Translational studies of adrenomedullin and related peptides regarding cardiovascular diseases Reviews Published on 2022-01-062022-10-05 Journal: Hypertension research : official journal of the Ja [Category] 바이오마커, [키워드] Administered adrenomedullin bloodstream cardiovascular disease clinical trial CVD derivative derivatives Diseases endothelial expand expected heart failure increase in Infarction Inflammation Inflammatory bowel disease intervals less limitation marker Myocardial infarction peptide physiological functions pulmonary hypertension reduce restrict severe inflammation subcutaneous injection therapeutic translational Vascular [DOI] 10.1038/s41440-021-00806-y [Article Type] Reviews
Ivermectin shows clinical benefits in mild to moderate COVID19: a randomized controlled double-blind, dose-response study in LagosRandomized Controlled Trial Published on 2022-01-052022-10-05 Journal: QJM: An International Journal of Medicine [Category] SARS, 임상, [키워드] 95%CI ANOVA clinical benefit Clinical management conducted Control controls correlated COVID COVID 19 COVID19 Day dose dose response double blind double-blind Efficacy Efficacy and safety group high risk inhibit Lago Lopinavir/ritonavir Mild moderate negativity parallel group Patient Placebo Platelet positive patients Prophylaxis question Randomized reduced remained repeated measure reported SAE shown significantly the SARS-CoV-2 translational Treatment treatment groups viral replication [DOI] 10.1093/qjmed/hcab035 PMC 바로가기 [Article Type] Randomized Controlled Trial
Review of Ribosome Interactions with SARS-CoV-2 and COVID-19 mRNA VaccineReview Published on 2022-01-012022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] addition adverse effects Antigen Antiviral antiviral therapeutics approved cellular Characteristics concurrent contribute coronavirus 2 COVID-19 COVID-19 mRNA vaccine COVID-19 mRNA vaccines Critical dose Efficacy epidemiological facilitate feature genomic Host host mRNA immune responses Impact Infection Interaction interfere knowledge mRNA mRNA translation mRNA vaccine Mutation nonstructural protein offer pandemic pathogen Protein protein synthesis reduce Replication respiratory review ribosome ribosomes SARS-CoV-2 Spike protein target the SARS-CoV-2 therapeutic translation translational Vaccines variants of concern virus VOCs [DOI] 10.3390/life12010057 PMC 바로가기 [Article Type] Review
How to translate the knowledge of COVID‐19 into the prevention of Omicron variantsCOVID-19에 대한 지식을 오미크론 변종 예방으로 번역하는 방법Editorial Published on 2021-12-122022-09-10 Journal: Clinical and Translational Medicine [Category] SARS, 변종, 치료기술, [키워드] Biology booster characterized clinical coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 detect diagnostic disease disease severity disease transmission Endemic Genetic changes Immune escape knowledge life MONITOR new strain omicron Omicron variants populations Prevent prevention Spread therapeutic Therapies therapy translate translational Transmissibility Vaccinations variant variants Virology [DOI] 10.1002/ctm2.680 PMC 바로가기 [Article Type] Editorial
Raman spectroscopy: current applications in breast cancer diagnosis, challenges and future prospects Reviews Published on 2021-12-102022-10-05 Journal: British Journal of Cancer [Category] 바이오마커, [키워드] accompany Asymptomatic biochemical Breast cancer Cancer change death develop diagnosed Diagnosis disease early stages improvement in vivo information lack management molecular morphological changes outcome Patient probe Raman spectroscopy required Research Sensitivity and specificity survival tissue translational treated tumour [DOI] 10.1038/s41416-021-01659-5 [Article Type] Reviews
Repurposing old molecules for new indications: Defining pillars of success from lessons in the pastReview article Published on 2021-12-012022-10-05 Journal: European journal of pharmacology [Category] 신약개발, [키워드] addition adopted approach attrition biological assay Biomarker Characteristics clinical evaluation clinical trial Compound recycling de novo defined develop Diseases drug Drug repurposing Drug rescue Effects Efficacy element Evidence Extended profiling Formulation identify include indication indications key factor knowledge lack Market exclusivity methodology observation off-label overcome pharmacological Regulatory Repositioning model repurposing resources robust therapeutic utility timelines translational [DOI] 10.1016/j.ejphar.2021.174569 [Article Type] Review article
