Environmental persistence of porcine coronaviruses in feed and feed ingredientsResearch Article Published on 2017-05-242022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] addition aliquot Blood Cell culture compared and analyzed Complete Concentration corn Corona coronavirus correlation Delta determine Dilution estimate ether Health inactivation incubated ingredient inoculated log Log reduction moderate negative correlation PEDV persistence plasma reduce Sample soybean survival temperature TGEV threat virus virus transmission Weibull model weighed [DOI] 10.1371/journal.pone.0178094 PMC 바로가기 [Article Type] Research Article
Aminopeptidase N is not required for porcine epidemic diarrhea virus cell entryArticle Published on 2017-03-282022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] alphacoronavirus aminopeptidase aminopeptidase N APN applied binding blocked cause Cell cell entry coronavirus diarrhea epidemic diarrhea examined exhibited expressed expressing expression functional gastroenteritis Genetic Genome had no HCoV-229E Hela host cell receptor Huh7 human cell line human coronavirus 229E indicated infect Infection intestinal epithelium knockout MDCK cell observation overexpression pathogenic coronavirus PEDV Porcine epidemic diarrhea virus preincubation Protein receptor reported required Result resulting S1 subunit Surface glycoprotein susceptibility susceptible TGEV these cell viral spike virus Virus cell entry viruses [DOI] 10.1016/j.virusres.2017.03.018 PMC 바로가기 [Article Type] Article
Bacillus subtilis and surfactin inhibit the transmissible gastroenteritis virus from entering the intestinal epithelial cellsResearch Articles Published on 2017-03-072022-10-28 Journal: Bioscience Reports [Category] Coronavirus, [키워드] addition aminopeptidase N Analysis Antiviral APN Apoptosis apoptotic cells B. subtilis Bacillus subtilis Bacillus subtilis OKB105 candidate Cell coronavirus declined develop dose-dependent manner EGFR ENhance Entry epidermal epithelial cell epithelial cell line experiment expression gastroenteritis growth factor host cell in vitro indicated Infection inhibit intestinal intestinal epithelial cell mechanisms Particle Pathogens performed Plaque assay Protein receptor receptors reduce reducing surfactin target TGEV Toll-like receptor up-regulating viral entry virus western blotting [DOI] 10.1042/BSR20170082 PMC 바로가기 [Article Type] Research Articles
Doxycycline Induces Mitophagy and Suppresses Production of Interferon-β in IPEC-J2 CellsMicrobiology Published on 2017-02-012022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] Coronavirus, [키워드] Apoptosis cell types cells coronavirus damaged demonstrated dose doxycycline Effect Evidence facilitated gastroenteritis IFN-β induce inhibit interrupt intestinal epithelium IPEC-J2 cells mitochondrial mitophagy morphology Production proliferation reactive oxygen specy Replication required ROS ROS production significantly TGEV viral infection [DOI] 10.3389/fcimb.2017.00021 PMC 바로가기 [Article Type] Microbiology
The Identification and Characterization of Two Novel Epitopes on the Nucleocapsid Protein of the Porcine Epidemic Diarrhea VirusArticle Published on 2016-12-192022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] addition Analysis Antisera cause characterization conserved contagious contribute coronavirus cross-reactivity death diagnostic diarrhea epidemic diarrhea epitope Freeze-thaw cycle hyperimmune identification IFA indicated indirect immunofluorescence intrinsically monoclonal antibody N protein Neonatal novel nucleocapsid protein overlapping PEDV protease residue screened significantly strain TGEV the N protein Treatment virus [DOI] 10.1038/srep39010 PMC 바로가기 [Article Type] Article
Characterization of an Immunodominant Epitope in the Endodomain of the Coronavirus Membrane ProteinArticle Published on 2016-12-102022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] antibody production assays can be used characterization coronavirus dominant endodomain epitope evaluated gastroenteritis IFA immunodominant immunodominant epitope immunofluorescence implication linear epitopes M protein mAb membrane membrane protein monoclonal antibody Protein Replication Research stimulate TGEV virus [DOI] 10.3390/v8120327 PMC 바로가기 [Article Type] Article
Transmissible Gastroenteritis Virus Infection Enhances SGLT1 and GLUT2 Expression to Increase Glucose UptakeResearch Article Published on 2016-11-162022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] activity basolateral cause coronavirus digestive disrupt EGFR Enzymes evaluate the effect expression Glucose GLUT2 increase infect infected cells Infection intestinal intestinal epithelial cells modulated promote reduce Replication target TGEV transmissible gastroenteritis virus uptake villus [DOI] 10.1371/journal.pone.0165585 PMC 바로가기 [Article Type] Research Article
TGEV infection up-regulates FcRn expression via activation of NF-κB signalingArticle Published on 2016-08-242022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] activated Activation addition Analysis binding site caused Cell characterized chromatin immunoprecipitation Degradation disease down-regulation electromobility shift assay Evidence expressed expression gastroenteritis IgG Infection inhibitor intestinal epithelial cell Neonatal Newborn NF-κB NF-κB signaling overexpression p65 pathogenic pathway Plasmid plasmids promoter promoter region PROTECT receptor regulated reported reporter Research TGEV transcription factor Transient Transport Treatment up-regulate up-regulated virus [DOI] 10.1038/srep32154 PMC 바로가기 [Article Type] Article
Tubulins interact with porcine and human S proteins of the genus Alphacoronavirus and support successful assembly and release of infectious viral particlesArticle Published on 2016-07-302023-06-16 Journal: Virology [Category] MERS, [키워드] assembly coronavirus incorporation Interaction intracellular transport microtubule Spike protein TGEV viral infectivity [DOI] 10.1016/j.virol.2016.07.022 PMC 바로가기 [Article Type] Article
New Chimeric Porcine Coronavirus in Swine Feces, Germany, 2012Letters to the Editor Published on 2016-07-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, MERS, [키워드] chimeric virus coronavirus feces Germany New PEDV PIGS porcine coronavirus Porcine epidemic diarrhea virus Recombination TGEV transmissible gastroenteritis virus viruses [DOI] 10.3201/eid2207.160179 PMC 바로가기 [Article Type] Letters to the Editor