A mRNA Vaccine Encoding for a RBD 60-mer Nanoparticle Elicits Neutralizing Antibodies and Protective Immunity Against the SARS-CoV-2 Delta Variant in Transgenic K18-hACE2 MiceRBD 60-mer 나노입자를 암호화하는 mRNA 백신은 형질전환 K18-hACE2 마우스에서 SARS-CoV-2 Delta 변이체에 대한 중화 항체 및 보호 면역을 유발합니다Article Published on 2022-07-062022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Against Antigen COVID-19 pandemic Delta delta variant displaying domain effective elicit encoding flexible hACE2 K18-hACE2 messenger Messenger RNA mRNA mRNA vaccine nanoparticle Neutralizing neutralizing antibody Neutralizing antibody response platform protective immunity provide RBD RBDs Receptor binding domain Receptor-binding domain RNA vaccine robust SARS-CoV-2 SARS-CoV-2 variant severe disease Spread the RBD the SARS-CoV-2 Transgenic mouse Vaccine [DOI] 10.3389/fimmu.2022.912898 PMC 바로가기 [Article Type] Article
The Impact of D614G Mutation of SARS-COV-2 on the Efficacy of Anti-viral Drugs: A Comparative Molecular Docking and Molecular Dynamics StudySARS-COV-2의 D614G 돌연변이가 항바이러스제의 효능에 미치는 영향: 분자 도킹 및 분자 역학 비교 연구Article Published on 2022-07-062022-09-11 Journal: Current microbiology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] affected Analysis antiviral drug antiviral drugs binding affinities binding affinity Cell cell surface Characteristics Comparative Coronaviruses cytarabine D614G D614G variant docking method docking result docking results drug Dynamics evaluated exhibited Impact In-vitro Interaction molecular docking molecular dynamics Molecular dynamics simulation mutated Mutation parameter rate of infection receptor reliability reported ribavirin Spike protein the binding affinity the RBD the spike protein was performed [DOI] 10.1007/s00284-022-02921-6 PMC 바로가기 [Article Type] Article
Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine Research Published on 2022-07-042022-10-05 Journal: Nature biomedical engineering [Category] COVID19(2023년), SARS, 임상, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome airway antibodies approved CD4+ CD8+ T cell coronavirus COVID-19 vaccine cytokine expression profile domain dose elicit elicited ENhance Exosome hamsters Immunity Infection Inflammatory Intramuscular injection live SARS-CoV-2 lung parenchyma Lungs mice mRNA vaccine mucosal IgA response Preclinical Testing RBD RBD-specific IgG reduced SARS-CoV-2 SARS-CoV-2 pseudovirus severe pneumonia temperature the RBD the vaccine Vaccine vaccine candidates Virus-like particle [DOI] 10.1038/s41551-022-00902-5 [Article Type] Research
A SARS-CoV-2 nanobody that can bind to the RBD region may be used for treatment in COVID-19 in animalsRBD 영역에 결합할 수 있는 SARS-CoV-2 나노바디는 동물의 COVID-19 치료에 사용될 수 있습니다Article Published on 2022-07-012022-09-11 Journal: Research in veterinary science [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] animals binding caused cells coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease in vitro in vivo infecting Infectious virus microorganism microorganisms nanobodies nanobody neutralizing antibody Prevent pseudovirus pseudoviruses RBD RBD protein respiratory S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 Spike RBD protein Severe acute respiratory syndrome spike the RBD the SARS-CoV-2 therapeutic effects therapeutic potential Treatment treatment of COVID-19 was obtained was used [DOI] 10.1016/j.rvsc.2022.02.003 PMC 바로가기 [Article Type] Article
Inhibition of SARS-CoV-2 pathogenesis by potent peptides designed by the mutation of ACE2 binding regionACE2 결합 영역의 돌연변이에 의해 설계된 강력한 펩티드에 의한 SARS-CoV-2 발병 억제Article Published on 2022-07-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding allergenicity angiotensin Angiotensin-converting enzyme antiviral peptide binding energy complex Computational approaches COVID-19 COVID-19 treatment criteria deaths determined by Diagnosis docked domain Drug development effective inhibitor entry inhibitors Final host receptor identify information inhibition inhibitor inhibitory action initial Interaction mechanism molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations Mutation OSPREY outbreak pandemic peptide Peptide design Peptide inhibitor Peptide Inhibitors peptides provided RBD RBD binding RBD residue RBD residues RBD-ACE2 Receptor-binding domain residue residues SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 pathogenesis screened Spike protein spread of COVID-19 targeting Template the RBD Therapeutics Treatment vaccination variant Viral entry inhibitors. viral infection virus was determined [DOI] 10.1016/j.compbiomed.2022.105625 PMC 바로가기 [Article Type] Article