Cancer prevention, risk reduction, and control: opportunities for the next decade of health care delivery research암 예방, 위험 감소 및 통제: 의료 전달 연구의 다음 10년을 위한 기회Editorial Published on 2021-11-302022-09-11 Journal: Translational behavioral medicine [Category] SARS, 치료기술, [키워드] accelerated adaptation Cancer cancer care cancer prevention cancer survivorship cancer treatment Care clinician conceptualization COVID-19 Critical Early detection effort Evidence exploration Health Health care health care delivery research health systems Impact implementation IMPROVE Innovation knowledge learning health systems outcome pandemic Precision precision prevention. promise Research risk risk reduction survivorship translational [DOI] 10.1093/tbm/ibab109 PMC 바로가기 [Article Type] Editorial
633. Preliminary Results from a Phase 1 Single Ascending-Dose Study Assessing Safety, Serum Viral Neutralizing Antibody Titers (sVNA), and Pharmacokinetic (PK) Profile of ADG20: an Extended Half-Life Monoclonal Antibody Being Developed for the Treatment and Prevention of Coronavirus Disease (COVID-19)Poster Abstracts Published on 2021-11-042022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] acute respiratory syndrome Administered adverse event AEs Ambrose ambulatory patient Assessing being binding BSN clinical development Cohort Concentration conserved consultant coronavirus COVID-19 COVID-19 mRNA vaccines Developed dose Ellie employee epitope Evidence Extended Fc region Frank geometric healthy human IgG1 hypersensitivity reaction Inc injection intramuscularly intravenously Ligand Mild Moderate COVID-19 monoclonal antibody neutralization pandemic participant phase Phase 1 PK modeling Placebo plaque reduction neutralization predicted prevention prevention of COVID-19 profile Randomized RBD Reactions reported Result Safety SARS-CoV-2 SARS-COV-2 infection SARS-like CoV serious AEs Serum neutralizing antibody single dose Support the receptor-binding domain the spike protein Therapeutics titer Tolerability translational Treatment Trial Variation were assessed were measured [DOI] 10.1093/ofid/ofab466.831 PMC 바로가기 [Article Type] Poster Abstracts
General recommendation for assessment and management on the risk of glucocorticoid-induced osteonecrosis in patients with COVID-19Research article Published on 2021-11-012022-10-05 Journal: Journal of Orthopaedic Translation [Category] 바이오마커, [키워드] acute respiratory syndrome average blood flow calculated caused China Clinical characteristics Clinical data conducted convalescent COVID-19 patients Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients cross-sectional cumulative Diagnosis disease Disease prevention and control dosage dose Evidence favor Follow-up glucocorticoid Glucocorticoid treatment Glucocorticoids High dose incidence induce Infection joint destruction joints management Meta-analysis Methylprednisolone observation occurred Occurrence osteonecrosis pathogen Pathogenesis Patient patients with COVID-19 performed Prognosis protocol receiving reduced Research Result risk SARS patient Severe acute respiratory syndrome similarity supported systematic review Therapeutic strategies therapy therapy for COVID-19 translational Treatment Wuhan [DOI] 10.1016/j.jot.2021.09.005 [Article Type] Research article
Positive flow cytometry crossmatch with discrepant antibody testing results following COVID-19 vaccinationCOVID-19 예방 접종 후 불일치 항체 테스트 결과와 긍정적인 유세포 분석 교차 일치Case Reports Published on 2021-11-012022-09-11 Journal: American journal of transplantation : official jou [Category] MERS, SARS, 진단, 치료기술, [키워드] Activation alloantibody Allograft alloimmunity alloreactivity antibody Antibody assays Antibody testing Antigen antigens assays B cell B lymphocyte B lymphocytes bystander candidate clinical research/practice collected COVID-19 COVID-19 vaccination COVID-19 vaccine crossmatch Donor Effect flow cytometry highlight histocompatibility HLA-DR7 immunization immunobiology immunological kidney kidney transplantation: living donor kidney transplantation/nephrology living donor Lymphocytes memory response multi organ organ transplantation panel-reactive antibody (PRA) Patient positive prozone receiving risk translational translational research/science Vaccine [DOI] 10.1111/ajt.16753 PMC 바로가기 [Article Type] Case Reports