Th2 – Page 7 – Communicable Diseases Research

The differential immune responses to COVID-19 in peripheral and lung revealed by single-cell RNA sequencing

Article

Published on 2020-10-202022-10-04
Journal: Cell Discovery [Category] 치료제,

A whole blood test to measure SARS-CoV-2-specific response in COVID-19 patients

Original Article

Published on 2020-10-102022-10-04
Journal: Clinical microbiology and infection : the official [Category] MERS, SARS, 진단,

[키워드] Abstract Activation Antigen approach characterized CMV COVID-19 COVID-19 patient diagnostic diagnostic test disease endothelial Enterotoxin evaluated expressed FGF fibroblast G-CSF GM-CSF granulocyte-colony stimulating factor growth factor IFN-γ IFN-γ IL-10 IL-12p70 IL-13 IL-15 IL-17A IL-1ra IL-2 IL-4 IL-5 IL-6 IL-7 IL-8 IL-9 Image immune response individual inflammatory protein interferon IP-10 Macrophage MCP-1 median MIP-1β monocyte chemoattractant protein-1 Multiplex analysis Necrosis objective parameters Patient PDGF peptide platelet-derived growth factor Protein RANTES regulated Result SARS-CoV-2 SARS-CoV-2 peptide SEB secreted Serology response significantly increased Specific response T cell T-cell T-cell based tests Th1 Th2 TNF-α Vaccine Vascular VEGF Whole blood with COVID-19
[DOI] 10.1016/j.cmi.2020.09.051 PMC 바로가기 [Article Type] Original Article

T-Cell Hyperactivation and Paralysis in Severe COVID-19 Infection Revealed by Single-Cell Analysis

단일 세포 분석으로 밝혀진 심각한 COVID-19 감염의 T-세포 과활성화 및 마비

Immunology

Published on 2020-10-082022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] abnormality activated CD25 CD4 CD4+ T-cell CD4+ T-cells Characteristics contribute COVID-19 COVID-19 patient cytokine Cytokine release syndrome differentiation dysregulation effector T-cell effector T-cells expressed expression facilitate FOXP3 furin Hyperactivation immunological immunopathology in silico lineages lung mechanism negative feedback negative feedback mechanisms pandemic paralysis Pathogenesis pathway promote protease receptor reduction regulatory T-cells (Tregs) Revealed RNA-seq dataset SARS-CoV-2 severe COVID-19 severe COVID-19 patient severe COVID-19 patients Single Cell single cell RNA-seq T-cell T-cell activation T-cells Th1 Th2 unique Viral viral entry
[DOI] 10.3389/fimmu.2020.589380 PMC 바로가기 [Article Type] Immunology

Immune Alterations in a Patient with SARS-CoV-2-Related Acute Respiratory Distress Syndrome

Original Article

Published on 2020-08-222022-10-30
Journal: Journal of Clinical Immunology [Category] COVID-19, MERS, SARS,

[키워드] Activation alteration antibody-secreting cells Antiviral Apoptosis approach Blood CD57 cell cytotoxicity clinical Cohort complementary conducted COVID-19 Cytokines effector T cell endothelial Europe Evolution exhibited expressing French hyperinflammatory status immune dysfunction immune response immunomodulator increase in longitudinal analysis lung trafficking marker Monocytes multiorgan failure nasopharyngeal NK-cell outcome pathophysiological Patient patients with COVID-19 populations pro-inflammatory cytokine storm Registered respiratory SARS-CoV-2 serum supplementary material T cell T cells Th1 Th2 Treatment viral replication
[DOI] 10.1007/s10875-020-00839-x PMC 바로가기 [Article Type] Original Article

Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates

Original Article

Published on 2020-07-282022-11-01
Journal: The New England Journal of Medicine [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome Analysis antibody Antigen BAL BAL fluid CD4 T-cell CD8 T-cell responses changes in coronavirus coronavirus disease detectable Dilution dose eight evaluate geometric mean titer groups histopathological Inflammation inhibitory lower airway lower airways lung mRNA-1273 mRNA-1273 vaccine nasal swab Neutralizing activity pathologic performed polymerase chain Prevent primate quantification Replication response Result robust SARS-CoV-2 serum Seven specimen specimens Spike protein T-cell T-cell Response Th2 type 1 helper undetectable Vaccine vaccine group viral genome viral replication were assessed
[DOI] 10.1056/NEJMoa2024671 PMC 바로가기 [Article Type] Original Article

Phenotype and kinetics of SARS-CoV-2-specific T cells in COVID-19 patients with acute respiratory distress syndrome

Research Articles

Published on 2020-06-262022-10-28
Journal: Science Immunology [Category] COVID-19, Fulltext, SARS,

[키워드] acute respiratory distress Admission ARDS CD4 CD8 Clinical outcome Coronaviruses COVID-19 COVID-19 case COVID-19 patient COVID-19 patients cross-reactivity cytokine deaths disease disease severity healthy control IL-10 IL-6 immune immunopathology in some Infection information intensive care Invasive mechanical ventilation longitudinal analysis moderate outbreak Patient patients phenotype produced required respiratory tract SARS-CoV-2 SARS-CoV-2-specific T cell Serum level Surface glycoprotein syndrome T cell T-cell T-cell Response Th1 cytokines Th17 Th2 the disease These data Vaccine design Variation
[DOI] 10.1126/sciimmunol.abd2071 PMC 바로가기 [Article Type] Research Articles

Can Unconventional Immunomodulatory Agents Help Alleviate COVID-19 Symptoms and Severity?

Opinion/Hypothesis

Published on 2020-05-132022-10-30
Journal: mSphere [Category] COVID-19, MERS, SARS,

Characterization of peritoneal cells from cats with experimentally-induced feline infectious peritonitis (FIP) using RNA-seq

Research Article

Published on 2018-08-072022-10-28
Journal: Veterinary Research [Category] Coronavirus,

[키워드] activated addition Allograft Alter Analysis APN Apoptosis Autoimmune disorders B cell Cell change characterization collected cytotoxicity DC-SIGN death deregulated disease Diseases dissemination down-regulated enrichment analysis Fever fold healthy Host immune complex indicated Interaction involved KEGG L-SIGN Laboratory less lymphopenia Macrophage mature macrophages MHC I mRNA mRNA expression NK cell other coronavirus pathogen pathway peritoneal macrophage populations receptor rejection RNA expression RNA-Seq serotype Signaling significantly Th1 Th2 transcript upregulated virus were infected
[DOI] 10.1186/s13567-018-0578-y PMC 바로가기 [Article Type] Research Article

Model of Persistent Salmonella Infection: Salmonella enterica Serovar Pullorum Modulates the Immune Response of the Chicken from a Th17-Type Response towards a Th2-Type Response

지속적인 살모넬라 감염 모델: 살모넬라 엔테리카 세로바 풀로룸이 닭의 면역 반응을 Th17 유형 반응에서 Th2 유형 반응으로 조절한다.

Article

Published on 2018-07-232024-08-22
Journal: Infection and Immunity [Category] 살모넬라증,

[키워드] Adaptive immunity CD4+ T cells chickens Macrophage macrophages persistent infection Salmonella Salmonella enterica serovar Enteritidis Salmonella enterica serovar Pullorum T cell immunity Th1 Th17 Th2

Helminths and malaria co-infections are associated with elevated serum IgE

헬민트와 말라리아 동시 감염은 혈청 IgE 수치 상승과 관련이 있다.

Research

Published on 2014-05-232024-08-13
Journal: Parasites & Vectors [Category] 말라리아,

[키워드] Ethiopia Helminths IgE malaria Th2
[DOI] 10.1186/1756-3305-7-240 PMC 바로가기 [Article Type] Research