS, [키워드] active site acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adenosine adenosine diphosphate Antiviral Antiviral agents antiviral target binding catalytic chemotype chemotypes conformational coronavirus counteract Data collection differential scanning fluorimetry docking effort enzyme Fluorescence foundation fragment heterogeneity homogeneous host-mediated antiviral adenosine diphosphate–ribosylation signaling inhibitor inhibitors isothermal titration calorimetry macrodomain macrodomain-binders massive Mutation nonpathogenic nonstructural protein 3 physiological temperature protein 3 provide respiratory SARS-CoV-2 selected severe acute respiratory syndrome Coronavirus Signaling starting point starting points Structure unique virus viruses X-ray data collection [DOI] 10.1126/sciadv.abf8711 PMC 바로가기 [Article Type] Research Article
Algae-Derived Bioactive Molecules for the Potential Treatment of SARS-CoV-2SARS-CoV-2의 잠재적 치료를 위한 조류 유래 생리활성 분자Review Published on 2021-04-082022-09-10 Journal: Molecules [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] accelerate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Algae algae compounds anti-SARS-CoV-2 antibody Antiviral antiviral agent attributes bioactive entities can be used caused Compound coronavirus COVID-19 COVID-19 disease COVID-19 treatment Defense diagnostics disease Diseases Effective vaccines extreme extreme environments Health Immunity immunomodulatory immunostimulatory IMPROVE mechanism metabolite microbial molecule ocean pharmacological pharmacological uses Potential public health threat Research respiratory robust SARS-CoV-2 scientist severe acute respiratory syndrome Coronavirus Spread starting point suppress therapeutic therapeutic aspects treat unique Vaccine Viral viral infections [DOI] 10.3390/molecules26082134 PMC 바로가기 [Article Type] Review
The Scoliosis Research Society adult spinal deformity standard outcome setConsensus Study Published on 2021-04-062022-10-29 Journal: Spine Deformity [Category] Coronavirus, MERS, SARS, [키워드] accelerate Adult spinal deformity ASD back pain Care cause classification claudication Clinical outcome clinically clinician Core outcome set DelPhi Delphi technique disability disease domain Efficacy expected increase increase in Intervention Metrics MONITOR outcome outcomes outcomes assessment Pain Patient patient reported Patient-reported outcomes plethora Prevalence Pulmonary function reached recent reported Result Society spine starting point supplementary material the timing Treatment was used [DOI] 10.1007/s43390-021-00334-2 PMC 바로가기 [Article Type] Consensus Study
An Agent-Based Model of the Local Spread of SARS-CoV-2: Modeling StudyOriginal Paper Published on 2021-04-062022-10-31 Journal: JMIR Medical Informatics [Category] COVID-19, [키워드] adopted affected agent Agent-based modeling approaches Brazil computation computational epidemiology Computational models Containment measure containment measures country COVID-19 COVID-19 cases deaths demonstrated diffusion Effect Epidemiology expected Germany Government ICU Immunity Infection intensive care Italy limit measure Model modeling National objective occupancy rate pandemic Policy populations produced provide provided public health reached reflected Regulation Result SARS-CoV-2 second wave Spread spread of COVID-19 starting point variable variables virus World Health Organization Wuhan, China [DOI] 10.2196/24192 PMC 바로가기 [Article Type] Original Paper
Repurposing of some anti-infective drugs for COVID-19 treatment: A surveillance study supported by an in silico investigationCOVID-19 치료를 위한 일부 항감염제의 용도 변경: in silico 조사에 의해 뒷받침되는 감시 연구Article Published on 2021-04-012022-09-11 Journal: International journal of clinical practice [Category] SARS, 신약개발, 치료기술, 치료제, [키워드] AAK1 added Admission ADP-ribose anti-infective drug antimicrobial Antimicrobials applied Azithromycin binding binding free energy binding mode binding modes Clinical finding Clinical findings clinical outcomes Combination Compound computational studies Computational study COVID-19 death detect diarrhoea docked docking experiment docking experiments docking score doxycycline drug effective Efficacy enrolled explain females four groups free energy Free energy calculations group IMPROVE in silico in vitro inhibitors intensive care kinase lead MDs Mild mild to moderate moderate Moderate COVID-19 moderate symptoms molecular molecular dynamic simulations nitazoxanide not seen outcomes phosphatase Protein target replacement reported repurposing required Reverse transcription-polymerase chain reaction ribose starting point subject subjects supported Surveillance Symptom symptomatic improvement therapeutic potential treated treating COVID-19 Treatment turn Viral [DOI] 10.1111/ijcp.13877 PMC 바로가기 [Article Type] Article