Physicochemical effect of the N501Y, E484K/Q, K417N/T, L452R and T478K mutations on the SARS-CoV-2 spike protein RBD and its influence on agent fitness and on attributes developed by emerging variants of concernSARS-CoV-2 스파이크 단백질 RBD에 대한 N501Y, E484K/Q, K417N/T, L452R 및 T478K 돌연변이의 물리화학적 효과와 에이전트 적합성 및 우려되는 신흥 변이체에 의해 개발된 속성에 대한 영향Review Published on 2022-07-012022-09-11 Journal: Virology [Category] COVID19(2023년), SARS, 변종, [키워드] addition agent Alter attribute attributes binding caused changes in complex component convalescent sera Effect evade Evolution favor greater immune pressure immunodominant immunogenic induce inducer infection control infection process involved K417N L452R manuscript Mutation mutations N501Y occur Occurrence physicochemical Physicochemical effects Protective antibody RBD Receptor binding domain regions SARS-CoV-2 selective Spike protein spike protein RBD T478K target cells the RBD the SARS-CoV-2 the spike protein therapy Transmissibility turn Vaccine variant variant of concern variants of concern Viral transmission virulence virus virus expansion virus genome VoC VOCs [DOI] 10.1016/j.virol.2022.05.003 PMC 바로가기 [Article Type] Review
In silico screening of some compounds derived from the desert medicinal plant Rhazya stricta for the potential treatment of COVID-19 Research Published on 2022-07-012022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 치료기술, 치료법, 치료제, [키워드] Acidic Analysis antiviral activity aromatic group average binding affinities binding affinity binding free energy binding interaction Ceftazidime Cell Compound coronavirus COVID-19 demonstrated docking exceptional exhibited FIVE fraction functional greater groups Health high stability HPLC Hydrogen bond in silico in vitro study Interaction less lowest MD simulation Molecular dynamics simulation occurred oxygen pandemic penetration Potential treatment predict Protein RBD RBD residue Receptor binding domain required retained SARS-CoV-2 SARS-CoV-2 viral selected similarity suggested the RBD the SARS-CoV-2 these compound Toxicity Treatment [DOI] 10.1038/s41598-022-15288-2 [Article Type] Research
Impact of B.1.617 and RBD SARS-CoV-2 variants on vaccine efficacy: An in-silico approachB.1.617 및 RBD SARS-CoV-2 변이체가 백신 효능에 미치는 영향: In-silico 접근Article Published on 2022-07-012022-09-11 Journal: Indian journal of medical microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 affecting angiotensin antibody Antibody neutralization approach B.1.617 binding affinity conformational COVID-19 vaccine COVID-19 vaccines CR3022 determine docking docking analysis effective Enzymes Factor genomic Genomic surveillance greater higher affinity Immune escape Impact IMPROVE in silico in-silico India Infection Interaction less majority management MD simulation molecular molecular dynamics molecular interaction neutralization performed RBD RBD region RBD variant RBD variants receptor Replication responsible SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant second wave Seven Spike protein stability Surveillance the disease the RBD the spike protein Transmissibility Vaccine vaccine efficacy variant variants virulence wild type wild-type strain Wuhan Wuhan, China [DOI] 10.1016/j.ijmmb.2022.03.009 PMC 바로가기 [Article Type] Article
Receptor binding domain of SARS-CoV-2 from Wuhan strain to Omicron B.1.1.529 attributes increased affinity to variable structures of human ACE2우한 균주에서 Omicron B.1.1.529까지의 SARS-CoV-2 수용체 결합 도메인은 인간 ACE2의 가변 구조에 대한 증가된 친화성을 특성으로 합니다.Article Published on 2022-07-012022-09-11 Journal: Journal of infection and public health [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] ACE2 ACE2 receptor ACE2 receptors ACE2 variant ACE2 variants ACE2-RBD affinity analysed Analysis angiotensin Angiotensin-converting enzyme attribute B.1.1.529 binding binding domain binding efficiency binding energy Care caused changes in coding region complexes contributing to COVID-19 detect determine docking dynamic Dynamic simulation enzyme Genetic variant genetic variants global pandemic help highlight homology model Homology models Human human ACE2 human host Infectious disease Interaction isolates lead management molecular molecular dynamics nucleotide omicron pathogenic polymorphism Protein docking RBD RBD complex RBDs receptor Receptor binding domain Repository retrieved risk RMSD RMSF Safe SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 virus SARS‐CoV‐2 selected severity single nucleotide stability Structural variant structural variants Structure the RBD Total variant Variation was performed wildtype Wuhan Wuhan strain [DOI] 10.1016/j.jiph.2022.06.004 PMC 바로가기 [Article Type] Article
A novel high-throughput single B-cell cloning platform for isolation and characterization of high-affinity and potent SARS-CoV-2 neutralizing antibodies고친화도 및 강력한 SARS-CoV-2 중화 항체의 분리 및 특성화를 위한 새로운 고처리량 단일 B 세포 클로닝 플랫폼Article Published on 2022-07-012022-09-12 Journal: Antiviral Research [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE-2 receptor antibody B-cell binding Blood coronavirus COVID-19 Critical diagnosing Diseases domain effective ELISA high affinity highlight human cell Isolation mAb mAbs mAbs. Neutralizing Neutralizing activity neutralizing antibody Patient platform RBD RBD domain reporter S1 subunit SARS-CoV-2 SARS-CoV-2 neutralizing antibody single B cell Single B-cell cloning SPR Strategy the RBD the spike protein was used Wuhan-Hu-1 [DOI] 10.1016/j.antiviral.2022.105349 PMC 바로가기 [Article Type] Article