Amino acid sensing pathway: A major check point in the pathogenesis of obesity and COVID-19아미노산 감지 경로: 비만과 코로나19 발병의 주요 체크포인트Review Published on 2021-04-012022-09-11 Journal: Obesity Reviews [Category] SARS, 유전자 메커니즘, [키워드] Activation aggravate Amino acid amino acid sensor GCN2 amino acids antiviral response Comorbidities Comorbidity correlation COVID-19 COVID-19 susceptibility deficiency effective GCN2 Host host cell host cells Hyperactivation IL-1β increase Infection Inflammation inhibiting interleukin interleukin-1 beta intestinal inflammation mammalian mechanism mitigate Mortality mTOR obesity obesogenic opposite overnutrition oxygen Pathogenesis Pathologies pathway pro-inflammatory cytokine Rapamycin reactive oxygen species reactive oxygen specy Replication reprogramming ROS SARS-CoV-2 serum shown suppresse susceptibility translation translational viral infections Viremia while with COVID-19 [DOI] 10.1111/obr.13221 PMC 바로가기 [Article Type] Review
In Vitro Antiviral Activities of Salinomycin on Porcine Epidemic Diarrhea VirusArticle Published on 2021-03-302022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Activation activity ameliorated antivirals can be used catastrophic coronavirus develop dose-dependent manner effective vaccine epidemic diarrhea Impact increase in independent Infection inhibit inhibited JNK lack MAPK MAPK pathway oxidative Particles pathway PEDV reactive Replication ROS Salinomycin signaling pathway significantly suppresse therapeutic option Vero Cell Vero cells viral-induced virus [DOI] 10.3390/v13040580 PMC 바로가기 [Article Type] Article
1 H, 13 C, and 15 N backbone chemical-shift assignments of SARS-CoV-2 non-structural protein 1 (leader protein)Article Published on 2021-03-262022-10-27 Journal: Biomolecular Nmr Assignments [Category] COVID-19, [키워드] 5′ untranslated region backbone biochemical C-terminus caused cleaved complexes coronavirus 2 COVID-19 COVID-19 pandemic domain drug target element ENCODE facilitate full-length SARS-CoV-2 Health Host immune function Interaction Lung disease N-terminal domain New drug targets NMR NMR spectroscopy non-structural protein non-structural proteins nsp1 Open reading frame ORF1a ORF1b ORFs overlapping physiological function polyprotein Protein Proteins Research respiratory RNA SARS-CoV-2 SARS-CoV-2 genome secondary structure Support suppresse the SARS-CoV-2 genome translation Treatment UTR Viral RNA virulence [DOI] 10.1007/s12104-021-10019-6 PMC 바로가기 [Article Type] Article
1 H, 13 C, and 15 N backbone chemical-shift assignments of SARS-CoV-2 non-structural protein 1 (leader protein)Article Published on 2021-03-262022-10-27 Journal: Biomolecular Nmr Assignments [Category] Coronavirus, COVID-19, SARS, [키워드] 5′ untranslated region backbone biochemical C-terminus caused cleaved complexes coronavirus 2 COVID-19 COVID-19 pandemic domain drug target element ENCODE facilitate full-length SARS-CoV-2 Health Host immune function Interaction Lung disease N-terminal domain New drug targets NMR NMR spectroscopy non-structural protein non-structural proteins nsp1 Open reading frame ORF1a ORF1b ORFs overlapping physiological function polyprotein Protein Proteins Research respiratory RNA SARS-CoV-2 SARS-CoV-2 genome secondary structure Support suppresse the SARS-CoV-2 genome translation Treatment UTR Viral RNA virulence [DOI] 10.1007/s12104-021-10019-6 PMC 바로가기 [Article Type] Article
Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice Research Published on 2021-03-252022-10-05 Journal: Nature [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE2 angiotensin-converting enzyme 2 antibodies antibody antibody cocktail approach approaches bind binding cellular receptor detectable disease Donor effective epitope escape mutant feasible IgG independent Lung inflammation mice monoclonal antibodies neutralize parental Prevent PROTECT RBD SARS-COV-2 infection SARS-CoV-2 variant Spike protein suppresse the RBD the receptor-binding domain the SARS-CoV-2 variants of concern viral escape virus wild-type SARS-CoV-2 [DOI] 10.1038/s41586-021-03461-y [Article Type] Research
SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibitionSARS-CoV-2 감염은 숙주 세포 대사를 다시 연결하고 잠재적으로 mTORC1 억제에 취약합니다Article Published on 2021-03-252022-09-12 Journal: Nature Communications [Category] SARS, 진단, [키워드] Activation Air-liquid interface Alter block carbon caused cell line cell lines change changes COVID-19 COVID-19 patient COVID-19 patients cultures determine Efficacy epithelial epithelial cell epithelial cells Evidence evidence of expression facilitate feasible Glucose Glutamine host cell host cell metabolism increase inhibitor kidney lung lung ALI cultures lung tissue mechanism Mechanisms of disease metabolism mTORC1 Mucosal immunology oxidative pandemic of COVID-19 patients Potential treatment potential treatments pyruvate reduce reduce viral replication Replication required SARS-CoV-2 SARS-COV-2 infection suppresse susceptible TCA cycle therapy TOR signalling Treatment understanding viral infection viral replication [DOI] 10.1038/s41467-021-22166-4 PMC 바로가기 [Article Type] Article
SARS-CoV-2-induced Overexpression of miR-4485 Suppresses Osteogenic Differentiation and Impairs Fracture HealingResearch Paper Published on 2021-03-252022-10-29 Journal: International Journal of Biological Sciences [Category] COVID-19, SARS, [키워드] ACE2 ACE2 receptor angiotensin-converting enzyme 2 biological activity Bone marrow cell entry COVID-19 patients differentiation Effect Fracture healing highlight in vitro in vivo miR-4485 Osteoblast Osteogenic receptor reduction regulate responsible SARS-CoV-2 suppresse target gene therapy tissue toll-like receptor 4 upregulated [DOI] 10.7150/ijbs.56657 PMC 바로가기 [Article Type] Research Paper
Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection알파-1 항트립신은 TMPRSS2 프로테아제 활성과 SARS-CoV-2 감염을 억제합니다Article Published on 2021-03-192022-09-10 Journal: Nature Communications [Category] SARS, 신약개발, 진단, 치료제, [키워드] acute phase airway epithelium Antiviral bind Bronchoalveolar lavage cell line cell lines circulating Concentration COVID-19 cultures Defense drug Factor fraction human airway epithelial identify infect inhibit inhibitor inhibitors inhibitors of SARS-CoV-2 innate immune knowledge membrane fusion Novel coronavirus physiological primary cell primary cells Protein respiratory respiratory pathogen respiratory tract SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 spike protein screened Serine serine protease serine protease inhibitor serine protease TMPRSS2 Spike protein suppresse the SARS-CoV-2 therapy TMPRSS2 TMPRSS2 protease Translational research Viral viral replication [DOI] 10.1038/s41467-021-21972-0 PMC 바로가기 [Article Type] Article
Cross-linking peptide and repurposed drugs inhibit both entry pathways of SARS-CoV-2가교 펩타이드 및 용도 변경 약물은 SARS-CoV-2의 두 진입 경로를 모두 억제합니다Article Published on 2021-03-092022-08-31 Journal: Nature Communications [Category] SARS, 신약개발, 치료제, [키워드] Antiviral approach Arbidol camostat cells Chloroquine cocktail Combination coronavirus Coronaviruses COVID-19 COVID-19 treatment Cross-linking drug combination Drug discovery effective Endocytic pathway Endosomal acidification ENhance entry pathway hamster hamsters identify in vitro in vivo inhibit inhibit SARS-CoV-2 inhibiting inhibitor mice pathway peptide Repurposed drug Repurposed drugs SARS-CoV SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 virus significantly suppress suppresse therapy TMPRSS2 TMPRSS2 inhibitor today treating COVID-19 Treatment treatment trial treatment trials umifenovir Viral viral replication virus entry [DOI] 10.1038/s41467-021-21825-w PMC 바로가기 [Article Type] Article
Hydroxychloroquine Effects on TLR Signalling: Underexposed but Unneglectable in COVID-19TLR 신호 전달에 대한 하이드록시클로로퀸 효과: 노출 부족이지만 COVID-19에서 무시할 수 없음Review Published on 2021-03-092022-09-10 Journal: Journal of Immunology Research [Category] SARS, 치료제, [키워드] balance Clinical data Clinical effect COVID-19 dependent on disease severity disease stage Effect Evidence HCQ Hydroxychloroquine Immunity Immunosuppression in vitro inhibit initial Interference outcome Prophylactic Randomized SARS-CoV-2 Side effects Stage supported suppresse target the disease therapeutic TLR Treatment treatment for COVID-19 Viral viral replication [DOI] 10.1155/2021/6659410 PMC 바로가기 [Article Type] Review